Clinical trials: Alcohol Abuse and Dependency
Alcohol Abuse/Dependence, Alcohol Use Disorder (AUD)
Ketamine and Neurofeedback as Combined Therapeutic Interventions to Target Glutamatergic Neurotransmission in Alcohol Use Disorder
The goal of this clinical trial is to learn about the effects of the combination of ketamine and realtime functional magnetic resonance imaging (fMRI) neurofeedback training on the treatment of individuals with alcohol use…
- Conditions
- Alcohol Abuse/Dependence, Alcohol Use Disorder (AUD), Alcoholism
- Trial name
- Nektar (NCT06969937)
- Testing
- Ketamine, Real-time fMRI Neurofeedback Training
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- Dr. med. Marcus Herdener
Bipolar Disorder, Alcohol Abuse/Dependence
Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence
The abuse of alcohol is especially common in people with bipolar disorder. However, very little is known about the pharmacotherapy of people with both bipolar disorder and alcohol abuse/dependence.
- Trial name
- NCT00223249
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Texas Southwestern Medical Center
Alcohol Use Disorder, Alcohol Drinking
Virtual Incentive Treatment for Alcohol
The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention.
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
- Trial name
- VITA (NCT06265506)
- Testing
- Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington State University
Alcohol Abuse, Alcohol Addiction
Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity?
This 26-week long, double-blinded randomized clinical trial aims to investigate the effects of the GLP-1 receptor agonist semaglutide s.c.
- Conditions
- Alcohol Abuse, Alcohol Addiction, Alcohol Dependence, Alcohol Use Disorder
- Trial name
- SEMALCO (NCT05895643)
- Testing
- Semaglutide Injectable Product
- Where
- Denmark
- Volunteers
- 108 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Alcoholism
Study of the Medication Prazosin for Alcohol Dependence
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.
- Trial name
- NCT00762710
- Testing
- Prazosin medication
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Alcohol Abuse, Alcohol Dependence
The iHealth Study in College Students
The objective of this project was to test the feasibility of electronic mail recruitment and web screening for hazardous drinking, to compare different approaches to encouraging screening, and to estimate the effects of minimal…
- Conditions
- Alcohol Abuse, Alcohol Dependence, Unhealthy Alcohol Use, Risky Alcohol Consumption Amounts
- Trial name
- NCT00183131
- Testing
- Brief Personalized Feedback
- Where
- United States
- Volunteers
- 4,300 people
- Sponsor
- Boston Medical Center
Alcohol Dependence
Combination of Naltrexone and Baclofen for Alcohol Dependence:A Pilot Study.
The purpose of this research study is to learn about the use of a combination of two medications, baclofen and naltrexone, for the treatment of alcohol dependence in men and women ages 25-60 years old.
- Trial name
- NCT00614328
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Abuse, Nicotine Dependence Tobacco Product
Reactions to E-cigs and Alcohol
The purpose of this study is to 1) examine cognitive acuity following e-cig use (as compared to no e-cig use), 2) examine motor coordination following beer and e-cig use (as compared to beer consumption only).
- Trial name
- NCT03449017
- Testing
- E-cig use
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Indiana University
Use; Tobacco, Harmful, Alcohol Abuse
Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use
The purpose of the project is to improve adolescent behavioral counseling services in healthcare settings with a new Internet/Intranet-based Motivational Enhancement Therapy (iMET) intervention that targets the use of tobacco…
- Conditions
- Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
- Trial name
- NCT00907309
- Testing
- iMET, iMET/TE
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Boston Children's Hospital
Alcohol Abuse, Alcohol Dependence
Remote Brief Intervention and Referrals to Treatment Service for Alcohol
The traditional paradigm that relies upon training physicians and nurses or uses on-site interventionists to perform screening, brief intervention, and referral to treatment (SBIRT) for alcohol has proven unsustainable in most…
- Trial name
- RBIRT (NCT02622984)
- Testing
- RBIRT, SBIRT
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Polaris Health Directions
Alcohol Dependence, Alcohol Consumption
ASAP Study - Hospital-Based Brief Intervention for Alcohol Problems
The objective of this project was to test whether screening and brief intervention for unhealthy alcohol use leads to improved alcohol-related outcomes (such as alcohol consumption and linkage to alcohol assistance) and is…
- Trial name
- NCT00183105
- Testing
- Brief Intervention (adaptation of motivational interviewing)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Boston Medical Center
Alcoholic Liver Disease, Alcoholic Fibrosis of Liver
Early Detection of Alcoholic Liver Disease
This is an observational study to identify the prevalence of advanced liver fibrosis among patients with excessive alcohol intake using a non-invasive method (FibroScan®) and to characterize the main environmental, genetic and…
- Conditions
- Alcoholic Liver Disease, Alcoholic Fibrosis of Liver, Alcoholic Cirrhosis, Excessive Drinking
- Trial name
- NCT04070508
- Sponsor
- University of Pittsburgh
Alcoholism, Alcohol Dependence
Alcoholism Assessment and Treatment
The purpose of this study is to gather information about people s drinking histories and to evaluate them for other research studies being conducted at the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
- Conditions
- Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems
- Trial name
- NCT00106093
- Where
- United States
- Volunteers
- 1,192 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Post Traumatic Stress Disorder, Alcohol Use Disorder
Zonisamide Outpatient Study
The objective of this study is to determine if, compared to placebo, zonisamide (400mg/day) is a safe and efficacious treatment for post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) in Veterans with PTSD and…
- Trial name
- NCT03376139
- Testing
- Zonisamide
- Where
- United States
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Alcohol Abuse, Anxiety Disorders
The Measurement of Mood Variability and Sustained Attention in Women With Alcohol Dependence.
The purpose of this study is to measure daily mood changes and to find out whether these mood changes are related to the ability to maintain attention on a task.
- Conditions
- Alcohol Abuse, Anxiety Disorders, Mood Disorders
- Trial name
- NCT00230425
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Saskatchewan
PTSD, Alcohol Abuse
Sequence of Symptom Change During AUD or PTSD Treatment for Comorbid PTSD/AUD
The broad, long-term objective of the current research is to improve treatment outcomes for individuals with comorbid posttraumatic stress disorder (PTSD) and alcohol abuse and dependence (AUD).
- Conditions
- PTSD, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01663337
- Testing
- Cognitive Processing Therapy (CPT), Relapse Prevention (RP)
- Where
- 2 sites in United States
- Volunteers
- 235 people
- Sponsor
- University of Washington
Alcohol Dependence, Problem Drinking
Alcohol Pharmacotherapy for HIV+ Prisoners
This is a randomized controlled trial of injectable intramuscular naltrexone (XR-NTX) versus intramuscular placebo among HIV-infected prisoners meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition…
- Conditions
- Alcohol Dependence, Problem Drinking, Hazardous Drinking, Human Immunodeficiency Virus
- Trial name
- INSPIRE (NCT01077310)
- Testing
- Vivitrol- Intramuscular naltrexone (depot-formulation)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Alcohol Abuse, Alcohol Dependence
Efficacy Trial of Warrior Check-Up
This study will develop and test a brief telephone-delivered motivational enhancement intervention for substance abusing military personnel who are not currently in treatment.
- Conditions
- Alcohol Abuse, Alcohol Dependence, Substance Abuse, Substance Dependence
- Trial name
- NCT01128140
- Testing
- Motivational Enhancement Therapy, Education
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- University of Washington
Bipolar Disorder, Alcoholism
Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder
The purpose of this study is determine whether the use of topiramate is effective in the treatment of alcohol dependence (i.e. decreases drinking) in patients with bipolar disorder.
- Conditions
- Bipolar Disorder, Alcoholism, Alcohol Dependence
- Trial name
- NCT00572117
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University