Clinical trials: Airflow Obstruction
Chronic Obstructive Pulmonary Disease
Biomarkers in Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide and is characterized by fixed airflow obstruction.
- Trial name
- NCT01145300
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Leiden University Medical Center
Asthma
How Airway Remodeling and Hyperresponsiveness Contribute to Airflow Obstruction in Asthma
Airway hyperresponsiveness is a characteristic feature of the asthma. It is known that there is an association between airway hyperresponsiveness and eosinophilic airway inflammation.
- Trial name
- NCT00186693
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- St. Joseph's Healthcare Hamilton
COPD (Chronic Obstructive Pulmonary Disease), Lung Cancer (Diagnosis)
Enhanced COPD Management in Suspected Lung Cancer Patients
Identifying and treating COPD in patients undergoing lung cancer evaluation is crucial. Early intervention could lead to better management of both diseases, improving health status, reducing healthcare costs, and potentially…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Lung Cancer (Diagnosis), Lung Neoplasm Malignant, Lung Carcinoma
- Trial name
- ECHELON (NCT07543601)
- Testing
- Tailored COPD consultations
- Where
- Denmark
- Volunteers
- 280 people
- Sponsor
- Ditte Krag-Hansen
Nasal Airway Obstruction
Thermal Imaging as a Potential Diagnostic Tool of Nasal Airflow
Currently, there are no tools that can measure nasal airflow in an objective manner that is non-invasive to the patient. This clinical study aims to address this by evaluating the use of thermal imaging as a diagnostic tool for…
- Trial name
- NCT03233373
- Testing
- Seek CompactPro thermal imager
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Chronic Obstructive Pulmonary Disease
Efficacy, Safety, and Tolerability of Aclidinium Bromide in the Treatment of Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-38)
The purpose of this study is to evaluate the efficacy, safety and tolerability of aclidinium bromide doses compared with placebo in the treatment of moderate to severe, stable chronic obstructive pulmonary disease.
- Trial name
- LAS-MD-38 (NCT01045161)
- Testing
- Aclidinium bromide
- Where
- 112 sites in United States, Canada
- Volunteers
- 544 people
- Sponsor
- AstraZeneca
Bronchiolitis Obliterans Syndrome
Early Detection and Management of Bronchiolitis Obliterans Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation
This study aims to determine whether or not early spirometric detection and management of obstructive lung disease with combined fluticasone/azithromycin/montelukast therapy (FAM) can attenuate declining lung function, prevent…
- Trial name
- NCT03072849
- Testing
- Pulmonary function testing, FAM Therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Obesity
Expiratory Airflow Limitation in Subjects With Obesity
The purpose of this study is to investigate posture dependent small airway obstruction in subjects with obesity, and to study the capacity of FOT as a measurement tool for small airways obstruction.
- Trial name
- EFL (NCT00865293)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Pulmonary Disease, Chronic Obstructive
Measure of the Long Term Influence of SPIRIVA® in Acute Respiratory Disorders
The objectives of this study were to evaluate the effect of a one-year treatment with inhaled tiotropium bromide 18 mcg once daily on lung function, incidence and severity of exacerbations in patients with chronic obstructive…
- Trial name
- NCT00274014
- Testing
- Tiotropium
- Where
- 55 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Boehringer Ingelheim
Nasal Obstruction, Nasal Septum; Deviation
Changes in Nasal Airflow Parameters After Septoplasty and Turbinoplasty
Pathological-anatomical changes in the nasal cavity (nasal septum/perforation, mucosal hypertrophy) negatively affect nasal airflow, increase resistance - cause nasal obstruction and are often an indication for surgery.
- Conditions
- Nasal Obstruction, Nasal Septum; Deviation, Nasal Mucosa Hypertrophy
- Trial name
- NCT04220853
- Testing
- Rhinomanometry in patients after septoplasty and/or turbinoplasty, Acoustic rhinometry in patients after septoplasty and/or turbinoplasty
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Asthma
Airflow Obstruction and Biomarkers of Airway Inflammation During and Following Acute Exacerbations of Childhood Asthma
This study is a longitudinal single-center pilot study designed to describe changes in lung function and levels of noninvasive biomarkers of airway inflammation in children ages 6-18 years over two months following…
- Trial name
- NCT01227070
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Chronic Airflow Obstruction
A Study on Smoking-related Lung Function Abnormalities and Correlation With Serum Biomarkers in Chinese
Tobacco-smoking causes lung function decline with airflow obstruction, which may be accelerated in persistent smokers.This would eventually lead to chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and…
- Trial name
- NCT01185652
- Where
- Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- The University of Hong Kong
Lung Disease, Obstructive, Tuberculosis
Tiotropium in Patients With Tuberculosis (TB) Destroyed Lung
The aim of this study to evaluate clinical efficacy of tiotropium in patients with airflow obstruction due to Tuberculosis (TB) destroyed lung.
- Trial name
- NCT01365702
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Bundang Hospital
Asthma
Effect of OPEP on Mucus Plugging and Airflow Obstruction in Patients with Moderate-to-severe Asthma
The goal of this randomized clinical trial is to evaluate the effect of daily AerobikaTM Oscillating Positive Expiratory Pressure (OPEP) device use on mucus plugging and airway function in adult patients with moderate-to-severe…
- Trial name
- AeroMUC (NCT06147453)
- Testing
- Aerobika OPEP device
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Chronic Obstructive Pulmonary Disease (COPD)
Pharmacokinetic, Safety and Tolerability Study of Aclidinium/Formoterol Fixed Dose Combination and Formoterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this Phase II study is to evaluate the pharmacokinetics, safety, and tolerability of aclidinium/formoterol fixed dose combination (FDC 400/12 μg via the Almirall Inhaler and formoterol 12 μg via the Foradil®…
- Trial name
- NCT01551888
- Testing
- Aclidinium/formoterol 400/12μg, Formoterol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
Does Severity of Airflow Obstruction Correlate to Static Lung Volumes
Obstructive lung disease is defined by limitations in expiratory airflow, caused by excess mucus, loss of muscle tone, and structural changes. Over time airflow reduction can lead to gas trapping in the lungs (hyperinflation).
- Trial name
- NCT05616780
- Testing
- Physiological test
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Virginia Hawkins
Respiratory Disorders
A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GlaxoSmithkline (GSK) Biologicals' Investigational Vaccine GSK2838504A When Administered to Chronic Obstructive Pulmonary Disease (COPD) Patients With Persistent Airflow Obstruction.
The purpose of this Phase II study is to assess the safety, reactogenicity and immunogenicity of the investigational Non-typeable Haemophilus influenzae (NTHi) vaccine in patients with moderate and severe persistent airflow…
- Trial name
- NCT02075541
- Testing
- NTHi-10-AS01E
- Where
- 14 sites in Sweden, United Kingdom
- Volunteers
- 145 people
- Sponsor
- GlaxoSmithKline