Clinical trials: Alertness
Caffeine, Cognitive Change
Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine
This will be a (2 visit) double-blind, randomized, crossover design clinical study to assess the potential benefits of ER-CAFF versus IR-CAFF by assessing its impact on side effect profiles, mood states, alertness, and cognitive…
- Conditions
- Caffeine, Cognitive Change, Mood, Mood Change
- Trial name
- NCT06441695
- Testing
- xumXR extended release caffeine, immediate release caffeine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Healthy, Circadian Rhythm
Effects of Different Colors of Light on Human Physiology
This study will determine which color of light is most effective in stimulating a range of biological functions in humans including activation of sleep-wake regulatory system (alertness, performance, microsleeps, brain activity)…
- Trial name
- NCT00200863
- Testing
- Monochromatic visible light exposure
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cognitive Performance, Sleep
Evaluating the Potentials of Biodynamic Lighting for Home Office Workers
This study examines the effectiveness of a biodynamic lighting intervention on the sleep, cognitive functions, and alertness of adults working from home.
- Conditions
- Cognitive Performance, Sleep, Alertness
- Trial name
- NCT05481424
- Testing
- Biodynamic
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Cognitive, Mood and Cognitive Performance
The Acute Effects of Onnit Alpha Brain on Cognition and Mood States
The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive…
- Conditions
- Cognitive, Mood and Cognitive Performance, Sleep Deprivation, Executive Function (Cognition)
- Trial name
- NCT07495592
- Testing
- Alpha Brain proprietary cognitive dietary supplement, Alpha Brain 2.0 proprietary cognitive dietary supplement
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Sleep Duration, Psychomotor Performance
Effect of a Wrist-worn Device That Produces a Small Vibration on Sleep and Performance That Can Occur During and After Night Shift Work
The overarching goal of this research study is to determine "proof of concept" of effect of a non-invasive sleep aid device on sleep and performance during sleep opportunities (naps) that occur during and after simulated night…
- Trial name
- Sleep-Vibe (NCT06665672)
- Testing
- Wrist worn vibro-acoustic device
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Daniel Patterson, PhD, NRP
Alert Fatigue, Health Personnel
Study to Evaluate Efficacy of EnXtra on Accuracy & Reaction Time, Perceived Alertness & Digital Fatigue for Video Gamers
In the present study, Sponsor aim to evaluate the effects of EnXtra® as to improve Accuracy \& Reaction Time, Perceived Alertness \& Digital Fatigue for Video Gamers.
- Trial name
- NCT05586880
- Testing
- Experimental: EnXtra 300 mg/ capsule, Microcrystalline cellulose (MCC) 300mg
- Where
- 2 sites in India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders
Light Exposure to Treat Sleep Disruption in Older People
The purpose of this study is to test whether shifts in the timing of the biological clock to a later hour (phase delay shifts of the human circadian system) can be produced in response to four successive evenings of light…
- Conditions
- Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia
- Trial name
- NCT00427323
- Testing
- light exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Attention, Memory
A Randomized, Placebo-Controlled, Double-Blind, Crossover Study to Evaluate the Effects of Three Doses of the Dietary Supplement oréVida™ on Alertness, Attention and Concentration in Healthy Men and Women
The purpose of this study is to investigate the effects of the dietary supplement oréVida™ (active ingredient on the basis of a culinary herb)administered twice daily in an acute study on an improvement in vigilance, attention…
- Conditions
- Attention, Memory, Alertness
- Trial name
- NCT01143194
- Testing
- oréVida™
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Sleep, Circadian Rhythm
Morning Bright Light Therapy and Daytime Functioning in University Students
This study tests whether a week of morning bright light therapy changes how well healthy young adults sleep and how alert, positive, and mentally sharp they feel during the day.
- Conditions
- Sleep, Circadian Rhythm, Daytime Sleepiness, Mood
- Trial name
- BLIGHT (NCT07685262)
- Testing
- Bright light therapy (10,000 lux light box)
- Where
- Hong Kong
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Sleep, Alertness
Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood During Nightshift Work on a 105-day Simulated Human Exploration Mission to Mars
The success of human expedition missions critically depend on the ability of the crew to be alert and maintain high levels of cognitive function while operating complex, technical equipment.
