Clinical trials: Antibiotic Prophylaxis, open to volunteers
Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis
STI Prophylaxis and Emergence of Antimicrobial Resistance
The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted…
- Conditions
- Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis, Antibiotic Resistance, Bacterial, Microbiome
- Trial name
- SPEAR (NCT06778083)
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University College, London
Congenital Syphilis
Evaluation of Antimicrobial Prophylaxis to Prevent Syphilis in Pregnancy in Patients at Risk in Rio de Janeiro, Brazil
The goal of this clinical trial is to learn if benzathine penicillin works to prevent maternal syphilis. It will also learn about the safety of benzathine penicillin.
- Trial name
- PRESERvE (NCT07189208)
- Testing
- Benzathine penicillin 2.4 million units, Counseling and intensified testing.
- Where
- 4 sites in Brazil
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthcare-associated Infections, Quality Culture and Leadership in Intensive Care
Perceptions of Leadership in Quality Culture for Infection Prevention Among Intensive Care Nurses and Unit-Based Assessment of Antimicrobial Resistance Indicators in Intensive Care Units
This study aims to examine intensive care nurses' perceptions of leadership in quality culture for infection prevention and to investigate antimicrobial resistance indicators at the intensive care unit level.
- Conditions
- Healthcare-associated Infections, Quality Culture and Leadership in Intensive Care, Infection Prevention and Control
- Trial name
- NCT07782372
- Volunteers
- 127 people
- Sponsor
- Yeliz Sapulu Alakan
Chromogenic Extrinsic Tooth Stains
Photodynamic Therapy for Preventing Recurrent Chromogenic Stains on Deciduous Teeth
Chromogenic extrinsic stains are common in children and frequently recur following conventional prophylaxis. Antimicrobial photodynamic therapy (aPDT) using methylene blue activated by red light has demonstrated antimicrobial…
- Trial name
- NCT07736339
- Testing
- Antimicrobial Photodynamic Therapy, Conventional Prophylaxis
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Overactive Bladder, Bladder Pain Syndrome
Bladder Botox UTI Antibiotic Prophylaxis
Overactive bladder (OAB) is a common condition with a prevalence of 17% in the general population that significantly affects quality of life.
- Trial name
- NCT06387329
- Testing
- Nitrofurantoin 100 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Urinary Tract Infections, Urinary Tract Infection (UTI)
Alternative Prophylaxis in Female Recurrent Urinary Tract Infections
Urological pathogens are effected by rising antimicrobial resistance rates due to the frequent use of antimicrobials for treatment and prophylaxis.
- Trial name
- AlP-FrUiT (NCT04095572)
- Testing
- intravesical instillation with HA-CS, intravesical instillation of sterile purified water
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Open Fracture
Placement of Antibiotic Powder in Wounds During the Emergency Room
This is the first prospective controlled study to determine whether the topical application of vancomycin powder reduces infection-related complications when applied to open fracture injuries in the acute emergency department…
- Trial name
- POWDER (NCT03765567)
- Testing
- Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Antibiotic Prophylaxis Surgery
Efficacy and Safety of Intraosseous Antibiotic Prophylaxis in Total Hip Replacement
The goal of this clinical trial is to learn if intraosseous antibiotic (cefazolin) administration can improve antibiotic levels in adults undergoing primary total hip replacement.
- Trial name
- NCT07549542
- Testing
- CeFAZolin 1000 MG, Saline (0.9%, sterile, for infusion)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Idiopathic Overactive Bladder, Postoperative Urinary Tract Infection
Antibiotic Prophylaxis for Bladder Botox
Injection of Botox into the bladder is a common treatment for overactive bladder. Postoperative bladder infection is one of the more frequently reported complications of this procedure.
- Trial name
- NCT04444440
- Testing
- Ciprofloxacin
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- University of Alberta
Early Ventilator Associated Pneumonia, Acute Brain Injuries
PK/PD Target Attainment of Ceftriaxone for the Prevention of Early Ventilator-associated Pneumonia in Neurologically Injured Patients
Critically ill patients admitted for acute brain injury are exposed to many heath-care associated infections such as ventilator associated pneumoniae (VAP).
- Trial name
- NeuroPKVAP (NCT07450404)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Preterm Premature Rupture of Membrane, Pregnancy, High Risk
Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)
To conduct an unblinded pragmatic randomized controlled trial (pRCT) "Improvement of PPROM Management with Prophylactic Antimicrobial Therapy (iPROMPT)" of a seven-day course of ceftriaxone, clarithromycin, and metronidazole…
- Conditions
- Preterm Premature Rupture of Membrane, Pregnancy, High Risk, Preterm Birth
- Trial name
- NCT06396078
- Testing
- Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ohio State University
Pneumonia, Ventilator-Associated
Tobramycin Nebulization to Prevent Multidrug-Resistant Ventilator-Associated Pneumonia
The TOP-MDRVAP trial will test whether inhaled tobramycin can safely prevent pneumonia caused by multidrug-resistant bacteria in adults who need a breathing machine. Tobramycin is an antibiotic.
- Trial name
- TOP-MDRVAP (NCT07856355)
- Testing
- Tobramycin inhalation solution
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Recurrent Acute Otitis Media
Effect of Ventilation Tubes in Otitis-prone Children
The purpose of this study is to investigate the effects of ventilation tubes in children with recurrent ear infections. By drawing lots, young children with recurrent ear infections will be assigned to one of two groups…
- Trial name
- NCT05348291
- Testing
- ventilation tubes
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Lund University
Gastric Cancer
Gastric Cancer Prevention for Indigenous Peoples
The incidence of gastric cancer in local indigenous peoples is higher than the non-Indigenous counterpart in Taiwan. How to design an effective prevention strategy for gastric cancer is of importance.
- Trial name
- NCT03900910
- Testing
- Gastric cancer prevention, Execution of the program
- Where
- Taiwan
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Breast Cancer, Breast Surgery
Evaluation of the Effect of Antibiotic Prophylaxis During Lumpectomy for Breast Cancer: Prospective Randomised Double-blind Noninferiority Study of Placebo vs Cefazolin
The goal of this clinical trial is to determine whether preoperative antibiotic prophylaxis with cefazolin is necessary to prevent surgical site infections in adult women undergoing breast-conserving surgery (lumpectomy or…
- Conditions
- Breast Cancer, Breast Surgery, Surgical Site Infection (SSI), Surgical Site Infection Prevention
- Trial name
- PROPHY-SEIN (NCT07898943)
- Testing
- Cefazolin 2 g Infusion
- Where
- 33 sites in France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Clermont-Ferrand
Kidney Transplant, Urinary Tract Infection(UTI)
Antibiotics for Kidney Transplant Recipients
The goal of this clinical trial is to learn if a common antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX) can help prevent urinary tract infections (UTIs) in children and young adults who recently had a kidney transplant.
- Conditions
- Kidney Transplant, Urinary Tract Infection(UTI), Antibiotic Prophylaxis, Remote Patient Monitoring
- Trial name
- TASK (NCT07106125)
- Testing
- Trimethoprim-Sulfamethoxazole (TMP-SMX), Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Critical Illness, Mechanical Ventilation
Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Controlled Trial
Ventilator-associated pneumonia (VAP) remains the most common hospital-acquired infection worldwide, affecting up to 40% of mechanically ventilated patients and contributing to increased morbidity, prolonged hospital stays, and…
- Trial name
- MICRO-VAP (NCT07463339)
- Testing
- Microbiome-guided inhaled antibiotic prophylaxis
- Volunteers
- 70 people
- Sponsor
- University of Calgary
Lung Transplantation
Film Array Pneumonia Plus Panel® Multiplex PCR for Early Adaptation of Antibiotic Prophylaxis During Lung Transplantation
Postoperative pneumonia significantly worsens the prognosis for patients undergoing lung transplantation (LT). It is therefore recommended to use antibiotic prophylaxis after LT, although the specific types of antibiotics or the…
- Trial name
- FilmArray-TP (NCT07792018)
- Testing
- Early adapation of antibiotic prophylaxis according to FAPP results.
- Volunteers
- 98 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Healthcare-Associated Infections (HAIs), Carbapenem-Resistant Enterobacteriaceae Colonization
Correlation Between Carbapenemase-Producing Enterobacterales Load, Environmental Contamination, and Transmission in Critical Care Units
Carbapenemase-producing Enterobacterales (CPE) are multidrug-resistant bacteria that can colonize the gastrointestinal tract of hospitalized patients and spread within intensive care units (ICUs).
- Conditions
- Healthcare-Associated Infections (HAIs), Carbapenem-Resistant Enterobacteriaceae Colonization, Antimicrobial Resistance (AMR)
- Trial name
- CPE-Load ICU S (NCT07685132)
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Italiano de Buenos Aires
Surgical Site Infection
Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study
This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections…
- Trial name
- CALIPSO (NCT05447559)
- Testing
- Cefazolin, Water for injection
- Where
- 27 sites in United States, Australia and 3 more
- Volunteers
- 9,180 people
- Sponsor
- Monash University