Clinical trials: Anesthesiology, open to volunteers
Postoperative Pain
Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of tranexamic acid (TXA) and aminocaproic acid (ε-Ahx) with local anesthetics and thrombin in all electively created surgical wound beds in hand surgery to provide…
- Trial name
- NCT07644923
- Testing
- Bupivacaine, Lidocaine, Thrombin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Lung Cancer (Diagnosis)
Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.
This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery.
- Trial name
- NCT07393490
- Testing
- Apnoeic Oxygenation, Standard Ventilation
- Where
- Croatia
- Volunteers
- 56 people
- Sponsor
- Osijek University Hospital
Inguinal Hernia Unilateral, Postoperative Pain Management
Transversalis Fascia Plane Block Versus Surgical Wound Infiltration for Postoperative Analgesia in Open Inguinal Hernia Repair
The purpose of this clinical trial is to evaluate whether two different analgesic techniques - ultrasound-guided Transversalis Fascia Plane Block (TFPB) and surgical wound infiltration - can improve postoperative pain control in…
- Conditions
- Inguinal Hernia Unilateral, Postoperative Pain Management, Regional Anaesthesia, Transversalis Fascia Plane Block
- Trial name
- TFPB-WIN (NCT07238829)
- Testing
- Ultrasound-Guided Transversalis Fascia Plane Block (TFPB), Surgical Wound Infiltration
- Volunteers
- 104 people
- Sponsor
- Ondokuz Mayıs University
Septic Shock, Sepsis
Delphi Septic Shock: Sub-phenotypes Using Point-of-Care Ultrasound in Patients With Septic Shock
The Delphi survey process is a well-established mechanism for generating consensus on a certain topic by using a panel "collective intelligence".
- Conditions
- Septic Shock, Sepsis, Shock
- Trial name
- NCT07616817
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Albany Medical College
Dexmedetomidine, Sedation
Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in Low-Monitoring Settings
The goal of this clinical trial is to assess the viability of dexmedetomidine hydrochloride nasal spray under minimal or no supervision and to further investigate novel clinical applications for this medication.
- Conditions
- Dexmedetomidine, Sedation, Safety, Preanesthetic Medication
- Trial name
- NCT07298525
- Testing
- Dexmedetomidine hydrochloride nasal spray
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Spinal Anaesthesia Induced Hypotension
Role of Ondansetron in Spinal Anaesthesia Induced Hypotension
The objective of this study is to determine the effect of ondansetron on the total consumption of norepinephrine infusion needed to prevent spinal anaesthesia induced hypotension in cesarean section.
- Trial name
- NCT06727201
- Testing
- Ondansetron (Zofran)
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assiut University
Varicocelectomy
Sedative and Analgesic Effects of Dexmedetomidine Versus Ketamine in Patients Undergoing Varicocelectomy Under Spinal Anaesthesia: A Prospective Randomized Comparative Trial
The demand for safe and effective sedation during spinal anesthesia has increased in recent years, particularly in ambulatory and minor surgical procedures.
- Trial name
- NCT07214701
- Testing
- Ketamine (0.5 mg/kg), Dexmedetomidine
- Volunteers
- 58 people
- Sponsor
- Assiut University
Hernia, Umbilical, Clonidine
Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty
This clinical trial aims to evaluate the effectiveness of an ultrasound-guided nerve block technique as the sole anesthetic method for patients undergoing outpatient umbilical hernia surgery.
- Conditions
- Hernia, Umbilical, Clonidine, Pain, Postoperative, Ambulatory Surgical Procedures
- Trial name
- NCT07062497
- Testing
- Rectus Sheath Block, Rectus Sheath Block with Clonidine
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Cognitive Impairment, Cognitive Impairment, Mild
Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk
Many older people can experience confusion, memory problems, or a decline in their thinking after major surgery. These problems are sometimes called 'postoperative neurocognitive disorders' or PND and can affect recovery and a…
- Conditions
- Cognitive Impairment, Cognitive Impairment, Mild, Cognitive Impairment, Progressive, Anesthesia
- Trial name
- CAPSULAR (NCT07470216)
- Testing
- Montreal Cognitive Assessment, biomarkers
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Carpal Tunnel Syndrome
Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block
Carpal tunnel syndrome (CTS) is the most commonly appearing entrapment neuropathy of the upper extremity. Treatment options include both non-operative and operative methods.
- Trial name
- PERSONNEL (NCT05372393)
- Testing
- Local infiltration anaesthesia in carpal tunnel release, Distal median nerve block with local infiltration anaesthesia in carpal tunnel release
- Where
- Finland
- Volunteers
- 118 people
- Sponsor
- Kuopio University Hospital
Anesthesia, Pain
Anesthetics and Analgesics in Children
The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.
- Trial name
- ANA01 (NCT03427736)
- Testing
- Ketorolac Tromethamine, Hydromorphone, Ketamine
- Where
- 13 sites in United States, Canada
- Volunteers
- 551 people
- Sponsor
- Chi Dang Hornik
Pain Management, Perioperative Analgesia
From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma
To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.
- Conditions
- Pain Management, Perioperative Analgesia, War-Related Injuries
- Trial name
- CRA-WAR-LIMB S (NCT07474506)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Communication Research, Patient Satisfaction
Breaking Bad News Skills of Doctors and Residents in the Surgical Setting
Breaking bad news is a very stressful and difficult situation for health care professionals, especially clinical doctors and surgeons.
- Conditions
- Communication Research, Patient Satisfaction, Communication Programs, Doctor Patient Relation
- Trial name
- NCT04308707
- Testing
- Breaking bad news skills
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Clinic of Barcelona
Respiratory, Monitored Anaesthesia Care
The PneumoRator Study
Healthcare workers measure heart rate, blood pressure, temperature, oxygen levels and breathing rate to monitor how unwell a patient is. All these apart from breathing rate are now normally measured by machines.
- Conditions
- Respiratory, Monitored Anaesthesia Care, Perioperative
- Trial name
- NCT07293299
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Ear and Nose Surgeries With Hypotensive Anaesthesia e.g FESS , MLS , TURBINECTOMY
Dexmedetomidine Versus Dexmedetomidine and Ketamine (Ketodex) in Ear and Nose Surgeries
The study aims to compare the efficacy, safety and overall effectiveness of dexmedetomidine and dexmedtomidine and ketamine (ketodex) in achieving controlled hypotension during Ear and nose surgeries.
- Trial name
- NCT06981494
- Testing
- Dexmedetomidine, Dexmedetomidine and ketamine ( Ketodex )
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Sohag University
Emergence Delirium, Anesthesia
The Effect of EEG and BIS-guided Anaesthesia on the Incidence of Emergent Delirium in Children
The aim of the study is to compare two modalities of measuring the depth of general anaesthesia on the incidence of emergent delirium in children.
- Trial name
- NCT07534215
- Testing
- EEG monitoring, BIS monitoring
- Where
- Czechia
- Volunteers
- 540 people
- Sponsor
- University Hospital Ostrava
Pain (Visceral, Somatic, or Neuropathic)
Comparison of Conventional Buccal Nerve Block Versus Buccal Nerve Trunk Block During Extraction of Posterior Mandibular Teeth
This randomised control trial will compare the efficacy of conventional buccal nerve block versus buccal trunk block using visual analogue scale to evaluate pain and additional anesthesia injection during extraction of mandibular…
- Trial name
- Buccal Trunk (NCT07330518)
- Testing
- Conventional Buccal Nerve Block, Buccal Nerve Trunk Block
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Watim Medical & Dental College
Transfusion Reaction, Transfusion Related Complication
Transfusion Surveillance in Anaesthesia
the aim of this register is to collect exhaustively the different data available surrounding a transfusion act in the context of an active haemorrhage.
- Conditions
- Transfusion Reaction, Transfusion Related Complication, Anesthesia, Anesthesia; Shock
- Trial name
- STAR (NCT06403163)
- Testing
- Transfusion
- Where
- Belgium
- Volunteers
- 50,000 people
- Sponsor
- Erasme University Hospital
Coughing Responses at Tracheal Extubation, Breathing Patterns
Endotracheal Tube Intolerance and Respiratory Airflow Perception
This is a case-control study designed to enroll 224 patients who will undergo tracheal intubation for general anesthesia in the operating rooms of Peking University People's Hospital between July 20, 2026, and October 31, 2026.
- Trial name
- NCT07759284
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Frailty
Preoperative Frailty and Postoperative Neurocognitive Disorders in Geriatric Patients in Georgia
The number of elderly people in the global population is growing, presenting an increasing challenge. Technological advances in medicine have made it possible to perform complex surgeries on geriatric patients, improving the…
- Trial name
- FRAILCOG-GE (NCT06700291)
- Testing
- Surgery
- Where
- Georgia
- Volunteers
- 230 people
- Sponsor
- New Hospitals Georgia