Clinical trials: Amyotrophic Lateral Sclerosis, completed
Familial Amyotrophic Lateral Sclerosis
SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS)
The objective of this study will be to evaluate the safety, tolerability and effect on SOD1 levels by pyrimethamine in patients with familial amyotrophic lateral sclerosis.
- Trial name
- NCT01083667
- Testing
- Pyrimethamine
- Where
- 5 sites in United States, Germany and 2 more
- Volunteers
- 32 people
- Sponsor
- Weill Medical College of Cornell University
Amyotrophic Lateral Sclerosis
A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in ALS Patients
This is a prospective study in a cohort of about 45 patients with ALS participating in the Neurosense PrimeC drug study (NCT05357950).
- Trial name
- NCT05407428
- Testing
- NeuraLight software-based platform
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- NeuraLight
Multiple Sclerosis, Stroke
An Assistive Powered Wheelchair: Stage 2 Trial
Preliminary evaluation of an obstacle alerting system to enhance the user's independent mobility by improving their confidence to drive and their safety in driving a powered wheelchair.
- Conditions
- Multiple Sclerosis, Stroke, Cystic Fibrosis, Motor Neurone Disease
- Trial name
- EDUCAT (NCT05292690)
- Testing
- Powered Wheelchair Obstacle Alerting System
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Amyotrophic Lateral Sclerosis (ALS)
Tamoxifen Therapy in Amyotrophic Lateral Sclerosis [ALS]
This is a single-center, phase 2 randomized clinical trial of tamoxifen on mean percent predicted isometric muscle strength in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT00214110
- Testing
- Tamoxifen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Amyotrophic Lateral Sclerosis (ALS)
Effects of L-Carnitine in Amyotrophic Lateral Sclerosis Patients With CHCHD10 Mutations
The study was designed as a single-center, open-label, single-arm pilot study to estimate the safety and efficacy L-carnitine in ALS patients with CHCHD10 mutations.
- Trial name
- NCT06849115
- Testing
- L-Carnitine Injection，1000mg once daily
- Where
- China
- Volunteers
- 4 people
- Sponsor
- ChaodongWang
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS)
MetFlex is an investigator led, open-label, single-arm, Phase 2a trial to determine the safety and tolerability of trimetazidine for the treatment of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND).
- Trial name
- MetFlex (NCT04788745)
- Testing
- Trimetazidine Dihydrochloride
- Where
- 3 sites in Australia, Netherlands and 1 more
- Volunteers
- 21 people
- Sponsor
- The University of Queensland
Motor Neurone Disease, Hypoxemia and/or Hypercapnia
The Relationship Between Arterial Stiffness and Respiratory Failure in Motor Neurone Disease
Patients with Motor Neurone Disease (MND) admitted to Lane Fox Unit /Royal Brompton Hospital and/or reviewed in Lane Fox Unit /Royal Brompton Hospital clinics and/or outreach review will be approached for participation in the…
- Trial name
- NCT03444428
- Testing
- Non Invasive Ventilation, Without Non Invasive Ventilation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Amyotrophic Lateral Sclerosis, Frontotemporal Lobar Degeneration
Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation
Background: Some people have a mutation in the C9ORF72 gene that causes amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). The mutation causes a small piece of DNA to repeat itself thousands of times.
- Trial name
- NCT01925196
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Autologous Multipotent Mesenchymal Stromal Cells in the Treatment of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that targets motor neurons. Prognosis is invariably fatal within 3-5 years since manifestation of the disease.
- Trial name
- AMSC-ALS-001 (NCT03828123)
- Testing
- Suspension of human autologous MSC 3P in 1.5 ml
- Volunteers
- 26 people
- Sponsor
- Bioinova, s.r.o.
Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease (PD)
The Meals Study for Amyotrophic Lateral Sclerosis and Parkinson's Disease
Brief summary template The goal of this trial is to test the feasibility and efficacy of the Mediterranean-DASH Intervention for Neurodegenerative Delay (the MIND diet) in people living with amyotrophic lateral sclerosis (ALS)…
- Trial name
- Meals (NCT07625605)
- Testing
- The MIND diet
- Where
- 3 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Amyotrophic Lateral Sclerosis
Influence of the Vitamin D Blood Levels on the Amyotrophic Lateral Sclerosis Phenotype
The main objective of this study is to investigate the correlation between the rate of motor decline and blood levels of Vitamin D total.
- Trial name
- NCT01823380
- Testing
- Blood test
- Where
- France
- Volunteers
- 127 people
- Sponsor
- University Hospital, Montpellier
Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Registry Rhineland-Palatinate
There is a lack of prospective and population-based epidemiological data on amyotrophic lateral sclerosis in Germany so far. The purpose of this registry is to investigate the incidence, course and phenotypic variety of ALS in…
- Trial name
- NCT01955369
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Klinikum Ludwigshafen
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS
Rehabilitation interventions such as physical training and neural stimulation after spinal cord injury (SCI) have been shown to increase neural plasticity.
- Trial name
- NCT03851302
- Testing
- Active Remote Ischemic Conditioning, Isometric hand exercise
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Bronx VA Medical Center
Amyotrophic Lateral Sclerosis
Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis
The objective of this study is to determine whether creatine slows disease progression in subjects with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT00005766
- Testing
- Creatinine
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Healthy, Amyotrophic Lateral Sclerosis
P300 Brain Computer Interface Keyboard to Operate Assistive Technology
The purpose of this research is to develop tools enable people who are paralyzed to operate technology and access computers. These tools are called brain computer interfaces (BCIs).
- Conditions
- Healthy, Amyotrophic Lateral Sclerosis, Neuromuscular Disease, Spinal Cord Injury
- Trial name
- NCT00860951
- Testing
- Brain Computer Interface Keyboard
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Amyotrophic Lateral Sclerosis (ALS)
Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)
The objective is to compare the efficacy and safety of masitinib in combination with riluzole in the treatment of patients suffering from Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT02588677
- Testing
- Masitinib (4.5), Riluzole, Masitinib (3.0)
- Where
- Spain
- Volunteers
- 394 people
- Sponsor
- AB Science
Amyotrophic Lateral Sclerosis
Hyperlipidemia and Statin Therapy in Amyotrophic Lateral Sclerosis
The role of hyperlipidemia and lipid lowering therapy (LLT) in Amyotrophic Lateral Sclerosis (ALS) pathophysiology and its impact on disease progression and survival is unclear.
- Trial name
- NCT01592084
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- The Methodist Hospital Research Institute
Sialorrhea
Efficacy and Safety Study of MYOBLOC® in the Treatment of Sialorrhea in Adult Subjects
This study will evaluate the efficacy and safety of MYOBLOC in the treatment of Sialorrhea (drooling), which can be a symptom of many disease conditions. MYOBLOC will be injected directly into the salivary glands.
- Trial name
- MYSTICOL (NCT01994109)
- Testing
- MYOBLOC
- Where
- 34 sites in United States, Russia and 1 more
- Volunteers
- 187 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC
Amyotrophic Lateral Sclerosis
Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS
A tele-health treatment study for individuals with early stage ALS with the aim to improve communication, cough response, and respiratory strength.
- Trial name
- NCT05003167
- Testing
- Expiratory Muscle Strength Training (EMST-150)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Purdue University
Amyotrophic Lateral Sclerosis
Virtual Seating Coach on Power Wheelchairs of Persons With Amyotrophic Lateral Sclerosis (ALS)
A literature review was completed related to the topic of use of the Virtual Seating Coach (VSC) device with clients with Amyotrophic Lateral Sclerosis (ALS) with no results.
- Trial name
- ALS (NCT05742828)
- Testing
- Virtual Seating Coach
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Wake Forest University Health Sciences