Clinical trials: Amputee
Lower Limb Amputation Below Knee (Injury)
Human-Prosthetic Interaction: Brain & Technology After Lower-Limb Loss
This study evaluates brain neuroplasticity and functional performance in people with unilateral lower limb amputation.
- Trial name
- HumanIT (NCT05818410)
- Testing
- Prosthetic device (Lunaris), No prosthetic device, Prosthetic device (Sach foot)
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Amputation Stumps, Amputees
Moisture Management Liner Effectiveness Study
The comfort and fit of the residual limb within a prosthetic socket are of primary concern for many amputees. The residual limb is typically covered by non-breathable and non- thermally conductive materials that can create a warm…
- Conditions
- Amputation Stumps, Amputees, Amputation, Lower Limb Deformities, Congenital
- Trial name
- NCT04427007
- Testing
- Moisture Management Liner, Control Liner
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Trauma Patients
Limb Salvage in Peripheral Arterial Trauma Patients
The aim of this study is to determine risk factors associated with failure of limb salvage in patients with periphral arterial injuries with or without attempts of revascularization.
- Trial name
- NCT06787495
- Testing
- Arterial repair
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mekhael Rezk Abd-Elmalak
Amputation
Assessment of a Hybrid Pump for Vacuum Suspension of Prosthetic Sockets for Persons With Lower Limb Loss to Characterize the Effects of Added Movement on Socket-reaction Torques
Prostheses can be suspended from the amputated limb using a variety of techniques, such as straps and suction. Suspending the prosthesis by creating a vacuum between the prosthetic socket and limb using a pump has benefits over…
- Trial name
- HIPPI (NCT04230512)
- Testing
- Pump prototype
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Diabetic Polyneuropathy, Amputation
Comparison of Joint Position Sense in Diabetic and Traumatic Transtibial Amputees
This study evaluated the effect of joint position sense on compliance with the prosthesis, balance and functional performance in individuals with lower extremity amputation due to diabetic polyneuropathy.
- Trial name
- NCT05542901
- Testing
- Joint Position Sense Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Amputation, Adult Disease
Revofit™ System Evaluation on Residual Limb Pain in Amputee Patients
At the early stage of the amputation, the residual limb presents post-surgical fluctuations related to post-operative phase, which would need a frequent prosthetic adjustment.
- Trial name
- NCT04276714
- Testing
- Socket without Revofit system, Socket with Revofit system
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Angers
Unilateral Trans-tibial Amputees
Hull Early Walking Aids for Transtibial Amputees - Randomised Control Trial (HEART)
Early walking aids are routinely used in UK for rehabilitation of patients with below knee amputations. The two main walking aids used commonly in practice include the non-articulated Pneumatic Post Amputation Mobility Aid…
- Trial name
- HEART (NCT01024023)
- Testing
- EWA
- Where
- 3 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Hull
Phantom Limb Pain
Predicting Pain Response to Transcranial Direct Current Stimulation for Phantom Limb Pain in Limb Amputees
This study explores the effects transcranial Direct Current Stimulation (tDCS, Soterix ©) on Phantom Limb Pain for patients experiencing chronic phantom limb pain in open-label study design.
- Trial name
- NCT02627495
- Testing
- transcranial Direct Current Stimulation (tDCS): (Soterix ©)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Spaulding Rehabilitation Hospital
Amputation, Traumatic Amputation of Lower Extremity
Sitting Balance in Lower Limb Amputees
The aim of this study is to compare the sitting and standing postural stability of transfemoral individuals with healthy individuals with similar demographic characteristics.
- Trial name
- NCT05597696
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Phantom Limb Pain
Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation
The study investigates the capabilities of peripheral magnetic stimulation (PMS) as a tool for creating somatosensory sensations of various submodalities and analyzing the dynamics of bioelectric signals of the brain (using…
- Trial name
- NCT06813937
- Testing
- Procedure: Peripheral Magnetic Stimulation (PMS), Electroencephalography (EEG)
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Amputation, Traumatic
Feasibility of Implantable Myoelectric Sensors to Control Upper Limb Prostheses
This study will evaluate the feasibility of using implanted myoelectric sensors (IMES) to control an electromechanical prosthetic wrist and hand.
- Trial name
- IMES (NCT01901081)
- Testing
- IMES
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The Alfred E. Mann Foundation for Scientific Research
Amputation Wound, Traumatic Amputation of Toe
Longitudinal Study of Weight Change Following Lower Limb Amputation
The purpose of this study is to assess weight change in a population of Veterans with amputations. Little is known about the how weight changes following an amputation.
- Conditions
- Amputation Wound, Traumatic Amputation of Toe, Dysvascular Amputation of Lower Limb
- Trial name
- NCT00932399
- Where
- United States
- Volunteers
- 4,549 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Amputees
Evaluation of a Multimodal Tactile Feedback System for Upper Limb-loss Users: Embodiment and Performance
The aim of this study is to evaluate the effect of integrating tactile feedback systems into a robotic upper-limb prosthesis. These systems deliver pressure stimuli (through small silicone chambers that inflate), vibration…
- Trial name
- THE_FBHAND (NCT07418645)
- Testing
- Pressure and vibrotactile feedbak, Pressure feedback, Vibrotactile feedback
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- University of Pisa
Amputation
Development of the ICF Based Amputee Mobility Scale
Lower limb amputation is a condition that reduces individuals' independence in daily life. Therefore, the main purpose of the rehabilitation process is to reintegrate the person as an independent and productive person as soon as…
- Trial name
- NCT04276467
- Volunteers
- 120 people
- Sponsor
- Hacettepe University
Amputees, Exercise Training
Spinal Stabilization Exercises in Individuals With Transtibial Amputatıon
Lower extremity amputation causes rapid changes in musculoskeletal system. With the effect of these changes, the energy requirement for prosthetic ambulance is much higher than normal ambulance.
- Conditions
- Amputees, Exercise Training, Physiotherapy, Energy Metabolism
- Trial name
- NCT04114175
- Testing
- Exercise BE, Exercise BE+SS
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Baskent University
Immunosuppression
Immunomodulation to Optimize Vascularized Composite Allograft Integration for Limb Loss Therapy
The purpose of this study is to determine the safety and efficacy of hand transplantation as a treatment for patients with loss of limb below the elbow, The study will focus on patients who have had loss of limb.
- Trial name
- NCT02310867
- Testing
- Belatacept, Hand transplant
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Linda Cendales
Amputation; Traumatic, Hand
Validation of User Needs of the Point Digit With Partial Hand Amputees
The objective of the device feasibility study will be to validate the user needs of the Point Digit system. This study will be a single group intervention model where one group of 5 partial hand amputees will be asked to perform…
- Trial name
- NCT04763278
- Testing
- Point Digit
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Point Designs
Diabetes Type 2, Amputation
Deploying Digital Prosthetic Interface Technology and Exercise in Dysvascular Amputees
The study will test a new approach to the design and implementation of socket and liner technology in individuals who lost a lower limb secondary to diabetes mellitus type II (herein referred to as dysvascular amputees).
- Trial name
- NCT05656924
- Testing
- digital prosthetic interface technology
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Spaulding Rehabilitation Hospital
Amputation, Traumatic
Changes in Trans Tibial Amputee Running Asymmetry During Prolonged Effort
The purpose of this study is to determine the effect of prolonged effort in long distance running on the biomechanical bilateral asymmetry in the lower limbs of trans tibial amputee running with running specific prosthesis.
- Trial name
- NCT02601456
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Amputation; Traumatic, Hand
To Assess the Utility of the Point Partial in a Clinical Take-home Study of Partial Hand Amputees
This study will allow us to assess whether the Point Partial confers functional and psychological benefit to persons with partial finger amputations in an unconstrained environment.
- Trial name
- NCT05012683
- Testing
- Point Partial
- Where
- 7 sites in United States
- Volunteers
- 11 people
- Sponsor
- Point Designs