Clinical trials: Angiogenesis
NSCLC, Angiogenesis
The Combination of Anlotinib and Immune Checkpoint Inhibitors for Advanced NSCLC Patients With Muti-line Therapy
Immunotherapy has made a major progress in Lung cancer.However, challenges such as primary and acquired resistance, small fraction of benefit population and lack of predictive and prognostic biomarkers even exist.
- Conditions
- NSCLC, Angiogenesis, Immunotherapy
- Trial name
- NCT04670107
- Testing
- Anlotinib in combination with Immune checkpoint inhibitors
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Ovarian Neoplasms, Fallopian Tube Neoplasms
Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian Cancer
Niraparib is an oral, potent and highly selective PARP1/2 inhibitor. It can be used as a single drug in HRD positive ovarian cancer patients for multi-line therapy.
- Conditions
- Ovarian Neoplasms, Fallopian Tube Neoplasms, Endocrine Gland Neoplasms, Neoplasms by Site
- Trial name
- AVANIRA3 (NCT04556071)
- Testing
- Niraparib, Bevacizumab
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Xiaoxiang Chen
Ovarian Cancer, Ovarian and Fallopian Tube Cysts and Neoplasms
Anlotinib Combined With Dose-reduced Olaparib in Patients With Platinum-Sensitive Recurrent Ovarian Cancer
PARP inhibitors have changed the treatment paradigm of ovarian cancer. Most patients using PARP(poly-ADP ribose polymerase) inhibitors will suffer different grades of adverse events(AEs), followed by dose reduction.
- Conditions
- Ovarian Cancer, Ovarian and Fallopian Tube Cysts and Neoplasms, Neoplasms by Site, Neoplasms
- Trial name
- ANLOLA (NCT04566952)
- Testing
- Anlotinib, Olaparib
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Xiaoxiang Chen
Breast Cancer, Angiogenesis
The Effect of Aspirin on Angiogenesis Proteins in Women on Tamoxifen Therapy
Changes in major angiogenic proteins have been seen following initiation of tamoxifen and aromatase inhibitor therapy in women with breast cancer. One source of these proteins is the circulating platelet pool.
- Trial name
- NCT00727948
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Vermont
Angiogenesis, Ischemic Stroke
Neovascularization Induced by Mechanical Barrier disrUption and Systemic Erythropoietin in Patients With Cerebral Perfusion Deficits
Neovascularization Induced by Mechanical Barrier disrUption and Systemic erythropoietin in patients with cerebral perfusion deficits (NIMBUS trial)
- Trial name
- NIMBUS (NCT02603406)
- Testing
- erythropoietin
- Volunteers
- 44 people
- Sponsor
- Ajou University School of Medicine
Cardiac Rehabilitation, Angiogenesis
HARapan kiTa ECP (External Counter Pulsation) Study HARTEC Study
External Counterpulsation Therapy (ECP) is a therapeutic procedure that performed on patients with angina or heart failure to relieve the ischaemic symptoms, improve functional capacity, and quality of life.
- Conditions
- Cardiac Rehabilitation, Angiogenesis, Refractory Angina
- Trial name
- HARTEC (NCT03991871)
- Testing
- External Counter Pulsation (ECP) therapy
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Chronic Venous Disease, Varicose Ulcer
Effects of Local Insulin on Varicose Ulcers for Wound Healing
A randomized, split-plot, double-blind, placebo-controlled trial. The varicose ulcer is divided into two (side A and B). Half of the wound's surface is treated locally with insulin (Glargine) applied at an approx depth of 3-4 mm.
- Conditions
- Chronic Venous Disease, Varicose Ulcer, Wound Healing, Insulin
- Trial name
- NCT04310280
- Testing
- Insulin Glargine, Saline
- Where
- Mexico
- Volunteers
- 13 people
- Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"
Solid Tumor, Tumor Angiogenesis
Vascular Dysfunction and Antiangiogenic Therapy
project is a pilot prospective, longitudinal, before-after, open label multicentric study.
- Conditions
- Solid Tumor, Tumor Angiogenesis, Endothelial Dysfunction, CML (Chronic Myelogenous Leukemia)
- Trial name
- DYVA-AAGG (NCT02161978)
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Angers
Colorectal Cancer, Angiogenesis
Micrometastases and Angiogenesis in Colon Cancer. Prognostic Value of VEGF.
According to current clinical guidelines adjuvant treatment in colon cancer is not recommended in patients with stage I and IIA, and in patients with high risk factors (IIB) adjuvant treatment has not shown a clear benefit in…
- Trial name
- VEGF-GC (NCT04145505)
- Testing
- COLORECTAL CANCER SURGERY
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Intracranial Arterial Stenosis, Intracranial Atherosclerosis
Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis
Stroke due to intracranial arterial atherosclerosis is a significant medical problem, carrying one of the highest rates of recurrent stroke despite best medical therapy, with annual recurrence rates as elevated as 25% in high…
- Conditions
- Intracranial Arterial Stenosis, Intracranial Atherosclerosis, Ischemic Stroke, Cerebral Angiogenesis
- Trial name
- ERSIAS (NCT01819597)
- Testing
- Encephaloduroarteriosynangiosis (EDAS)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Cedars-Sinai Medical Center
Angiogenesis Inhibitors，Ovarian Neoplasms
Efficacy and Safety of Apatinib As Third Line Therapy in Patients With Advanced Ovarian Cancer
The study is to investigate the efficacy and safety of apatinib in patients with advanced ovarian cancer,who has received second-line chemotherapy and failed.
- Trial name
- NCT03262545
- Testing
- apatinib
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Glioblastoma Multiforme, Angiogenesis
Application of Proteome Profiler Antibody Arrays to Find Angiogenetic Predictors in Glioma Paitents.
Bevacizumab has become the standard of care of recurrent glioblastoma based on promising clinical trial results with with response rates up to 50% and progression-free survival up to 9 months.
- Trial name
- NCT03225963
- Testing
- Chemoradiation with temozolomide
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taichung Veterans General Hospital
Ischemic Attack, Ischemic Stroke
Multiple Burrhole Therapy With Erythropoietin for Unstable Moyamoya
In this study, the investigators aim to evaluate the indirect revascularization outcomes of a new combination therapy of multiple burrhole procedure with promotion of arteriogenesis by intravenous (IV) erythropoietin (EPO)…
- Conditions
- Ischemic Attack, Ischemic Stroke, Moyamoya Disease, Burr Hole
- Trial name
- NCT03162588
- Testing
- erythropoietin
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Ajou University School of Medicine
Myelodysplastic Syndromes, Leukemia, Myelomonocytic, Chronic
Efficacy Study of Revlimid® and Low Dose Continuously Administered Melphalan to Treat High Risk MDS
Angiogenesis increases in higher risk MDS patients and those with proliferative CMML. Angiogenesis is associated with increased risk of leukemic transformation and poorer prognoses.
- Conditions
- Myelodysplastic Syndromes, Leukemia, Myelomonocytic, Chronic, Angiogenesis
- Trial name
- REMMYDYS (NCT00744536)
- Testing
- Lenalidomide and melphalan
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Anaplastic Astrocytoma, Glioblastoma Multiforme
The Effect of Radiotherapy and Temozolomide on the Tumor Vasculature and Stem Cells in Human High-grade Astrocytomas
The purpose of the current trial is to explore whether the standard treatment with radiotherapy and temozolomide affect the tumor vasculature in patients with high-grade astrocytomas.
- Conditions
- Anaplastic Astrocytoma, Glioblastoma Multiforme, Tumor Angiogenesis
- Trial name
- Gliomstudien (NCT00473408)
- Testing
- Functional MRI (DCE-MRI), Blood sample, Tumor sample
- Where
- Norway
- Volunteers
- 1 people
- Sponsor
- Haukeland University Hospital
Angiogenesis, Breast Cancer
The Efficacy and Safety of Endostar Combined With Taxane-based Regimens for HER-2-negative MBC Patients
The purpose of the present study was to prospectively evaluate the efficacy and safety of endostar, a recombinant product of endostatin, combined with taxane-based regimens for HER-2 negative metastatic breast cancer (MBC)…
- Trial name
- NCT02865304
- Testing
- endostar
- Volunteers
- 80 people
- Sponsor
- Fujian Cancer Hospital
Angiogenesis
Effects of Local Insulin on Wound Angiogenesis
Randomized, split plot, double-blind, placebo controlled trial. Half of the wounds surface was applied daily with insulin and the other half with saline solution as placebo.
- Trial name
- NCT02396888
- Testing
- Insulin
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"
Breast Cancer, Tumor Angiogenesis
The Role of the Novel 99mTc-NC100692 Tracer in Patients at High Risk or Known Breast Cancer
Technetium-99m NC100692 Injection is under development as a diagnostic radiopharmaceutical for targeting angiogenesis associated with diseases such as primary and metastatic cancer, and for targeting active fibrosis in cardiac…
- Trial name
- NCT01503697
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cardiac and Hemodynamic Response, Blood Flow Distribution and Oxygen Uptake Efficiency
Effects of Aerobic Interval and Continuous Exercise Trainings in Patients With Chronic Heart Failure
Heart failure (HF) is a major and increasingly common cardiovascular syndrome, and is the end result of many cardiovascular disorders.
- Conditions
- Cardiac and Hemodynamic Response, Blood Flow Distribution and Oxygen Uptake Efficiency, Hemorheology Modulated by Erythrocyte, Atherothrombosis Modulated by Monocyte
- Trial name
- NCT01229670
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Proliferative Diabetic Retinopathy, Angiogenesis
Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular Angiogenesis
Fractalkine (FKN) is a chemoattractant and adhesion molecule for leukocytes. Angiogenic effect of FKN also has been reported. We investigate FKN-mediated angiogenesis in ocular angiogenic disorders.
- Trial name
- NCT00728598
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital