Clinical trials: Alertness
Anesthesia, Surgical Procedures, Elective
A Safety and Efficacy Study of Dexmedetomidine in Patients Requiring Sedation During Monitored Anesthesia Care (MAC)
The objective of this study is to evaluate the safety and efficacy of dexmedetomidine as compared to placebo when used for the sedation of subjects requiring monitored anesthesia care (MAC).
- Trial name
- NCT00398827
- Testing
- Dexmedetomidine
- Where
- 27 sites in United States
- Volunteers
- 326 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Caffeine, Cognitive Change
Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine
This will be a (2 visit) double-blind, randomized, crossover design clinical study to assess the potential benefits of ER-CAFF versus IR-CAFF by assessing its impact on side effect profiles, mood states, alertness, and cognitive…
- Conditions
- Caffeine, Cognitive Change, Mood, Mood Change
- Trial name
- NCT06441695
- Testing
- xumXR extended release caffeine, immediate release caffeine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Cognitive, Mood and Cognitive Performance
The Acute Effects of Onnit Alpha Brain on Cognition and Mood States
The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive…
- Conditions
- Cognitive, Mood and Cognitive Performance, Sleep Deprivation, Executive Function (Cognition)
- Trial name
- NCT07495592
- Testing
- Alpha Brain proprietary cognitive dietary supplement, Alpha Brain 2.0 proprietary cognitive dietary supplement
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Alert Fatigue, Health Personnel
Study to Evaluate Efficacy of EnXtra on Accuracy & Reaction Time, Perceived Alertness & Digital Fatigue for Video Gamers
In the present study, Sponsor aim to evaluate the effects of EnXtra® as to improve Accuracy \& Reaction Time, Perceived Alertness \& Digital Fatigue for Video Gamers.
- Trial name
- NCT05586880
- Testing
- Experimental: EnXtra 300 mg/ capsule, Microcrystalline cellulose (MCC) 300mg
- Where
- 2 sites in India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Attention, Memory
A Randomized, Placebo-Controlled, Double-Blind, Crossover Study to Evaluate the Effects of Three Doses of the Dietary Supplement oréVida™ on Alertness, Attention and Concentration in Healthy Men and Women
The purpose of this study is to investigate the effects of the dietary supplement oréVida™ (active ingredient on the basis of a culinary herb)administered twice daily in an acute study on an improvement in vigilance, attention…
- Conditions
- Attention, Memory, Alertness
- Trial name
- NCT01143194
- Testing
- oréVida™
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Alertness
Characterizing the Pharmacokinetic Profile of a Novel Encapsulated Caffeine Beverage and Associated Mood and Physiological Effects
This study is designed to compare self-reported mood states for encapsulated caffeine compared to dose-matched free caffeine, when consumed as a ready-to-drink beverage in healthy subjects.
- Trial name
- NCT05096780
- Testing
- Flavored caffeinated beverage
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Sleep Apnea, Obstructive
Divided Attention Steering Simulator Alertness Test
Driving simulator programmes are used under a wide range of conditions, and a correlation of driving performance and real accident risks in patients with obstructive sleep apnoea syndrome(OSAS)could be shown.
- Trial name
- DASS (NCT01460173)
- Testing
- Divided Attention Steering Simulator (DASS)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Mental Fatigue, Alertness
Effect of Coffeeberry on Mood and Cognitive Performance
The primary aim of this randomised, double-blind, placebo-controlled, cross-over study is to assess the short-term cognitive effects of two beverages containing 100 and 300 mg coffeeberry extract (obtained from the fruit of the…
- Conditions
- Mental Fatigue, Alertness, Mood, Cognition
- Trial name
- NCT04975802
- Testing
- Coffeeberry, Caffeine
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Sleep, Sleep Disturbance
Sounds Locked to ElectroEncephalogram Phase For the Acceleration of Sleep Onset Time
This study seeks to test whether auditory stimulation delivered at specific phases of the alpha oscillation (as measured by electroencephalogram) can accelerate sleep onset.
- Trial name
- SLEEPFAST (NCT05743114)
- Testing
- Elemind Neuromodulation (ENMod)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Elemind Technologies, Inc.
Sleep
Study to Assess Impact of Dietary Supplement on Sleep Health
Sleep is essential for health and wellness. Sleep disruption can occur due to emotional stress, advancing age, hormonal imbalance, medications, and many other causes, some of which are presently unknown.
- Trial name
- NCT05971771
- Testing
- Treatment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Mental Fatigue
A Study to Evaluate Efficacy of IP on Alertness and Mental Fatigue
The current study is design to asses the effect of E-AG-01/ E-AG-02/ E-AG-03 on mental alertness as compared to placebo.
- Trial name
- ALERMEN (NCT02816827)
- Testing
- AG-01, AG-05, AG-06
- Where
- India
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Fatigue, Mental Alertness
A Study to Evaluate the Effect of EnXtra® and EnXtra® + Caffeine on Mental Alertness and Fatigue in Healthy Individuals
Acute Stage: The present study is a randomized, double-blind, placebo-controlled, single-dose, 4-way, cross-over, study. Approximately not more than 170 individuals will be screened and considering a screening failure rate of…
- Trial name
- NCT06560008
- Testing
- EnXtra® (300 mg) + Caffeine (200 mg)
- Where
- 3 sites in India
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Fatigue, Mental, Alertness
Effect of Coffeeberry on Mood, Motivation and Cognitive Performance
The primary purpose is to test the short-term effects of the acute consumption of two novel beverages made from coffeeberries, the fruit of the coffee plant (Coffea arabica) benchmarked against caffeine on several aspects of…
- Conditions
- Fatigue, Mental, Alertness, Mood, Motivation
- Trial name
- NCT04974606
- Testing
- Cherry-flavored still beverage
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis (ME)
The Synergy Trial: Methylphenidate Plus a CFS-Specific Nutrient Formula as a Treatment for Chronic Fatigue Syndrome
The Synergy Trial will evaluate the safety and efficacy of a currently available medication (methylphenidate hydrochloride) combined with a CFS-specific dietary supplement (CFS Nutrient Formula) to treat Chronic Fatigue Syndrome…
- Trial name
- NCT01966276
- Testing
- Methyl-P plus Nutrient Formula
- Where
- 4 sites in United States
- Volunteers
- 134 people
- Sponsor
- K-PAX Pharmaceuticals, Inc.
Longevity, Quality of Life
Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures
The goal of this clinical study has two objectives. The Primary Objective is to evaluate the effectiveness of microdosed GLP-1 receptor agonists in improving measures of health, quality of life, and longevity.
- Conditions
- Longevity, Quality of Life, Mood, Inflammation
- Trial name
- NCT07092605
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- AgelessRx
Fatigue
Tolerability and Benefit of IQP-AS-121 on Fatigue and Mental Alertness
The purpose of this study is to evaluate the tolerability and benefit of IQP-AS-121 on reducing fatigue and tiredness and to improve mental alertness.
- Trial name
- NCT02871271
- Testing
- IQP-AS-121
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- InQpharm Group
Anxiety, Stress
A Clinical Trial of De-stress and Focus Capsule in the Management of Stress.
The current study focuses in clinical validation of the efficacy of nutraceutical product in the management of mental focus and cognition. The benefits of these nutraceuticals extend beyond mere cognitive enhancement.
- Conditions
- Anxiety, Stress, Stuporous
- Trial name
- NCT06569849
- Testing
- De-Stress and Focus capsule- U001, De-Stress and Focus capsule - I001
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Herbolab India Pvt. Ltd.
Attention Difficulties
Guayusa: The Effect of an Herbal Extract on Alertness and Mental Fatigue
The primary objective of this randomized, double-blind, placebo-controlled, cross-over study is to assess the acute effects of a novel ingredient, guayusa on alertness and mental fatigue compared to a placebo.
- Trial name
- NCT05530915
- Testing
- Gel capsule
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Common Cold
Effects of Two Doses of a Common Cold Treatment on Alertness
This study will investigate any improvement in alertness and performance based on cognitive function and mood assessment in subjects suffering the common cold, when taking a novel paracetamol and caffeine combination verses…
- Trial name
- NCT01686646
- Testing
- paracetamol + caffeine, paracetamol
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- GlaxoSmithKline
Mood, Stress
Investigation of a Dietary Supplement Liquid Shot Product on Aspects of Mood Both At Rest and During a Laboratory Stressor Task.
This is a single center, randomized, double blind, placebo-controlled, crossover study to determine the acute effect of a developmental dietary supplement liquid shot product of aspect of mood both at rest and during laboratory…
- Conditions
- Mood, Stress, Alertness
- Trial name
- NCT06785142
- Testing
- Functional Shot
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Water Street Collective