Clinical trials: Alcohol Drinking
Alcohol Use Disorder, Alcoholism
Naltrexone in AUD Reward Drinkers
This study is a phase IV, two-arm, randomized, double-blind, placebo-controlled study to assess whether individuals identified as primarily reward drinkers are significantly more likely to reduce heavy drinking if they receive…
- Trial name
- NCT05028062
- Testing
- XR-NTX 380 mg, intramuscular injection, Medical Management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Liver Diseases, Alcoholic, Alcohol Use Disorder
Alcohol Misuse Treatment to Patients Newly Diagnosed With Alcohol-related Liver Disease: a Randomized Controlled Trial
To evaluate the efficacy of systematically offering newly diagnosed ALD patients to AUD treatment, in the hepatology clinic, on alcohol abstinence after 6 months.
- Conditions
- Liver Diseases, Alcoholic, Alcohol Use Disorder, Treatment Adherence, Alcoholism
- Trial name
- NCT06493773
- Testing
- Offer of specialized alcohol use disorder treatment in the hepatology clinic
- Where
- Denmark
- Volunteers
- 221 people
- Sponsor
- Zealand University Hospital
Prevention of Hangover Using N-Acety Cysteine
Use of NAC in Prevention of Hangover Symptoms; Independent Alcohol Consumption Protocol
This is a double-blinded study involving healthy non-alcoholic (self-reported) volunteers over the age of 21. Consent is obtained prior to participation in the study while the participant is sober.
- Trial name
- NCT03104959
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital and Health Network, Pennsylvania
Alcohol Abuse, Mental Disorder
Drinks:Ration - Combat Stress Randomized Controlled Trial
Alcohol misuse is higher in the United Kingdom (UK) Armed Forces (AF) than the general population. Previous research has shown that interventions delivered via smartphone are efficacious in promoting self-monitoring of alcohol…
- Conditions
- Alcohol Abuse, Mental Disorder, Mental Health Issue
- Trial name
- Drinks:Ration (NCT04494594)
- Testing
- Drinks:Ration app
- Where
- United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- King's College London
Alcohol Use Disorder
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder.
- Trial name
- ABSTAIN (NCT06426303)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milky Kohno
Cannabis, Youth Drinking
Development and Evaluation of HighAlert
In Canada, youth ages 16-24 have the highest rates of cannabis use, impaired driving, and express the least concern for driving under the influence of cannabis (DUIC).
- Trial name
- NCT06098573
- Testing
- High Alert, Information condition, No contact
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- Western University, Canada
Alcohol Abuse, Alcohol Dependence
Disseminating Organizational SBI Services at Trauma Centers
The goal of the Disseminating Organizational Screening and Brief Interventions Services (DO-SBIS) investigation is to capitalize on the unique opportunity afforded by the American College of Surgeons' mandate by taking early…
- Trial name
- DO-SBIS (NCT00607620)
- Testing
- Brief Intervention
- Where
- United States
- Volunteers
- 878 people
- Sponsor
- University of Washington
Alcohol Use Disorder (AUD), Transcranial Magnetic Stimilation
Assessing the Impact of dTMS on Neural Targets Associated With Alcohol Use Disorder
The purpose of this study is to evaluate the efficacy of deep transcranial magnetic stimulation as a treatment for Veterans with Alcohol Use Disorder (AUD) to decrease the exceedingly high rate of relapse associated with this…
- Trial name
- NEST-A (NCT06949423)
- Testing
- Deep Transcranial Magnetic Stimulation (dTMS) H7 coil - Active
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
PTSD, Alcohol; Use, Problem
Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma
The U.S. Deaf community - a group of more than one million Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure…
- Trial name
- NCT06278922
- Testing
- Seeking Safety + Signs of Safety toolkit, Treatment as usual
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Use Disorder
Internet-delivered Therapy for Alcohol Misuse: Investigating Patient Preference for Self-guided or Guided Treatment
Internet-delivered cognitive behaviour therapy (ICBT) shows promise as a method of treating alcohol misuse. In this form of treatment, patients complete online lessons over several weeks that assist patients in developing skills…
- Trial name
- NCT04611854
- Testing
- Guidance, ICBT for alcohol misuse
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Regina
Borderline Personality Disorder, Alcohol Use Disorder
Psychodynamic Therapy For Co-occurring Borderline Personality Disorder and Alcohol Use Disorder
The purpose of the study is to determine the feasibility and effectiveness of a modified form of psychodynamic psychotherapy for persons suffering from co-occurring borderline personality disorder and an alcohol use disorder.
- Trial name
- NCT00145678
- Testing
- Psychodynamic Therapy, Optimized Community Care
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
HIV/AIDS, Dysglycemia
Alcohol & Metabolic Comorbidities in PLWHA: Evidence Driven Interventions
Cross-sectional and prospective studies are proposed to test the prediction that a higher proportion of HIV+ individuals with hazardous alcohol drinking with subclinical fasting dysglycemia will present with impaired oral glucose…
- Conditions
- HIV/AIDS, Dysglycemia, Alcohol Use Disorder
- Trial name
- ALIVE-Ex (NCT03299205)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Alcohol Drinking, Alcohol Use Disorder
Understanding Alcohol Reward in Social Context
In this study, the investigators examine whether emotional and social reward from alcohol varies depending on the social context of consumption.
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use
- Trial name
- NCT03449095
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Alcohol Use Disorder
Remote Alcohol Monitoring to Facilitate Abstinence From Alcohol: Exp 2
Directly reinforcing abstinence from alcohol with monetary incentives is an effective treatment for alcohol dependence, but barriers in obtaining frequent, verified biochemical measures of abstinence limit the dissemination of…
- Trial name
- NCT03942770
- Testing
- Contingency Management
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Mikhail N Koffarnus
Alcohol Use Disorder, Alcohol-associated Liver Disease
LGG Supplementation in Patients With AUD and ALD
To test the efficacy of 6-month LGG compared to placebo in treating Alcoholic Use Disorder (AUD) and liver injury in Alcoholic Hepatitis (AH).
- Trial name
- AUD+ALD (NCT05178069)
- Testing
- Lactobacillus Rhamnosus GG
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Louisville
Alcohol Use
Remote Monitoring and Contingency Management Reinforcement for Alcohol Abstinence
This pilot project proposes to monitor real-world alcohol use using a novel technology-cell phone videorecordings in conjunction with breathalyzer recordings-and to conduct a small randomized study of this technology for…
- Trial name
- NCT01307345
- Testing
- contingency management for abstinence
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- UConn Health
Alcohol Consumption, Insulin Resistance
Identification of Biomarkers for Acute Intake of Beer and Alcohol and Acute Effects on Plasma and Insulin Response
The objective of the study is to identify biomarkers for acute intake of beer and alcohol in individuals with a high or low habitual intake.
- Trial name
- METABEER (NCT02449577)
- Testing
- Beverage sequence ABCD, Beverage sequence CADB, Beverage sequence DACB
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Posttraumatic Stress Disorder
Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Acceptability
This qualitative study will use focus groups, small group interviews, and individual interviews (both in person and over the phone) to compile a range of perspectives on service members' decision-making processes and information…
- Trial name
- NCT03302312
- Where
- 3 sites in United States, Germany
- Volunteers
- 54 people
- Sponsor
- RTI International
Alcohol Dependence, Alcohol Abuse
A Smartphone Based Intervention for the Prevention of Relapse in Alcohol Dependence
The rate of relapse following an inpatient alcohol rehabilitation program has been around 50% for a number of years. Offered treatments mainly focus on conscious and controllable aspects of behaviour, but research has found that…
- Conditions
- Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- SPIRA (NCT03952429)
- Testing
- Anti Alcohol App with Active Cognitive Bias, Inactive Cognitive Bias Modification
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Salus Klinik Lindow
Alcohol Drinking in College
Alcohol Brief Intervention Plus Personalized Mobile Chat-based Intervention for High-risk Drinking University Students
The aims of this pilot study are: 1. To examine the factors associated with alcohol drinking and alcohol use disorder 2. To examine the effect of face-to-face alcohol brief intervention on drinking reduction 3.
- Trial name
- NCT03675373
- Testing
- Mobile chat-based instant messages, Alcohol brief intervention
- Where
- Hong Kong
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong