Clinical trials: Alzheimer's
Rheumatoid Arthritis
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- DREAM (NCT04529876)
- Testing
- Tofacitinib, Abatacept
- Where
- United States
- Volunteers
- 29,464 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Alzheimer Disease, Early Onset, MCI
The Interactive Physical and Cognitive Exercise System
This study is intended to clarify the benefits to brain health and thinking processes that result from different forms of exercise.
- Conditions
- Alzheimer Disease, Early Onset, MCI, Aging, Mild Cognitive Impairment
- Trial name
- iPACES™ (NCT03069391)
- Testing
- physical exercise alone (PES) first, cognitive exercise alone (iCE) first, interactive Physical and Cognitive Exercise (iPACES™)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Union College, New York
Lewy Body Dementia (LBD), Alzheimer Dementia (AD)
Targeting Neuroinflammation as a Contributing Pathology in Alzheimer's Disease Dementia and Related Dementias
This study is being done to research the usefulness of PET/CT imaging for measuring brain inflammation and its relation to Alzheimer's Disease Dementia and related dementias.
- Trial name
- NCT04786223
- Testing
- C-11 ER-176, Blood Test
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Val Lowe
Family Caregivers, Dementia
Financial Counseling for Dementia Family Caregivers in Early and Middle Adulthood
The goal of this National Institutes of Health (NIH) Stage 1a study is to develop and pilot test a research- and community-informed financial counseling and advocacy (FCA) intervention for dementia family caregivers in early and…
- Conditions
- Family Caregivers, Dementia, Financial Wellbeing, Financial Coaching
- Trial name
- FCA 4 FC-EAMA (NCT07681401)
- Testing
- Financial Counseling and Advocacy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Utah
Mild Cognitive Impairment, Mild Alzheimer's Disease
Early Detection of Mild Cognitive Impairment in Individual Patients
Our central hypothesis is that the early metabolic lesions of MCI can be reliably detected in individual subjects by objective analysis of [18]F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) brain images, earlier…
- Trial name
- NCT00243451
- Testing
- PET scan & fMRI
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Alzheimer Disease
Brain Connectivity Marker for Alzheimer's Disease
The main purpose of this project is to establish whether changes in brain connectivity can be used to predict the development of Alzheimer's disease (AD).
- Trial name
- BRAINCONN (NCT06874231)
- Testing
- Neuroimaging
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Health Promotion
Caregiver Stress: Interventions to Promote Health and Wellbeing
More and more family members are providing care to their loved ones with prolonged and progressive illnesses. Chronic intense caregiving represents a situation of chronic stress, which takes a toll on one's mental and physical…
- Trial name
- NCT01188070
- Testing
- Usual Care, Psycho-education, Psycho-education plus physical exercise
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Emory University
Alzheimer Disease
Nutrition Interventions for Cognitive Enhancement
By doing this study, researchers hope to learn how the Mediterranean and low-fat eating patterns affect memory, brain volume, brain antioxidant status and cardio-metabolic biomarkers, such as blood pressure and blood glucose, in…
- Trial name
- NICE (NCT03841539)
- Testing
- Mediterranean Diet, Study Supplement, Low-fat Diet
- Where
- United States
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Rheumatoid Arthritis
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs Hydroxychloroquine
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- NCT04691505
- Testing
- Methotrexate, Hydroxychloroquine
- Where
- United States
- Volunteers
- 133,553 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dementia, Alzheimer's Disease
In-Home Technology for Dementia Caregivers
This study aims to develop and evaluate in-home assistive technology that is designed to alleviate anxiety, burden, and loneliness in spousal and familial caregivers of individuals with Alzheimer's disease and frontotemporal…
- Conditions
- Dementia, Alzheimer's Disease, Frontotemporal Dementia
- Trial name
- NCT03828383
- Testing
- In-home technology, Limited in-home technology
- Where
- 5 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Alzheimer Disease
Study Evaluating GSI-953 in Healthy Young and Alzheimer's Patients
To assess the pharmacodynamics (PD) of biomarkers amyloid beta peptide 40 and 42 (Ab40 and Ab42) in CSF, following single oral doses of GSI-953, an investigational drug, in healthy young subjects and patients with Alzheimer…
- Trial name
- NCT00479219
- Testing
- GSI-953
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Alzheimer's Disease
MRI of Alzheimer's Disease Imaging Amyloid Plaques in Persons With and Without Memory Problems
The study will investigate the possibility of detecting early signs of Alzheimer's disease using magnetic resonance imaging (MRI).
- Trial name
- NCT00413621
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer's Disease
Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid
The number of Americans diagnosed with Alzheimer's disease (AD) is expected to triple by 2050. Compared to the general population, Veterans have a greater risk of AD, likely in part due to their increased incidence of traumatic…
- Trial name
- BRAVE-EPA (NCT02719327)
- Testing
- icosapent ethyl (IPE)
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alzheimer s Disease, MCI Conversion to Dementia
Development of a Home Test for Measuring Blood P-tau217 in Alzheimer's Disease Using the Tasso Lancet Device
This study compares p-tau217 concentrations in blood collected via the Tasso device versus standard venipuncture in subjects with and without Alzheimer's disease, including a subset with confirmed amyloid pathology.
- Conditions
- Alzheimer s Disease, MCI Conversion to Dementia, pTau217, Biomarkers
- Trial name
- NCT07701161
- Where
- 5 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Neurogen Biomarking LLC
Alzheimer's Disease
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Background: Normal aging, as well as dementias such as Alzheimer s disease, can cause changes in the brain that affect memory, attention, and thinking.
- Trial name
- NCT07721467
- Testing
- Psilocybin, Cognitive Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Financial Hardship, Alzheimer's Disease (AD)
Development of Measures to Screen for Financial Hardship in Alzheimer's Disease and Dementia
Alzheimer's Disease and related dementias (AD/ADRD) are common and debilitating conditions. Financial hardship, a multidimensional construct of financial strain, financial stress and asset depletion, is common in AD/ADRD due to…
- Conditions
- Financial Hardship, Alzheimer's Disease (AD), Alzheimer's Disease and Related Dementia (ADRD)
- Trial name
- AD/ADRD (NCT06922188)
- Where
- United States
- Volunteers
- 2,460 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Alzheimer Disease, Healthy Aging
Developing an Artificial Intelligence System to Detect Cognitive Impairment
Alzheimer's disease dementia (AD) is a debilitating and prevalent neurodegenerative disease in older adults globally. Cognitive impairment, a hallmark of AD, is assessed through verbal tests that require high specialization, and…
- Conditions
- Alzheimer Disease, Healthy Aging, Mild Cognitive Impairment
- Trial name
- NCT05794451
- Where
- Israel
- Volunteers
- 3,413 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Remote Digital Assessments for Cognitive Disorders
Memory and thinking problems in older adults, including mild cognitive impairment (MCI) and Alzheimer's disease (AD), can be difficult to assess promptly because evaluation often depends on in-person specialist visits.
- Trial name
- MonitorCog-AI (NCT07883746)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer's Disease (AD)
Effects of Auditory Brain Stimulation by "Pink Noise" on Memory Capacities in Alzheimer's Disease: Proof of Concept Study
Alzheimer's disease (AD) is a neurodegenerative disorder affecting almost 6% of the world's population over the age of 65. This disease, in its most typical sporadic form, is characterized by an episodic memory impairment linked…
- Trial name
- PINK-AD (NCT04570761)
- Testing
- Dreem headband
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Alzheimer Disease
Study of Genetic Alzheimer's Disease Mutation Carriers in Preclinical Stages of the Disease 18F-Florbetaben Positron Emission Tomography Study
The main purpose of the study is to assess safety of a single dose of FBB followed by PET scan in individuals at risk of genetic Alzheimer's disease.
- Trial name
- NCT02362880
- Testing
- Florbetaben
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Judit Pich Martínez
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