Clinical trials: Allergic Rhinosinusitis
Allergic Rhinitis, Conjunctivitis
Efficacy of the Anti-Bet v 1 Monoclonal Antibodies (Given Subcutaneously) to Reduce Allergic Rhinitis and Conjunctivitis Symptoms and Skin Test Reactivity Upon Exposure to Birch Allergen in Adult Participants
Primary objective: To assess the efficacy of a single dose of the anti- Bet v 1 monoclonal antibodies (mAb(s ) in the reduction of allergic nasal symptoms during an out-of-season birch allergen environmental exposure unit (EEU)…
- Trial name
- NCT05430919
- Testing
- REGN5713, REGN5714, REGN5715
- Where
- 3 sites in Canada
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Rhinitis Allergic
Evaluation of Efficacy of Dellegra in Exposure Unit
Primary Objective: To collect and analyze clinical data of Allergic Rhinitis patients' Total Nasal Symptom Score (TNSS) change after Dellegra internal use under high density pure Japanese cedar pollen exposure.
- Trial name
- NCT02175485
- Testing
- Fexofenadine HCl 30 mg+Pseudophedrine HCl 60 mg
- Where
- Japan
- Volunteers
- 24 people
- Sponsor
- Sanofi
Allergic Rhinitis
The Efficacy Of Elonide Nasal Corticosteroids In Managing Allergic Rhinitis
The aim of this clinical study is to compare the efficacy of Elonide Nasal Spray to Nasonex Nasal Spray and Placebo (non-active ingredient) in the management of allergic rhinitis. There are two hypotheses of this study: 1.
- Trial name
- NCT05912192
- Testing
- Elonide Nasal Spray, Nasonex Nasal Spray, Normal saline
- Where
- Malaysia
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Respiratory Hypersensitivity
Safety and Efficacy of House Dust Mite Allergoid in the Treatment of Bronchial Asthma
The trial is performed to assess efficacy and safety of the Allergopharma house dust mite allergoid in bronchial asthma.
- Trial name
- NCT00263640
- Testing
- Acaroid
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Allergopharma GmbH & Co. KG
Seasonal Allergic Rhinitis
Acupuncture at the Sphenopalatine Ganglion in the Treatment of Moderate-to-severe Seasonal Allergic Rhinitis
Allergic rhinitis (AR) is an immunoglobulin E-mediated inflammatory disease1 caused by hypersensitivity of the immune system to an allergen, affecting 100 million people in Europe 2and 400 million of the global population.The…
- Trial name
- NCT04815668
- Testing
- Acupuncture group, Rescue medication group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Allergic Rhinitis Due to Grass Pollens
M-Gard Particulate EW Efficacy Study on Seasonal Allergic Rhinitis
The goal of this clinical trial is to assess the efficacy and safety of M-Gard supplementation for alleviating the symptoms of allergic rhinitis.
- Trial name
- NCT06907680
- Testing
- M-Gard
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RDC Clinical Pty Ltd
Seasonal Allergic Rhinitis
Efficacy Park Study Assessing Rhinix™ Nasal Filters for Hay Fever
This study will evaluate the effects of RHINIX™ nasal filters on seasonal allergic rhinitis (hay fever) in a park setting.
- Trial name
- NCT02108574
- Testing
- Rhinix Nasal Filter
- Where
- Denmark
- Volunteers
- 69 people
- Sponsor
- University of Aarhus
Allergic Rhinitis Due to Weed Pollen, Allergic Rhinitis
Trial of INI-2004 in Healthy Volunteers and Participants With Allergic Rhinitis.
This is a Phase I/Ib, randomised, double-blind, placebo-controlled study of INI-2004, administered as single or multiple doses. This study will be conducted in two parts: Phase I single ascending dose (SAD) and Phase Ib multiple…
- Trial name
- NCT06038279
- Testing
- INI-2004
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Inimmune Corporation
Rhinitis, Allergic, Seasonal
Study of GW685698X In Patients With Seasonal Allergic Rhinitis
This study was designed to compare the efficacy and safety of an investigational nasal spray compared with placebo nasal spray and commonly used drug in the treatment of seasonal allergic rhinitis.
- Trial name
- NCT00363740
- Testing
- GW685698X Aqueous Nasal Spray
- Volunteers
- 38 people
- Sponsor
- GlaxoSmithKline
Allergic Rhinitis
Efficacy and Safety of the Mometasone Nasal Gel in the Treatment of Persistent Allergic Rhinitis
The purpose of this study is to evaluate the non-inferiority of the clinical efficacy of the mometasone nasal gel in the treatment of allergic rhinitis.