- Conditions
- Sleep, Alertness, Fatigue
- Trial name
- Mars 105 (NCT01169233)
- Testing
- Bright Light Box
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Alertness, Fatigue, Mood, and Performance, Calorie Restriction and Light Intervention
Fatigue in Long-Haul Operations
The purpose of the present study is to test novel countermeasures to reduce fatigue among airline pilots during long-haul flight operations.
- Trial name
- LHops26 (NCT07761611)
- Testing
- Caloric restriction, Light exposure
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Lifestyle, Healthy, Sleepiness
Lifestyle Coaching for Fatigue Mitigation in Emergency Medicine Residents
The purpose of this study is to determine whether personalized lifestyle coaching minimizes the negative impact of circadian disruption on performance and recovery in emergency medicine physician trainees during night shifts.
- Conditions
- Lifestyle, Healthy, Sleepiness, Alertness, Shift-Work Related Sleep Disturbance
- Trial name
- NCT06015646
- Testing
- Personalized lifestyle coaching and educational handout, Handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Glaucoma
Altered Non-Visual Photoreception in Patients With Glaucoma: Impacts on Sleep, Alertness, Mood, and Cognition
The goal of this study is to understand how light sensitivity in the eye affects sleep, mood, alertness, and cognition in adults with glaucoma compared to healthy individuals aged 45-75 years.
- Trial name
- EyeQ (NCT07364929)
- Testing
- Full-spectrum light exposure, Standard indoor light exposure (Control)
- Where
- 2 sites in Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Human Sleep and Chronobiology
Benefits and Risks of Artificial Light Exposure: Characterisation of Effects on Alertness, Sleep, Cognitive Performance, Mood and Biological Rhythms
The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances.
- Trial name
- LumEnColor (NCT05232383)
- Testing
- polychromatic light, red light, green light
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
At Home Setting, Coffee With or Without Caffeine
Do It Yourself (DIY) Coffee Study; Test Effect of Coffee on Cognition in an at Home Setting
Subjects will perform experiments in an at home-setting. The effect of caffeine in coffee will be tested in subjects with computer tests on attention and alertness.
- Trial name
- NCT02061982
- Testing
- Coffee consumption
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TNO
Behavior
Sensory Stimulation During Simulated Driving
The purpose of this study is to examine the effect of three specific odors on simulated driving performance. It is hypothesized that the presence of peppermint, rosemary, and zest/pulp will increase memory recall for navigation…
- Trial name
- NCT03726840
- Testing
- Fragrance
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Reaction Time, Alertness
tFUS to Enhance Alertness and Performance
The investigators goal is to target FUS energy to the centromedian nucleus of the thalamus (CMT), the core of arousal, which is inaccessible by traditional non-invasive neuromodulation devices.
- Trial name
- NCT06461221
- Testing
- Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Shift-Work Related Sleep Disturbance
Shift Work Intervention Strategies for Night Shift Workers
The goal of this intervention study is to test behavioral interventions in night shift workers. The main question it aims to answer is: Can personalized sleep or nutrition intervention strategies help against the negative health…
- Trial name
- GRIP (NCT06147089)
- Testing
- Sleep Intervention, Nutritional intervention
- Where
- Netherlands
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Alertness
Characterizing the Pharmacokinetic Profile of a Novel Encapsulated Caffeine Beverage and Associated Mood and Physiological Effects
This study is designed to compare self-reported mood states for encapsulated caffeine compared to dose-matched free caffeine, when consumed as a ready-to-drink beverage in healthy subjects.
- Trial name
- NCT05096780
- Testing
- Flavored caffeinated beverage
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Sleep Apnea, Obstructive
Divided Attention Steering Simulator Alertness Test
Driving simulator programmes are used under a wide range of conditions, and a correlation of driving performance and real accident risks in patients with obstructive sleep apnoea syndrome(OSAS)could be shown.
- Trial name
- DASS (NCT01460173)
- Testing
- Divided Attention Steering Simulator (DASS)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV