Clinical trials: Anabolic Resistance
Aging, Musculoskeletal Diseases
Mode of Exercise and Bone Biomarkers in Older Veterans
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions.
- Conditions
- Aging, Musculoskeletal Diseases, Osteoporosis
- Trial name
- MOVE (NCT05266976)
- Testing
- 10 Weeks of Supervised Resistance Exercise Training, 10 Weeks of Supervised Endurance Exercise Training
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Anabolic Steroid Overdose, Infertility
Prospective, Longitudinal Study on FItness DOping in DenmarK
The aim of this prospective longitudinal study is to investigate the risks associated with use of anabolic steroids in fitness circles in Denmark in order to assess the scope of therapeutic need existing as a consequence of use.
- Conditions
- Anabolic Steroid Overdose, Infertility, Cardiovascular Complication, Illicit Drug Use
- Trial name
- FIDO-DK/RH (NCT05599438)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Caroline Michaela Kistorp
Inactivity, Physical, Aging
Impact of Postprandial 'Exercise Snacks' on Protein and Glucose Metabolism Following a Period of Step Reduction in Older Adults
The purpose of this study is to assess the impact of 3-days reduced physical activity (<1500 steps/day) with/without 'exercise snacks' (15 chair stands with calf raises every 30 min) on skeletal muscle metabolic health.
- Conditions
- Inactivity, Physical, Aging, Healthy Aging, Sarcopenia
- Trial name
- NCT05810272
- Testing
- Metabolic Trial, 15 sit-to-stands with calf raises
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Physical Inactivity
Translational Control of Anabolic Resistance in Aging Muscle
This is an interventional study enrolling older individuals aged 60-85y to observe changes during physical inactivity. This study is investigating the relation between short-term physical inactivity and the impact of muscle…
- Trial name
- NCT03839628
- Testing
- Reduced Physical Activity
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sarcopenia, Muscle Hypotrophy
Systemic Hormones and Muscle Protein Synthesis
This study evaluates the effect of increase in testosterone levels in older males and the effects of decrease in testosterone levels in young males on muscle protein synthesis.
- Conditions
- Sarcopenia, Muscle Hypotrophy, Muscle Atrophy
- Trial name
- NCT03054168
- Testing
- Sustanon 250, Zoladex
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sedentary Behavior, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity in Young and Older Adults at Different Activity Levels
Recent work in the investigators laboratory has examined the ability of a non-invasive 13CO2 breath-test to assess differences in amino acid oxidation rates and net balance in young healthy males following protein feeding and…
- Conditions
- Sedentary Behavior, Aging, Sarcopenia, Amino Acids
- Trial name
- ARBT (NCT05216809)
- Testing
- Habitual Physical Activity, Step-Reduction
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Sleep, Inadequate
Recovery Protein Nutrition as a Countermeasure for Anabolic Resistance Following Sleep Loss
The current study will determine protein nutritional status (MPS and WBPB) in response to military-relevant sleep loss, and whether an even protein nutrition distribution during recovery optimally supports MPS and WBPB.
- Trial name
- PSL (NCT06073080)
- Testing
- Protein Nutrition During Recovery
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Ketosis, Resistance Exercise
Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males
The goal of this trial is to determine if ketone monoester supplementation in conjunction with protein supplementation in the post exercise period can augment whole-body protein metabolism following resistance exercise in older…
- Conditions
- Ketosis, Resistance Exercise, Dietary Protein, Aging
- Trial name
- KET-OLD-M (NCT07884513)
- Testing
- Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McGill University
Exercise, Resistance Training
Muscle Response to High Intensity Interval Resistance Training (HIIRT)
Resistance training (RT) is one of the most important stimuli for muscle hypertrophy and it plays an important role on weight loss and fatty acid oxidation increase.
- Trial name
- HIIRT (NCT04321772)
- Testing
- High Intensity Interval Resistance Training, Traditional Resistance Training
- Where
- Italy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Padova
Older Adults (65 Years and Older)
RESISTANCE TRAINING AND CAPILLARIZATION - ROLE ON THE ANABOLIC RESPONSE IN OLDER ADULTS
The goal of this clinical trial is to learn how muscle capillaries influence the response to resistance exercise training in older adults.
- Trial name
- RECAP (NCT07680036)
- Testing
- Exercise
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Padova
Ketosis, Blood Hormones
The Impact of Ketone Monoester Intake on Post-exercise Hormonal Responses After Resistance Exercise in Young Males
This study investigates how orally ingested exogenous ketone monoester supplements affect circulating hormone concentrations in healthy young adult males after a single session of resistance exercise.
- Conditions
- Ketosis, Blood Hormones, Testing Effect of Intervention, Resistance Exercise
- Trial name
- NCT06683547
- Testing
- Ketone Monoester (KET), Resistance Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- McGill University
Sarcopenia
Role of MicroRNAs on Age and Contraction-induced Skeletal Muscle Growth
Sarcopenia is a predictor of functional-limitation, leading to loss of independence, lowered quality of life, and ultimately death.
- Trial name
- NCT02638454
- Testing
- Acute Resistance Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Atrophy, Disuse, Muscle Atrophy
Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse
This study will characterize intramuscular molecular mechanisms underlying anabolic resistance to protein ingestion during muscle disuse.
- Conditions
- Atrophy, Disuse, Muscle Atrophy, Muscular Disorders, Atrophic, Disuse Atrophy
- Trial name
- NCT06228742
- Testing
- Unilateral leg immobilization, Contralateral active leg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Muscle Disuse, Muscle Disuse Atrophy
Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization
Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy).
- Trial name
- NCT07069426
- Testing
- 20 grams protein, 40 grams protein
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Sarcopenia, Anabolic Resistance
Strength Training and Resveratrol
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether…
- Trial name
- STaR (NCT06585865)
- Testing
- Resistance training, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Cricket Protein, Whey Protein
Insect vs Animal Protein for Building Muscle
This research is being carried out to investigate the potential of insects (crickets) as a sustainable protein source for supporting human muscle tissue by comparing cricket protein to a commonly used animal protein (whey).
- Trial name
- GAINZ (NCT07159919)
- Testing
- protein supplement
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Amino Acids
The Effect of ProHydrolase® on the Amino Acid, Intramuscular Anabolic Signaling, and Endocrine Response to Resistance Exercise in Trained Males
To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL).
- Trial name
- NCT04144114
- Testing
- ProHydrolase®, Whey protein
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes
Sarcopenia, Frailty
Protein and Skeletal Muscle in Older Twins: Role of the Gut Microbiome
Research Question: Does the gut microbiome contribute to muscle anabolic resistance to protein supplementation in older adults? Background: Loss of muscle occurs with age and skeletal muscle in older adults can display anabolic…
- Conditions
- Sarcopenia, Frailty, Age-Related Sarcopenia
- Trial name
- PROMOTe (NCT04309292)
- Testing
- Prebiotic food supplement, Protein supplement
- Where
- United Kingdom
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- King's College London
Older Adults Without Any Specific Clinical Condition
Essential Amino Acid Supplementation Enhances Post-prandial Amino Acid Availability Following a Standard-protein Breakfast in Older Adults
Healthy older adults and those who have acute and chronic conditions suffer from reduced protein intake and are at risk of developing both chronic and acute sarcopenia.
- Trial name
- NCT07754760
- Testing
- Essential amino acid supplement
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Healthy
Forearm Immobilization, Metabolic Health, and Muscle Loss
The present study will investigate the impact of altered substrate availability on muscle atrophy, insulin sensitivity and muscle protein synthesis following short-term forearm immobilization
- Trial name
- NCT03866512
- Testing
- Forearm immobilization
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Exeter