Clinical trials: Agitation in Dementia
Psychomotor Agitation
Haloperidol vs. Valproate in Agitation
The aim of this study is to compare the efficacy of haloperidol and valproate in management of people with agitation in emergency department
- Trial name
- NCT01750541
- Testing
- Haloperidol, Valproate
- Where
- Iran
- Volunteers
- 56 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Dementia or a Related Disorder, Mental Health Diagnoses
Effectiveness and Implementation of Montessori Approaches in Person-Centered Care Within VA
Background: Addressing behavioral and neuropsychiatric symptoms of Veterans with dementia and serious mental illness (SMI) such as schizophrenia can be challenging for staff in VA long-term care settings, called Community Living…
- Conditions
- Dementia or a Related Disorder, Mental Health Diagnoses, Symptoms of Agitation or Aggression
- Trial name
- MAP-VA (NCT04829500)
- Testing
- Montessori Approaches to Person-Centered Care (MAP-VA)
- Where
- United States
- Volunteers
- 356 people
- Sponsor
- VA Office of Research and Development
Delirium, Agitation
Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial)
The primary purpose of the study is to evaluate whether dexmedetomidine is effective in treating agitated delirium of non-intubated ICI patients
- Trial name
- 4D (NCT03317067)
- Testing
- Dexmedetomidine
- Where
- France
- Volunteers
- 168 people
- Sponsor
- University Hospital, Clermont-Ferrand
Alzheimer's Disease
Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
The primary purpose of this study is to determine whether ELND005 is effective in treating symptoms of agitation and aggression in patients with Alzheimer's disease
- Trial name
- NCT01735630
- Testing
- ELND005
- Where
- 70 sites in United States, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- OPKO Health, Inc.
Pain, Agitation on Recovery From Sedation
Assessment and Management of Pain, Agitation, Delirium and Sleep Deprivation (PADS) in ICU by PADS Protocol, Thailand
The investigators proposed that pain, agitation, delirium and sleep deprivation protocol (PADS) will help improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free…
- Conditions
- Pain, Agitation on Recovery From Sedation, Delirium
- Trial name
- NCT04270331
- Testing
- PADS protocol
- Where
- Thailand
- Volunteers
- 509 people
- Sponsor
- Mahidol University
Dementia
Individualized Music Playlist Based on ISO-Principle for De-escalating Agitation of People Living With Dementia
Abstract: Agitation is exhibited by almost every dementia patient during the course of illness, and that leads to detrimental consequences on both patients and caregivers.
- Trial name
- NCT04236557
- Testing
- Music listening, Audio Book Listening
- Where
- Hong Kong
- Volunteers
- 24 people
- Sponsor
- The Hong Kong Polytechnic University
Agitation, Anesthesia
Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children
Emergence delirium (ED) from general anesthesia posts risk and harm to pediatric population undergo general anesthesia. The purpose of the study is to compare the use of dexmedetomidine versus placebo in reducing the incidence…
- Conditions
- Agitation, Anesthesia, Pediatrics
- Trial name
- DexPeds (NCT00857727)
- Testing
- Dexmedetomidine, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Dementia
Multidisciplinary Intervention for Challenging Behaviour (Agitation) in Patients With Dementia
The increasing prevalence of dementia is a major challenge to the health authorities in most countries. Nearly all the persons suffering from dementia experience behavioural and psychological symptoms (BPSD).
- Trial name
- TID (NCT01183351)
- Testing
- Psychosocial intervention
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Sykehuset Innlandet HF
Dementia Alzheimers
Interest of the Reborn® Doll as a TO in the Care of Residents With Alzheimer's Disease or a Related Disorder
The primary objective of this study is to evaluate the benefits of the Reborn®doll as an OT for the care of residents with Alzheimer's disease or related disorders, by assessing the frequency of resident agitation.
- Trial name
- PROTMA (NCT06396377)
- Testing
- Reborn doll (Therapeutic object - OT)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Agitation
Butorphanol Mitigate Emergence Agitation in Patients Undergoing Functional Endoscopic Sinus Surgery
Emergence agitation is one of the common postoperative complications after functional endoscopic sinus surgery（FESS). The objective of present study is to explore the effectiveness of butorphanol in the alleviation of emergence…
- Trial name
- NCT03398759
- Testing
- Butorphanol
- Where
- China
- Volunteers
- 700 people
- Sponsor
- RenJi Hospital
Agitation, Dementia
Life's End Benefits of cannaBidiol and tetrahYdrocannabinol
This is a multicenter randomized double-blind placebo-controlled Phase 2 study of an oral combination of tetrahydrocannabinol (THC) and cannabidiol (CBD) compared to placebo over 12 weeks.
- Trial name
- LiBBY (NCT05644262)
- Testing
- T2:C100
- Where
- 10 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Entropion
The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery
The investigators evaluate extubation time and recovery profiles in children undergoing entropion surgery.
- Trial name
- NCT02916407
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Inje University
Agitation, Alzheimer Disease
Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
This is a study to evaluate the efficacy, safety, and tolerability of BMS-986368, a FAAH/MAGL inhibitor, for the treatment of agitation in participants with Alzheimer's Disease.
- Trial name
- NCT06808984
- Testing
- BMS-986368
- Where
- 77 sites in United States, Argentina and 2 more
- Volunteers
- 120 people
- Sponsor
- Celgene
Delirium, Ventilators
Helping Older Persons Emerge Stronger
Select Specialty, a national network of more than 100 LTACHs across the United States, has expressed the desire to adopt the ABCDEF bundle as a "standard of care" for its patients.
- Conditions
- Delirium, Ventilators, Pain, Agitation
- Trial name
- HOPES (NCT02863081)
- Testing
- Survey, interview
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ohio State University
Agitation Management, Aggression
Effect of Verbal De-Escalation-Based Simulation on Agitation Management, Perception of Aggression, and Impact of Aggression in Emergency Department Nurses
This mixed-methods randomized controlled study aims to evaluate the effects of verbal de-escalation-based simulation training on emergency department nurses' knowledge of agitation management, perceptions of aggression, and the…
- Conditions
- Agitation Management, Aggression, Verbal De-Escalation
- Trial name
- NCT07784868
- Testing
- Standard Verbal De-Escalation Training, Verbal De-Escalation-Based Simulation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Agitation
Naturalistic Adasuve Clinical Trial Study
There is limited information on the best psychoactive medication to treat agitated patients in the emergency department. The intent of this study is to fill in knowledge gaps in the current practice of treating psychiatric…
- Trial name
- NCT02877108
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mt Sinai Hospital, Chicago
Alzheimer's Disease, Vascular Dementia
Personalized Music Therapy and Agitation in Dementia
Symptoms of agitation include abuse or aggressive behaviour toward self or others, appropriate behaviour performed with inappropriate frequency, or behaviours that are inappropriate according to social standards.
- Trial name
- NCT02147652
- Testing
- Personalized music
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Agitation
Effects of Serotonin Inhibitors on Patient-controlled Analgesia Related Nausea and Vomiting
ED50 of dexmedetomidine for prevention of emergence agitation after tonsillectomy or adenoidectomy in children
- Trial name
- NCT01517438
- Testing
- agitation
- Volunteers
- 21 people
- Sponsor
- Seoul National University Hospital
Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use
Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation
The primary objective of this study is to determine the noninferiority of inhaled loxapine compared to intramuscular haloperidol/lorazepam on agitation reduction at 120 minutes.
- Conditions
- Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use, Lorazepam Causing Adverse Effects in Therapeutic Use, Loxapine Causing Adverse Effects in Therapeutic Use
- Trial name
- loxapine (NCT03110900)
- Testing
- Haloperidol + lorazepam, Loxapine
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Alzheimer's Disease, Psychosis
Treatment of Psychosis and Agitation in Alzheimer's Disease
Clinically, many patients with AD show no response or minimal response to antipsychotics for symptoms of agitation/aggression or psychosis, or they have intolerable side effects on these medications.
- Conditions
- Alzheimer's Disease, Psychosis, Agitation
- Trial name
- NCT02129348
- Testing
- Lithium
- Where
- 4 sites in United States
- Volunteers
- 77 people
- Sponsor
- New York State Psychiatric Institute