Clinical trials: Antibiotic Stewardship
Reproductive Tract Infections
Evaluation of Immediate v. Delayed CT/NG Test for Treatment in the ED
The purpose of this study is to determine if immediate availability of GeneXpert® CT/NG test results reduces the overtreatment rate for ED patients with suspected gonorrhea or chlamydia and to assess changes in clinician…
- Trial name
- NCT01989130
- Testing
- Roche AMPLICOR CT/NG, Cepheid Xpert CT/NG Test
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- George Washington University
Infectious Disease
Antibiotic Stewardship in Infectious Disease Departement
Consensual antibiotic protocols have been developed and validated locally by infectious disease specialists, internists and emergency physicians, in order to encourage their compliance.
- Trial name
- NCT03636711
- Testing
- antibiotic protocol, according to a syndromic approach
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Community Acquired Pneumonia
Biomarker Guided Antibiotic Treatment in Community-Acquired Pneumonia
The purpose of this study is to determine the efficacy of C-reactive protein and procalcitonin based guidelines versus standard of care to reduce duration of antibiotic exposure in patients hospitalized with community acquired…
- Trial name
- BIO-CAP (NCT03146182)
- Testing
- CRP-algorithm, PCT-algorithm
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Gertrud Baunbaek Egelund
Ventilator Associated Pneumonia
Antimicrobial Stewardship Program and Ventilator Associated Pneumonia
Antibiotic Stewardship Programs (ASPs) help clinicians improve the quality of patient care and improve patient safety through increased infection cure rates, reduced treatment failures; however, there are different techniques…
- Trial name
- NCT04097899
- Testing
- implementation of antimicrobial stewardship comprehensive care bundle program on ventilator associated pneumonia patients
- Volunteers
- 25 people
- Sponsor
- Zagazig University
Febrile Neutropenia (FN), Pediatric Cancer
Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia
The goal of this clinical trial is to evaluate whether stopping antibiotic treatment early is safe in paediatric patients with cancer who develop high-risk febrile neutropenia but show good clinical evolution and low biomarker…
- Conditions
- Febrile Neutropenia (FN), Pediatric Cancer, Hematologic Malignancies, Solid Tumors
- Trial name
- E-STOP2 (NCT07590648)
- Testing
- Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy
- Where
- 4 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Supracondylar Humerus Fracture, Infection
Supracondylar Pinning Antibiotic Stewardship (SPAS) Trial
Prospective, multi-center, randomized controlled trial studying infection rate with or without prophylactic antibiotics at the time of closed reduction and percutaneous pinning of pediatric supracondylar humerus fractures.
- Trial name
- SPAS (NCT04288206)
- Testing
- Cefazolin, normal saline
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Legacy Health System
Otitis Media, Antimicrobial Stewardship
Digital Otoscope Versus Education and Feedback for Otitis Media in Young Children
Randomized controlled trial involving 40 pediatric primary care clinicians with high rates of diagnosing and treating middle ear infections.
- Trial name
- NCT06731660
- Testing
- Education with personalized performance feedback, Use of digital otoscope
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Antibiotic Side Effect, Behavioral Changes
Improving Antibiotic Use in Urgent Care Facilities
This study will implement a comprehensive outpatient stewardship program targeting a large network of Urgent Care (UC) clinics within Intermountain Helathcare.
- Trial name
- SCORE_UC (NCT03932708)
- Testing
- CDC Core Elements of Outpatient Stewardship
- Where
- United States
- Volunteers
- 700,000 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Community Acquired Pneumonia in Children, Antibiotic Stewardship
Antibiotic Prescription in Children Hospitalized for Community-acquired Pneumonia
A study to observe how often antibiotics are prescribed in children hospitalized for pneumonia and how doctors decide if a child needs antibiotics or not. Parent satisfaction will also be recorded.
- Trial name
- NCT04681339
- Testing
- Antibiotic treatment, No antibiotic treatment
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Respiratory Infection (for Example, Pneumonia, Bronchitis), Antibiotic
Intermountain Stewardship in Community Outpatient Settings-Resources & Engagement-Pediatrics
The goal of this implementation project is to detail the process of implementing the best practice of antibiotic stewardship in the pediatric population across the Intermountain Health medical system.
- Conditions
- Respiratory Infection (for Example, Pneumonia, Bronchitis), Antibiotic, Antibiotic Duration, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- SCORE-Peds (NCT07334795)
- Testing
- Implementation strategies including training & education, EMR tools, audit & feedback reports, and facilitation
- Where
- United States
- Volunteers
- 259,000 people
- Sponsor
- Intermountain Health Care, Inc.
Infection, Antimicrobial Stewardship Program
Molecular Microbiology- Guided Antimicrobial Stewardship Versus Standard Stewardship in Hospitalized Patients
The goal of this clinical trial is to learn whether integrating rapid multiplex molecular microbiology results with predefined clinical and laboratory criteria into an antimicrobial stewardship program improves antimicrobial use…
- Conditions
- Infection, Antimicrobial Stewardship Program, Antimicrobial Resistance, Multiplex PCR
- Trial name
- PROACT (NCT07684300)
- Testing
- Protocolized Antimicrobial Stewardship Strategy, Standard Antimicrobial Stewardship
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Maria Espinosa Perez
Pleural Empyema
Evaluating Antibiotic Course Upon Adequate Treatment of Empyema
The study compares treatment strategies for treatment of pleural empyema (infected fluid in the chest). It will compare standard of care antibiotic course, 2-6 weeks, to a shorter course of antibiotics, 7 days.
- Trial name
- EvACUATE (NCT07862361)
- Testing
- shortened antibiotic course, Standard medical treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Pneumonia
Decreasing Unnecessary Antibiotics Prescribed for Possible Pneumonia Despite Normal Respiratory Rate and Oxygenation
The purpose of this study is to decrease unnecessary antibiotics prescribed to hospitalized patients for possible pneumonia by flagging patients with respiratory rates and oxygenation levels within reference ranges given prior…
- Trial name
- NCT05172791
- Testing
- Antibiotic stewardship messaging
- Where
- United States
- Volunteers
- 643 people
- Sponsor
- Brigham and Women's Hospital
Febrile Neutropenia, Hematological Malignancy
Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO
A multicenter open-label non-inferiority randomized clinical trial comparing the safety (non-inferiority) of short antibiotic treatment (72 hours) with an anti-pseudomonal carbapenem with regard to treatment failure in comparison…
- Trial name
- SHORT (NCT02149329)
- Testing
- Discontinuation of imipenem-cilastatin or meropenem
- Where
- 2 sites in Netherlands
- Volunteers
- 276 people
- Sponsor
- Amsterdam UMC, location VUmc
Multi-Drug Resistant Organisms, Late-Onset Sepsis, Neonatal
Using Antibiotics Wisely - An Antimicrobial Stewardship Program
There are significant variations in antimicrobial consumption across Canadian Neonatal Intensive Care Units (NICUs). Inappropriate and overuse of antibiotics can result in antimicrobial resistance and adverse outcomes among…
- Conditions
- Multi-Drug Resistant Organisms, Late-Onset Sepsis, Neonatal, Antimicrobial Resistance
- Trial name
- NCT04388293
- Testing
- Exposure of interest
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University of British Columbia
Community-acquired Pneumonia
DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia
Rationale: Uncertainty in the clinical and etiological diagnosis of community-acquired pneumonia (CAP) often leads to incorrect treatment and unnecessary use of broad-spectrum antibiotics.
- Trial name
- CAP-NEXT (NCT03360851)
- Testing
- low-dose CT, PoC-PCR
- Where
- 7 sites in Netherlands
- Volunteers
- 3,555 people
- Sponsor
- MJM Bonten
Surgical Site Infection, Antibiotic Resistant Infection
Antibiotic Stewardship Program in Pancreatic Surgery: a Multicenter Time Series Analysis (BIOSTEPS).
Rationale: Surgical site infection (SSI) is one of the most frequently reported postoperative complication, occurring in up to one-third of patients.
- Trial name
- BIOSTEPS (NCT04199494)
- Testing
- Antibiotic Stewardship Program
- Where
- 2 sites in Italy
- Volunteers
- 1,200 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Acute Respiratory Tract Infection, Otitis Media
Broad Implementation of Outpatient Stewardship
Reducing inappropriate antibiotic use is a key strategy to mitigate antibiotic resistance and adverse health effects associated with antibiotic exposure.
- Conditions
- Acute Respiratory Tract Infection, Otitis Media, Pharyngitis, Acute Sinusitis
- Trial name
- BIOS (NCT05127161)
- Testing
- Broad Implementation of Outpatient Stewardship (BIOS) intervention
- Where
- 5 sites in United States
- Volunteers
- 1,032 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Human Microbiome, Antibiotic Resistant Infection
Clinical/Microbiological Impact of a Specific Antimicrobial Stewardship Program for Nursing Homes
Background: In nursing homes, excessive and inappropriate use of antimicrobials, adverse events caused by these drugs, and infections by multidrug-resistant bacteria (MDRB) are more frequent than in the general population, posing…
- Conditions
- Human Microbiome, Antibiotic Resistant Infection, Nursing Homes
- Trial name
- PROA-SENIOR (NCT03543605)
- Testing
- PROA Experimental, PROA Control
- Where
- Spain
- Volunteers
- 1,667 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Infectious Disease
Infectious Diseases Experts as Part of the Antibiotic Stewardship Team in Primary Care
A cluster-randomised multicentre blinded clinical trial will be performed in six primary care centres located in the southern metropolitan area of Barcelona (Spain).
- Trial name
- IDASP (NCT04848883)
- Testing
- Advanced AMS program, Standard AMS program
- Where
- Spain
- Volunteers
- 1,389 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge