Clinical trials: Alcohol Use Disorders
Binge Drinking
Afferent Neurocardiac Signals, Cue Reactivity, and Cognitive Control
Conscious attempts to regulate alcohol use are often undermined by automatic attention and arousal processes activated by alcohol cues, as well as by diminished ability to inhibit in-the-moment behaviors.
- Trial name
- NCT05369169
- Testing
- Resonance breathing, Low demand cognitive task
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Use Disorder (AUD)
Records for Alcohol Care Enhancement
Unhealthy alcohol use (the spectrum from risky consumption through alcohol use disorder, AUD) is a leading cause of preventable death in the US (88,424 deaths annually costing $249 billion a year), and alcohol-related health…
- Trial name
- RACE (NCT05492942)
- Testing
- Best Practice Advisory (BPA) and Population Health Management (PHM), Best Practice Advisory (BPA) and Clinical Care Management (CCM), Best Practice Advisory (BPA) and Population Health Management (PHM) and Clinical Care Management (CCM)
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Hazardous Alcohol Use
PrEP and Alcohol - Enhancing HIV Pre-Exposure Prophylaxis (PrEP)
The present investigation entails a pilot randomized controlled trial to explore whether a stand-alone, alcohol-reduction, brief intervention (with a module on substance use and depression) would be feasible, acceptable, and…
- Trial name
- NCT05097430
- Testing
- Alcohol-focused brief intervention
- Where
- 3 sites in Canada
- Volunteers
- 122 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Use Disorder (AUD), PTSD
Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building
This is a two-part study to develop and test a brief, virtual therapy program for lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people who have experienced trauma and use alcohol.
- Trial name
- RISE (NCT07217795)
- Testing
- CBT + expressive writing, Wait-List Control
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Rhode Island
Ketoses, Metabolic, Ketogenic Dieting
Effect of Nutritional Ketosis on Alcohol Metabolism
The research study is being conducted in health controls to better understand the effects of ketosis on brain functioning after 3 different, randomly assigned, 3-day dietary interventions and the acute effects of alcohol after…
- Conditions
- Ketoses, Metabolic, Ketogenic Dieting, Alcohol Intoxication, Magnetic Resonance Imaging
- Trial name
- KAM (NCT06065657)
- Testing
- Ketone Supplement, Control Diet, Ketogenic diet
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Primary Alcohol Use Disorder
Ketamine for Reduction of Alcoholic Relapse
96 recently detoxified alcoholics will be randomized to receive either 3 sessions ketamine (0.8 mg/kg IV over 45 minutes) or placebo plus manualised psychological therapy, or 3 sessions of ketamine or placebo plus simple…
- Trial name
- KARE (NCT02649231)
- Testing
- Ketamine, Psychological Therapy, Alcohol Education
- Where
- 2 sites in United Kingdom
- Volunteers
- 96 people
- Sponsor
- University College, London
Ptsd, Alcohol Use Disorder
Early Intervention Following Sexual Assault
This study is for women who have experienced a sexual assault in the past six weeks and use alcohol. The research involves completing a five week behavioral treatment for stress and alcohol use.
- Conditions
- Ptsd, Alcohol Use Disorder, Sexual Assault and Rape
- Trial name
- NCT04582695
- Testing
- Written Exposure Therapy Integrated with Cognitive Behavioral Therapy for Alcohol Use Disorder, Written Exposure Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Alcoholism
Use of Naltrexone in a Clinical Setting
This 12-week trial will compare individuals receiving naltrexone or placebo plus substance abuse counseling therapy versus those receiving only substance abuse counseling therapy in a rural, nonacademic setting.
- Trial name
- NCT00000445
- Testing
- naltrexone (Revia)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Addiction, Substance, COVID-19
Evolution of Psychoactive Substances Consumption in Connection With COVID-19 Containment
The current containment linked to COVID-19 will have consequences for people suffering from addiction and there is a risk of overdoses when the containment ends.
- Trial name
- EPILOGUE (NCT04343339)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Alcohol; Use, Problem
Using EMA Data to Inform a Web-intervention for Couples Concerned About Drinking
Alcohol misuse is a prevalent and serious problem with significant harms to society, individuals, and their relationships. Romantic partners have a strong influence on their partner's behavior, uniquely positioning them as a…
- Trial name
- NCT06501677
- Testing
- WBI
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mental Health Issue, Alcohol Use Disorder
Acceptability and Feasibility of Cognitive Behavioral Therapy for Treatment-Seeking (CBT-TS) With Deaf Individuals
The current study aims to assess the acceptability and feasibility of an adapted version of Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS) for use with signing Deaf adults.
- Conditions
- Mental Health Issue, Alcohol Use Disorder, Depression, Anxiety
- Trial name
- NCT05520190
- Testing
- Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Rochester
Depressive Disorder, Major, Alcoholism
Vortioxetine for Treatment of Depressive Mood and Alcohol Use
This is a randomized, double-blinded, placebo-controlled, multicenter study. A total of 128 subjects will be randomly assigned to a test group or placebo group in a 1:1 ratio.
- Trial name
- NCT04498897
- Testing
- Vortioxetine, Acamprosate
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Hanyang University Seoul Hospital
Alcohol Use Disorder, Post Traumatic Stress Disorder
Stress, Emotion Regulation, and Alcohol in Women Veterans
The purpose of the study "Stress, Emotion Regulation, and Alcohol in Women Veterans" is to learn about the effects of negative emotion and stress on behavior (including alcohol use) among women Veterans, including women with and…
- Trial name
- SERA (NCT04393623)
- Testing
- Cognitive Reappraisal, Psychoeducation
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Opioid Use Disorder, Alcohol Intoxication
Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder
The goal of this clinical trial is to examine whether individuals with co-occurring opioid use disorder and alcohol use (OUD+ALC) experience heightened pain sensitivity, pain-related negative affect, and greater alcohol…
- Conditions
- Opioid Use Disorder, Alcohol Intoxication, Pain
- Trial name
- NCT07894276
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Alcohol Use Disorder, Contingency Management
Dual Reinforcement Contingency Management for Alcohol Use Disorders
Phosphatidylethanol (PEth) is a direct biomarker of alcohol that can detect moderate to heavy drinking with high sensitivity and specificity over 3-week periods.
- Trial name
- Peth (NCT04064463)
- Testing
- Standard care, Contingency management
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- UConn Health
Alcohol Use Disorder
Methylphenidate and Response to Alcohol Cues
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues.
- Trial name
- NCT07306078
- Testing
- Methylphenidate Pill
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alcohol Drinking
Neural and Behavioral Effects of Cognitive Bias Modification (CBM)
This study seeks to better understand mechanisms of behavior change for heavy drinkers who are interested in changing their drinking.
- Trial name
- NCT04430543
- Testing
- Cognitive Bias Modification
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston University Charles River Campus
Alcohol-induced Disorders, Alcohol Drinking
Strengths-based Linkage to Alcohol Care (SLAC) for Hazardous Drinkers in Primary Care
This pilot study will determine the feasibility, acceptability, and efficacy of Strengths-based Linkage to Alcohol Care (SLAC; a behavioral intervention) to link Veterans, identified as hazardous drinkers in VHA primary care, to…
- Conditions
- Alcohol-induced Disorders, Alcohol Drinking, Mental Health
- Trial name
- NCT05023317
- Testing
- Strengths-based linkage to alcohol care, Usual care
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcoholism
Oxytocin in Alcohol Use Disorder
Background: Oxytocin is a naturally occurring substance in the body. Studies show that oxytocin may affect how the body responds to alcohol. Researchers believe oxytocin may be a possible treatment for alcoholism.
- Trial name
- NCT02711189
- Testing
- Oxytocin
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina