Clinical trials: Alcohol-Related Disorders
Alcoholic Liver Disease
Quantitative MRI for Non-invasive Assessment of Severity of Alcoholic Liver Disease (ALD)
The current goal in the treatment of Alcoholic Liver Disease (ALD) is to manage ALD-associated complications as there are no disease-specific therapies.
- Trial name
- NCT03113929
- Testing
- MRI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Alcohol Dependence, Cocaine Dependence
Combined Treatment for Cocaine-Alcohol Dependence - 1
The purpose of this study is to examine whether Naltrexone and cognitive behavioral therapy can be helpful in patients who want to stop using cocaine and alcohol.
- Trial name
- NCT00218569
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Affect, Alcohol Consumption
Automated Telephone Follow-up in the Swedish Prison and Probation Services
The purpose of this study is to investigate whether automated telephony may be used for daily assessments of paroled offenders, and whether a brief intervention based on these daily assessments may result in a more positive…
- Conditions
- Affect, Alcohol Consumption, Substance Abuse
- Trial name
- NCT01727882
- Testing
- Brief feedback, Daily assessments
- Where
- Sweden
- Volunteers
- 108 people
- Sponsor
- Region Skane
HIV, Tobacco Use
Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol Use Among PWH in Nairobi, Kenya
People with HIV (PWH) smoke tobacco cigarettes and drink alcohol at higher rates than the general population, both in the US and internationally, including low- and middle-income countries.
- Conditions
- HIV, Tobacco Use, Alcohol Use Disorder
- Trial name
- NCT06790342
- Testing
- Cystine, Positively Smoke Free, Standard of Care
- Where
- 2 sites in Kenya
- Volunteers
- 300 people
- Sponsor
- University of Chicago
Alcohol Use Disorder
Supporting Adolescent Alcohol Treatment With Computer-Based ('Path180') Skills Training
This 8-week clinical trial will test a computer-based skills training program called Path180 with 112 adolescents aged 13 to 19 who are receiving mental health counseling or outpatient substance use treatment.
- Trial name
- NCT07713251
- Testing
- Path180
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Dependence, Anxiety
Doxazosin an a1 Antagonist for Alcohol Dependence
Norepinephrine system represents an important treatment target for alcohol dependence (AD) and the α1 -blocker prazosin may reduce alcohol drinking in rodents and alcoholic patients.
- Trial name
- NCT01437046
- Testing
- Doxazosin
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Brown University
Alcohol Use Disorder, Substance Use Disorders
Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treatment for Substance Use Disorder
The aim of this project is to investigate the potential of transcranial direct current stimulation (tDCS) to reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD), with a focus on…
- Trial name
- NCT06959342
- Testing
- Transcranial direct current stimulation (tDCS), Inhibition Training
- Where
- 2 sites in Germany
- Volunteers
- 162 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Acute Pancreatitis
Pentoxifylline Treatment of Acute Pancreatitis
The purpose of this study is to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis, to see if it can improve blood tests associated with inflammation (tissue damage).
- Trial name
- NCT01292005
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Alcoholic Liver Diseases
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease
The study will assess the effect of treatment with formulation containing S-Adenosyl methionine and choline, on patients with alcoholic liver disease.
- Trial name
- NCT03938662
- Testing
- formulation containing S-Adenosyl methionine and choline
- Where
- Serbia
- Volunteers
- 44 people
- Sponsor
- University Clinic Dr Dragisa Misovic-Dedinje
Binge Drinking
Afferent Neurocardiac Signals, Cue Reactivity, and Cognitive Control
Conscious attempts to regulate alcohol use are often undermined by automatic attention and arousal processes activated by alcohol cues, as well as by diminished ability to inhibit in-the-moment behaviors.
- Trial name
- NCT05369169
- Testing
- Resonance breathing, Low demand cognitive task
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Alcoholic Hepatitis, Alcoholic Liver Disease
Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone
Treatment of reference of severe alcoholic hepatitis is based on corticosteroids, given for 28 days. However, about 25-35% of patients do not take benefit from this treatment and die within the 6 months following the diagnosis.
- Trial name
- AntibioCor (NCT02281929)
- Testing
- Amoxicillin, Prednisolone
- Where
- 20 sites in France
- Volunteers
- 297 people
- Sponsor
- University Hospital, Lille
Substance Dependence
A Pilot Clinical Trial of Varenicline as a Treatment for Alcohol Dependence
Purpose: This is an outpatient, randomized, double-blinded, placebo-controlled study in which either varenicline (twice daily) or placebo will be administered over a 12 week study period to examine genetic influences on treatment…
- Trial name
- NCT01011907
- Testing
- varenicline
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of California, San Francisco
Alcohol Use Disorder (AUD)
Records for Alcohol Care Enhancement
Unhealthy alcohol use (the spectrum from risky consumption through alcohol use disorder, AUD) is a leading cause of preventable death in the US (88,424 deaths annually costing $249 billion a year), and alcohol-related health…
- Trial name
- RACE (NCT05492942)
- Testing
- Best Practice Advisory (BPA) and Population Health Management (PHM), Best Practice Advisory (BPA) and Clinical Care Management (CCM), Best Practice Advisory (BPA) and Population Health Management (PHM) and Clinical Care Management (CCM)
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Substance Abuse
Hair Testing to Assess Consumption of Illicit Psychotropic Agents and Alcohol by Patients Treated With High-dose Buprenorphine and Methadone. Search for a Pharmacogenetic Contribution to Low Efficacy of Substitution Medications
Justification and aims of the study: The principal aim of use of opiate substitutes such as methadone or high-dose buprenorphine (HDB) is to reduce the need or the desire to consume the opiate to which the patient is addicted.
- Trial name
- NCT01285856
- Testing
- hair and saliva samples
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hazardous Alcohol Use
PrEP and Alcohol - Enhancing HIV Pre-Exposure Prophylaxis (PrEP)
The present investigation entails a pilot randomized controlled trial to explore whether a stand-alone, alcohol-reduction, brief intervention (with a module on substance use and depression) would be feasible, acceptable, and…
- Trial name
- NCT05097430
- Testing
- Alcohol-focused brief intervention
- Where
- 3 sites in Canada
- Volunteers
- 122 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Use Disorder (AUD), PTSD
Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building
This is a two-part study to develop and test a brief, virtual therapy program for lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people who have experienced trauma and use alcohol.
- Trial name
- RISE (NCT07217795)
- Testing
- CBT + expressive writing, Wait-List Control
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Rhode Island
Ketoses, Metabolic, Ketogenic Dieting
Effect of Nutritional Ketosis on Alcohol Metabolism
The research study is being conducted in health controls to better understand the effects of ketosis on brain functioning after 3 different, randomly assigned, 3-day dietary interventions and the acute effects of alcohol after…
- Conditions
- Ketoses, Metabolic, Ketogenic Dieting, Alcohol Intoxication, Magnetic Resonance Imaging
- Trial name
- KAM (NCT06065657)
- Testing
- Ketone Supplement, Control Diet, Ketogenic diet
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Intoxication, Delirium Tremens (DTs)
Preventox - a Digital Intervention for Patients With Intoxications in Intensive Care
Background and purpose At present, occasional referral to psychiatric or addiction services is the only aftercare option offered following an intoxication/overdose requiring intensive care.
- Conditions
- Intoxication, Delirium Tremens (DTs), Poisoning by Psychoactive Substances, Suicidal Attempt
- Trial name
- NCT07819500
- Testing
- Preventox, a digital self-help tool for patients with intoxications in intensive care., Preventox control group
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Alcohol Dependence
The Approach and Avoidance Task (AAT) in Alcoholic Inpatients
The approach and avoidance task (AAT) has evolved as a promising treatment add-on in the realm of psychology. Certain psychiatric diseases, such as behavioural addictions, social anxiety disorder, and arachnophobia, are…
- Trial name
- NCT04054336
- Testing
- Inhibit AAT, classical AAT, Control Group
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ptsd, Alcohol Use Disorder
Early Intervention Following Sexual Assault
This study is for women who have experienced a sexual assault in the past six weeks and use alcohol. The research involves completing a five week behavioral treatment for stress and alcohol use.
- Conditions
- Ptsd, Alcohol Use Disorder, Sexual Assault and Rape
- Trial name
- NCT04582695
- Testing
- Written Exposure Therapy Integrated with Cognitive Behavioral Therapy for Alcohol Use Disorder, Written Exposure Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina