Clinical trials: Alcohol Abstinence
Alcoholic Cirrhosis, Alcohol Abstinence
Safety & Efficacy of Baclofen for Alcohol Withdrawal in Chronic Liver Disease With Active Alcohol Consumption
This study examines the safety and effectiveness of baclofen as a treatment for alcohol withdrawal in patients with chronic liver disease who continue drinking.
- Conditions
- Alcoholic Cirrhosis, Alcohol Abstinence, Alcohol Withdrawal, Medication Toxicity
- Trial name
- BAWIC (NCT06840652)
- Testing
- Baclofen
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Corporacion Parc Tauli
Alcohol Use Disorder
Mental Contrasting With Implementation Intentions for Alcohol Use Disorders
Mental Contrasting (MC) consists of imaging a desired future and comparing it with obstacles of the present reality in order to increase goal commitment when expectations of success are high.
- Trial name
- MCIIAUD (NCT03684798)
- Testing
- MCII, Treatment as usual
- Where
- Switzerland
- Volunteers
- 122 people
- Sponsor
- Susanne Rösner
Alcohol Dependence
Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal
Alcohol dependence is accompanied by several neurological mechanisms involving neuronal plasticity and neoneurogenesis, requiring Brain Derived Neurotrophic factor (BDNF) synthesis.
- Trial name
- NCT01491347
- Where
- 4 sites in France
- Volunteers
- 389 people
- Sponsor
- Centre Hospitalier Esquirol
Alcohol Use Disorder (AUD), Alcohol Abstinence
SER-ABS-AUD: Neuropsychosocial-Spiritual Correlates of Serene Abstinence in Adults With AUD
SER-ABS-AUD is a single-centre, non-interventional, mixed retrospective-prospective longitudinal cohort study of 70 adults aged 18-70 years with documented alcohol use disorder, at least 12 consecutive months of continuous…
- Trial name
- SER-ABS-AUD (NCT07561749)
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Alcohol Use Disorder (AUD), Withdrawal From Addictive Substance; Detoxification
Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving
Cannabidiol (CBD), one of the most prevalent cannabinoids in cannabis (marijuana) has been shown to reduce alcohol withdrawal symptoms in laboratory animals.
- Conditions
- Alcohol Use Disorder (AUD), Withdrawal From Addictive Substance; Detoxification, Craving
- Trial name
- NCT07148843
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Johns Hopkins University
Smoking Cessation, Alcohol Drinking
Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking
Alcohol misuse and smoking constitute two of the three leading preventable causes of death in the United States. The purpose of this research study is to develop an intervention designed to help people stop drinking alcohol and…
- Trial name
- NCT02995915
- Testing
- Nicotine Replacement Therapy, Bupropion, Cognitive Behavioral Treatment
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Alcohol Drinking, Heavy Drinking
Reset Challenge: Reducing High-risk Drinking for Cancer Prevention
This is a single-arm, non-randomized, prospective study to evaluate the feasibility and preliminary efficacy of a 30-day mobile Health (mHealth) Reset Challenge for reducing high-risk drinking.
- Conditions
- Alcohol Drinking, Heavy Drinking, Binge Drinking
- Trial name
- NCT07591428
- Testing
- 30-Day Alcohol Abstinence Challenge
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Oklahoma
Alcohol Use Disorder
Medication Development in Alcoholism: Apremilast Versus Placebo
The primary hypotheses under test are that alcohol dependent subjects treated with apremilast will report decreased craving for alcohol following alcohol exposure in the laboratory and report significantly less drinking under…
- Trial name
- NCT03175549
- Testing
- Apremilast
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The Scripps Research Institute
Alcohol Abuse
Motivational Incentives for Alcohol Abstinence in American Indian and Native Alaskan Adults
This study examines the impact of a culturally tailored version of contingency management treatment on alcohol in 400 alcohol dependent American Indians and Alaskan Natives.
- Trial name
- NCT02174315
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Washington State University
Liver Cirrhosis
Effect of Naltrexone in Achieving and Maintaining Abstinence From Alcohol in Patients With Cirrhosis.
The aim of the study is to study the safety and tolerability of Naltrexone in patients with Alcohol liver disease over a 12 week duration without liver related side effects.
- Trial name
- NCT04391764
- Testing
- Naltrexone
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcohol Liver Disease
Efficacy of Baclofen Vs Naltrexon in Achieving & Maintaining Abstinence in Alcohol Dependence.
ALD is the most common cause of liver cirrhosis in western world. In patients with ALD persistent alcohol intake is associated with increased mortality while cessation of alcohol consumption improve survival.
- Trial name
- NCT06175507
- Testing
- Naltrexon, Baclofen
- Where
- India
- Volunteers
- 110 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcohol Use Disorder
Therapeutic Education for Harm Reduction in People With Alcohol Use Disorder
Alcohol is the most harmful psychoactive substance in terms of overall damage. Although abstinence remains the objective of most pharmacological and non-pharmacological approaches addressing alcohol use disorder (AUD), new…
- Trial name
- ETHER (NCT03954054)
- Testing
- "Choizitaconso" - therapeutic patient education programme
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Substance Use Disorder, Drug Dependence,
Impact of Prevention Awareness Group (PAG) on Treatment Attendance and Drug Abstinence Among Substance User
Substance Use Disorder has been showing a rising trend all over the world including India. The project tested whether a Integrated community wide effort of Prevention and Awareness Groups (PAG) to manage substance use would have…
- Conditions
- Substance Use Disorder, Drug Dependence,, Alcohol Dependence
- Trial name
- NCT02173041
- Testing
- Prevention Awareness Groups (PAG), Standard Care
- Where
- India
- Volunteers
- 152 people
- Sponsor
- Macmillan Research Group UK
Alcohol Use Disorder
Sex Differences in the Response to Abstinence From Alcohol.
In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that…
- Trial name
- SPAR (NCT03827460)
- Testing
- Abstinence from alcohol, Usual drinking, Intravenous Alcohol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcohol Use Disorder (AUD), Alcohol Dependence
Evaluation of the Efficacy of Sodium Oxybate in the Long-term Maintenance of Abstinence in Alcoholic Patients
Additional pharmacotherapies in the treatment of alcohol dependence are needed. Sodium oxybate showed efficacy in the maintenance of abstinence in alcohol-dependent patients in several small randomized trials of short duration.
- Trial name
- GATE2 (NCT04648423)
- Testing
- Sodium Oxybate
- Volunteers
- 314 people
- Sponsor
- Laboratorio Farmaceutico Ct S.r.l.
Alcohol Use Disorder, Alcohol Abstinence
Feasibility of Telephone-based Acceptance and Commitment Therapy in Hong Kong Chinese Young Adults With Alcohol Use Disorder: A Pilot Study
Objective: The proposed study aims to develop a protocol of telephone-based Acceptance and Commitment Therapy (ACT) for Alcohol Use Disorder (AUD) and examine the feasibility of implementing such intervention among the Hong Kong…
- Trial name
- NCT07501130
- Testing
- ACT, Social support
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Alcohol Use Disorder, Eligible to go Into the MRI Scanner
Clinical Intervention in Alcohol Use Disorder
Long-term abstinence from alcohol is supported by a compensatory mechanism in functional brain connectivity, a potential brain biomarker that could be an intervention target.
- Conditions
- Alcohol Use Disorder, Eligible to go Into the MRI Scanner, Short-term Abstinence From Alcohol Use (2 Week Abstinent)
- Trial name
- NCT02168400
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Minnesota
Alcohol Use Disorder
Medication Development for Protracted Abstinence in Alcoholism: CORT118335 Versus Placebo
The hypotheses under test are that subjects with alcohol use disorder (AUD) of moderate or greater severity treated with CORT118335 will report decreased craving for alcohol following alcohol exposure in the laboratory and report…
- Trial name
- NCT04466215
- Testing
- Miricorilant
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Scripps Research Institute
Alcohol Use Disorder
Intensive Virtual Treatment With Remote Abstinence Monitoring for Alcohol Use Disorder
This single-arm pilot study will recruit participants with moderate to severe alcohol use disorder for a 4-week virtual intensive outpatient program (IOP).
- Trial name
- NCT05722483
- Testing
- Virtual Intensive Outpatient Program
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Centre for Addiction and Mental Health
Alcoholism
Integrative Therapy in Alcoholism
The main aim of this project consists in the investigation of the interaction of behavior therapy and Acamprosate in the outpatient treatment of alcoholic patients in a randomized, prospective and (regarding study medication…
- Trial name
- NCT00159107
- Testing
- Acamprosate, Integrative behavior therapy
- Where
- Germany
- Volunteers
- 371 people
- Sponsor
- Heinrich-Heine University, Duesseldorf