Clinical trials: Amputation Pain
Pain, Postoperative, Amputation
Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations
Through this pilot prospective trial, we aim to obtain preliminary data investigating the effectiveness of perineural catheters and liposomal bupivacaine, both currently accepted as standard care at Maine Medical Center, for the…
- Trial name
- NCT05140499
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride 0.5 % Injectable Solution
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Aurora Quaye
Post-Amputation Pain, Phantom Limb Pain
Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System
The purpose of this study is to determine if electrical stimulation (small levels of electricity) can safely and effectively reduce post-amputation pain. This study involves a device called the SPRINT System.
- Conditions
- Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain
- Trial name
- NCT01996254
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- SPR Therapeutics, Inc.
Amputation
Kinesiophobia and Associated Factors in Patients With Traumatic Lower Extremity Amputation
There are limited studies examining kinesiophobia and factors associated with kinesophobia in patients with lower limb amputation.
- Trial name
- NCT04775667
- Testing
- questionnaires for clinical assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Neuroma, Cryoablation
Proximal Nerve Cryoablation Versus Perineuroma Cryoablation for Chronic Neuroma Pain After Combat-Related Amputation
atients with combat-related amputations frequently develop chronic neuroma pain that interferes with rehabilitation, prosthesis use, mobility, sleep, and quality of life.
- Trial name
- AXON-FREEZE (NCT07618689)
- Testing
- Perineuroma Cryoablation, Proximal Nerve Cryoablation
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Phantom Limb Pain
Telerehabilitation Using Mirror Therapy in Patients With Phantom Limb Pain Following Lower Limb Amputation.
The overall aim of this randomized controlled study is to investigate the effectiveness of mirror therapy supported by telerehabilitation on the intensity, duration and frequency of phantom limb pain and daily activities compared…
- Trial name
- NCT02076490
- Testing
- Physical/Occupational therapy
- Volunteers
- 105 people
- Sponsor
- Zuyd University of Applied Sciences
Phantom Limb Pain
Home-based Self-delivered Mirror Therapy for Phantom Limb Pain
The goals of the study are to determine whether self-delivered, home-based mirror therapy decreases the frequency and intensity of phantom limb pain and improves mood and physical function in persons with phantom limb pain.
- Trial name
- NCT00827294
- Testing
- Mirror Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Neuropathic Pain, Lower Limb Amputation
Pre-emptive Analgesia With Qutenza in Lower Limb Amputation
Neuropathic (nerve pain) following amputation of a limb is very common, affecting 60-80% of patients (Sherman et al, 1984). It can prolong their recovery making it difficult to fit protheses and mobilise.
- Trial name
- NCT01748435
- Testing
- Qutenza
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde
Low Back Pain, Amputation
The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation
Patients with combat-related lower limb amputations frequently experience chronic low back pain during long-term rehabilitation and prosthetic use.
- Trial name
- LEVEL-BACK (NCT07626294)
- Where
- Ukraine
- Volunteers
- 300 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Traumatic Transfemoral Amputation, Painful Bone Spur
Efficacy of Extracorporeal Shockwave Therapy on Painful Bone Spur in Traumatic Transfemoral Amputees
Painful bone spur is one of the causes of residual limb pain in individuals with traumatic lower extremity amputation and can be a significant problem in rehabilitation clinics.
- Trial name
- NCT07440550
- Testing
- Extracorporeal shockwave therapy (ESWT), Therapeutic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Phantom Limb
Virtual Integrated Environment in Decreasing Phantom Limb Pain
The purpose of this study is to determine if observing a virtual arm decreases phantom limb pain (PLP) in upper extremity amputees.
- Trial name
- VIE (NCT01462461)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Phantom Pain Following Amputation of Lower Limb, Amputation
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb.
- Trial name
- PLP Home-Based (NCT07044323)
- Testing
- Active Virtual Reality Treatment
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Albert Einstein Healthcare Network
Phantom Pain
Neural Bases of Phantom Pain After Amputation
The amputation of a limb results in chronic pain associated with the lost limb in the majority of patients, which persists over time.
- Trial name
- Phantom limb (NCT05545358)
- Testing
- Questionnaires, Brain and Spinal Cord functional Magnetic Resonance Imaging, Proprioceptive training
- Volunteers
- 75 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Phantom Limb Pain
Study to Assess the Efficacy of Direct Observation and Mental Visualization of Foot Movements to Treat Bilateral Lower Limb Phantom Limb Pain
Because bilateral lower extremity amputees do not have an intact limb for use with the mirror, we are now proposing to conduct a pilot trial of two treatments for phantom limb pain (PLP) - direct observation of another person's…
- Trial name
- NCT00639431
- Testing
- direct observation, mental visualization
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Traumatic Amputation
Strength, Pain and Function in Operation Iraqi Freedom/Operation Enduring Freedom Amputees: A Nurse-Managed Program
The purpose of this randomized control study is to determine if administering neuromuscular electrical stimulation (NMES) to the thigh muscles of a below the knee amputee is more effective than the current standard of care in…
- Trial name
- NCT00942890
- Testing
- NMES (EMPI 300PV stimulator) plus standard of care, TMARP standard of care
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Tennessee
Pain, Complications
Comparison of Two Kinds of Postoperative Analgesia After Amputation
Pain after amputation is a significant problem among amputees. Phantom limb pain may appear in up to 85% of patients and is usually resistant to a wide variety of treatments.It is believed that regional anesthesia, by preventing…
- Trial name
- NCT02114463
- Testing
- Local analgesic, Intravenous analgesic, ropivacaine
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Chronic Pain, Amputation
Chronic Pain and Amputation: A Quality of Life Comparison
The aim of this observational, cross-sectional study is to investigate and compare the impact of chronic pain and amputation on patients' quality of life.
- Trial name
- NCT06704386
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Kastamonu University
Amputation
The Effect of Perioperative Intravenous Lidocaine Infusion on Post-amputation Pain in Amputee Patients
This study aimes to evaluate whether perioperative intravenous lidocaine infusion effectively relieves postoperative pain, enhances recovery, and reduces chronic stump and phantom limb pain after amputation, thereby informing…
- Trial name
- NCT07783867
- Testing
- Lidocaine Hydrochloride, Injectable, 0.9% normal saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- West China Hospital
Phantom Limb Pain
Study of Phantom Limb Pain Suppression Using Neuromodulation Methods
This study assesses the effectiveness of neuromodulation in alleviating pain through the stimulation of peripheral nerves. The research involves implanting electrodes for test stimulation of peripheral nerves (PNS - Peripheral…
- Trial name
- NCT06644807
- Testing
- Motor Cortex Stimulation, Spinal cord stimulation, Peripheral Nerve Stimulation
- Where
- 2 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Skolkovo Institute of Science and Technology
VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation
Venous Thromboembolism and Chronic Pain After Major Limb Trauma
Major limb trauma is associated with a high risk of venous thromboembolism (VTE) due to systemic inflammation, endothelial injury, immobilization, and hypercoagulability.
- Conditions
- VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation, Chronic Pain, Chronic Pain Due to Injury
- Trial name
- THROMBO-PAIN (NCT07475910)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Pain Management
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation (Experiment 1)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom…
- Trial name
- NCT04750525
- Testing
- BreEStim, EStim
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston