Clinical trials: Alcohol Consumption
ER+ Breast Cancer, Breast Cancer
Alcohol and Breast Cancer (ABC) Trial
This research study is a pilot study, which is the first time investigators are examining the effect of light alcohol consumption on sex hormones among postmenopausal women with estrogen receptor-positive (ER+) breast cancer…
- Conditions
- ER+ Breast Cancer, Breast Cancer, Aromatase Inhibitors
- Trial name
- NCT05423730
- Testing
- White Wine, Grape Juice
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Beth Israel Deaconess Medical Center
Alcohol-Related Disorders, Substance-Related Disorders
The Women's Recovery Group Study: Stage I Trial
The purpose of this study was to develop a gender-specific 12-session, manual-based relapse prevention group for women with substance use disorders (SUDs).
- Trial name
- NCT00230100
- Testing
- The Women's Recovery Group, mixed-gender Group Drug Counseling
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mclean Hospital
Alcohol Use, Tobacco Use
Journey of Transformation Curriculum for Native American Adolescents
The investigators will conduct a waitlist control trial to test the efficacy of the Journey of Transformation-Native Youth Health Leadership Program (JOT) in terms of delaying or reducing tobacco and other substance use and…
- Conditions
- Alcohol Use, Tobacco Use, Substance Use, Sexual Health
- Trial name
- JOT (NCT05274217)
- Testing
- Journey of Transformation-Native Youth Health Leadership Program curriculum
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Washington
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI
The goal of the proposed project is to improve the treatment of veterans with co-occurring traumatic brain injury (TBI) and hazardous or harmful alcohol use.
- Trial name
- VAT (NCT01750268)
- Testing
- Medical Management Counseling, Topiramate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
HIV, Hypertension
SEARCH SAPPHIRE Phase A: A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa
The randomized trials in this record will assess effectiveness, fidelity and cost of prevention and treatment interventions for HIV and hypertension with the objective of informing a population-based study of multi-sectored…
- Conditions
- HIV, Hypertension, Alcohol Drinking, Maternal Child Health
- Trial name
- SAPPHIRE PhA (NCT04810650)
- Testing
- Mobility Dynamic Treatment Intervention, Health Living Intervention for Heavy Alcohol Users, Hypertension Linkage
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 2,233 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Schizophrenia, Alcoholism
Risperidone and Desipramine in Alcohol Use and Schizophrenia
Note: In June 2013, the study design was changed from a randomized controlled study of risperidone + despiramine vs. risperidone vs. placebo to an open label pre-post study of risperidone (or risperidone-like drug) + desipramine.
- Conditions
- Schizophrenia, Alcoholism, Dual Diagnosis
- Trial name
- RADIAUS (NCT01411085)
- Testing
- Risperidone + Desipramine
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Alcohol; Use, Problem
Alcohol & Mobile Phone Study to Reduce High-risk Alcohol Use and Consequences
The proposed study will develop a smartphone/mobile app intervention that incorporates ecological momentary assessment (i.e., two brief surveys per day) and daily intervention messaging (2 messages per day) for three weeks to…
- Trial name
- AMPS (NCT04213846)
- Testing
- Experimental: Mobile Alcohol Expectancy Intervention
- Where
- United States
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Use Disorder
Cognitive Enhancement Through Computerized Training
Alcohol use disorder is characterized by widespread neurocognitive impairments, however despite substantial advances in the intervention and treatment of alcohol use disorders, exceptionally few studies have been directed to…
- Trial name
- NCT04244032
- Testing
- Working Memory Training, Inhibitory Control Training, Bias Modification Training
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Florida
HIV, Alcohol Use
Improving HIV and Alcohol-Related Outcomes Among HIV+ Persons in Clinic Settings
Alcohol use is increasingly recognized as a key factor in morbidity and mortality among HIV-positive individuals and represents an important public health concern, given its associations with medication non-adherence, increases…
- Conditions
- HIV, Alcohol Use, Medication Adherence
- Trial name
- PLUS (NCT02390908)
- Testing
- Immediate PLUS intervention, Wait-list PLUS intervention
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Alcohol Use Disorder, Couples
Building and Pilot Testing a Couples-based Smartphone Systems to Address Alcohol Use Disorder
This project will develop and pilot test a new smartphone-based system for AUD patients, their partners, and clinicians called PartnerCHESS. PartnerCHESS will integrate key features of ABCT and A-CHESS.
- Conditions
- Alcohol Use Disorder, Couples, Behavior, Addictive
- Trial name
- NCT04059549
- Testing
- PartnerCHESS, A-CHESS
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Wisconsin, Madison
Alcohol Drinking, Alcohol Drinking Related Problems
Effects of a New Behavioral Intervention on Alcohol Craving and Drinking
Background: Sights, sounds, and smells can be associated with alcohol and tempt people to drink. The connection between encountering cues and wanting to drink might be reduced by behavioral techniques, like giving the cues at…
- Trial name
- NCT02831049
- Testing
- Retrieval-extinction, Alcohol-related cues, Soft-drink related cues
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
PTSD, Alcohol Use Disorder
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
The primary study objective is to determine the efficacy of pregabalin administered orally for a period of 12 weeks in reducing risky drinking and symptoms of posttraumatic stress disorder who have selected genotypes at the…
- Trial name
- NCT02884908
- Testing
- Pregabalin plus BBCET
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Maryland, Baltimore
Oral Cancer, Esophageal Cancer
Evaluations of Alcohol Warning Labels
The goal of this study is to determine the effectiveness of pictorial warning labels (PWLs) featuring narrative (vs. non-narrative) content in communicating the cancer risk of alcohol.
- Conditions
- Oral Cancer, Esophageal Cancer, Larynx Cancer, Alcohol Drinking
- Trial name
- NCT06129487
- Testing
- Narrative pictorial warning labels for alcoholic beverages, Non-narrative pictorial warning labels for alcoholic beverages
- Where
- United States
- Volunteers
- 1,053 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Insomnia, Alcohol; Harmful Use
The Insomnia Treatment and Problems Study for Veterans
This project aims to evaluate improvement of insomnia as a mechanism of improvement in alcohol use outcomes.
- Trial name
- iTAP-V (NCT03804788)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygeine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
College Drinking, Underage Drinking
Revolutionizing Normative Re-education
Personalized Normative Feedback (PNF), the most widely-used college alcohol intervention approach, suffers from several limitations innovatively remedied in the current proposal through CampusGANDR, a smartphone-based app for…
- Conditions
- College Drinking, Underage Drinking, Alcohol Use Disorder
- Trial name
- GANDR (NCT04356261)
- Testing
- Gamified Personalized Normative Feedback
- Where
- United States
- Volunteers
- 1,143 people, healthy volunteers welcome
- Sponsor
- Loyola Marymount University
Alcohol Use, Unspecified, Sexual Violence
Text Message Intervention for Alcohol Use and Sexual Violence in College Students
This study is designed to pilot a text message (TM) delivered behavior change intervention to decrease binge drinking and to increase use of sexual violence (SV) harm reduction strategies among college students.
- Conditions
- Alcohol Use, Unspecified, Sexual Violence, Sexual Assault
- Trial name
- NCT05065918
- Testing
- sexual violence and alcohol use harm reduction text message content, alcohol use reduction content
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Alcohol Reactivity
Effect of Varenicline on Fixed-Dose Alcohol Administration in Participants With Alcohol Use Disorders
The purpose of this study is the examine the effect of varenicline on cognition to a high dose (0.08 g/dL) of alcohol (vs. placebo alcohol) over the ascending and descending limb of the blood alcohol curve.
- Trial name
- NCT01000987
- Testing
- varenicline
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Yale University
Alcohol and Substance-Related Mental Disorders
Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia
This is a randomized controlled trial (RCT) evaluating the effectiveness of a screening, brief intervention, and referral to treatment (SBIRT) stepped-care system in reducing unhealthy AOD use among Congolese refugees and the…
- Trial name
- NCT05471921
- Testing
- SBIRT, Treatment as usual
- Where
- 2 sites in United States, Zambia
- Volunteers
- 400 people
- Sponsor
- Columbia University
PTSD, Alcohol Use Disorder
Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
The investigators propose to conduct a clinical trial to evaluate sertraline treatment efficacy in a large sample of military veterans with a dual diagnosis of PTSD and Alcohol Use Disorder who are receiving Cognitive and…
- Trial name
- DDx (NCT02504931)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Healthy Volunteers, Alcohol Drinking Related Problems
A Response Modulation Hypothesis of Socioemotional Processing Associated With Alcohol Use Disorder
Background: Problem drinking affects nearly half the people who drink alcohol. Drinking alcohol affects a person's social behavior and brain structure, but researchers don't have a good understanding of how.
- Conditions
- Healthy Volunteers, Alcohol Drinking Related Problems, Alcohol-Related Disorders
- Trial name
- NCT03535129
- Testing
- Real time fMRI neurofeedback
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- National Institutes of Health Clinical Center (CC)