Clinical trials: Analgesia, open to volunteers
Surgical Procedure, Unspecified, Pain, Postoperative
Continuous Infusions vs Scheduled Bolus Infusions
The goal of the study is to compare continuous infusions and scheduled bolus infusions for peripheral nerve blocks and their effect on post-surgical pain.
- Trial name
- NCT03230565
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Stanford University
Postoperative Pain, Postoperative Nausea and Vomiting (PONV)
Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain
The goal of this clinical trial is to learn whether different frequencies of transauricular vagus nerve stimulation (tVNS) can reduce postoperative pain and opioid consumption in adults undergoing abdominal or urologic surgery.
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting (PONV), Opioid Consumption, Postoperative
- Trial name
- TVNS-PAIN (NCT07633444)
- Testing
- Transauricular Vagus Nerve Stimulation (tVNS)
- Where
- Brazil
- Volunteers
- 174 people
- Sponsor
- Federal University of Bahia
Spine Surgery
The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.
This study will investigate whether a combination of three anesthetic medications will reduce intraoperative and postoperative pain in patients undergoing complex spine surgery, and whether it will reduce the use of opioid pain…
- Trial name
- NCT07365800
- Testing
- Methadone-dexmedetomidine-ketamine combination
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- University of Missouri-Columbia
Postoperative Pain
Comparison of TAP and QL Blocks for Postoperative Analgesia in Open Inguinal Hernia Repair
Background Postoperative pain management after open inguinal hernia repair remains a clinical challenge despite spinal anesthesia.
- Trial name
- NCT07527065
- Testing
- Transversus Abmoninis Plane Block, Quadro-Iliac Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hitit University
Total Knee Arthroplasty for Gonarthrosis
"The Effect of Adductor Canal Block Performed With Postoperative Thigh Tourniquet Application on Pain After Total Knee Arthroplasty"
The biggest fear for patients undergoing knee replacement surgery is that persistent pain felt at the back of the knee postoperatively.
- Trial name
- NCT07539467
- Testing
- Tourniquet-Assisted Adductor Canal Block (T-ACB) grou, Standard Adductor Canal Block (S-ACB)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Orthodontic Pain (D013850), Pain Management (D016146)
A Randomized Clinical Trial of the Effectiveness of Acupressure in Relieving Orthodontic Pain
Orthodontic treatment with fixed appliances often causes pain, which peaks within 24 hours after archwire placement and lasts for several days.
- Conditions
- Orthodontic Pain (D013850), Pain Management (D016146), Acupressure (D056351), Analgesics, Non-Narcotic (D000700)
- Trial name
- NCT06812936
- Testing
- Acetaminophen, Acupressure
- Where
- Iraq
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Gastrectomy, Postoperative Analgesia
Efficacy and Safety of Anrikefon Injection for the Treatment of Postoperative Pain in Patients Undergoing Totally Laparoscopic Radical Distal Gastrectomy
Anruikefen is a peripherally highly selective kappa receptor agonist that does not easily cross the blood-brain barrier, resulting in a low incidence of central adverse reactions such as respiratory depression, sedation, and…
- Trial name
- NCT07330063
- Testing
- Anruikefen (Intravenous Bolus), Anruikefen (Intravenous Infusion)
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Postoperative Pain, Cardiac Surgery
Efficacy of Serratus Posterior Superior Intercostal Plane Block on Post-operative Pain in Cardiac Surgery.
Cardiac surgery, particularly procedures involving median sternotomy, is associated with significant postoperative pain. Acute postoperative pain is severe in cardiac patients undergoing sternotomy, and pain intensity is more…
- Trial name
- NCT07175298
- Testing
- conventional opioid-based technique, SPSIPB Group
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Postoperative Pain
Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery
The aim of this study is to evaluate the ganglion Impar block in the prevention of postoperative pain after anal surgery.
- Trial name
- NCT04110132
- Testing
- Ganglion impar block with Bupivacaine., Ganglion impar block with normal saline
- Volunteers
- 60 people
- Sponsor
- University of Alexandria
Postoperative Pain After Arthroscopic Knee Surgery
Adductor Canal Block Versus Parasartorial Compartment Block for Pain Relief and Recovery After Arthroscopic Knee Surgery
The goal of this clinical trial is to compare adductor canal block and parasartorial compartment block for pain relief and functional recovery in adults undergoing elective arthroscopic knee surgery.
- Trial name
- NCT07790393
- Testing
- Meperidine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Brain Tumor Adult, Cerebrovascular Disease
The Analgesic Effect of Scalp Nerve Block Using Bupivacaine Liposomes for Postoperative Pain Relief After Craniotomy
After undergoing craniotomy, 60% to 84% of neurosurgery patients experience moderate to severe acute pain, primarily in the first 48 hours. This pain is mostly superficial, affecting the muscles and soft tissues around the skull.
- Trial name
- NCT07049094
- Testing
- scalp nerve block with 0.25% hydrochloride bupivacaine and 0.67% bupivacaine liposome solution, scalp nerve block with 0.50% hydrochloride bupivacaine
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Zhejiang University
Post Operative Pain Control, Endodontic Treatment
Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain
The aim of this research is to assess the effect of intentionally extruding a corticosteroid intracanal solution into the periapical tissues on the postoperative pain after root canal treatment in patients with symptomatic…
- Trial name
- NCT06894069
- Testing
- Dexamethasone
- Volunteers
- 80 people
- Sponsor
- University of Jordan
Pain Management, Abortion
Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement
The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure.
- Conditions
- Pain Management, Abortion, Second Trimester Abortion, Dilation and Evacuation
- Trial name
- PCB-KinD (NCT07487246)
- Testing
- Ketorolac, oral ibuprofen, Lidocaine HCl 1%
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Rush University Medical Center
Foot Surgery, Ankle Surgery
Periarticular Injection Versus Popliteal Block
This study aims to determine the effectiveness and safety of two standard of care perioperative procedures for controlling pain following ankle and hindfoot osteotomy or fusion or ankle fracture repair.
- Trial name
- PvP (NCT04575688)
- Testing
- Exparel, Bupivicaine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Campbell Clinic
Lung Cancer (Diagnosis)
Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1
The goal of this clinical trial is to assess how the location of local anesthetic medication affects pain control capabilities in adult patients undergoing thoracic(chest)-only minimally invasive surgery.
- Trial name
- CALMS-1 (NCT07254650)
- Testing
- Arm 1 "LipoB-I": Liposomal Bupivacaine via Multi-Level Intercostal Nerve Block, Arm 2 "LipoB-S": Liposomal Bupivacaine via Serratus Anterior Plane Block, Arm 3 "LipoB-C": Liposomal Bupivacaine Administered via Combination Block
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Lumbar Disc Herniation, Postoperative Pain
Comparison of TLIP Block and QIP Block for Postoperative Analgesia After Lumbar Spine Surgery
This study compares two regional anesthesia techniques used for pain control after lumbar spine surgery: the classic thoracolumbar interfascial plane (TLIP) block and the quadratus lumborum-iliac plane (QIP) block.
- Trial name
- TLIP-QIP (NCT07750418)
- Testing
- Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine, Quadratus Lumborum-Iliac Plane (QIP) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Vezirköprü State Hospital
Breast Cancer
Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesia in Mastectomy
This study aims to evaluate the effect of serratus posterior superior intercostal plane (SPSIP) block on postoperative pain, opioid consumption, and analgesic requirements in patients undergoing mastectomy and axillary lymph node…
- Trial name
- NCT07579650
- Testing
- SPSIP Block With Bupivacaine, SPSIP Block With Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Opioid Use Disorder, Alcohol Intoxication
Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder
The goal of this clinical trial is to examine whether individuals with co-occurring opioid use disorder and alcohol use (OUD+ALC) experience heightened pain sensitivity, pain-related negative affect, and greater alcohol…
- Conditions
- Opioid Use Disorder, Alcohol Intoxication, Pain
- Trial name
- NCT07894276
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Shoulder Arthroscopy, Postoperative Pain
Magnesium Sulfate With Standard Combined Costoclavicular-Suprascapular Block for Pain Relief After Shoulder Arthroscopy.
This study aims to evaluate whether adding magnesium sulfate to a combined costoclavicular and suprascapular nerve block improves postoperative pain control in patients undergoing shoulder arthroscopy.
- Conditions
- Shoulder Arthroscopy, Postoperative Pain, Regional Anesthesia
- Trial name
- CCSS-Mg (NCT07798115)
- Testing
- Bupivacaine, Magnesium sulfate (MgSO4), Normal Saline (NS)
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
Percutaneous Nephrolithotomy (PCNL)
Erector Spinae Block vs Conventional Analgesia for Postoperative Analgesia in PCNL
50 adult patients scheduled for percutaneous nephrolithotomy in Sohag university hospitals will be devided in two groups one of them will receive Sonographic guided erector spinae plane block using 20 ml volume of bupivacaine…
- Trial name
- NCT06935006
- Testing
- Sonographic guided Erector spinae plane block, Intravenous opioid
- Volunteers
- 50 people
- Sponsor
- Sohag University