Clinical trials: Alcoholism
Alcohol Abuse, Alcohol Dependence
Internet-based vs Face-to-face Treatment for Alcohol Dependence
A brief treatment program (MI/CBT) via face-to-face or via internet is tested in association with an outpatient addictions clinic.
- Conditions
- Alcohol Abuse, Alcohol Dependence, Harmful Alcohol Use, Alcohol Use Disorder
- Trial name
- IMS (NCT02888002)
- Testing
- Guide to better alcohol habits
- Where
- Sweden
- Volunteers
- 310 people
- Sponsor
- Karolinska Institutet
Alcoholism, Alcohol Abuse
Predicting Alcoholics' Treatment Responses to a Selective Serotonin Re-uptake Inhibitor (SSRI)
This study is being done to determine if citalopram is safe and effective in the treatment of alcohol dependence. A second purpose is to evaluate whether alcohol dependent individuals who differ in a specific genetic marker…
- Trial name
- NCT00249405
- Testing
- Citalopram + MI
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Cincinnati
Alcoholism, Gambling
Effectiveness of Sertraline in Treating Pathological Gamblers With a Diagnosis of Alcohol Dependence - 1
Pathological gamblers often are also dependent on alcohol and clinically depressed. Sertraline (Zoloft) is currently used to treat depression, panic disorder, and obsessive-compulsive disorder.
- Trial name
- NCT00249431
- Testing
- Sertraline, Relapse Prevention Therapy
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder
Pilot Trial to Evaluate PROblem Solving Therapy and APPLE Watch for College Students
The goals of this Pilot Trial are to test the preliminary efficacy of Problom-Solving Therapy (PST)-APPLE Watch in a 2-arm pilot Randomized Control Trial (RCT), vs education only-control to reduce alcohol use disorder symptoms…
- Trial name
- NCT06333288
- Testing
- PST-APPLE Watch group, Education-only control group
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Bipolar Disorder, Anxious Disorder
Effectiveness of TCC Followed by MBCT and Predictive Factors (Genetic, Clinical and Cognitive) Response
The purpose of this study is to determine whether a Cognitive and Behavioral group Therapy (CBT) + Mindfulness Based Cognitive Therapy (MBCT) decreased relapses and hospitalizations and improved outcomes (depressive and manic…
- Conditions
- Bipolar Disorder, Anxious Disorder, Alcohol Dependence
- Trial name
- TCC-MBCT (NCT02472483)
- Testing
- Cognitive and Behavior Therapy (CBT), Mindfulness Based Cognitive Therapy (MBCT)
- Where
- France
- Volunteers
- 158 people
- Sponsor
- Centre Hospitalier St Anne
Alcohol Use Disorder
Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study
Study to enroll up to 90 individuals, those with an alcohol use disorder (AUD) (up to n=60) and non-dependent healthy volunteers (HV) (up to n=30).
- Trial name
- AUD (NCT05885594)
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Psychosis, Alcohol Use Disorder
Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis
Psychotic disorders impact 4.6 people per 1000 globally, with approximately 1.5 million Canadians affected. The age of onset for psychotic disorders often begin during the critical years of youth and early adulthood, resulting in…
- Conditions
- Psychosis, Alcohol Use Disorder, Cannabis Use Disorder
- Trial name
- NCT07056894
- Testing
- Action-Based Cognitive Remediation
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Depression, Alcohol Dependence
Ketamine for Depression and Alcohol Dependence
The purpose of this study is to evaluate the efficacy of ketamine in reducing depressive symptoms in subjects with a comorbid major depressive episode and alcohol dependence.
- Trial name
- KetamineDep (NCT01551329)
- Testing
- Ketalar (ketamine)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Alcoholism
Combined Pharmacotherapies for Alcoholism (Naltrexone/Ondansetron)
This study will compare the effectiveness of ondansetron (Zofran) and naltrexone (ReVia) both alone and in combination in treating Early Onset Alcoholics versus Late Onset Alcoholics.
- Trial name
- NCT00027079
- Testing
- ondansetron (Zofran), naltrexone (ReVia), Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Obesity, Alcohol Dependence
Imaging of Cannabinoid 1 Receptors Using [11C]OMAR and PET
The aim of the present study is to conduct a human trial of [C-11]OMAR, a new PET imaging agent for the brain cannabinoid type 1 receptors (CB1), to determine its pharmacokinetics and binding characteristics.
- Conditions
- Obesity, Alcohol Dependence, High Stress
- Trial name
- NCT01719497
- Testing
- [C-11]OMAR
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder
Ibudilast for the Treatment of Alcohol Use Disorder
This study is a double-blind, placebo-controlled randomized clinical trial of Ibudilast (IBUD) (50mg twice a day) for the treatment of Alcohol Use Disorder (AUD).
- Trial name
- NCT03594435
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of California, Los Angeles
Alcoholism
Quetiapine Fumarate (Seroquel) for the Treatment of Alcohol Dependence.
The purpose of this study is to determine whether seroquel is effective in the treatment of type A and type B alcohol dependence.
- Trial name
- NCT00124059
- Testing
- Seroquel
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Pennsylvania
Alcoholism
Combined Pharmacotherapies for Alcoholism
This study would like to test whether the combination of ondansetron and naltrexone will be superior to either medication alone or placebo in the treatment of alcohol dependence.
- Trial name
- NCT00768508
- Testing
- Ondansetron 4 ug/kg b.i.d. + Cognitive Behavioral Therapy, Naltrexone 50 mg/day + Cognitive Behavioral Therapy, Ondansetron 4 ug/kg b.i.d.+ Naltrexone 50 mg/day + Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Bankole Johnson
Alcohol Use Disorder
Study of Mindfulness Practice Efficacy in Alcoholic Relapse Prevention
Among behavioral cognitive psychotherapies, new "Mindfulness" interventions allow patient to identify, pay attention and accept external (sensory stimuli) and internal (cognition and emotions) phenomena.
- Trial name
- Mindfulness (NCT03150550)
- Testing
- Mindfulness practice, Relapse prevention
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Alcohol, Alcohol Use Disorders
A Phase I Study of the Interaction of Alcohol With Oral AFA-281 in Healthy Volunteers
The goal of this clinical trial is to evaluate if alcohol interacts with the drug candidate AFA-281 in adults (healthy volunteers). This trial will evaluate blood concentration levels of AFA-281 and ethanol.
- Trial name
- NCT06719908
- Testing
- AFA-281 is a small molecule, orally available, Alcohol (Ethanol)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Alcoholism, Liver Disease
Transient Elastography in the Determination of Advanced Fibrosis in Alcoholic Liver Disease.
Alcoholic liver disease is the most frequent complication of excessive alcohol consumption. Early diagnosis of alcoholic liver disease is essential to avoid its complications that could be fatal.
- Conditions
- Alcoholism, Liver Disease, Liver Fibrosis
- Trial name
- FIBR-OH (NCT01789008)
- Testing
- Determination of Advanced Fibrosis in Alcoholic Liver Disease
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Rennes University Hospital
Opioid Use, Alcohol Use Disorder
rTMS as Add on Treatment for Substance Use Disorders
This pilot study is designed to test feasibility and superiority of rTMS types and target locations for the optimal rTMS intervention for individuals seeking treatment for Alcohol Use Disorder (AUD) or Opioid Use Disorder (OUD).
- Trial name
- NCT06963476
- Testing
- repetitive transcranial magnetic stimulation (rTMS) for AUD, repetitive transcranial magnetic stimulation (rTMS) for OUD
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Yale University
Alcohol Use Disorder
Inpatient Alcohol Detox & Psychotherapy
The aim of the study is to evaluate effectiveness of inpatient detoxification and psycho-therapeutic support, measured in terms of readiness to change and abstinence maintenance.
- Trial name
- NCT03988478
- Testing
- Detoxification & psychotherapeutic support
- Volunteers
- 109 people
- Sponsor
- Tribhuvan University, Nepal
Alcohol Use Disorder, Substance Use Disorders
A Dialectical Behavioral Therapy Digital Health Solution for Outpatients Seeking Support for Substance Use
The purpose of this study is to compare the feasibility, acceptability, and efficacy of a dialectical behavior therapy skills training webapp known as "Pocket Skills" in outpatients and community members seeking treatment for…
- Trial name
- NCT05094440
- Testing
- Dialectical behavioral therapy skills training (DBT-ST)
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Dependence, Cocaine Dependence
Novel Pharmacotherapy for Dual Dependence
The purpose of this study is to evaluate the effects of Topiramate and Cognitive Behavioral Therapy for the treatment of alcohol and cocaine dependence.
- Trial name
- NCT00448825
- Testing
- Topiramate + Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Bankole Johnson