Clinical trials: Antibiotic Side Effect
Side-effect of Antibiotic, Efficacy
Pharmacokinetics and Pharmacodynamics of Linezolid Continuous and Intermittent Administration
The purpose of this study is to evaluate the therapeutic efficacy expressed in pharmacokinetic/pharmacodynamic (PK/PD) indices, the clinical response and the risk of adverse reactions following the continuous and intermittent…
- Conditions
- Side-effect of Antibiotic, Efficacy, Pharmacokinetics, Critical Illness
- Trial name
- NCT05801484
- Testing
- Linezolid continuous infusion
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Cluj Municipal Clinical Hospital
Changes in the Gut Microbiota During an Antibiotic Treatment
Gut Microbiota and Antibiotics - Prevention of Side Effects by New Prebiotics
Antibiotics disturb the balance of gut microbiota causing dysbiosis. The purpose of this double-blind placebo controlled intervention study is to investigate whether a new prebiotic product could prevent the side effects of…
- Trial name
- NCT03523936
- Testing
- Prebiotic product
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
Allergy Drug
De-labeling of Patients With False Diagnosis of Penicillin Allergy
The purpose of this study is to estimate the prevalence of penicillin allergy, evaluate the diagnostic value of the allergologic work-up used in the study, and the health effects of penicillin allergy.
- Trial name
- NCT03581604
- Testing
- Allergy work-up, Blood samples
- Where
- Norway
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Antibiotics Causing Adverse Effects in Therapeutic Use
Utility Assessment of a Pharmacy-to-Dose Daptomycin
A pharmacy-to-dose (PTD) service, also referred to as pharmacy-based dosing, describes an established practice where providers can consult pharmacists for the dosing of various medications.
- Trial name
- NCT05224687
- Testing
- Retroactive review of patient data of those receiving a dose of daptomycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Methodist Health System
Drug-Induced Liver Injury
Risk of Acute Liver Injury in Users of Antimicrobials
Moxifloxacin is a broad-spectrum antibacterial agent used to treat common community-acquired respiratory tract infections, complicated intra-abdominal infections, and pelvic inflammatory disease.
- Trial name
- NCT01434173
- Testing
- Moxifloxacin (Avelox, BAY12-8039), Amoxicillin, Amoxicillin plus clavulanic acid, Cefuroxime, Clarithromycin, Doxycycline, Levofloxacin, Telithromycin
- Where
- United States
- Volunteers
- 1,299,056 people
- Sponsor
- Bayer
Antibiotic Side Effect
Evaluation of Bifidobacterium Breve PRL2020 in Preventing Antibiotic-Associated Side Effects From Amoxicillin or Amoxicillin/Clavulanic Acid
This study aims to evaluate the efficacy and safety of the probiotic Bifidobacterium breve PRL2020 in preventing gastrointestinal and extra-intestinal side effects caused by Amoxicillin or Amoxicillin/Clavulanic Acid in pediatric…
- Trial name
- NCT06850714
- Testing
- Bifidobacterium breve PRL2020 (Brevicillin®), Amoxicillin or Amoxicillin/Clavulanic Acid
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Antibiotic Allergy
Support Tool for Antibiotic Allergy deLabeling
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%).
- Trial name
- STAAL (NCT06771440)
- Testing
- EPR search
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Urinary Tract Infections, Antiobiotic Stewardship
Post-Emergency Optimization of Antibiotic Therapy for Urinary Tract Infection (UTI)
Prospective, multicenter, non-interventional study conducted over 6 months, including patients presenting to the emergency department with suspected urinary tract infection managed as outpatients and discharged with or without…
- Conditions
- Urinary Tract Infections, Antiobiotic Stewardship, Emerging Infectious Disease
- Trial name
- REVIU48 (NCT07559318)
- Testing
- Adaptation of antibiotics therapy for outpatient urinary infection following emergency care
- Where
- 3 sites in France
- Volunteers
- 330 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Infection, Adverse Effects
Towards Reducing Resistance and Hematological Toxicity of Linezolid
The study will evaluate and improve the performance of pharmaco-statistical models previously developed in the compassionate use program in patients being treated with linezolid under clinical usage conditions.
- Trial name
- NCT00177723
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Antibiotic-associated Diarrhea
Antibiotic-Associated Diarrhea and the Role of Microorganisms in the Gut
Amoxicillin-clavulanate is an antibiotic commonly prescribed to treat a myriad of community-acquired infections. One of the most common adverse effects of amoxicillin-clavulanate is antibiotic-associated diarrhea (AAD).
- Trial name
- NCT04156555
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Head and Neck Neoplasms, UADT Neoplasm
Post-Operative Antibiotic Efficacy in Clean Contaminated Head and Neck Surgery: A Randomized Controlled Trial
The "Post-Operative Antibiotic Efficacy in Clean Contaminated Head and Neck Surgery" (PEACH) trial is a study designed to assess the necessity of post-operative antibiotics for preventing surgical site infections (SSIs) in…
- Conditions
- Head and Neck Neoplasms, UADT Neoplasm, Cancer of the Head and Neck, Antibiotic Resistant Infection
- Trial name
- PEACH (NCT06672471)
- Testing
- No Post Operative Antibiotics for intervention group, Post Operative Antibiotics for one day
- Where
- Pakistan
- Volunteers
- 170 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Drug Allergy, Antibiotic Allergy
Improved Basophil Activation Test (BAT) in the Diagnostics of Drug Allergy
Current study evaluates the use of the improved Basophil Activation Test (BAT) in the diagnostics of IgE-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs).
- Conditions
- Drug Allergy, Antibiotic Allergy, NSAID-Induced Anaphylactoid Reaction
- Trial name
- NCT03164044
- Where
- Belarus
- Volunteers
- 45 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology