Clinical trials: Anesthetics, Local
Anesthetics, Local, Esophagogastroduodenoscopy
Preoperative Viscous Lidocaine for Upper Gastrointestinal Endoscopy
In this randomized placebo-controlled clinical trial, patients will be randomized to be administered viscous lidocaine or placebo preoperatively to elective upper GI endoscopy
- Trial name
- LIDOGAS (NCT04725695)
- Testing
- Viscous Lidocaine
- Where
- Denmark
- Volunteers
- 119 people
- Sponsor
- Bispebjerg Hospital
Spinal Anesthesia, Local Anesthetic
Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia for Elective Infra-Umbilical Surgeries
Pediatric anesthesia presents distinctive challenges, particularly concerning appropriate dosage administration of local anesthetics for spinal anesthesia (SA).
- Conditions
- Spinal Anesthesia, Local Anesthetic, Bupivacaine
- Trial name
- NCT06801600
- Testing
- Weight-based dosing, Age-based dosing
- Volunteers
- 60 people
- Sponsor
- Cairo University
Regional Anesthesia, Local Anesthetic
Mixed Local for Sciatic Block
Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration.
- Trial name
- NCT06671028
- Testing
- Ropivacaine and Lidocaine, Ropivacaine 0,5%
- Volunteers
- 110 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Analgesics, Opioid, Anesthetics, Local
Opioid Use of Local Anaesthetic Agents in Open Heart Surgery and Its Effect on Recovery
The aim of this randomized controlled study was to investigate the effect of injecting local anesthetic agents into the sternotomy incision site and around the drains on the amount of opioids used in the postoperative period and…
- Trial name
- NCT06642077
- Testing
- LIDOFAST 40 mg/2 ml + 0.025 mg/2 ml
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Anesthetics, Local
Split Face Study of the Duration of Local Anesthetics
This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for.
- Trial name
- NCT05767749
- Testing
- lidocaine + epinephrine 1:100,000, Ropivacaine 0.5% Injectable Solution, Bupivacaine 0.5% Injectable Solution
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Local Anesthetic Complication
Evaluation of the Anti-anaesthetic Effects of Low-Level Laser Therapy on Children's Soft Tissue
Evaluate the effect of the photobiomodulation mode of the diode laser on the anaesthetic area and find the best parameter that would accelerate the withdrawal of anaesthesia.
- Trial name
- laser (NCT06193460)
- Testing
- low-level laser therapy
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Local Anesthetic, Ultrasound
TAP Block With Methyl-prednisolone as a Pain Treatment Modality After Total Abdominal Hysterectomy Procedures
The aim of this work to compare between the efficacy of ultrasound guided TAP block with dexamethasone as an adjuvant versus ultrasound guided TAPB with methyl prednisolone as an adjuvant to local anesthetic for postoperative…
- Conditions
- Local Anesthetic, Ultrasound, Pain, Acute
- Trial name
- NCT06131593
- Testing
- TAPB with dexamethasone as an adjuvant to local anesthetics, TAPB with methylprednisolone as an adjuvant to local anesthetics
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Anesthetics, Local, Blepharoplasty
Distraction Techniques in Periocular Anesthesia: Tapping vs Vibration
To compare the efficacy of topical tapping vs vibration in lowering pain scores for periocular anesthesia injections.
- Conditions
- Anesthetics, Local, Blepharoplasty, Age-Related Ptosis, Adult
- Trial name
- NCT06355817
- Testing
- Vibration, Tapping
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Manitoba
Local Anesthetic Complication
The Effect of Adding Sodium Bicarbonate 8.4% to Local Anesthesia on Pain During Upper Canine Infiltration
The aim of the present study was to evaluate the pain during local anesthetic buccal infiltration for the maxillary canines after adding Sodium Bicarbonate 8.4% during local anesthesia.
- Trial name
- NCT06302907
- Testing
- Buffered Local anaesthesia, Unbuffered Local anaesthesia
- Where
- Syria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Wataniya University
Thoracic Paravertebral Block, Thoracotomy
Different Local Anesthetic Volumes for TPVB in Post-thoracotomy Analgesia
Thoracotomy is one of the most painful operations known. Therefore, it causes severe acute pain. If pain is not controlled, it increases the frequency of postoperative pulmonary complications and postoperative morbidity.
- Conditions
- Thoracic Paravertebral Block, Thoracotomy, Postoperative Analgesia, Acute Pain
- Trial name
- NCT05700357
- Testing
- TPVB with 20 ml, TPVB with 25 ml, TPVB with 30 ml
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ankara City Hospital Bilkent
Serratus Anterior Plane Block, Pain, Postoperative
Effect of Different Local Anesthetic Volumes of Serratus Anterior Plan Block After Video-Assisted Thoracoscopic Surgery
Video-assisted thoracic surgery (VATS) has become a common procedure in thoracic surgery. Severe postoperative pain may be encountered in patients undergoing VATS.
- Conditions
- Serratus Anterior Plane Block, Pain, Postoperative, Thoracic Surgery, Video-Assisted, Local Anesthetic
- Trial name
- NCT05255536
- Testing
- Serratus Anterior Plan Block with 20 ml, Serratus Anterior Plan Block with 30 ml
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Regional Anesthesia Morbidity, Local Anesthetic Drug Adverse Reaction
Plasma Ropivacaine Concentrations After Sciatic Nerve Block in Patients With Chronic Kidney Disease
This prospective observational study aimed to examine the pharmacokinetics of ropivacaine in patients with chronic kidney disease after sciatic nerve block.
- Trial name
- NCT03666845
- Testing
- Sciatic nerve block
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Hospital
Colorectal Disorders, Regional Anesthesia Morbidity
Transversus Abdominis Plane Blocks With and Without Dexamethasone
Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.
- Conditions
- Colorectal Disorders, Regional Anesthesia Morbidity, Analgesia, Local Anesthetic Complication
- Trial name
- TAP-DEX (NCT05432934)
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Safety Issues, Post Operative Pain
Safety and Efficacy of Wide Awake Local Anesthesia no Tourniquet Technique (WALANT) in Ankle Removal of Implant Surgery
Safety and efficacy of wide awake local anesthesia no torniquet technique (WALANT) in ankle surgery. Studying risks and benefits from WALANT compared to general anesthesia .
- Conditions
- Safety Issues, Post Operative Pain, Local Anesthetic Complication
- Trial name
- NCT05864664
- Testing
- Wide awake local anaesthesia no tourniquet technique
- Where
- Kuwait
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ali Lari
Post Operative Pain, Laparoscopic Surgery
Modified Thoracoabdominal Nerve Block(M-TAPA) in Pediatric Laparoscopic Appendectomies
To compare the effect of M-TAPA block and port-site local anesthetic infiltration on postoperative pain in pediatric laparoscopic appendectomies.
- Conditions
- Post Operative Pain, Laparoscopic Surgery, Pediatrics, Regional Anesthesia
- Trial name
- M-TAPA (NCT06039150)
- Testing
- M-TAPA Block, Local anesthetic infltration to port sites
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Gulhane Training and Research Hospital
Local Anesthetic Complication
Comparative Effect of Palatal Injection in Pediatric Patient
The aim of this study is to compare the pain perception of pediatric patients during extraction with and without palatal injection and to show whether articaine HCl and lidocaine HCl can provide palatal anesthesia in maxillary…
- Trial name
- NCT06025825
- Testing
- Articaine Hydrochloride + Epinephrine, Lidocaine Hydrochloride + Epinephrine
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ankara Yildirim Beyazıt University
Tourniquets, Anesthesia, Conduction
Femoral Artery Block for Reduction of Tourniquet Induced Hypertension
A randomised controlled trial to assess the impact of femoral artery block on the incidence of tourniquet hypertension in patients receiving cruciate ligament surgery with > 30 minutes of tourniquet under combined anaesthesia…
- Conditions
- Tourniquets, Anesthesia, Conduction, Anesthetics, Local, Hypertension
- Trial name
- NCT05954689
- Testing
- Femoral artery block
- Volunteers
- 50 people
- Sponsor
- Hospital da Luz, Portugal
Opioid Use, Post-thoracotomy Pain Syndrome
Serratus Anterior Plane Block for Management of Post Thoracotomy Pain
This is a single-center, randomized, prospective study evaluating the effect of serratus anterior plane block performed after induction of anesthesia, but before the start of surgery on postoperative opioid requirements.
- Conditions
- Opioid Use, Post-thoracotomy Pain Syndrome, Local Anaesthetic Agent Overdose, Local Anesthetic Complication
- Trial name
- SAPB (NCT04258436)
- Testing
- Serratus anterior block
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Indiana University
Pain, Postoperative, Local Anesthetic
The Utility of Long-acting Local Anesthetic Agents in Reducing Post-operative Opioid Requirements Following Rhinoplasty
On average, more than 130 Americans die every day from opioid overdose. Surgeons provide 37% of all opioid prescriptions in the United states, second only behind pain management physicians.
- Trial name
- NCT04377204
- Testing
- marcaine bupivacaine, Lidocaine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Our Lady of the Lake Hospital
Local Anesthetic Toxicity, Regional Anesthesia Morbidity
Ropivacaine Plasma Concentrations After Fascial Blocks in Elective Cardio-thoracic and Abdominal Surgery
Primary aim: observe the incidence of systemic toxicity from local anesthetic (LAST) after performing fascial blocks in patients undergoing elective cardio-thoracic and abdominal surgery.
- Conditions
- Local Anesthetic Toxicity, Regional Anesthesia Morbidity, Postoperative Pain
- Trial name
- NCT05592691
- Testing
- Fascial block
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy