Clinical trials: Alcohol Withdrawal
Alcohol Use Disorder
Ibudilast and Withdrawal-Related Dysphoria
Alcohol use disorder (AUD) is a prevalent and disabling psychiatric disorder with few, and only moderately efficacious, treatment options.
- Trial name
- NCT03489850
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, Los Angeles
Alcohol-Induced Disorders, Ostracism
Role of Adverse Childhood Events and Rejection Sensitivity on Alcohol Use in Recently Withdrawn Individuals With Alcohol Use Disorder
Low utilization of addiction treatment is a public health problem. A number of factors are associated with lack of treatment, including public stigma, self-stigma, and beliefs that people with addiction should solve their problem…
- Trial name
- TRAC (NCT05787106)
- Testing
- Cyberball task
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Alcohol Withdrawal Delirium
Treatment Of Alcohol Withdrawal Syndrome: Dexmedetomidine Vs Diazepam In A Hospital O'horán
The cessation of alcohol consumption of people suffering from alcohol abuse frequently leads to the development of an alcohol withdrawal syndrome (AWS).
- Trial name
- NCT03877120
- Testing
- Dexmedetomidine 0.004 MG/ML, Diazepam Injectable Solution
- Where
- Mexico
- Volunteers
- 2 people
- Sponsor
- Centro Medico Nacional La Raza, IMSS
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Alcohol Withdrawal
A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal
The purpose of this study is to compare the efficacy of two commonly used medications in the treatment of alcohol withdrawal, diazepam and lorazepam.
- Trial name
- NCT00523185
- Testing
- Lorazepam, Diazepam
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Stanford University
Alcohol Use Disorder, Alcohol Withdrawal
Baclofen in Managing Acute Alcohol Withdrawal
The study goal is to investigate whether administration of oral baclofen forms an adequate treatment option in the management of acute alcohol withdrawal.
- Trial name
- NCT03293017
- Testing
- Diazepam 10 MG, Baclofen 30mg, Baclofen 60mg
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Universitair Ziekenhuis Brussel
Substance Withdrawal Syndrome
Abuse and Addiction in ICU
Investigators are seeking to determine the impact of recent alcohol, smoking or psychotropic drug use prior to intensive care unit (ICU) admission on incidence of delirium and sedation requirements.
- Trial name
- NCT02951793
- Testing
- AUDIT-C, Smoking history, Prior psychotropic medication use
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Alcohol-Induced Disorders
Magnesium After Alcohol Withdrawal Treatment
The primary purpose is to see if magnesium tablet supplementation will decrease elevated GGT enzyme activity in alcoholic patients immediately after they had been treated for alcohol withdrawal.
- Trial name
- NCT00325299
- Testing
- Magnesium
- Where
- Finland
- Volunteers
- 178 people
- Sponsor
- Finnish Foundation for Alcohol Studies
Alcohol Withdrawal, Alcohol Withdrawal Delirium
Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit
Our aim is to compare outcomes of patients with benzodiazepine-refractory alcohol withdrawal syndrome who are treated with either a phenobarbital-based or a lorazepam based protocol.
- Trial name
- PARTI (NCT04156464)
- Testing
- Phenobarbital, Lorazepam
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- OSF Healthcare System
Impulsivity, Active Suicidal Ideation
Impulsivity and Thought Process Disorder in Patients With Active Suicidal Ideation and Depression
This study is dedicated to achieving a better understanding of how the brain processes information. Specifically, the investigators are studying cognitive function, thought process, and impulsivity in people with and without…
- Conditions
- Impulsivity, Active Suicidal Ideation, Depression
- Trial name
- NCT01770600
- Testing
- Riperidone
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Alcohol Withdrawal Syndrome
Treatment of Alcohol Withdrawal Syndrome With Alpha-2 Agonists and/or Anticonvulsants
Complicated alcohol withdrawal syndrome (AWS) increases morbidity and mortality of hospitalized, medically ill patients. The Psychosomatic Medicine Service is commonly consulted to assist in the management of these patients when…
- Trial name
- NCT05438641
- Testing
- BZDP-Sparing Protocol, BZDP-Based Protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Acute Alcohol Withdrawal
Dexmedetomidine as Adjunctive Therapy for Alcohol Withdrawal
This study is designed to evaluate dexmedetomidine as adjunctive therapy of severe alcohol withdrawal of medical ICU patients. Specifically, this study will assess whether adjunctive dexmedetomidine reduces the doses of…
- Trial name
- DATA (NCT00936377)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Colorado, Denver
Alcohol Use Disorder
Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder
Alcohol use disorder (AUD) is a major health concern amongst Veterans as it causes functional impairments and decreased quality of life.
- Trial name
- NCT06399653
- Testing
- Cervical transcutaneous vagus nerve stimulation (active comparator)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Alcohol Withdrawal, Substance Use Disorders
NCARE, Transition to Recovery
This study tests the effectiveness of patient navigation for increasing enrollment in substance abuse treatment programs and preventing readmission to detoxification.
- Trial name
- NCT03737864
- Testing
- Patient navigation, Motivational interviewing (MI)
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- University of Colorado, Denver
Alcohol Abuse, Alcoholism
Consequences of At-risk Alcohol Consumption in ICU Patients
At-risk drinking is known to cause a high incidence of alcohol withdrawal syndrome which has a high impact on morbidity and mortality.
- Trial name
- NCT03565016
- Testing
- no interventional study
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Nantes University Hospital
Alcoholism, Substance-Related Disorders
Intranasal Oxytocin Effects in Alcohol Withdrawal and Dependence; Follow-up Study
This study is an assessment of the long-term effect of oxytocin nasal spray on alcohol withdrawal and dependence in adults admitted for detoxification of alcohol after 60 days and 1 year.
- Trial name
- NCT03339024
- Testing
- intranasal oxytocin spray, intranasal spray without oxytocin
- Where
- Norway
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Alcohol Use Disorder, Addiction
Portrayal of Hospital Alcohol Detoxification in France
Even if hospital alcohol detoxifications are frequent in France, their caracteristicscharacteristics remain unknown. The investigators aim to describe the clinical and paraclinical caracteristicscharacteristics of their patients…
- Conditions
- Alcohol Use Disorder, Addiction, Alcohol Withdrawal Syndrome
- Trial name
- Alcostop (NCT04973202)
- Testing
- Stay for alcohol detoxification
- Where
- France
- Volunteers
- 50,000 people
- Sponsor
- University Hospital, Montpellier
Alcohol Withdrawal Syndrome
Preventing Alcohol Withdrawal Syndrome With Oral Baclofen
Adult medical/surgical inpatient hospital care is more difficult and more expensive when complicated by alcohol dependency (AD), especially for patients who develop alcohol withdrawal syndrome (AWS).
- Trial name
- NCT02052440
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Denver Health and Hospital Authority
Alcohol Withdrawal Delirium, Alcohol Withdrawal
Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome
Severe acute alcohol withdrawal syndrome is a potentially life-threatening condition characterized by agitation, confusion, abnormal heart rhythms and seizures.
- Conditions
- Alcohol Withdrawal Delirium, Alcohol Withdrawal, Alcohol Withdrawal Seizures
- Trial name
- PHENOMANAL (NCT03586089)
- Testing
- Phenobarbital Sodium
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Unity Health Toronto
Alcohol Dependence
Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal
Alcohol dependence is accompanied by several neurological mechanisms involving neuronal plasticity and neoneurogenesis, requiring Brain Derived Neurotrophic factor (BDNF) synthesis.
- Trial name
- NCT01491347
- Where
- 4 sites in France
- Volunteers
- 389 people
- Sponsor
- Centre Hospitalier Esquirol