- Trial name
- NCT02953379
- Testing
- EMS Mometasone gel, Mometasone spray nasal
- Sponsor
- EMS
Seasonal Allergic Rhinitis
Compare CE-Budesonide Nasal Solution & Rhinocort Aqua in an EEC Study of AR
The primary objective of this study was to compare the relative efficacy of Budesonide administered via Captisol-Enabled Budesonide nasal solution and Rhinocort Aqua in patients with seasonal allergic rhinitis (SAR) exposed to…
- Trial name
- NCT00938613
- Testing
- Budesonide
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Ligand Pharmaceuticals
Rhinitis, Allergic, Perennial
To Assess the Safety and Efficacy of Ciclesonide Applied as a Nasal Spray in the Treatment of Perennial Allergic Rhinitis (BY9010/M1-402)
The primary objective of this study is to demonstrate the efficacy of ciclesonide applied as a nasal spray once daily in patients with PAR. The secondary objectives are to evaluate Quality-of-Life and safety.
- Trial name
- NCT00659750
- Testing
- Ciclesonide
- Where
- 23 sites in United States
- Volunteers
- 418 people
- Sponsor
- AstraZeneca
Seasonal Allergic Rhinitis, Hay Fever
PK/PD and Steady State Efficacy Study of Bilastine Compared With Placebo Given Orally in the Treatment of the Symptoms of SAR in an EEC Model (5-arm)
The purpose of this study is to evaluate the relative efficacy of four dosing regimens of bilastine tablets versus placebo in subjects with SAR exposed in controlled ragweed pollen using the EEC model based on the mean change…
- Conditions
- Seasonal Allergic Rhinitis, Hay Fever, Rhinoconjunctivitis
- Trial name
- NCT00574210
- Testing
- Bilastine
- Where
- Canada
- Volunteers
- 502 people
- Sponsor
- Faes Farma, S.A.
Allergic Rhinitis
Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis
Allergic diseases represent a major health issue worldwide and epidemiological studies in Melbourne, Australia, have reported a high prevalence of rhinitis (hayfever) and atopy (genetic tendency to make allergy antibody) in Asian…
- Trial name
- NCT02014623
- Testing
- Grass pollen sublingual immunotherapy tablet, Control
- Where
- Australia
- Volunteers
- 51 people
- Sponsor
- Bayside Health
Effects of Immunotherapy
Serum MicroRNAs 223 and 146a in Allergic Rhinitis Patients as Biomarkers for Efficacy of Sublingual Immunotherapy
The aim of the study is: to evaluate the serum levels of miR-223 and miRNA146a and to assess their correlation with disease severity in allergic rhinitis patients and their role as biomarkers for efficacy of sublingual…
- Trial name
- NCT04813380
- Testing
- Sublingual immunotherapy
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Zagazig University
Allergic Rhinitis
Effect of Bacterial Lysate on Nasal Carriage of Staphylococcus Aureus
This study assesses the effectiveness of Polyvalent Mechanical Bacterial Lysate (PMBL-Ismigen) in reducing nasal methicillin-resistant Staphylococcus aureus (MRSA) colony growth in children with pollen allergic rhinitis (AR) aged…
- Trial name
- NCT04637425
- Testing
- Ismigen
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Lublin
Nasal Congestion, Common Cold
Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers
The goal of this observational post-market clinical follow-up study is to evaluate the safety and performance of the CE-marked nasal spray for the relief of nasal congestion in infants and toddlers aged 6 to 48 months at day 5…
- Conditions
- Nasal Congestion, Common Cold, Allergic Rhinitis, Rhinosinusitis
- Trial name
- NASBY (NCT07257224)
- Testing
- Quinton Medical Nasal Health Baby®
- Where
- 2 sites in Spain
- Volunteers
- 83 people
- Sponsor
- Laboratoires Quinton International S.L.
Allergic Rhinitis
Allergic Rhinitis Combination Pharmacotherapy Efficacy Study
Combination pharmacotherapy is often used in people who have failed mono-therapies in managing their bothersome allergic rhinitis symptoms .
- Trial name
- NCT04601324
- Testing
- Fluticasone Propionate, Azelastine hydrochloride and fluticasone propionate, Rupatadine
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Paul's Sinus Centre
Allergic Rhinitis Due to House Dust Mite
Radiofrequency Ablation of Bilateral Inferior Turbinate Followed by Subcutaneous Immunotherapy Trial
Allergic rhinitis (AR) is a global health issue adversely impacting the quality of life (QoL) of affected individuals and exerting a huge public health burden.
- Trial name
- RABIT (NCT05510024)
- Testing
- Radiofrequency ablation of bilateral inferior turbinate followed by subcutaneous immunotherapy, SCIT
- Volunteers
- 392 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Seasonal Allergic Rhinitis
A Study to Evaluate the Safety & Effectiveness of a Nasal Spray to Treat Seasonal Allergies
The Purpose of this study is to determine if one allergy medication (0.15% azelastine hydrochloride) is more effective than Placebo alone
- Trial name
- NCT00719862
- Testing
- 0.15% azelastine hydrochloride Nasal Spray
- Where
- 34 sites in United States
- Volunteers
- 481 people
- Sponsor
- Meda Pharmaceuticals