Clinical trials: Alertness
Aging, Sleep Restriction
Impact of Chronic Circadian Disruption vs. Chronic Sleep Restriction on Metabolism
The overall objectives of the proposed study are to examine the consequences of chronic circadian disruption and chronic sleep restriction on metabolic function in healthy adults.
- Conditions
- Aging, Sleep Restriction, Circadian Disruption
- Trial name
- NCT02171273
- Testing
- Circadian Disruption, Sleep Restriction, Control
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Anxiety, Stress
A Clinical Trial of De-stress and Focus Capsule in the Management of Stress.
The current study focuses in clinical validation of the efficacy of nutraceutical product in the management of mental focus and cognition. The benefits of these nutraceuticals extend beyond mere cognitive enhancement.
- Conditions
- Anxiety, Stress, Stuporous
- Trial name
- NCT06569849
- Testing
- De-Stress and Focus capsule- U001, De-Stress and Focus capsule - I001
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Herbolab India Pvt. Ltd.
Sleep Deprivation, Sleep Restriction
Acoustic Stimulation During Restricted Sleep After Sleep Deprivation
The purpose of this study is to determine if brief sounds or tones presented within a restricted period of recovery sleep after a period of sleep deprivation will enhance restorative properties and improve performance during a…
- Conditions
- Sleep Deprivation, Sleep Restriction, Acoustic Stimulation, Performance
- Trial name
- NCT05309473
- Testing
- Philips SmartSleep Acoustic Stimulation Device
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Sleep Apnea, Obstructive
Divided Attention Steering Simulator Alertness Test
Driving simulator programmes are used under a wide range of conditions, and a correlation of driving performance and real accident risks in patients with obstructive sleep apnoea syndrome(OSAS)could be shown.
- Trial name
- DASS (NCT01460173)
- Testing
- Divided Attention Steering Simulator (DASS)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Shift-Work Related Sleep Disturbance
Shift Work Intervention Strategies for Night Shift Workers
The goal of this intervention study is to test behavioral interventions in night shift workers. The main question it aims to answer is: Can personalized sleep or nutrition intervention strategies help against the negative health…
- Trial name
- GRIP (NCT06147089)
- Testing
- Sleep Intervention, Nutritional intervention
- Where
- Netherlands
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Burnout, Professional
VR Breaks on Shift-worker Alertness
Physician wellness is a hot topic today. Fatigue and alertness are common challenges faced during long work hours. Virtual reality is an immersive technology which has been demonstrated to distract people from pain, stress, and…
- Trial name
- NCT04132141
- Testing
- Virtual Reality Headset with curated content
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- George Washington University
Reaction Time, Alertness
tFUS to Enhance Alertness and Performance
The investigators goal is to target FUS energy to the centromedian nucleus of the thalamus (CMT), the core of arousal, which is inaccessible by traditional non-invasive neuromodulation devices.
- Trial name
- NCT06461221
- Testing
- Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Human Sleep and Chronobiology
Benefits and Risks of Artificial Light Exposure: Characterisation of Effects on Alertness, Sleep, Cognitive Performance, Mood and Biological Rhythms
The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances.
- Trial name
- LumEnColor (NCT05232383)
- Testing
- polychromatic light, red light, green light
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Circadian Rhythm Disorders
Human Circadian Sensitivity to Very Short Light Pulses
The mammalian eye serves both visual and non-image-forming functions. New information about the non-image-forming anatomy and physiology of the eye has revealed effects of ocular light stimuli on human circadian rhythms…
- Trial name
- NCT01330992
- Testing
- Ocular light or darkness exposure
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Behavior
Sensory Stimulation During Simulated Driving
The purpose of this study is to examine the effect of three specific odors on simulated driving performance. It is hypothesized that the presence of peppermint, rosemary, and zest/pulp will increase memory recall for navigation…
- Trial name
- NCT03726840
- Testing
- Fragrance
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders
Light Exposure to Treat Sleep Disruption in Older People
The purpose of this study is to test whether shifts in the timing of the biological clock to a later hour (phase delay shifts of the human circadian system) can be produced in response to four successive evenings of light…
- Conditions
- Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia
- Trial name
- NCT00427323
- Testing
- light exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Caffeine, Cognitive Change
Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine
This will be a (2 visit) double-blind, randomized, crossover design clinical study to assess the potential benefits of ER-CAFF versus IR-CAFF by assessing its impact on side effect profiles, mood states, alertness, and cognitive…
- Conditions
- Caffeine, Cognitive Change, Mood, Mood Change
- Trial name
- NCT06441695
- Testing
- xumXR extended release caffeine, immediate release caffeine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Cognitive, Mood and Cognitive Performance
The Acute Effects of Onnit Alpha Brain on Cognition and Mood States
The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive…
- Conditions
- Cognitive, Mood and Cognitive Performance, Sleep Deprivation, Executive Function (Cognition)
- Trial name
- NCT07495592
- Testing
- Alpha Brain proprietary cognitive dietary supplement, Alpha Brain 2.0 proprietary cognitive dietary supplement
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Fatigue, Mental Alertness
A Study to Evaluate the Effect of EnXtra® and EnXtra® + Caffeine on Mental Alertness and Fatigue in Healthy Individuals
Acute Stage: The present study is a randomized, double-blind, placebo-controlled, single-dose, 4-way, cross-over, study. Approximately not more than 170 individuals will be screened and considering a screening failure rate of…
- Trial name
- NCT06560008
- Testing
- EnXtra® (300 mg) + Caffeine (200 mg)
- Where
- 3 sites in India
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Sleep, Sleep Disturbance
Sounds Locked to ElectroEncephalogram Phase For the Acceleration of Sleep Onset Time
This study seeks to test whether auditory stimulation delivered at specific phases of the alpha oscillation (as measured by electroencephalogram) can accelerate sleep onset.
- Trial name
- SLEEPFAST (NCT05743114)
- Testing
- Elemind Neuromodulation (ENMod)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Elemind Technologies, Inc.
Theanine, (L)-Isomer
The Effect of the Amino Acid L-Theanine on Alertness and Vigilance
The amino acid l-theanine (the active ingredient in green tea) is considered to have a calming effect without causing sleepiness.
- Trial name
- NCT01851122
- Testing
- L-theanine capsule
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston