Clinical trials: Alcohol Use
Alcohol Use Disorder, Alcoholic Liver Disease
Alcoholic Liver Disease and the Gut Microbiome
Background: Significant sex differences exist in regard to alcohol use disorder (AUD) and alcoholic liver disease (ALD). To date, no studies have examined the brain-gut-microbiome (BGM) axis (which is the relationship between the…
- Conditions
- Alcohol Use Disorder, Alcoholic Liver Disease, Microbiome
- Trial name
- NCT05007470
- Testing
- VSL #3 112.5 Capsule
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alcohol Use Disorder
Study of Mechanisms of Emotion Regulation in Alcohol-abstinent Patients
Background: Difficulties in assigning and identifying emotional states, or to regulate the emotional costs are recognized as one of the major factors of relapse.
- Trial name
- REAL (NCT02881983)
- Testing
- the presentation of pictures (static stimuli) or videos (dynamic stimuli)
- Where
- 2 sites in France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Alcohol Use Disorder
Development of a Selective ALDH2 Inhibitor to Treat AUD
Alcohol use disorder (AUD) represents a highly prevalent, costly, and often untreated condition in the United States. Pharmacotherapy offers a promising avenue for treating AUD and for improving clinical outcomes for this…
- Trial name
- NCT04311294
- Testing
- ANS-6637 Low Dose, ANS-6637 High Dose
- Where
- United States
- Sponsor
- University of California, Los Angeles
Alcohol Use Disorder
Effect of Repetitive TMS on Executive Function in Alcohol Use Disorder
Alcohol Use Disorder (AUD) is a major public health problem that affects the physical, social, family, and mental integrity of the sufferer.
- Trial name
- NCT05997212
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Universidad Nacional Autonoma de Mexico
Pain, Alcohol Drinking
The Alcohol-Pain Connection: Mechanisms and Genetic/Psychological Correlates
The societal impact of heavy alcohol consumption and chronic pain is substantial and warrants the existing research investment into their etiology and treatment.
- Conditions
- Pain, Alcohol Drinking, Acute Pain, Drinking Behavior
- Trial name
- NCT03311594
- Testing
- Low Alcohol, Moderate Alcohol, Pain Induction
- Where
- United States
- Volunteers
- 379 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Alcoholism
Individualized Assessment and Treatment for Alcoholism II
The object of this study is to develop a treatment for alcohol use disorders that is more effective than current CB treatments. Through a 2009 R-21 pilot project the investigators developed a cognitive-behavioral (CB) treatment…
- Trial name
- IATP2 (NCT03233802)
- Testing
- Individualized Assess & Treatment (IATP), Packaged Cognitive-Behavioral (PCBT), Case Management (CaseM)
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- UConn Health
Alcohol Use Disorder, HIV/AIDS
Understanding and Intervening With Heavy Drinking Among Patients With HIV and HCV
Among patients with HIV, especially those also infected with HCV, heavy drinking is associated with significant risks to health.
- Conditions
- Alcohol Use Disorder, HIV/AIDS, Hepatitis C, Binge Drinking
- Trial name
- NCT03652675
- Testing
- Intervention: (Clinician's Guide + HealthCall for HIV/HCV)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- New York State Psychiatric Institute
Substance Use (Drugs, Alcohol)
Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention
The purpose of this research study is to learn if an emergency department screening and telehealth intervention reduces substance use among individuals receiving emergency department treatment at The Ohio State University Wexner…
- Trial name
- ED-SMART (NCT07527871)
- Testing
- ED-SMART intervention, Substance use information
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Purdue University
Cannabis Use, Alcohol Use, Unspecified
CARS: Cannabis and Alcohol Reduction Study
The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.
- Conditions
- Cannabis Use, Alcohol Use, Unspecified, Substance Use, Substance Use Disorders
- Trial name
- CARS (NCT05486234)
- Testing
- modified Approach-Avoidance Task (mAAT), which aims to modify automatic approach bias, modified Approach-Avoidance Task (mAAT) that does not aim to modify automatic approach bias.
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Medical University of South Carolina
Alcoholism, Alcohol Abuse
Varenicline Treatment of Alcohol Dependence in Smokers
The purpose of this study is to determine whether varenicline is effective in the treatment of alcohol dependence in smokers.
- Conditions
- Alcoholism, Alcohol Abuse, Smoking, Alcohol Drinking
- Trial name
- NCT01553136
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Yale University
Addiction, Alcohol Use Disorder
Semaglutide Therapy for Alcohol Reduction (STAR)
Background: Alcohol use disorder (AUD) is a problematic pattern of alcohol use accompanied by clinically significant medical consequences.
- Trial name
- NCT06015893
- Testing
- Take Control, Semaglutide
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder
Compensatory Cognitive Training Via Telehealth for Veterans With Alcohol Use Disorders
Most individuals entering treatment for alcohol use disorders (AUDs) present with cognitive deficits across a range of cognitive domains, and these deficits frequently persist for six months or longer following remission.
- Trial name
- CCT-A (NCT06134128)
- Testing
- Motivationally Enhanced Compensatory Cognitive Training for Addictions Group
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Portland VA Medical Center
Alcohol Drinking, Depression
Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism
The two purposes of this study are 1. to determine what effect the chronic and moderate/heavy drinking of alcoholic beverages has 1.
- Conditions
- Alcohol Drinking, Depression, Smoking Cessation, Attention Deficit Disorder
- Trial name
- NCT00330434
- Testing
- Trial Withdrawn 1, Trial Withdrawn 2
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Oral Cancer
The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer
The human oral cavity is a diverse habitat that contains approximately 700 prokaryotic species. The oral microbiome is comprised of 44% named species, 12% isolates representing unnamed species, and 44% phylotypes known only from…
- Trial name
- NCT03304132
- Testing
- Classification of Oral Microbiome Using 16S rRNA gene sequence-based approach, Classification of Oral Microbiome Using taxonomic approach
- Where
- United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Sexual Assault
Prevention of Alcohol-related Sexual Revictimization in College
This pilot randomized controlled trial (RCT) is designed to test a new intervention designed to reduce college women's risk for sexual revictimization (SRV).
- Trial name
- RPCW (NCT05257603)
- Testing
- RPCW, HEC
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Alcohol Drinking, Marijuana Smoking
Brief Counseling to Reduce Injuries Among Emergency Department Patients Who Report Alcohol and Substance Use
The purpose of this study is to determine the effectiveness of two brief counseling sessions delivered to emergency department (ED) patients who report conjoint alcohol and marijuana use, in reducing injuries and other negative…
- Trial name
- NCT00547963
- Testing
- brief counseling
- Where
- United States
- Volunteers
- 554 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
High Risk Drinking, College Student Drinking
Biomarker Feedback Intervention
The goal of the study is to examine alcohol use behaviors of young adults through the use of testing the feasibility of adding an innovative brief personalized alcohol biomarker feedback component (TAC feedback) to an existing…
- Trial name
- NCT07307326
- Testing
- eCHECKUP TO GO (eCTG), eCHECKUPTOGO + brief personalized alcohol biomarker feedback intervention (eCTG + TAC)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Penn State University
Alcohol Abuse, Alcohol Use Disorder
The Effect of Comorbid Alcohol/Substance Use
Study Design This study was designed as a comparative, cross-sectional case-control study examining the effect of comorbid alcohol and substance use disorder (ASUD) on clinical course and social inclusion among individuals with…
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Substance Use Disorders, Severe Mental Disorder
- Trial name
- NCT07692984
- Testing
- case (comorbid diagnosis), control
- Where
- Turkey (Türkiye)
- Volunteers
- 297 people
- Sponsor
- Abant Izzet Baysal University
Alcohol Use Disorder
Effectiveness of Internet-Based Self-Help ACT With Behavioral Activation in Improving Alcohol Use Abstinence Among Ethnic Minority Young Adults With Alcohol Use Disorder
The goal of this clinical trial is to examine the preliminary effectiveness and feasibility of internet-based self-help acceptance and commitment therapy with behavioral activation for ethnic minority young adults with alcohol…
- Trial name
- NCT06779006
- Testing
- Self-help acceptance and commitment therapy with behavioral activation
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Generalized Anxiety Disorder, Panic Disorder
Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
This project is designed to determine if a computer-delivered cognitive-behavioral treatment can improve the otherwise poor alcohol use disorder treatment outcomes for individuals with a co-occurring anxiety disorder.
- Conditions
- Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, Alcohol Use Disorder
- Trial name
- NCT05117255
- Testing
- Negative Emotions and Addiction Tools Program (NEAT)- Cognitive Behavioral Therapy, Progressive Muscle Relaxation Training (PMRT)
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of Minnesota