Clinical trials: Ankylosing Spondylitis (AS)
Axial Spondyloarthritis (axSpA), Ankylosing Spondylitis (AS)
Evaluation of the Expression and Functions of the KIR3DL2 Receptor and the Anti-inflammatory Activity of IPH4102 in Blood Samples
the main objectives are 1. to study the pathophysiological role of KIR3DL2 in axSpA and its relationship with Th17 immunity in HLA-B27 + and HLA-B27- patients and 2.
- Trial name
- KIR3DL2 (NCT03322618)
- Testing
- blood samples
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ankylosing Spondylitis
Canadian Humira Post Marketing Observational Epidemiological Study: Assessing Effectiveness in Ankylosing Spondylitis
The current study will assess the real - life effectiveness of adalimumab in the management of Ankylosing Spondylitis (AS) with emphasis on the prevention and management of extra-articular manifestations.
- Trial name
- Complete-AS (NCT01387802)
- Where
- 56 sites in Canada
- Volunteers
- 722 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Ankylosing Spondylitis
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Ankylosing Spondylitis
The purpose of the study is to demonstrate the efficacy, safety and tolerability of bimekizumab administered subcutaneously (sc) compared to placebo in the treatment of subjects with active ankylosing spondylitis (AS).
- Trial name
- BE MOBILE 2 (NCT03928743)
- Testing
- Bimekizumab
- Where
- 83 sites in United States, Belgium and 12 more
- Volunteers
- 332 people
- Sponsor
- UCB Biopharma SRL
Ankylosing Spondylitis
Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs
The goal of this research is to assess the percentage of non-responders to ≥ 2 NSAIDs candidates a biological therapy that could adequately respond to treatment with etoricoxib This study confirm the result of a previous study in…
- Trial name
- NCT01091675
- Testing
- Etoricoxib
- Where
- 14 sites in Spain
- Volunteers
- 58 people
- Sponsor
- Spanish Foundation of Rheumatology
Ankylosing Spondylitis (AS), Irisin
The Effect of Exercise on Serum Irisin Levels and Clinical Parameters in Patients With Axial Spondyloarthritis.
This study aimed to investigate the effects of high-intensity intermittent exercise and moderate-intensity continuous exercise on serum irisin levels, disease activity, functional status, and quality of life in patients with…
- Trial name
- NCT07327073
- Testing
- High-Intensity Interval Training, Moderate-Intensity Continuous Exercise, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Osteoarthritis, Rheumatoid Arthritis
Observational Study on Non-steroid Anti-inflammatory Drugs (NSAIDs) Treated Patients With Arthritic Disorder
The aim of this study is to find out how patients with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis receiving NSAID-therapy are treated and managed by their doctor in usual clinical practice, how patients…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- EVIDENCE (NCT01176682)
- Where
- 244 sites in Belgium, France and 10 more
- Volunteers
- 1,149 people
- Sponsor
- AstraZeneca
Ankylosing Spondylitis, Therapeutic Agent Toxicity
A Randomized Open-labeled Study for Comparing Methods of Using Imrecoxib to Treat AS
The selective cox-2 inhibitor has been widely used in the treatment of Ankylosing spondylitis (AS). The Imrecoxib is a new cox-2 inhibitor. But the treatment strategy has not been decided yet.
- Trial name
- NCT04400786
- Testing
- intermittent treatment, continuous treatment
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Shanghai Zhongshan Hospital
Ankylosing Spondylitis(AS)
Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS)
1. To determine the effect of Golimumab treatment on the number and function of Endothelial Progenitor Cells (EPCs) in Ankylosing Spondylitis(AS) patients as a possible mechanism for the effect of this treatment on endothelial…
- Trial name
- AS (NCT01212653)
- Testing
- Simponi, 0.9ml sodium chloride
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Ankylosing Spondylitis
Modeling Spinal Mobility in Ankylosing Spondylitis: Towards New Telekinetic Biomarkers
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease that mainly affects the spine and pelvis in its axial form.
- Trial name
- TELESPA (NCT05570656)
- Testing
- XSENS-Awinda
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Spondyloarthropathies, Ankylosing Spondylitis (AS)
Psychosocial and Functional Factors in AxSpA
This observational, cross-sectional study aims to characterize patients with axial spondyloarthritis (AxSpA) from a biopsychosocial perspective.
- Trial name
- NCT06688929
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Universidad de Extremadura
Ankylosing Spondylitis
A Study to Evaluate the Long Term Safety and Efficacy of Bimekizumab in Subjects With Ankylosing Spondylitis
This is a study to assess the long term safety and tolerability of bimekizumab in subjects with ankylosing spondylitis
- Trial name
- BE AGILE 2 (NCT03355573)
- Testing
- Bimekizumab
- Where
- 50 sites in United States, Bulgaria and 8 more
- Volunteers
- 255 people
- Sponsor
- UCB Biopharma SRL
Spondyloarthritis
A Study to Evaluate Efficacy and Safety of Upadacitinib in Adults With Axial Spondyloarthritis
This protocol includes 2 standalone studies with randomization, data collection, analysis and reporting conducted independently.
- Trial name
- SELECT-AXIS 2 (NCT04169373)
- Testing
- Upadacitinib
- Where
- 212 sites in United States, Argentina and 23 more
- Volunteers
- 734 people
- Sponsor
- AbbVie
Rheumatoid Arthritis, Ankylosing Spondylitis
An Observational, Prospective Study to Assess the Efficacy and Safety of Adalloce in Patients With RA and AS
This Study is to Assess the Efficacy and Safety of Adalloce in Patients With Rheumatoid Arthritis and Ankylosing Spondylitis, An Observational, Prospective Study
- Trial name
- NCT05835518
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Yuhan Corporation
Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA)
German Spondyloarthritis Inception Cohort
The German Spondyloarthritis Inception cohort (GESPIC) was started 2000 as a prospective, longitudinal, multicentre, nationwide study in Germany on patients with early SpA including ankylosing spondylitis (AS, also known as…
- Conditions
- Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA), Axial Psoriatic Arthritis (axPsA), Acute Anterior Uveitis (AAU)
- Trial name
- GESPIC (NCT01277419)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Axial Spondyloarthritis, Ankylosing Spondylitis (AS)
The Disease Progression of Chinese Axial Spondyloarthritis in a Real-word Cohort Study
An observational, ambispective cohort to learn about the disease progression of axial spondyloarthritis (axSpA) according to the changes from baseline in measures of disease activity, function, and imaging.
- Trial name
- DPCASPA (NCT06844643)
- Where
- China
- Volunteers
- 2,250 people
- Sponsor
- China-Japan Friendship Hospital
Pharmacokinetics, Safety Issues
A Clinical Study With Adalimumab Biosimilar
The study aims to evaluate the pharmacokinetic profile, safety profile, and immunogenic potential of adalimumab of a new citrate-free formulation of adalimumab (Adalimumab Richmond) [Test Product] vs.
- Trial name
- NCT06291948
- Testing
- Humira® (adalimumab) AC Pen [Reference Product], Adalimumab Richmond [Test Product]
- Where
- Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Laboratorios Richmond S.A.C.I.F.
Spondylarthropathies; Spondylitis, Ankylosing
Safety of Etoricoxib (MK-0663) in Patients With Spondyloarthropathy (SpA)/Ankylosing Spondylitis (AS) in Sweden (EP07013.013.11.082)
The study is intended to provide additional post-marketing safety data regarding the use of etoricoxib for the indication of ankylosing spondylitis.
- Trial name
- NCT01327638
- Testing
- etoricoxib, Other COX-2 inhibitor, nsNSAIDs
- Volunteers
- 21,108 people
- Sponsor
- Organon and Co
Ankylosing Spondylitis
Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients
To identify new candidate genes and proteins that are differentially expressed in responders' vs non-responders to anti-TNF alpha therapy at the several time points the investigators will use the transcriptomic and proteomic…
- Trial name
- NCT02492217
- Testing
- Adalimumab
- Where
- Portugal
- Volunteers
- 69 people
- Sponsor
- Universidade Nova de Lisboa
Ankylosing Spondylitis
Investigating the Use of Salaso to Improve Physiotherapy Management of Ankylosing Spondylitis (AS).
This is a pilot study to investigate the use of Salaso, a web based exercise app, to increase access to physiotherapy and improve physical activity in patients attending St James's Hospital Rheumatology for Ankylosing Spondylitis…
- Trial name
- NCT03457285
- Testing
- Physiotherapy
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- St. James's Hospital, Ireland
Rheumatoid Arthritis, Ankylosing Spondylitis
Quality of Life Outcomes of HUMIRA in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS) After Unsustainable Response to Biologicals and Disease Modifying Antirheumatic Drugs
The aim of this post-marketing observational study is to obtain further data on the evaluation of quality of life outcomes of HUMIRA® in routine clinical use in patients with Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01083693
- Where
- 20 sites in Austria
- Volunteers
- 162 people
- Sponsor
- Abbott