Clinical trials: Allergic Rhinitis, open to volunteers
Seasonal Allergic Rhinitis
Study of CM310 in Patients With Uncontrolled Seasonal Allergic Rhinitis
Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E after exposure to allergens in atopic individuals.
- Trial name
- MEGREZ (NCT06300203)
- Testing
- Interleukin-4 receptor responders
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tongren Hospital
Rhinitis, Allergic
Study on the Mechanism of ZhenQiFuZheng in the Treatment of Allergic Rhinitis Based on Intestinal Flora and Metabolites
ZhenQi FuZheng granules has been used to improve the immune function of human body, protect the bone marrow and adrenal cortex function and promote the recovery of positive function in traditional Chinese medicine care…
- Trial name
- NCT06427577
- Testing
- ZhenQi FuZheng granules (ShiDaiYangGuang)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Allergic Rhinoconjunctivitis
Investigating Nasal and Ocular Immune Response to Conjunctival Allergen Exposure
The goal of this pilot study is to develop an eye allergen challenge model, called a conjunctival allergen challenge (CAC), using timothy grass as the allergen.
- Trial name
- INQUIRE (NCT07801625)
- Testing
- Standardized Allergen Extract, Timothy Grass (Phleum pratense)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dr. Anne Ellis
Non-Allergic Rhinitis With Eosinophilia Syndrome
Efficacy and Safety of Stapokibart in Non-Allergic Rhinitis With Eosinophilia Syndrome
The goal of this clinical trial is to learn if Stapokibart (CM310) works to treat Non-Allergic Rhinitis with Eosinophilia Syndrome (NARES) in adults. It will also learn about the safety of CM310.
- Trial name
- ESSNARES (NCT07240376)
- Testing
- Stapokibart (CM310)
- Where
- 11 sites in China
- Volunteers
- 90 people
- Sponsor
- Huazhong University of Science and Technology
Allergic Rhinitis With Asthma
Efficacy and Safety of Yiqi Wenyang Sanhan Formula Combined With Acupoint Application in Patients With Combined Allergic Rhinitis and Asthma Syndrome During Remission and Yang-Deficiency Syndrome
Allergic rhinitis-asthma syndrome is a clinical comorbid condition involving both upper and lower airway allergic inflammation, reflecting the concept of "one airway, one inflammatory response." Epidemiological studies have…
- Trial name
- NCT07540351
- Testing
- Yiqi Wenyang Sanhan Formula Combined with Acupoint Application
- Volunteers
- 188 people
- Sponsor
- Beijing Daxing District Hospital of Integrated Chinese and Western Medicine
Conjunctivitis Allergic
A Study to Identify and Characterize Adults and Pediatric Participants With Cat and/or Birch Allergy
The purpose of this Patient Identification and Characterization (PIC) study is to collect information and perform limited allergy-related procedures to determine if participants can qualify for cat and/or birch tree pollen…
- Trial name
- NCT07710846
- Testing
- Noninterventional
- Volunteers
- 1,500 people
- Sponsor
- Regeneron Pharmaceuticals
Allergic Rhinitis, Asthma
ClimAIr: AI to Assess the Impact of Pollution and Climate on Respiratory Health in Europe
The ClimAIr project will expand the evidence-based understanding of climate change, air pollution, and non-communicable respiratory diseases by using Artificial Intelligence (AI) tools.
- Trial name
- ClimAIr (NCT07107009)
- Volunteers
- 1,906 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Healthy Individuals, Allergic Rhinitis
Health Effects of Wood Smoke and Traffic-Related Air Pollution Exposures: a Necessary Comparison
Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time.
- Trial name
- WADE (NCT06749093)
- Testing
- Filtered Air (FA), Wood Smoke (WS), Diesel Exhaust (DE)
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Allergic Rhinitis, Allergic Asthma
Safety and Immunogenicity of Cat-allergen Intralymphatic Immunotherapy in Patients With Cat Allergy With and Without Asthma
The goal of this clinical trial is to evaluate the safety and tolerability of intralymphatic immunotherapy (ILIT) with ALUTARD SQ Felis domesticus in patients with cat allergy-induced allergic rhinitis and asthma.
- Trial name
- NCT06960382
- Testing
- ALUTARD SQ® Felis domesticus
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Seasonal Allergic Rhinitis
Acupuncture at the Sphenopalatine Ganglion in the Treatment of Moderate-to-severe Seasonal Allergic Rhinitis
Allergic rhinitis (AR) is an immunoglobulin E-mediated inflammatory disease1 caused by hypersensitivity of the immune system to an allergen, affecting 100 million people in Europe 2and 400 million of the global population.The…
- Trial name
- NCT04815668
- Testing
- Acupuncture group, Rescue medication group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Allergic Rhinitis, Allergic Rhinoconjunctivitis
Specific Immunotherapy With Mannan-Conjugated Allergoids for HDM-Allergic Rhinitis/Rhinoconjunctivitis. MM09-SIT-063.
The goal of this clinical trial is to learn whether EP-088_MM09 works to treat house dust mite allergy. It will also assess the treatment's safety.
- Conditions
- Allergic Rhinitis, Allergic Rhinoconjunctivitis, Allergic Asthma
- Trial name
- MM09-SIT-063 (NCT07904052)
- Testing
- EP-088_MM09
- Where
- 16 sites in Portugal, Spain
- Volunteers
- 250 people
- Sponsor
- Inmunotek S.L.
Chronic Rhinosinusitis With Nasal Polyps, Allergic Rhinitis
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
During this project, the investigators want to explore in vitro changes in basal cells and the crosstalk with residing immune cells as potential pathogenic mechanisms in CRSwNP vs healthy controls by using surgically resected…
- Trial name
- NCT06129552
- Testing
- Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Allergic Rhinitis, Seasonal
A Study of IL4Rα Monoclonal Antibody in Patients With Seasonal Allergic Rhinitis
Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E after exposure to allergens in atopic individuals.
- Trial name
- NCT07154342
- Testing
- GR1802 injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Allergic Rhinitis, Allergic Asthma
Clinical Trial to Evaluate the Efficacy and Safety of Polymerized, Mannan-Conjugated Dermatophagoides Allergen Extract
Prospective, randomised, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of polymerized and mannan conjugated allergen extract of Dermatophagoides for the treatment of allergic…
- Conditions
- Allergic Rhinitis, Allergic Asthma, Allergic Rhinoconjunctivitis, Allergy to House Dust Mite
- Trial name
- MM09-SLIM (NCT05641272)
- Testing
- 3,000 MM09, 9,000 MM09
- Where
- Argentina
- Volunteers
- 90 people
- Sponsor
- Inmunotek S.L.
Allergic Rhinitis
Impact of Pet Cats on Nasal and Gut Microbiota in Patients With Cat Allergen Allergy
It has been reported that the incidence of allergic rhinitis (AR) is as high as 24.1% in adults and 16.8% in children in China. A study explored the changes in the incidence of AR in China, and the study showed that the incidence…
- Trial name
- NCT07110311
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Allergic Rhinitis
Study on the Effect and Mechanism of Aescine Sodium in the Treatment of Allergic Rhinitis
Allergic rhinitis is a common chronic non-infectious inflammatory disease of the upper respiratory tract, which affects patients' health, quality of life and work efficiency for a long time.
- Trial name
- NCT06709079
- Testing
- Aescine Sodium Tablets (Ocai®, Green Leaf Pharmaceuticals)
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cheng Lei
Allergic Rhinitis
Study of Yupingfeng Powder Treating Allergic Rhinitis (AR)
Rhinitis is broadly defined as inflammation of the nasal mucosa. It is a common disorder that affects up to 40% of the population.
- Trial name
- RCMARb (NCT06608017)
- Testing
- Chinese Herbal Medicine granules
- Where
- Hong Kong
- Volunteers
- 140 people
- Sponsor
- Chinese University of Hong Kong
Perennial Allergic Rhinitis (PAR)
Study of CM512 Injection in Patients With Perennial Allergic Rhinitis on Background Therapy
This is a randomized, double-blind, placebo-parallel controlled phase II study to evaluate the safety and efficacy of CM512 in patients with perennial allergic rhinitis on background therapy
- Trial name
- NCT07890350
- Testing
- CM512
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Keymed Biosciences Co., Ltd.
Anaphylaxis, Allergy
Comparative PK/PD of FMXIN002 and EpiPen, in Healthy Adults With Allergic Rhinitis
The study will evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) responses of FMXIN002, an intranasal epinephrine powder, compared with the EpiPen® intramuscular autoinjector, after single and double doses, in healthy…
- Trial name
- NCT07228325
- Testing
- FMXIN002 single dose, Epinephrine autoinjector single dose, FMXIN002 single dose + NAC
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nasus Pharma
Allergic Rhinitis
Evaluation of a Digital Tool to Improve Aeroallergen Immunotherapy Adherence. NavigAITme Project
Aaeroallergen Immunotherapy (AIT) is indicated in the treatment of allergic rhinitis and asthma, and has shown efficacy to control symptoms and induce immunomodulatory changes that support post discontinuation efficacy.
- Trial name
- NavigAIT (NCT07419230)
- Testing
- Active Adherence-booster App, Inactive Adherence-booster App
- Where
- Spain
- Volunteers
- 880 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa