Clinical trials: Alertness
Sleep Deprivation, Sleep Restriction
Acoustic Stimulation During Restricted Sleep After Sleep Deprivation
The purpose of this study is to determine if brief sounds or tones presented within a restricted period of recovery sleep after a period of sleep deprivation will enhance restorative properties and improve performance during a…
- Conditions
- Sleep Deprivation, Sleep Restriction, Acoustic Stimulation, Performance
- Trial name
- NCT05309473
- Testing
- Philips SmartSleep Acoustic Stimulation Device
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Delirium, Confusion
Intelligent Intensive Care Unit
Delirium, as a common complication of hospitalization, poses significant health problems in hospitalized patients. Though about a third of delirium cases can benefit from intervention, detecting and predicting delirium is still…
- Trial name
- ICU_Delirium (NCT02465307)
- Testing
- Confusion Assessment Method, Accelerometer, Commercially available camera
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sleep Apnea, Insufficient Sleep Syndrome
Improving Outcomes for Patients With SDB and Insufficient Sleep
The purpose of this study is to look at how sleep disordered breathing (SDB) and not getting enough sleep each night contribute to daytime sleepiness.
- Conditions
- Sleep Apnea, Insufficient Sleep Syndrome, Sleep, Hypertension
- Trial name
- RESTORE (NCT04279834)
- Testing
- PAP Treatment, Sleep Education I
- Where
- United States
- Volunteers
- 561 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Abdominal Obesity
Effects of Weight Reduction on Sleep and Alertness in Long-distance Truck and Bus Drivers
The study is a year-long health-behaviour intervention in obese, male truck-drivers to lose weight moderately by 10%, using monthly individual counseling.
- Trial name
- SF-Truck (NCT00893646)
- Testing
- weight loss counseling
- Where
- 3 sites in Finland
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- UKK Institute
Caffeine, Cognitive Change
Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine
This will be a (2 visit) double-blind, randomized, crossover design clinical study to assess the potential benefits of ER-CAFF versus IR-CAFF by assessing its impact on side effect profiles, mood states, alertness, and cognitive…
- Conditions
- Caffeine, Cognitive Change, Mood, Mood Change
- Trial name
- NCT06441695
- Testing
- xumXR extended release caffeine, immediate release caffeine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Anesthesia Recovery Period
Street Fitness in Surgical Patients Undergoing General Anesthesia After Reversal of Neuromuscular Blockade
Rationale: Recovery from outpatient anesthesia includes dissipation of anesthetics agents, normalization of physiological function, observation for medical or surgical complications, treatment of immediate side effects of…
- Trial name
- SFINX (NCT01453530)
- Testing
- Sugammadex, Neostigmine/Glycopyrrolate
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Mental Fatigue, Alertness
Effect of Coffeeberry on Mood and Cognitive Performance
The primary aim of this randomised, double-blind, placebo-controlled, cross-over study is to assess the short-term cognitive effects of two beverages containing 100 and 300 mg coffeeberry extract (obtained from the fruit of the…
- Conditions
- Mental Fatigue, Alertness, Mood, Cognition
- Trial name
- NCT04975802
- Testing
- Coffeeberry, Caffeine
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Behavior
Sensory Stimulation During Simulated Driving
The purpose of this study is to examine the effect of three specific odors on simulated driving performance. It is hypothesized that the presence of peppermint, rosemary, and zest/pulp will increase memory recall for navigation…
- Trial name
- NCT03726840
- Testing
- Fragrance
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders
Light Exposure to Treat Sleep Disruption in Older People
The purpose of this study is to test whether shifts in the timing of the biological clock to a later hour (phase delay shifts of the human circadian system) can be produced in response to four successive evenings of light…
- Conditions
- Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia
- Trial name
- NCT00427323
- Testing
- light exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Anesthesia, Surgical Procedures, Elective
A Safety and Efficacy Study of Dexmedetomidine in Patients Requiring Sedation During Monitored Anesthesia Care (MAC)
The objective of this study is to evaluate the safety and efficacy of dexmedetomidine as compared to placebo when used for the sedation of subjects requiring monitored anesthesia care (MAC).
- Trial name
- NCT00398827
- Testing
- Dexmedetomidine
- Where
- 27 sites in United States
- Volunteers
- 326 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Mental Fatigue
A Study to Evaluate Efficacy of IP on Alertness and Mental Fatigue
The current study is design to asses the effect of E-AG-01/ E-AG-02/ E-AG-03 on mental alertness as compared to placebo.
- Trial name
- ALERMEN (NCT02816827)
- Testing
- AG-01, AG-05, AG-06
- Where
- India
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Anesthesia
Correlation of Narcotrend Index and the Observer's Assessment of Alertness/Sedation (OAA/S) Scale
Narcotrend index is a widely used quantitative parameter for evaluating anesthesia and sedation levels.Dexmedetomidine is a novel sedative,providing sedation while patients remain cooperative and can be easily aroused.
- Trial name
- NCT02845661
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Sleep Duration, Psychomotor Performance
Effect of a Wrist-worn Device That Produces a Small Vibration on Sleep and Performance That Can Occur During and After Night Shift Work
The overarching goal of this research study is to determine "proof of concept" of effect of a non-invasive sleep aid device on sleep and performance during sleep opportunities (naps) that occur during and after simulated night…
- Trial name
- Sleep-Vibe (NCT06665672)
- Testing
- Wrist worn vibro-acoustic device
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Daniel Patterson, PhD, NRP
Healthy, Circadian Rhythm
Effects of Different Colors of Light on Human Physiology
This study will determine which color of light is most effective in stimulating a range of biological functions in humans including activation of sleep-wake regulatory system (alertness, performance, microsleeps, brain activity)…
- Trial name
- NCT00200863
- Testing
- Monochromatic visible light exposure
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep, Sleep Disturbance
Sounds Locked to ElectroEncephalogram Phase For the Acceleration of Sleep Onset Time
This study seeks to test whether auditory stimulation delivered at specific phases of the alpha oscillation (as measured by electroencephalogram) can accelerate sleep onset.
- Trial name
- SLEEPFAST (NCT05743114)
- Testing
- Elemind Neuromodulation (ENMod)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Elemind Technologies, Inc.
Smoking, Nicotine
Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking
Tobacco use is the leading cause of preventable death in the U.S., with 480,000 deaths per year and 7.7 million deaths globally.
- Conditions
- Smoking, Nicotine, Tobacco, Addiction
- Trial name
- NCT07328594
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Legacy Health System
Longevity, Quality of Life
Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures
The goal of this clinical study has two objectives. The Primary Objective is to evaluate the effectiveness of microdosed GLP-1 receptor agonists in improving measures of health, quality of life, and longevity.
- Conditions
- Longevity, Quality of Life, Mood, Inflammation
- Trial name
- NCT07092605
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- AgelessRx
Human Sleep and Chronobiology
Benefits and Risks of Artificial Light Exposure: Characterisation of Effects on Alertness, Sleep, Cognitive Performance, Mood and Biological Rhythms
The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances.
- Trial name
- LumEnColor (NCT05232383)
- Testing
- polychromatic light, red light, green light
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Delayed Sleep Phase Disorder, Jet-lag
Melatonin Treatment for Induced Transient Insomnia
Melatonin supplements have been reported to be an effective treatment for circadian rhythm sleep disorders, including shift work dyssomnia, jet-lag, delayed sleep phase syndrome, and sleep disruption suffered by many blind…
- Conditions
- Delayed Sleep Phase Disorder, Jet-lag, Shift-work Disorder
- Trial name
- NCT00950885
- Testing
- Low Dose Melatonin, High Dose Melatonin
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Circadian Rhythm Disorders
Human Circadian Sensitivity to Very Short Light Pulses
The mammalian eye serves both visual and non-image-forming functions. New information about the non-image-forming anatomy and physiology of the eye has revealed effects of ocular light stimuli on human circadian rhythms…
- Trial name
- NCT01330992
- Testing
- Ocular light or darkness exposure
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital