Clinical trials: Antibiotic-Associated Diarrhea
Antibiotic-Associated Diarrhea
Preventing Childhood Antibiotic-associated Diarrhea by Prebiotics
Prospective randomized double-blind study on the effect of prebiotics (inulin and fructo-oligosaccharides) in the prevention of antibiotic-associated diarrhea in children.
- Trial name
- WGAAD (NCT00826137)
- Testing
- Inulin and fructo-oligosaccharides.
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Soroka University Medical Center
Antibiotic-Associated Diarrhea
Probiotics at the Treatment of Antibiotic Associated Diarrhea
The purpose of this study is to know the efficacy of the treatment with probiotics, Lactobacillus casei and Bifidobacterium breve, on clinical evidences and occurence of relapses on antibiotic-associated diarrhea.
- Trial name
- NCT00700557
- Testing
- Probiotics - Lactobacillus casei and Bifidobacterium breve, Maize starch
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Federal University of Uberlandia
Acute Diarrhea
Probiotics for the Prevention of Antibiotic-Associated Diarrhea
In North America, one of the most common reasons for hospitalization in previously healthy children is for the treatment of infections with antibiotics.
- Trial name
- PAID (NCT02817165)
- Testing
- Probiotic (BioK+)
- Where
- 2 sites in Canada
- Volunteers
- 16 people
- Sponsor
- The Hospital for Sick Children
Antibiotic-Associated Diarrhea
Probiotics for Prevention of Antibiotic-associated Diarrhea
The purpose of this study is to evaluate if ingestion of a probiotic formula (Jarrow-Dophilus EPS)reduces incidence of diarrhea and improves the quality of life of patients receiving antibiotic therapy.
- Trial name
- NCT00641199
- Testing
- Jarro-Dophilus EPS probiotics
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- University of Saskatchewan
Enterocolitis, Pseudomembranous Colitis
Addition of Lactobacillus to Metronidazole in Treatment of CDAD
The purpose of this study is to determine whether dietary supplementation with Lactobacillus GG will reduce the rate of failure or relapse following treatment of CDAD with metronidazole.
- Conditions
- Enterocolitis, Pseudomembranous Colitis, Antibiotic-associated Colitis
- Trial name
- NCT00304863
- Testing
- Lactobacillus GG
- Where
- United States
- Sponsor
- Michael E. DeBakey VA Medical Center
Enterocolitis, Pseudomembranous Colitis
Fecal Bacterial Flora in Clostridium Difficile-Associated Diarrhea
The investigators propose to study intensively the bacteriology of feces in C. difficile associated diarrheal disease, using a variety of conventional and very up-to-date techniques.
- Conditions
- Enterocolitis, Pseudomembranous Colitis, Antibiotic-Associated Colitis
- Trial name
- NCT00304876
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Critical Illness, Antibiotic-associated Diarrhea
Probiotics For The Prevention of Antibiotics Associated Diarrhea in the Pediatric Intensive Care Unit
The goal of this prospective trial is to learn about lactobacillus use in critically ill pediatric patients. The main question[s] it aims to answer are: Is lactobacillus GG effective in preventing antibiotic associated diarrhea…
- Trial name
- NCT06109740
- Testing
- lactobacillus GG
- Volunteers
- 21 people
- Sponsor
- University of South Alabama
Antibiotics
Non-Inferiority Trial Comparing Eurofarma's Experimental Product Saccharomyces Boulardii Versus Floratil® in the Prevention of Antibiotic-Associated Diarrhea
The study's objective is to evaluate the efficacy and safety of two formulations for the prophylactic treatment of diarrhea in subjects using antibiotics.
- Trial name
- ACROSS (NCT01463943)
- Testing
- Probiotic
- Where
- 17 sites in Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Appendicitis, Appendicitis; Perforation
Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis
To determine the effectiveness of the use of probiotics in patients with a diagnosis of complicated appendicitis on antibiotic associated diarrhea (AAD).
- Trial name
- NCT04529980
- Testing
- Lactobacillus rhamnosus GG (LGG) Probiotic
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Children's Health
Clostridium Difficile Infection
Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea
This clinical study is conducted to assess the efficacy of cadazolid compared to vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD).
- Trial name
- NCT01983683
- Testing
- Cadazolid, Vancomycin
- Volunteers
- 631 people
- Sponsor
- Actelion
Antibiotic-associated Diarrhea
Efficacy and Safety of Sinquanon for Prevention of Antibiotic-associated Diarrhea in Adults
The purpose of this study is to evaluate the efficacy of a probiotic, SINQUANON, on the reduction of the occurrence of diarrhea associated with antibiotic use in adults.
- Trial name
- SPAADA (NCT05607056)
- Testing
- Sinquanon
- Where
- 3 sites in Bulgaria
- Volunteers
- 565 people
- Sponsor
- Neopharm Bulgaria Ltd.
Antibiotic-associated Diarrhea, Clostridium Difficile
Probiotic Saccharomyces Boulardii for the Prevention of Antibiotic-associated Diarrhoea
When patients in hospitals receive antibiotics they often develop diarrhoea. The consequences may be grave for the patient. Thus far, no preventive measure is available.
- Conditions
- Antibiotic-associated Diarrhea, Clostridium Difficile, Diarrhea
- Trial name
- SacBo (NCT01143272)
- Testing
- Saccharomyces boulardii
- Where
- 14 sites in Germany
- Volunteers
- 477 people
- Sponsor
- Bernhard Nocht Institute for Tropical Medicine
Clostridium Difficile
AssessmeNT of the Incidence of Clostridium Difficile Infections in Hospitalized Patients on Antibiotic TrEatment
During or after antibiotic treatment, antibiotic residues impair the intestinal microbiota (gut flora) and lead to adverse effects such as the emergence of bacterial resistance or the occurrence antibiotic-associated diarrhoea…
- Trial name
- ANTICIPATE (NCT02896244)
- Testing
- no intervention
- Where
- 34 sites in France, Germany and 4 more
- Volunteers
- 1,007 people
- Sponsor
- MJM Bonten
Diarrhoea
Probiotics for the Prevention of Antibiotics Associated Diarrhoea and Clostridium Difficile Associated Diarrhoea
The investigators aim to investigate whether the routine use of the probiotic formulation VSL#3 co-prescribed with antibiotics reduces the incidence of both Antibiotic associated diarrhoea and Clostridium Difficile associated…
- Trial name
- NCT00973908
- Testing
- VSL#3
- Where
- 5 sites in United Kingdom
- Volunteers
- 231 people
- Sponsor
- National Health Service, United Kingdom
Antibiotic Associated Diarrhea, Clostridium Difficile Infection
Probiotic Lactobacillus Reuteri to Prevent Antibiotic-associated Diarrhea and Clostridium Difficile-related Infections in Hospitalized Children
The purpose of this study is to determine if the daily intake of the probiotic Lactobacillus reuteri prevents antibiotic-associated diarrhoea and related Clostridium difficile infections in children and adolescents.
- Conditions
- Antibiotic Associated Diarrhea, Clostridium Difficile Infection, Gastroenteritis
- Trial name
- AADreuter (NCT01295918)
- Testing
- L reuteri in children on antibiotics
- Where
- 2 sites in Bulgaria
- Volunteers
- 100 people
- Sponsor
- St Marina University Hospital, Varna, Bulgaria
Radical Cystectomy, Surgical Site Infection
Optimized Perioperative Antibiotic Prophylaxis in Radical Cystectomy
Cystectomy with urinary diversion (ileal conduit, orthotopic ileal bladder substitute, continent catheterizable pouch) is the best treatment option for patients with muscle-invasive bladder cancer.
- Conditions
- Radical Cystectomy, Surgical Site Infection, Urologic Cancer, Perioperative/Postoperative Complications
- Trial name
- PAPRAC (NCT03305627)
- Testing
- Short PAP, Extended PAP
- Where
- 2 sites in Switzerland
- Volunteers
- 196 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Antibiotic Side Effect, Antibiotic-associated Diarrhea
Metagenomic and Metabolomic Reconstitution of Gut Microbiota After Broad Spectrum Antibiotic Therapy
In the United States, healthcare providers prescribe over 270 million antibiotic prescriptions each year. While antibiotics have transformed medicine and methods of treating life-threatening bacterial infection, broad spectrum…
- Conditions
- Antibiotic Side Effect, Antibiotic-associated Diarrhea, Antibiotic-induced Dysbiosis, Antibiotic-induced Epithelial Barrier Disintegrity
- Trial name
- NCT04171466
- Testing
- Ciprofloxacin + Metronidazole, SH-DS01
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Seed Health
Antibiotic-associated Diarrhea
L Rhamnosus ATCC 53103 & L Reuteri DSM 29063 Compared With L Rhamnosus ATCC 53103 for Preventing AAD in Children
This study will use a noninferiority design to examine whether the administration of L rhamnosus ATCC 53103 \& L reuteri DSM 29063 (Flostrum Baby) is no worse than (or as good as) the…
- Trial name
- FLOSTRUM (NCT04277156)
- Testing
- Lactobacillus rhamnosus ATCC 53103 & Lactobacillus reuteri DSM 29063, L rhamnosus ATCC 53103
- Where
- Poland
- Volunteers
- 892 people
- Sponsor
- Medical University of Warsaw
Antibiotic-Associated Diarrhea, Clostridium Difficile
Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapy
To determine whether symptomatic treatment of the diarrhea in CDAD reduces morbidity and mortality of this serious nosocomial infection in patients who have antibiotic-associated diarrhea. Both C.
- Trial name
- loperamide (NCT00591357)
- Testing
- loperamide
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Antibiotic-associated Diarrhea
Prevention of Antibiotic-Associated Diarrhoea With Prolardii
Prolardii contains intestinal bacteria, a yeast, a fructo-oligosaccharide and a plant extract that can contribute to the intestinal comfort.
- Trial name
- PAADI (NCT03256708)
- Testing
- Prolardii
- Where
- Belgium
- Volunteers
- 220 people
- Sponsor
- Therabel Pharma SA/NV