Clinical trials: All-Cause Mortality
Myocardial Infarction, Ischemic Stroke
Emulation of the Moderate Alcohol and Cardiovascular Health Trial (MACH15)
The aim of this study is to assess how long-term alcohol consumption influences health risks by emulating the Moderate Alcohol and Cardiovascular Health Trial (MACH15).
- Conditions
- Myocardial Infarction, Ischemic Stroke, Angina Pectoris, Coronary Revascularization
- Trial name
- NCT06583161
- Testing
- Moderate drinking, Quitting, Social drinking
- Volunteers
- 503,325 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
All-Cause Mortality, Circulatory and Other Disease Mortality
Hyperthyroid Follow-Up Study
Background: Hyperthyroidism is a common disease. It is very common for women. It is usually treated with Radioiodine (I-131). Some people think that this might cause cancer, even many years later.
- Conditions
- All-Cause Mortality, Circulatory and Other Disease Mortality, Thyroid and Other Cancer Mortality
- Trial name
- NCT02989103
- Where
- United States
- Volunteers
- 35,593 people
- Sponsor
- National Cancer Institute (NCI)
Severe Burns
Effect of Early Dexamethasone on Major Complications and All-cause Mortality in Severe Burns
Burns affect more than 11 million people worldwide each year. These injuries are responsible for severe morbidity resulting in a high societal burden and account for more than 180,000 yearly deaths especially in low- and…
- Trial name
- DEXA-BURN (NCT06968559)
- Testing
- Dexamethasone
- Where
- 10 sites in France
- Volunteers
- 478 people
- Sponsor
- Nantes University Hospital
Chronic Kidney Disease
Renal Sympathetic Denervation in Patients With Chronic Kidney Disease and Resistant Hypertension
To study whether renal sympathetic denervation(RSD) is safe and effective in patients with chronic kidney disease and resistant hypertension
- Trial name
- RSD4CKD (NCT01737138)
- Testing
- RSD, medicine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Myocardial Infarction, Death
BAMI. The Effect of Intracoronary Reinfusion of Bone Marrow-derived Mononuclear Cells(BM-MNC) on All Cause Mortality in Acute Myocardial Infarction
This is a multinational, multicentre, randomised open-label, controlled, parallel-group phase III study. Its aim is to demonstrate that a single intracoronary infusion of autologous bone marrow-derived mononuclear cells is safe…
- Trial name
- BAMI (NCT01569178)
- Testing
- Bone Marrow aspiration and intracoronary reinfusion
- Where
- 33 sites in Belgium, Czechia and 8 more
- Volunteers
- 375 people
- Sponsor
- Queen Mary University of London
COVID-19
Effect of Anticoagulation Therapy on Clinical Outcomes in COVID-19
Patients with moderate to severe COVID-19 present a very high risk of thromboembolic disease.This multicenter, prospective, randomized, event-driven study evaluates rivaroxaban compared with standard of care with…
- Trial name
- COVID-PREVENT (NCT04416048)
- Testing
- Rivaroxaban, Standard Of Care (SOC)
- Where
- 24 sites in Germany
- Volunteers
- 111 people
- Sponsor
- Charite University, Berlin, Germany
Change in Albumin to Creatinine Ratio and Glomerular Filtration Rate, Progression of Kidney Failure and or All-cause Mortality
"Association of Proteinuria and Progression of Kidney Dysfunction in Sickle Cell Disease"Disease
To describe change in ACR and eGFR during study follow-up, and assesss the association of baseline and change in ACR and eGFR, with progression of kidney failure and/or all-cause mortality.
- Trial name
- CSEG101A0FR01 (NCT05407740)
- Testing
- no intervention study
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Soutien aux Actions contre les Maladies du Globule Rouge
Atrial Fibrillation, Ischemic Stroke
Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs DOACs)
The purpose of this study is to assess safety and effectiveness of direct oral anticoagulants (DOACs) for stroke prevention in patients with non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Systemic Embolization, Major Bleed
- Trial name
- NCT03568916
- Testing
- Apixaban (ATC B01AF02), Dabigatran (ATC B01AE07), Rivaroxaban (ATC B01AF01)
- Where
- Canada
- Volunteers
- 227,579 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Overall Survival (All-cause Mortality)
Exercise and Mortality in Middle-Aged and Older Adults
This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to…
- Trial name
- NCT07224659
- Testing
- Control, Exercise
- Where
- United States
- Volunteers
- 19,000 people
- Sponsor
- City of Hope Medical Center
Malaria
Evaluation of the Public Health Impact of Seasonal Intermittent Preventive Treatment (IPT) in Children in Senegal
In areas of seasonal malaria transmission the burden of severe disease and mortality due to malaria is mainly among children under 5 years of age.
- Trial name
- NCT00712374
- Testing
- sulfadoxine-pyrimethamine plus amodiaquine
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Childhood Mortality
Mortality Reduction After Oral Azithromycin: Morbidity Study
The long-term goal of this study is to more precisely define the role of mass azithromycin treatments as an intervention for reducing childhood morbidity and increasing growth, and for the potential selection of antibiotic…
- Trial name
- MORDORMorb (NCT02048007)
- Testing
- Azithromycin
- Where
- 6 sites in United States, Malawi and 3 more
- Volunteers
- 72,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
COVID-19 Pandemic, Morality
Evaluation of Corticosteroids Use and Clinical Outcomes in Hospitalized COVID-19 Patients: A Retrospective Study
Despite the recommendations to avoid using corticosteroids systematically for hospitalized coronavirus disease of 2019 (COVID-19) patients, healthcare professionals used personalized treatments, including corticosteroids, as…
- Trial name
- NCT05844410
- Testing
- Corticosteroid
- Where
- Lebanon
- Volunteers
- 422 people
- Sponsor
- Lebanese University
Renal Dialysis
Study of the Relationship Between rHuEPO Dose, Serum ADPN, and Mortality in Patients Beginning Hemodialysis (HD)
High recombinant human erythropoietin requirement and elevated serum adiponectin were significant determinants of long-term mortality in patients who started hemodialysis therapy.
- Trial name
- NCT00308698
- Sponsor
- Hamamatsu University
All Cause Mortality, MACE
ROOBY Trial Follow-up Extension
The Department of Veterans Affairs "Randomized On/Off Bypass" (ROOBY) Trial (CSP #517) was funded in 2001. ROOBY was designed to compare the short-term (30-day) and intermediate-term (1-year) outcomes for patients undergoing…
- Trial name
- NCT01924442
- Where
- United States
- Volunteers
- 2,203 people
- Sponsor
- VA Office of Research and Development
Coronary Artery Disease, Atrial Fibrillation
Rivaroxaban Estimation With Warfarin in Atrial Fibrillation Patients With Coronary Stent Implantation Study (REWRAPS)
Antiplatelet therapy is indispensable for the prevention of stent thrombosis in patients who underwent coronary artery stenting.
- Conditions
- Coronary Artery Disease, Atrial Fibrillation, Stroke, Fetal Blood Loss
- Trial name
- REWRAPS (NCT02024230)
- Testing
- Rivaroxaban or Warfarin
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Fujita Health University
HPV Infection
All-cause and Diseases-specific Mortality of High-risk HPV Infection
The corresponding prevention strategies and treatment routes of HPV infection can be provided through investigating causes of death due to HPV infection and specialized diseases.
- Trial name
- NCT06631495
- Testing
- Observation
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Tricuspid Regurgitation
Tricuspid RegurgitAtion rIsk modeL Study (TRAIL Study)
This study is a multicenter cohort study including patients diagnosed with tricuspid regurgitation during hospitalization. The primary outcome of the study is all-cause death, and the secondary outcome is cardiovascular events.
- Trial name
- NCT06926959
- Where
- 7 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-sen University
Heart Failure
International Study to Determine if AdreView Heart Function Scan Can be Used to Identify Patients With Mild or Moderate Heart Failure (HF) That Benefit From Implanted Medical Device
This is an event-driven Phase IIIb, multicentre, randomised, clinical study to demonstrate the efficacy of AdreView™ imaging for appropriately guiding the decision of implantable cardioverter defibrillator (ICD) implantation, in…
- Trial name
- ADMIRE-ICD (NCT02656329)
- Testing
- Iobenguane I -123 Injection, Implantable Cardioverter Defibrillator, Thyroid blocking
- Where
- 94 sites in United States, Canada and 8 more
- Volunteers
- 395 people
- Sponsor
- GE Healthcare
Hypertension, Stroke
A Cluster-Randomized Controlled Trial
The goal of this study is to learn if an AI-generated personalized health report combined with face-to-face guidance from cardiologists can help rural adults with high blood pressure control their blood pressure better and reduce…
- Conditions
- Hypertension, Stroke, Cardiovascular, Coronary Heart Disease
- Trial name
- NCT07845448
- Testing
- AI-powered personalized health report with cardiologist consultation and prescription optimization, Integrated management (follow-up, education, quality control) without AI report and cardiologist consultation
- Volunteers
- 14,400 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Osteoporosis, Osteoporosis Fracture
Post-fracture Medication and Mortality
Osteoporotic fracture is a common public-health problem in the whole world. Although postfracture usage of anti-osteoporosis medications, may reduce mortality, recent results have been inconsistent.
- Conditions
- Osteoporosis, Osteoporosis Fracture, Drug Therapy, Mortality
- Trial name
- NCT05366621
- Testing
- Anti-osteoporosis medications
- Where
- Taiwan
- Volunteers
- 216,155 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital