Clinical trials: Analgesia
Trauma
TRAUMA HELP: Healing and Analgesia With Propranolol
The purpose of this study is to determine whether propranolol can decrease pain symptoms in a common subset of patients admitted to a trauma center after injury.
- Trial name
- TRAUMA_HELP (NCT01007084)
- Testing
- Propranolol, Propranolol ER, Sugar pills
- Where
- United States
- Sponsor
- University of North Carolina, Chapel Hill
Serratus Anterior Plane Block, Erector Spinae Plane Block
Serratus Anterior Plane Block Versus Erector Spinae Plane Block With Dexmedetomidine Added to Bupivacaine for Ultrasound-Guided Pain Management After Mastectomy
This study aimed to compare the serratus plane block versus the erector spinae plane block with dexmedetomidine added to bupivacaine for acute pain management after breast surgeries.
- Conditions
- Serratus Anterior Plane Block, Erector Spinae Plane Block, Dexmedetomidine, Bupivacaine
- Trial name
- NCT06737458
- Testing
- Bupivacaine + Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Laparoscopic Cholecystectomy Surgery, Postoperative Pain Management
The Efface of Ketamine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy
This prospective interventional study was conducted at Liaquat National Hospital and Medical College to compare the postoperative analgesic effects of ketamine and magnesium sulphate in patients undergoing laparoscopic…
- Trial name
- NCT07248358
- Testing
- IV ketamine 0.5 mg/kg, IV 2mg of Magnesium Sulphate
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Liaquat National Hospital & Medical College
Postoperative Analgesia
Magnesium and Ketamine in Postoperative Analgesia
90 female patients scheduled for cancer breast surgeries will be assigned to 2 groups, each of 45. Group (K) will receive a bolus of 0.5 mg/kg ketamine with induction of anaesthesia, followed by ketamine infusion 0.12 mg/kg/hour…
- Trial name
- NCT04111848
- Testing
- Ketamine, ketamine and magnesium
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Knee Arthroscopy, General Anesthesia
Patient Satisfaction and Postoperative Analgesia Between Subarachnoid Block With 2-chloroprocaine Versus General Anesthesia for Knee Arthroscopy
The study evaluates the efficacy of two different anesthetic techniques in patients undergoing unilateral knee arthroscopy. Participants will be randomized to receive either subarachnoid block with 2-chloroprocaine or general…
- Conditions
- Knee Arthroscopy, General Anesthesia, Subarachnoid Block
- Trial name
- NCT03173326
- Testing
- General anesthesia, Subarachnoid block
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University Medical Center
Analgesia, Congenital Heart Disease
Morphine IV vs Paracetamol IV in Neonates and Infants After Cardiac Surgery
The goal of this clinical trial is to compare pain management in neonates and infants under 3 years of age undergoing cardiac surgery with use of cardiopulmonary bypass.
- Conditions
- Analgesia, Congenital Heart Disease, Surgery
- Trial name
- PACS (NCT05853263)
- Testing
- paracetamol, Morphine
- Volunteers
- 208 people
- Sponsor
- Erasmus Medical Center
Total Hip Arthroplasty
An Iliopsoas Plane Block After Total Hip Arthroplasty
Nielsen et al. reported that when iliopsoas plane block was performed on healthy volunteers, the injection solution in Hip MRI was confined to the myofascial compartment, which was known to include all sensory branches of the…
- Trial name
- NCT05212038
- Testing
- iliopsoas plane block group
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Gangnam Severance Hospital
Opioid-Related Disorders, Substance-Related Disorders
Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000255
- Testing
- Nitrous oxide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Chronic Low Back Pain, Chronic Neck Pain
Effect of Combined Morphine and Duloxetine on Chronic Pain
A double-blind, randomized, and placebo-controlled clinical study examining whether duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), could enhance opioid analgesia and reduce overall opioid use.
- Trial name
- Duloxetine (NCT03249558)
- Testing
- Morphine, Duloxetine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Massachusetts General Hospital
Ileus
Thoracic Epidural for Postoperative Ileus
The investigators try to find whether thoracic epidural analgesia (TEA) shortens the first gas-out time compared to iv-PCA and promotes earlier discharge after major upper abdominal surgery.
- Trial name
- NCT02491385
- Testing
- thoracic epidural analgesia, iv-PCA
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Samsung Medical Center
Acute Appendicitis
Management of Acute Appendicitis Pain in the Emergency Department
This study aims to compare the effectiveness of TAP (Transversus Abdominal Plane) block, ESPB (Erector Spinal Plane Block), and tramadol in preoperative pain management for patients diagnosed with acute appendicitis and…
- Trial name
- NCT06808087
- Testing
- Transversus abdominis plane blockage, Erector spinae plane blockage, Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Pain
The Analgesic Efficacy of Wound Infiltration With Tramadol
This double-blind, randomized trial examined whether tramadol wound infiltration decreased postoperative pain following cesarean delivery under general anesthesia or reduced the need for analgesics in the immediate postoperative…
- Trial name
- NCT02518438
- Testing
- Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yeditepe University Hospital
Colon Neoplasm, Rectum Neoplasm
Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit
The Transversus Abdominis Block (TAP) block is known to be an effective means of reducing patient pain after abdominal surgery. In the meantime, the general TAP block has been studied in patients who were in the recovery room and…
- Conditions
- Colon Neoplasm, Rectum Neoplasm, Perforated Colon, Perforated Bowel
- Trial name
- NCT03198338
- Testing
- 0.25% Bupivacaine, 0.5mL/kg, Normal Saline, Ultrasound
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Pain, Postoperative
Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain
The purpose of this study is to compare intravenous (IV) and oral acetaminophen for the treatment of acute moderate to severe pain in combination with standard patient-controlled analgesia (PCA) in adult subjects following total…
- Trial name
- NCT02746263
- Testing
- IV acetaminophen, Oral acetaminophen, Morphine
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Mallinckrodt
Thyroid Diseases, Parathyroid Diseases
Ropivacaine Plus Magnesium Sulphate Infiltration
In the domain of endocrine gland surgery, thyroidectomy is the most common procedure. Patients report moderate to severe discomfort postoperatively, which is induced by a variety of mechanisms, the most common of which are…
- Conditions
- Thyroid Diseases, Parathyroid Diseases, Postoperative Pain, Anesthesia, Local
- Trial name
- NCT05294393
- Testing
- Ropivacaine 10%, Ropivacaine 10% plus magnesium sulphate 10mg/kg
- Where
- Greece
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Tonsillitis
Suprazygomatic Maxillary Nerve Block in Pediatric Tonsillectomy
Tonsillectomies are among the most common surgical procedures performed in pediatric populations, with more than 14,000 procedures performed annually in Ontario, with more than 80% being performed to treat sleep-disordered…
- Trial name
- NCT07176533
- Testing
- Suprazygomatic maxillary nerve block (SZMN) with bupivacaine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Analgesia, ICU Patients Requiring Invasive Mechanical Ventilation
Clinical Study on the Efficacy and Safety of Hydromorphone for ICU Analgesia
This study is a prospective, single-center clinical study to evaluate the advantages, extensibility and safety of hydromorphone as an analgesic drug in ICU, and to compare it with remifentanil, a traditional sedative drug.
- Trial name
- NCT06848452
- Testing
- no-intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Affiliated Hospital of Nantong University
Neck Pain Treatment
Immediate Effect of Irradiation With Low-level Laser Therapy on the Electromyographic Activity of the Upper Trapezius Muscles and the Level of Pain Among Patients With Non-specific Neck Pain
The aim of the present study is to assess the immediate effect of irradiation with low level laser therapy (LLLT) on the electromyographic activity of upper trapezius muscles and the amount of pain felt by patients with…
- Trial name
- NCT02498249
- Testing
- low level laser therapy
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Nove de Julho
Hip Hemiarthroplasty
Quality Of Recovery After Pericapsular Nerve Group (PENG) Block For Hip Hemiarthroplasty Under Spinal Anesthesia
Patients undergoing hip hemiarthroplasty can benefit significantly from regional anesthesia in terms of pain management and recovery . There is a wide range of regional anesthetic techniques.
- Trial name
- NCT06369948
- Testing
- Pericapsular Nerve Group (PENG) Block, elective hip hemiarthroplasty without receiving a PENG block., bupivacaine 0.5% injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Fayoum University Hospital
Pain Management, Orthopedic Procedure Pain
The Analgesic Efficacy of Nefopam in Orthopedics Surgery
Pain-free and relief are one of the anesthesiologist's most important concerns during the operation. General aim is always to effectively control pain but while simultaneously reducing opioid requirements to reduce opioid related…
- Trial name
- NCT06680609
- Testing
- Nefopam 20 MG/ML
- Where
- Jordan
- Volunteers
- 49 people
- Sponsor
- King Abdullah University Hospital