Clinical trials: Anosmia
Clinical Trial
Effect of Nasal Steroid in the Treatment of Anosmia Due to COVID-19 Disease
Background: Anosmia is a debilitating common symptom of COVID-19. The therapeutic effect of systemic steroid for the treatment of anosmia has been studied with various findings of its efficacy.
- Trial name
- NCT04569825
- Testing
- Ophtamesone
- Where
- Iraq
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Of Anbar
COVID-19
Detection Dogs as a Help in the Detection of COVID-19
Canine olfactive detection has proven its efficacy in numerous situations (explosives, drugs, bank notes…) including for early diagnosis of human diseases: various cancers, alert of diabetic or epileptic people in immediate alarm…
- Trial name
- COVDOG (NCT05205655)
- Testing
- collection of odour samples
- Where
- Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hôpital Universitaire Sahloul
Obesity & Overweight, Insulin Resistance Syndrome
SENSILINS: Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level
This single-center, randomized, single-blind, 2-period crossover interventional study will evaluate whether exposure to a pleasant food odor 10 minutes before a 75 g oral glucose tolerance test (OGTT) modifies glucose homeostasis…
- Trial name
- SENSILNS (NCT07638111)
- Testing
- Pleasant Food Odor Stimulation, Control Environmental Condition
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
COVID-19
Study of Neurological Damage From Coronavirus Disease (COVID-19)
The objective of this study is to support the exploration of the NEURO-COVID-19 database and in particular to carry out the post-treatments necessary to derive quantitative information on the characterization of the lesion load…
- Trial name
- NeuroBiomarK (NCT05079373)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
Acromegaly, Olfactory Disorder
Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients
A prospective, controlled, single blinded study was planned. 20 patients with Acromegaly (Acromegaly Group) and 20 healthy subjects (Control Group) were planned to include in the study.
- Trial name
- NCT04138537
- Testing
- OB volume, CCCRC test
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Anosmia, Ageusia
Efficacy of Photobiomodulation in the Rehabilitation of Olfactory Dysfunctions Induced by Long COVID-19
On January 30, 2020, the WHO (World Health Organization) declared the new coronavirus pandemic as the sixth public health emergency of international concern.
- Conditions
- Anosmia, Ageusia, COVID-19, Rehabilitation
- Trial name
- NCT06423495
- Testing
- low-intensity laser treatment
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gaffree & Guinle Universitary Hospital
COVID-19
Qualitative and Quantitative Evaluation of Anosmia Over Time in Clinically Symptomatic Patients Tested for COVID-19 Infection
Loss of sense of smell and taste has been anecdotally reported during the covid-19 epidemic. The study investigators wanted to describe the prevalence of olfactory and gustatory dysfunction and assess the factors associated with…
- Trial name
- Anosmie-COVID (NCT04354857)
- Testing
- olfactory and gustatory tests
- Where
- France
- Volunteers
- 454 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Traumatic Anosmia
The Effect of Oral Theophylline on Traumatic Anosmia
This study aimed to improve the treatment outcomes of patients with post-traumatic anosmia through medication and olfactory training.
- Trial name
- theophylline (NCT07171021)
- Testing
- Theophylline 200 mg, olfactory training
- Where
- Taiwan
- Volunteers
- 158 people
- Sponsor
- Taichung Veterans General Hospital
Alcohol Dependence
Feasibility of Integrating Olfactory Stimuli Into Virtual Reality Cue Exposure for Patients With Alcohol Dependence
Alcohol dependence (AD) is a prevalent and burdensome clinical condition with high relapse rates. A central risk factor for relapse is craving for alcohol, which can be evoked by both real-world and virtual cues in immersive…
- Trial name
- NCT07388693
- Testing
- VR Cue-Exposure Including Olfactory Stimuli
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Idiopathic Anosmia, Idiopathic Hyposmia
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
Test of early warning signs and RT-QuIC in patients with idiopathic olfactory dysfunction
- Conditions
- Idiopathic Anosmia, Idiopathic Hyposmia, Idiopathic Olfactory Dysfunction
- Trial name
- AROMA (NCT05740683)
- Testing
- RT-QuiC
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Dementia Research Centre
Post COVID-19 Anosmia (Loss of Smell)
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.
Investigating the potential role of Aerosolized retinoic acid, a potent Vitamin A metabolite for treating COVID-19 Anosmia and retinoic acid insufficiency .A novel approach for regaining Sense of Smell.
- Trial name
- NCT05002530
- Testing
- Aerosolized 13 cis retinoic acid plus Vitamin D, Aerosolized All trans retinoic acid plus Vitamin D, Standard therapy
- Where
- 3 sites in China, Egypt and 1 more
- Volunteers
- 10,000 people
- Sponsor
- Kafrelsheikh University
Anosmia
Does Cardiopulmonary Bypass Change Olfaction?
The loss of the sense of smell, anosmia, can have profound effects on the lives of those who suffer from it. In our clinical practice, we have encountered several patients complaining of anosmia after recently undergoing surgery…
- Trial name
- Anosmia (NCT02179554)
- Where
- United Kingdom
- Sponsor
- Manchester University NHS Foundation Trust
Smell Disorders
Efficacy and Safety of Phototherapy in the Treatment of Loss of Smell Post Acute Infection of Coronavirus 19
The aim of this study is to assess whether the use of a therapy combining olfactory training, corticoids, and phototherapy improves the PROMS compared to the use of olfactory training and corticosteroids only.
- Trial name
- NCT05177445
- Testing
- Phototherapy, OT+Corticosteroids
- Where
- Ecuador
- Volunteers
- 40 people
- Sponsor
- Respiralab
COVID-19
Diagnostic Value of Patient - Reported and Clinically Verified Olfactory Disorders (COVID-19)
Participants are healthcare workers and adult outpatients referred in a COVID-19 screening center. Patients-reported symptoms are collected, then participants underwent a simple olfactory test (CODA for Clinical Olfactory…
- Trial name
- COVID-OLFA (NCT04407494)
- Testing
- Reporting of anosmia, ageusia and other clinical symptoms
- Where
- France
- Volunteers
- 809 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Testicular Cancer
Taste, Smell and Chemotherapy (TASTY)
Taste and smell abnormalities are common in cancer patients undergoing chemotherapy, with a prevalence ranging from 46% to 77% for taste changes, and 35% to 75% for smell changes.
- Trial name
- TASTY (NCT01641172)
- Testing
- Dexa scan, audiogram, measurement of heart rate variability and baroreflex sensitivity
- Where
- Netherlands
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Covid19, Olfactory Dysfunction
Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function.
- Trial name
- DysOSMIC (NCT06482138)
- Testing
- Biopsy and Cytobrush
- Where
- 7 sites in Belgium, Germany and 1 more
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Anosmia
Efficacy of Platelet-rich Plasma in Management of Anosmia
Olfactory dysfunction is a prevalent disorder that affects up to 20% of the general population and has significant effects on a person's quality of life as well as increased morbidity and mortality (Croy I et al., 2014;Nordin S…
- Trial name
- NCT06930248
- Testing
- Platelet rich plasma injection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Sequelae of; Infection, Post Infection Glomerulonephritis
Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2
Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period.
- Conditions
- Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder)
- Trial name
- sequelae (NCT04846010)
- Testing
- PurWet, FurFat, PurApo
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- All Natural Medicine Clinic, LLC
Anosmia, Hyposmia
Stellate Ganglion Block for COVID-19-Induced Olfactory Dysfunction
Chronic olfactory dysfunction from the COVID-19 pandemic is a growing public health crisis with up to 1.2 million people in the Unites States affected.
- Conditions
- Anosmia, Hyposmia, Parosmia, Olfactory Disorder
- Trial name
- NCT05445921
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Anosmia, Asymptomatic COVID-19
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
The purpose of this study is to learn more about how to better track smell recovery in people who have been infected with the SARS-CoV-2 virus (which causes COVID-19).
- Conditions
- Anosmia, Asymptomatic COVID-19, COVID-19 Respiratory Infection, Influenza
- Trial name
- NCT05040659
- Testing
- AROMHA Longitudinal Smell Test
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital