Clinical trials: Anesthesia; Functional
Anesthesia; Functional
Effects of Analgesics in Cesarean Section Elective
Two approved treatments for spinal anesthesia will be compared in women undergoing cesarean section. It is usual to perform cesarean sections using spinal anesthesia with a local anesthetic (bupivacaine) plus some opioid, such as…
- Trial name
- CES (NCT03386630)
- Testing
- Hyperbaric bupivacaine+Sufentanil, Hyperbaric bupivacaine+Morphine
- Where
- Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Postoperative Cognitive Dysfunction
Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon, which affect patients' short-term and long-term outcome.
- Trial name
- NCT02931877
- Testing
- sevoflurane, propofol
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xinqiao Hospital of Chongqing
Thyroid Cancer
Effect of Perioperative Intravenous Lidocaine Infusion and Magnesium Infusion on the Functional Recovery After General Anesthesia in the Patients Undergoing Thyroid Surgery
Studies have attempted to control pain and increase patients' recovery satisfaction following many kinds of operations by using as small an opioid analgesic dose as possible and adding a nonopioid analgesic to reduce the side…
- Trial name
- NCT02018276
- Testing
- Lidocaine, Magnesium
- Where
- South Korea
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Anesthesia; Functional
Success Rate of Anterior Middle Superior Alveolar (AMSA) Nerve Block in Three Different Sites of Injection
AMSA nerve block injection is targeted anterior superior alveolar nerve and middle superior alveolar nerve branches of infraorbital nerve through nutrient canals.
- Trial name
- NCT02012257
- Testing
- AMSA nerve block injectio
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Prone Position, Cardiac Output
Effect of Prone Position on Liver Blood Flow and Function
Recent occurrence of significant post-operative liver impairment at Nottingham University Hospitals NHS Trust has prompted investigation into whether interaction between general anaesthesia and prone positioning (lying face down)…
- Conditions
- Prone Position, Cardiac Output, Liver Circulation
- Trial name
- PLiF (NCT01781260)
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Exposed to Anesthesia
Functional Magnetic Resonance Imaging (fMRI) Findings in Children With Early Exposure to General Anesthesia
General anesthetic medications have been shown to cause neuronal cell death in the brains of infant rodents. Ethanol and general anesthetics both act on NMDA and GABA receptors,and appear to have similar mechanisms of toxicity in…
- Trial name
- NCT01229514
- Testing
- fMRI
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Cognitive Dysfunction
Changes of Cognitive Function and Orphanin FQ in Diabetic Patients Under General Anesthesia.
This study is the first to investigate the relationship between the changes of serum calcium and orphanin fq and the changes of cognitive function in patients with diabetes.To general anesthesia surgery of patients with diabetes…
- Trial name
- NCT04576767
- Testing
- anaesthetic
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Neurodevelopmental Disorders, Child Behavior Disorders
Impact of General Anesthesia in Childhood on Cognitive Processes
This study aims to evaluate the potential long-term cognitive effects of general anesthesia administered before the age of 4. Specifically, it investigates executive functions-including inhibition, working memory, and cognitive…
- Trial name
- NCT07141797
- Testing
- Executive functions assessment
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Mental Function
Restoration of Consciousness With Ultrasonic Deep Brain Stimulation During Anesthetic Sedation
The purpose of this study is to see if mental functions take place during different levels of anesthesia using two commonly used drug (propofol and dexmedetomidine) and will include low-intensity focused ultrasound pulsation…
- Trial name
- NCT07221539
- Testing
- Propofol for fMRI, Dexmedetomidine for fMRI, Dorsolateral prefrontal cortex (DLPFC) pulsation
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anesthesia, Pain
Memory & Conditioning Under Anesthesia
The purpose of this study is to determine the effects of pain on long-term memory and conditioned physiologic responses in the presence and absence of distinct intravenous anesthetics.
- Trial name
- MCA (NCT04062123)
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Anesthesia
Tranexamic Acid in Functional Endoscopic Sinus Surgery
The purpose of the study is to compare the effect of oral tranexamic acid vs. intravenous in decreasing bleeding and improving the field during FESS.
- Trial name
- NCT05686005
- Testing
- Oral tranexamic acid, Intravenous tranexamic acid
- Where
- Egypt
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Neurocognitive Disorders, Anesthesia
Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study
Traditionally, general anesthesia is maintained with inhalational anesthesia (GAS), but there is a gap in knowledge regarding whether intravenous anesthesia (IV) can prevent deleterious postoperative outcomes in the geriatric…
- Conditions
- Neurocognitive Disorders, Anesthesia, Post-operative Delirium, Post-operative Cognitive Dysfunction
- Trial name
- TIVA GAS (NCT06036095)
- Testing
- Sevoflurane, Propofol
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Mothers, Cesarean Section Complications
The Effect of Chewing Gum After Cesarean Section on Gastrointestinal System Functions, Pain and Sleep Quality
The study will be conducted on mothers who had planned cesarean section.After the birth, the information about the surgery in the personal information form will be completed.
- Trial name
- NCT05945095
- Testing
- Gum chewing group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Artvin Coruh University
Anesthesia; Functional, Anesthesia
The Efficacy of 20 mg Parecoxib as an Adjunct to 0.75% Ropivacaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery
This clinical trial aims to investigate the efficacy of 20 mg Parecoxib when it is given as an addition to 20 ml 0.75% ropivacaine in patients receiving ultrasound-guided supraclavicular brachial plexus block prior to the upper…
- Trial name
- RCT (NCT03480165)
- Testing
- Parecoxib 20 MG/ML, Ropivacaine
- Where
- Malaysia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Anesthesia, Conduction, Nerve Block
Neurologic Complications in Peripheral Regional Anesthesia - An Evaluation Based on a Standardized Protocol
To evaluate the incidence of neurologic complications as a consequence of peripheral regional anesthesia, all patients receiving peripheral nerve blocks will be evaluated according to a standardized protocol screening pain…
- Conditions
- Anesthesia, Conduction, Nerve Block, Adverse Effects
- Trial name
- NCT00445016
- Testing
- peripheral regional anesthesia
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- BG Unfallklinik Murnau
This Study Was Focused to Evaluate Feasibility of Doppler Tissue Monitoring During the Induction Anesthesia,, and Evaluate Routine Propofol Induction's Effect on Myocardial Tissue Motion, Using Non-invasive Doppler Tissue and 2D Speckle Tracking Imaging.
Propofol Induction's Effect on Cardiac Function
Background: Propofol effects dose-dependent myocardial depression, but there is little clinical data available regarding the direct impact of propofol induction on myocardial function.
- Conditions
- This Study Was Focused to Evaluate Feasibility of Doppler Tissue Monitoring During the Induction Anesthesia,, and Evaluate Routine Propofol Induction's Effect on Myocardial Tissue Motion, Using Non-invasive Doppler Tissue and 2D Speckle Tracking Imaging., This is the First Study, to Our Knowledge, Which Has Evaluated the Possible Impact of Propofol Induction on LV Function.
- Trial name
- NCT02408341
- Where
- South Korea
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Changes in Brain Network Connectivity
Anesthesia and Functional Connectivity: An Analysis of fMRI Changes
Functional connectivity is defined as a correlation in neural activity between distinct regions of the brain. Several recent studies have demonstrated areas of low-frequency functional connectivity inherent to brain tissue at…
- Trial name
- NCT02196259
- Testing
- Anesthetics, Dissociative
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Rotator Cuff Tear
Effect of Dexmedetomidine on Postoperative Cognitive Function in Patients Undergoing Shoulder Arthroscopy With Beach Chair Position Under Desflurane Anesthesia
Investigate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing shoulder arthroscopy with beach chair position under desflurane anesthesia.
- Trial name
- NCT02643017
- Testing
- Dexmedetomidine, normal saline
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Neurocognitive Function
Neurocognitive Function After Regional and General Anesthesia (245_14 B)
Postoperative cognitive dysfunction (POCD) is a disease with restricted cognitive memory function and intellectual skills, which occurs after surgery with and without anesthesia.
- Trial name
- 245_14_B (NCT02505815)
- Testing
- Surgery, Cortisol Level Measurement, Neurocognitive Testing
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University