Clinical trials: Alveolar Bone Resorption
Periodontal Diseases, Periimplant Diseases
Markers of Bone Destruction and Oxidative Stress in Peri-implantitis
The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant…
- Trial name
- NCT07397884
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Alveolar Bone Grafting
E-Polycaprolactone-Containing Membrane in Alveolar Bone Regeneration
This study aimed to evaluate the effectiveness of synthetic polycaprolactone (PCL) bioscaffold membranes used for alveolar augmentation in maxillofacial surgery for increasing the amount of newly formed bone after…
- Trial name
- NCT06627621
- Testing
- Alveolar Ridge Reconstruction
- Where
- Turkey (Türkiye)
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- cem üngör
Alveolar Bone Loss
Alveolar Ridge Preservation (ARP) in the Posterior Maxilla After the Extraction of Maxillary Molars
Dental implants are a fixed replacement solution with reported long-term survival rates between 94-98% over 20-40 years. In order to ensure successful implant therapy, adequate bone and soft tissue as well as correct 3D…
- Trial name
- NCT07433322
- Testing
- Ossix mineralized grafting immediately at extraction, Delayed grafting at implant placement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Alveolar Bone Resorption
LPRF Block vs. DBBM in Horizontal Bone Reconstruction
split-mouth RCT. 12 patients. horizontal GBR performed. 2 grafts were compared: test was LPRF block, control was 50% autogenous bone and 50% DBBM. 25 months follow-up.
- Trial name
- NCT07584629
- Testing
- guided bone regeneration
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alveolar Bone Resorption
Radiographic and Histological Evaluation of Regenerated Bone After Grafting Using Allograft Shell and Autogenous Chips
The clinical cases in the present study described the khoury shell technique using an allograft plate and autogenous chips, for horizontal reconstruction of the anterior alveolar ridge in the esthetic zone.
- Trial name
- Shell grafting (NCT04324697)
- Testing
- Horizontal alveolar bone augmentation
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- October 6 University
Periodontal Bone Loss, Periodontitis Stage III
Treatment of Periodontal Intrabony Defects With Liquid Platelet-Rich Fibrin Mixed With Denaturated Albumin Gel (ALB_PRF)
The objective of study also is to assess radiographic linear defect depth, and radiographic defect bone density following the application of liquid Platelet-Rich Fibrin (PRF) mixed with denaturated Albumin gel (ALB-PRF) or with…
- Conditions
- Periodontal Bone Loss, Periodontitis Stage III, Intra-bony Pockets
- Trial name
- ALB-PRF (NCT06798116)
- Testing
- Experimental: open flap debridement and demineralized freeze-dried bone allograft and mixed with liquid (PRF, defects will be treated with open flap debridement and liquid (PRF) mixed with denatured albumin gel (ALB-PRF) will be injected in periodontal intrabony defects, defects will be treated with open flap debridement , DFDBA mixed with liquid (PRF) and collagen membrane
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Mansoura University
Alveolar Bone Loss
Accuracy Assessment of Chin Graft for Ridge Augmentation Using Tooth-supported Guide Versus Free Hand Technique
This study compares the accuracy of osteotomies positions using patient specific guides for onlay bone shells harvested from the chin then the graft positioning for 3D upper anterior ridge augmentation using patient-specific…
- Trial name
- NCT07365852
- Testing
- 3D ridge augmentation using tooth-supported patient-specific guide
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alveolar Bone Loss, Edentulous Jaw
Alloplastic Graft vs Xenograft for Horizontal Alveolar Ridge Augmentation
This prospective split-mouth randomized controlled trial compared horizontal alveolar ridge augmentation using alloplastic bone graft versus xenograft, both performed simultaneously with implant placement using the decompression…
- Trial name
- NCT07608744
- Testing
- Alloplastic bone graft, Xenograft
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ege University
Alveolar Bone Loss, Tooth Extraction
Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing
This study evaluates two different treatments used to help the jawbone heal after a tooth is removed. When a tooth is extracted, the surrounding bone often shrinks, which can make it difficult to place dental implants later.
- Conditions
- Alveolar Bone Loss, Tooth Extraction, Bone Regeneration
- Trial name
- MSC-EXO vs PRF (NCT07508033)
- Testing
- MSC-Derived Exosomes, Platelet-rich fibrin (PRF)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al Salam University
Alveolar Bone Loss
Piezosurgical Buccal Plate Repositioning Technique for Horizontal Alveolar Ridge Augmentation
Achieving prosthetically driven implant placement is a highly predictable treatment modality with reliable long-term results. Different surgical procedures have been used as a solution for reconstructing of the alveolar ridge…
- Trial name
- NCT05317039
- Testing
- silica-calcium phosphate nanocomposite SCPC, freezed dried bone
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Hams Hamed Abdelrahman
Partially Edentulous Maxilla, Alveolar Bone Atrophy
Effectiveness and Safety of Method of Maxilla Alveolar Process Reconstruction Using Synthetic Tricalcium Phosphate and Autologous MMSCs
Autologous MMSCs will be isolated from oral mucosa biopsy sample and expanded in vitro.Tissue engineered construction will be created using synthetic tricalcium phosphate and autologous MMSCs.
- Conditions
- Partially Edentulous Maxilla, Alveolar Bone Atrophy, Alveolar Bone Loss
- Trial name
- NCT02209311
- Testing
- Oral mucosa biopsy, Sinus lift with implantation of tissue engineered construction, Dental implant
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Periodontal Diseases, Periodontal Pocket
Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study
The goal of this split-mouth clinical trial is to evaluate the effects of Manuka honey applied into periodontal pockets after initial periodontal therapy (NSPT) in the treatment of stage 3 periodontitis.
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontal Bone Loss, Periodontal Attachment Loss
- Trial name
- NCT05631600
- Testing
- Manuka honey
- Where
- Croatia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Periodontitis, Alveolar Bone Loss* / Therapy
Clinical Study of BMP-2 Injectable Hydrogel for Promoting Alveolar Bone Regeneration
This project aims to construct an injectable self-healing hydrogel loaded with BMP-2, with optimized gelation time and mechanical strength to meet the requirements for periodontal pocket filling, for the treatment of…
- Trial name
- NCT07611617
- Testing
- treatment group
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Alveolar Bone Atrophy, Bone Resorption
Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans
This study evaluates the effect of citric acid demineralization in autogenous bone blocks consolidation. Half of participants will receive citric acid treatment at the bone block and recipient site.
- Trial name
- NCT03357068
- Testing
- Control, Acid
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo
Tooth Loss
Azento IIS 3 Year Outcomes Implant Study
The revised purpose of this study is to compare and evaluate the stability of the implant body, survival rate, bone-level changes, and the implant's soft-tissue outcomes over a period of 1 year.
- Trial name
- NCT04255342
- Testing
- Implant Placement and Temporary Crown using AstraTech Implant System EV, Final Crown Delivery
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Christopher Barwacz
Alveolar Bone Loss, Loss of Teeth Due to Extraction
Evaluation of OSSIX-Plus Resorbable Collagen Membranes for Alveolar Ridge Preservation Following Exodontia
The purpose of this study is to evaluate clinically, histologically and radiographically the healing of extraction sockets covered with a resorbable collagen membrane (OSSIX-Plus) 12 weeks following exodontia.
- Conditions
- Alveolar Bone Loss, Loss of Teeth Due to Extraction, Edentulous Alveolar Ridge
- Trial name
- OSSIX (NCT00639860)
- Testing
- OSSIX-Plus
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- William Giannobile
Alveolar Bone Loss
Subperiosteal Implants Constructed With Digital Technology
Atrophied jaw is a condition where there is insufficient bone quantity to place root form implants. Several treatment plans are available for treating atrophied jaws, including subperiosteal implants.
- Trial name
- NCT06012643
- Testing
- The purpose of this systematic review of case reports and case series was to evaluate the spectrum of subperiosteal implants for severely atrophied jaws using digital technology.
- Where
- Egypt
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Alveolar Bone Loss, Edentulous Maxilla, Atrophic
Guided Bone Regeneration Combined With PRGF for Atrophic Edentulous Maxilla
This prospective interventional clinical study evaluated guided bone regeneration combined with plasma rich in growth factors for vertical and horizontal augmentation of the atrophic edentulous maxilla.
- Conditions
- Alveolar Bone Loss, Edentulous Maxilla, Atrophic, Alveolar Ridge Deficiency, Jaw Atrophy
- Trial name
- GBR-PRGF-Maxil (NCT07654218)
- Testing
- Guided Bone Regeneration Combined With Plasma Rich in Growth Factors
- Where
- Portugal
- Volunteers
- 11 people
- Sponsor
- Universidade do Porto
Alveolar Bone Loss
Using Boned-Apatite Cement at the Time of Extraction for Ridge Preservation at These Sites
To assess efficiency of ridge preservation (in vertical and horizontal dimensions) after tooth extraction using Calcium Sulfate with hydroxyapatite(®Bond-apatite) compared to the use of bovine bone substitute (BioOss®) and to…
- Trial name
- NCT02440048
- Testing
- Bond Apatite synthetic bone substitute, BioOss bovine bone substitute
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Alveolar Bone Loss
Comparison of Extra-short (4 mm) Implants Used as Distal Support of a Maxillary Full-arch Fixed Dental Prosthesis vs. 10 mm Implants Installed After Sinus Floor Elevation.
Recently, 4 mm long implants with a standard diameter have been used for the restoration of the posterior edentulous mandible with favorable results.
- Trial name
- NCT03958448
- Testing
- Placement of extra short implants, maxillary sinus lift, maxillary sinus elevation, maxillary sinus augmentation, placement of standard implant
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ARDEC Academy