Clinical trials: Altitude
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in patients with pulmonary arterial hypertension PAH, who live permanently…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude, Echocardiography
- Trial name
- NCT07804524
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Hypoxia
Human Adaptation to High Altitude
This scientific study aims at studying human adaptations to high altitude and the studies will be conducted at the University of Zürich and during a 4 week high altitude "expedition" to the Jungfraujoch research station at 3450 m…
- Trial name
- NCT01627652
- Testing
- altitude
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Zurich Center for Integrative Human Physiology
Hypoxia, Altitude Sickness
Hypoxia Adaptation Promotes Cerebral Functional Connectivity With Neuromuscular Efficiency Decrement
The study utilized a trimodal setup comprising EEG, EMG, and fNIRS modules. Participants wore a 64-channel dry EEG cap, while EMG electrodes were placed on the right biceps brachii, the flexor digitorum profundus of the forearm…
- Trial name
- NCT07018817
- Testing
- motor execution motor imagery
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Multiple Myeloma
A Study of Dara-RVd and Teclistamab-RVd in People With Multiple Myeloma
The purpose of this study is to find out whether Tec-RVd (teclistamab, lenalidomide, bortezomib, and dexamethasone) after 3 treatment Cycles of Dara-RVd (daratumumab, lenalidomide, bortezomib, and dexamethasone) is a safe…
- Trial name
- NCT07099391
- Testing
- Dara-RVd, Tec-RVd
- Where
- 7 sites in United States
- Volunteers
- 65 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in patients with pulmonary arterial hypertension PAH, who live permanently >2600m.
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, Polygraphy, Sleep
- Trial name
- NCT07801963
- Testing
- Descent to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Acute Mountain Sickness
Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness
Acute mountain sickness (AMS) is a common condition that can occur when healthy people travel quickly to high altitude. Typical symptoms include headache, nausea, tiredness, dizziness, and poor sleep.
- Trial name
- NCT07653516
- Testing
- Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Covid19, High Altitude
Prevalence of COVID-19 in High Altitude : Insights From the Highest City of the World
Since the beginning of 2020, SARS-CoV-2 outbreak spread over the world, conducting in a pandemic state declared by the world health organization in March 2020.
- Trial name
- RINCOVID (NCT04604249)
- Testing
- SARS-CoV-2 rapid diagnostic test (COVID-PRESTO® IgM/IgG, AAZ, Boulogne-Billancourt, France)
- Where
- Peru
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
High Altitude Pulmonary Hypertension, Maximal Exercise Capacity
Maximal Exercise Capacity at 2500 m of High Altitude
The impact of hypoxia on maximal work rate during incremental ramp exercise within 3-6 hours after arriving at 2500m of high altitude in patients with precapillary pulmonary hypertension
- Trial name
- NCT05264324
- Testing
- Maximal Exercise Capacity
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Hepatic Echinococcosis
5G Remote Robotic Surgery for Hepatic Echinococcosis in High-Altitude Region
Hepatic echinococcosis (HE) is a serious endemic parasitic disease in high-altitude regions like Xizang. Radical hepatectomy is the primary curative treatment, but expert resources are often concentrated in large medical centers.
- Trial name
- HAT (NCT07551063)
- Testing
- 5G-based Telerobotic Hepatectomy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- West China Hospital
Hypoxia, High Altitude
Supraglottic Jet Oxygenation and Ventilation for Gastrointestinal Endoscopy at High-altitude
This study aims to determine whether the use of SOJV could reduce the rate of hypoxia during gastrointestinal endoscopic procedures in deeply sedated patients sedated at high altitude comparing to the supplemental oxygen…
- Trial name
- NCT05304923
- Testing
- Supraglottic jet oxygenation and ventilation, Nasal cannula oxygen supply
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
High-altitude Sleep Disturbance
Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude
More than 70% of visitors to high altitude suffer poor sleep. The present study seeks to answer the question: Which medication is associated with better sleep at high altitude: temazepam or acetazolamide? The investigators…
- Trial name
- NCT01519544
- Testing
- Temazepam, Acetazolamide
- Where
- Nepal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anemia, Critically Ill
Survey of Blood Transfusion Practices in Critically Ill Patients at High Altitude
The purpose of this study is to describe current practice on red blood cell transfusion in critically ill patients of intensive care units located in high altitude areas
- Trial name
- NCT03019900
- Testing
- Red blood cells transfusions
- Where
- Ecuador
- Volunteers
- 352 people
- Sponsor
- Universidad Tecnológica Equinoccial
Acute Mountain Sickness
Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude
In this investigation the researchers explore whether different types of breathing procedures can improve the peripheral oxygen saturation to reduce the risk of becoming a acute mountain sickness or a high altitude pulmonary…
- Trial name
- NCT01468194
- Testing
- Breathing procedure 1, Breathing procedure 2
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Healthy, Growth Hormone
Ghrelin, Growth Hormone and Growth Factors at High Altitude
Regulation of ghrelin, growth hormone and growth factors at high altitude and their change during ascent to high altitude has not been studied in depth yet.
- Trial name
- NCT00966134
- Testing
- exposure to high altitude
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Prophylaxis of Acute Mountain Sickness
Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing
This is a phase 4, randomized, double-blinded interventional trial comparing alternative doses of Acetazolamide for the prevention of High Altitude Illness.
- Trial name
- NCT01993667
- Testing
- Low Dose Acetazolamide, Normal Dose Acetazolamide
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Utah
High-altitude Polycythemia, HAPC
High-Altitude Polycythemia Study
This study aims to evaluate the clinical efficacy of non-invasive ventilation (NIV) in treating patients with high-altitude polycythemia (HAPC).
- Trial name
- NIV-HAPC (NCT07600086)
- Testing
- Non-invasive ventilator
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- Tibet Autonomous Region People's Hospital
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Vascular Reactivity at High Altitude
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05525416
- Testing
- Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine
- Where
- 2 sites in Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Altitude Hypoxia
Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on postural control in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536429
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Intermittent Hypoxia
Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude
Low oxygen at altitude causes pauses in breathing during sleep, called central sleep apnea. Central sleep apnea causes repeated awakenings and poor sleep.
- Trial name
- NCT03588676
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Robert L. Owens
High Altitude
HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men
Randomized clinical trial evaluating the effect of acetazolamide on pulmonary artery pressure in women compared to men travelling to 3600 m.
- Trial name
- NCT06498505
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich