Clinical trials: Amputation
Upper Limb Amputation at the Wrist
A Bidirectional MyoKinetic Implanted Interface for Natural Control of Artificial Limbs
This is a European project that it will develop an innovative robotic hand prosthesis, whose movements can be controlled in a natural and intuitive way.
- Trial name
- MYKY (NCT06176482)
- Testing
- Magnetic markers implantation
- Where
- Italy
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Amputation, Lower Limb
Quantifying Bone and Skin Movement in the Residual Limb of Individuals With Transtibial Amputation Using Dynamic Stereo X-Ray
Individuals with lower extremity amputation are often challenged by complications that arise from poor prosthetic fit, including movement of the residual limb in the socket, known as pistoning.
- Trial name
- NCT05287646
- Testing
- Suction Suspension First, Elevated Vacuum Suspension First
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Peripheral Artery Disease, Critical Limb Ischemia
Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Temsirolimus Perivascular Injection 0.1 mg/mL on the incidence of ischemia-driven major amputation, clinically driven target lesion…
- Trial name
- TANGO-3 (NCT04433572)
- Testing
- Temsirolimus
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Mercator MedSystems, Inc.
Amputation, Traumatic
The Relationship Between Thicknesses and Isokinetic Strength of Hip Flexor and Extensor Muscles
The aim of this study is to investigate the relationship of hip muscle thicknesses measured by ultrasonography with hip flexion and extension strength and clinical parameters in prosthesis users with unilateral traumatic…
- Trial name
- NCT05827744
- Testing
- Isokinetic evaluations, Ultrasonographic evaluations
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Gait, Balance
Gait Stability of People With Lower-limb Amputations
The purpose of this study is to evaluate whether there are quantifiable differences in walking stability, as measured by the acceleration of the trunk or the variation in step length, between people with unilateral below-knee…
- Trial name
- NCT00915109
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kim Parker
Critical Limb Ischemia, Peripheral Arterial Disease
ALD-301 for Critical Limb Ischemia, Randomized Trial
This study will treat patients with such severe lower leg ischemia or vascular compromise that they have pain at rest. The goal is to compare treatment of the patient's painful disorder by injecting cells into the calf of the leg…
- Conditions
- Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
- Trial name
- CLI-001 (NCT00392509)
- Testing
- ALDH-br bone marrow cells vs. mononuclear bone marrow cells
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aldagen
Amputation
Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users
The goal of this research is to analyze data from smartphone-based and wearable sensors, using advanced machine-learning and data-mining techniques, and to combine this information with performance-based measures…
- Trial name
- NCT03930199
- Testing
- Needs-based intervention (physical, psychological, or both)
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Shirley Ryan AbilityLab
Amputation, Traumatic, Hand Injuries
Microvascular Partial Toe Transfer
Microvascular partial toe transfer for reconstruction of traumatic amputation of the digits
- Trial name
- NCT04192084
- Testing
- microvascular partial toe transfer
- Volunteers
- 20 people
- Sponsor
- Assiut University
Amputation
Dynamic Management of Excess Residual Limb Pressure With New Smart Socket Technology/Intelligent Prosthetic Socket With Variable Volume and Elevated Vacuum Systems
This study centers around the imaging of internal structures of residual limb by means of modern radiographic imaging techniques (Dynamic Radiography-DRSA).
- Trial name
- SMARTsocket- (NCT01108536)
- Testing
- adaptive prosthetic socket
- Where
- 3 sites in United States, Cyprus
- Volunteers
- 60 people
- Sponsor
- University of Wisconsin, Milwaukee
Lower Limb Amputation Above Knee (Injury)
Decoding Motion Planning Using Cortical Potentials
The team will investigate the user's intention to move by using cortical activity during a sit to stand movement performance in people with a transfemoral amputation and able-bodied individuals.
- Trial name
- NCT04325516
- Testing
- Daily activities
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Transradial Amputation, Wrist Disarticulation
Comparison of Standard Myoelectric Hand and Bionic Hand Use in Individuals With Upper Limb Amputation
This single-center, prospective, comparative study aims to compare hand function, quality of life, patient satisfaction, task completion time, fatigue, and compensatory elbow, shoulder, and cervical movements in individuals with…
- Trial name
- NCT06684730
- Testing
- Hand Function Assessment Scales, Prosthesis Satisfaction Scale, Quality of Life Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Critical Limb Ischemia
Effect of Evolocumab in Patients With Critical Limb Ischemia (Evol-CLI)
Critical limb ischemia (CLI), is the most severe form of peripheral arterial disease (PAD), and clinically is characterized by pain at rest or non-healing ulcers of the lower extremities.
- Trial name
- Evol-CLI (NCT04306471)
- Testing
- Evolocumab 140mg/mL Injector 1milliliter (mL) Pen x 3 for a monthly dose of 420 mg for 12 months.
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Leonardo Clavijo
Transfemoral Amputation
Active Knee Prosthesis Study
The purpose of the study is to investigate the clinical and functional outcomes of a powered knee prosthesis for people with a transfemoral amputation in the domain of gait, free space control, and embodiment
- Trial name
- NCT06700668
- Testing
- MIT Powered Knee
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts Institute of Technology
Distal Amputation of the Fingers
Lipofilling Versus Conservative Treatment in Fingertips Injuries Sequelae
The purpose of this study is to evaluate the contribution of autologous graft reinjection (lipofilling) in the treatment of dysaesthesic pulp.
- Trial name
- LIPOFILLING (NCT04076397)
- Testing
- autologous transplant reinjection, desensitization
- Where
- 2 sites in France
- Sponsor
- University Hospital, Brest
Pain Management
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation (Experiment 1)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom…
- Trial name
- NCT04750525
- Testing
- BreEStim, EStim
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetic Foot Ulcer
The Effect of Implementing a Limb Loss Prevention Program on Amputation Rates
The investigators plan to do a retrospective chart review on patients admitted to Parkland Hospital with diabetic foot infections, ulcers, and bone injuries from 2005 (5 years prior to the start of the diabetic limb preservation…
- Trial name
- NCT03978715
- Testing
- No intervention-retrospective study
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Amputation, Traumatic
Relationship Between Gait Variability and Sensation
Twenty individuals who were referred to receive physiotherapy will be participants of the study. Participants with lower limb loss will evaluate with the following assessment tools: Demographic datas; age, gender, height, body…
- Trial name
- NCT02934074
- Testing
- No intervention
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Diabetic Foot, Amputation
Pattern and Type of Amputation and Mortality Rate Associated With Diabetic Foot in Jeddah, Saudi Arabia: A Retrospective Cohort Study
This study explored the pattern and type of amputations performed on patients with diabetic foot who were admitted to our institution, as well as the 7-year mortality rate of patients with diabetic foot at the same institution.
- Trial name
- NCT05123157
- Testing
- NO intervention
- Where
- Saudi Arabia
- Volunteers
- 358 people
- Sponsor
- King Abdulaziz University
Diabetes, Foot Ulcer
Preventing Amputations by Tailored Risk-based Intervention to Optimize Therapy
The PATRIOT study will evaluate a risk-based personalized behavioral intervention to improve foot self-care, self-monitoring, and modifiable risks for amputation such as blood glucose, blood pressure and cholesterol in order to…
- Trial name
- PATRIOT (NCT02356757)
- Testing
- Personalized Behavioral Intervention, Current Best Practice
- Where
- United States
- Volunteers
- 406 people
- Sponsor
- VA Office of Research and Development
Fingertip Amputation, Finger Injuries
Semi-occlusive Dressing for Pediatric Fingertip Amputations
The aim of this prospective cohort study is to assess the outcome and pain progression of fingertip (partial) amputations treated with a semi-occlusive wound dressing (regular care) in childhood and adolescence.The main questions…
- Trial name
- NCT07552753
- Testing
- semi-occlusive dressings
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz