Clinical trials: Anal Fissure
Pharmacokinetics, Healthy Subjects
Pharmacokinetics Trial of Isosorbide Mononitrate 0.5% Gel for Intra Anal Application in Healthy Subjects
This is a Phase I trial to evaluate pharmacokinetics and safety of Isosorbide Mononitrate gel for intra anal administration in healthy subjects.
- Trial name
- NCT04729088
- Testing
- Isosorbide mononitrate
- Volunteers
- healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica
Pain, Postoperative
Sitz Bath vs no Sitz Bath in Acute Anal Fissure Treatment
To compare the efficacy of 'sitz bath' and 'no sitz bath' treatment in terms of pain improvement, rate of cure and fissure healing in Acute Anal Fissure.
- Trial name
- NCT05666648
- Testing
- Sitz Bath
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital Quetta
Anal Fissure
Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure
No study to date has compared topical DTZ to MEBO ointment in the treatment of anal fissure. Therefore, the present study aims to compare the efficacy and safety of DTZ to MEBO in the treatment of acute anal fissure.
- Trial name
- MEBO (NCT04153032)
- Testing
- Diltiazem, Mebo
- Where
- Lebanon
- Volunteers
- 183 people
- Sponsor
- American University of Beirut Medical Center
Acute Anal Fissure
Pain and Bleeding in Subjects With Acute Anal Fissure: Comparative Evaluation of Three Treatments
Starting from the observation that acute anal fissure (AAF) in 6-8 weeks can heal spontaneously and that some of the commonly used commercial products in clinical practice would seem to be useful, the rationale of the comparative…
- Trial name
- PBSAAF (NCT03355846)
- Testing
- Centella, Proctocella, Flavonil® cps
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- University of Roma La Sapienza
Anal Fissure, Constipation
Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS Trial
The existing literature stresses the better efficacy of polyethylene glycol (PEG) over other stool softeners like lactulose or isabgol to improve functional constipation.
- Trial name
- PEGASIS (NCT05341180)
- Testing
- Polyethylene Glycol, Isabgol + Lactulose
- Where
- India
- Volunteers
- 144 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Anal Fissure Chronic
Pulsed Electromagnetic Field on Chronic Anal Fissure Healing
The purpose of this study is to find the effect of Pulsed Electromagnetic Field on chronic Anal fissure healing. Included both male and female aged 30-60 suffering from Anal fissure symptoms.
- Trial name
- PEMF (NCT07729709)
- Testing
- PEMS, Lidocaine and general advice, Lidocaine cream and general advice
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Galala University
Anal Fissure Chronic
The Efficacy of Botulinum Toxin Alone Versus Combined Botulinum Toxin and Topical Diltiazem in Chronic Anal Fissure
Anal fissure (AF) is a painful tear extending from the anal canal to the dentate line. Although the exact pathophysiology is not known, an increase in anal tonus, decreased ano-dermal blood flow and local ischemia are possible…
- Trial name
- NCT05797220
- Testing
- Botulinum Toxin Type A Injection [Botox], Botulinum Toxin Type A Injection [Botox] + Diltiazem Hydrochloride 20 Mg/G Rectal Gel
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people
- Sponsor
- Istanbul Medipol University Hospital
Anal Fissure
Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure
This randomized trial aims to compare two topical treatments in the treatment of chronic anal fissure: minoxidil gel and glycreyl trintrate cream.
- Trial name
- NCT03528772
- Testing
- Minoxidil, Glyceryl trinitrate
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Mansoura University
Chronic Anal Fissure
Outcomes of the Use of CO2 (Carbon Dioxide) Laser in the Treatment of Chronic Anal Fissure
Outcomes of using CO2 (Carbon Dioxide) laser in the management of chronic anal fissure as an alternative to conventional methods
- Trial name
- NCT03872765
- Testing
- Laser surgery
- Volunteers
- 236 people
- Sponsor
- University of Nineveh
Fissure in Ano
Pediatrics Anal Fissures Treatment With Polyethylene Glycol
To evaluate whether effectively treating anal fissure-associated constipation using oral PEG alone can eliminate the inconvenience of add topical agent such as DTZ.
- Trial name
- NCT02419534
- Testing
- Polyethylene glycol, Polyethylene glycol with Diltiazem
- Where
- Saudi Arabia
- Volunteers
- 46 people
- Sponsor
- King Saud University
Anal Fissure
A Novel Method for Chronic Anal Fissure Treatment
Investigators performed a prospective pilot study to test the feasibility and safety of autologous adipose derived regenerative cell (ADRC) transplantation in treatment of anal fissures.
- Trial name
- NCT02628522
- Testing
- ADRCs therapy, Celution, Tulip cannulas
- Volunteers
- 6 people
- Sponsor
- Clinical Centre of Serbia
Chronic Anal Fissure
Botulinum Toxin Type A in the Treatment of Chronic Anal Fissure
This study is aimed at studying the effectiveness and safety of surgical treatment of chronic anal fissure.
- Trial name
- BTATCAF (NCT05598164)
- Testing
- Botulinum toxin type A
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Anal Fissure
Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure
RECTIV® is an ointment containing 0.4% nitroglycerin (NTG) for the treatment of moderate to severe pain associated with chronic anal fissure approved in June 2011 by the US Food and Drug Administration (FDA) for adults.
- Trial name
- NCT01920074
- Testing
- Nitroglycerin Ointment 0.4%
- Where
- 6 sites in United States
- Sponsor
- Forest Laboratories
Fissure in Ano
The Role of Fitostimoline Proctogel in Symptoms Relief and Healing in Patients Affected by Anal Fissure
Evaluate the effectiveness of fitostimoline proctogel in the anal fissure healing and in the need for invasive interventions (primary endpoints) and in the healing of the fissure (secondary endpoint) using Fitostimoline in…
- Trial name
- NCT04714684
- Testing
- Fitostimoline proctogel, Fitostimoline proctogel + muscle relaxant
- Volunteers
- 100 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Chronic Anal Fissure
Comparison of Lateral Internal Sphincterotomy Techniques for Chronic Anal Fissure
This prospective randomized controlled trial compares three lateral internal sphincterotomy (LIS) techniques in patients with chronic anal fissure refractory to medical treatment: (1) Spasm-Controlled LIS (serial small…
- Trial name
- SPHINX (NCT07520552)
- Testing
- Spasm-Controlled Lateral Internal Sphincterotomy, Lateral Internal Sphincterotomy up to Fissure Apex, Lateral Internal Sphincterotomy up to Dentate Line
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Çanakkale Onsekiz Mart University
Chronic Anal Fissure
Surgical Treatment of a Chronic Anal Fissure
This study is aimed at studying the effectiveness and safety of surgical treatment of chronic anal fissure.
- Trial name
- STCAF (NCT05117697)
- Testing
- lateral subcutaneous sphincterotomy
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Hemorrhoids, Anal Fistula
Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery?
The aim of this single-center prospective observational trial is to study the influence of physical and psychological factors on the intensity of pain syndrome after anorectal interventions and to determine the association…
- Conditions
- Hemorrhoids, Anal Fistula, Anal Fissure, Incontinence
- Trial name
- NCT06049524
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Center of Endourology "Endocenter"
Perianal Fistula, Fissure in Ano
Perianal Nerval Block in Proctological Interventions
The aim of this study is to evaluate whether a local perianal block performed during a proctological intervention can reduce the postoperative pain.
- Conditions
- Perianal Fistula, Fissure in Ano, Hemorrhoids
- Trial name
- NCT03405922
- Testing
- 40 mL Ropivacain 0.5%
- Where
- Switzerland
- Volunteers
- 166 people
- Sponsor
- University Hospital, Basel, Switzerland
Pain
Comparison of Botulinum Toxin and Sphincterotomy in the Treatment of Chronic Anal Fissure
Intra-sphincteric injection of botulinum toxin seems to be a reliable option causing temporary alleviation of sphincter spasm and allowing the fissure to heal.
- Trial name
- NCT01095900
- Testing
- conservative lateral internal sphincterotomy, Intra-sphincteric Botulinum-toxin injection
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Theodor Bilharz Research Institute
Adult Subjects With Anal Fissures.
An Open-Label, Single- and Multi-Dose Pharmacokinetic (PK) Study of Oral Diltiazem and Topical Diltiazem Hydrochloride
The study is a single-center, open-label, safety and pharmacokinetic study in12 adult subjects with Anal Fissures. Subjects will be screened to determine eligibility within 7 days of treatment.
- Trial name
- NCT01816191
- Testing
- Diltiazem Hydrochloride Cream and Oral Diltiazem
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ventrus Biosciences, Inc