Clinical trials: Aging Disorder
Cognitive Decline
Trial of a Nutritional Blend to Prevent Cognitive Decline in Older Adults
To demonstrate the beneficial effects of 1-year intervention with a nutritional blend of ingredients on blood levels of nutritional biomarkers known to be linked with cognitive decline in non-demented adults with subjective…
- Trial name
- NCT03080675
- Testing
- Nutrional blend of ingredients including vitamins and fish oil, Control
- Where
- France
- Volunteers
- 362 people
- Sponsor
- Société des Produits Nestlé (SPN)
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
Early Onset Alzheimer Disease, Mild Cognitive Impairment
Reference Database & Longitudinal Registry of the Normal and Pathological Aging Brain
Establishment of a BNA reference database for the Adult and Elderly Population. Hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between clinical…
- Conditions
- Early Onset Alzheimer Disease, Mild Cognitive Impairment, Depression, Aging
- Trial name
- (BNA™) (NCT02875496)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Fall, Mild Cognitive Impairment (MCI)
Digital STEADI Efficacy
The aging of the U.S. population, combined with health care workforce shortages and insufficient access to effective fall prevention and exercise programs, has contributed to a high burden of fall-related injuries in older…
- Conditions
- Fall, Mild Cognitive Impairment (MCI), Aging
- Trial name
- NCT07852650
- Testing
- Digital STEADI-1, STEADI Standard of Care, Digital STEADI-2
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Friendi.fi Corporation
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy
Risk Prediction of Taxane Chemotherapy-Induced Peripheral Neuropathy
This is an observational study to discover risk factors of chemotherapy-induced peripheral neuropathy (CIPN) in 350 patients with early stage breast cancer undergoing taxane-based chemotherapy at two main sites (University of…
- Conditions
- Breast Cancer, Chemotherapy-induced Peripheral Neuropathy, Aging
- Trial name
- SENSE (NCT04932031)
- Where
- 2 sites in United States
- Volunteers
- 123 people
- Sponsor
- Sapere Bio
Anemia
Study to Evaluate Efficacy and Safety of BGE-117 in the Treatment of Anemia of Aging
The primary objectives of this study to evaluate the safety, tolerability and efficacy of BGE-117 in the treatment of anemia of aging in participants ≥ 65 years of age.
- Trial name
- NCT04815603
- Testing
- BGE-117
- Where
- 13 sites in Australia
- Sponsor
- BioAge Labs, Inc.
Work Related Stress, Psychologic Adaptation
CO-ADAPT: Adaptive Environments and Conversational Agent Based Approaches for Healthy Ageing and Work Ability
The purpose of this study is to identify effective methodologies to help people improve their ability to adapt to psychological stress.
- Trial name
- NCT04809090
- Testing
- SMT, App CA
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tommaso Ciulli
Impaired Glucose Tolerance
Preliminary Safety and Efficacy Study of Extracellular Vesicle Infusion in the Intervention of Age-related Phenotypes With Impaired Glucose Tolerance.
The objective of this exploratory study was to evaluate the initial safety of human mesenchymal stem cell-derived extracellular vesicle infusion in an age-related phenotype with impaired glucose tolerance
- Trial name
- NCT06495437
- Testing
- Intravenous infusion of extracellular vesicle preparation derived from Wharton's jelly mesenchymal stem cells.
- Volunteers
- 20 people
- Sponsor
- BEAUTECH
Metabolic Syndrome, Premature Aging
The Safety and Efficacy Study of RiaGev in Healthy Adults
This current randomized, double-blind, comparator-controlled, cross over study investigates the efficacy and safety of RiaGev™ via evaluation of NAD+, ATP, glucose, insulin, glutathione, and cortisol levels in healthy adults of…
- Trial name
- NCT04483011
- Testing
- RiaGev
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bioenergy Life Science, Inc.
Aging, Cognitive Decline
Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes
This is a parallel group, randomized, double-blind, placebo-controlled clinical study assessing the safety and effects of a novel nutritional product on self-reported cognitive function and health in adults that reside in the…
- Conditions
- Aging, Cognitive Decline, Brain Fog, Cognitive Function
- Trial name
- CLARITY (NCT07060898)
- Testing
- Active Product
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Dementia, Mild Cognitive Impairment
HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
This study will investigate the validity of the HOGAR EEG/PSG monitoring kit designed by Bitbrain as a tool for characterizing and assessing cognitive function in older adults, as well as for detecting and predicting cognitive…
- Conditions
- Dementia, Mild Cognitive Impairment, Dementia Alzheimers, Dementia, Mixed
- Trial name
- Hogar (NCT06993207)
- Testing
- Home Lab
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bitbrain
Open Angle Glaucoma (OAG), NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions)
The goal of this clinical trial is to evaluate the safety and tolerability of a single dose of ER-100 in adults with optic nerve conditions, specifically Open Angle Glaucoma (OAG) and Non-Arteritic Anterior Ischemic Optic…
- Trial name
- NCT07290244
- Testing
- ER-100 epigenetic therapy
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Life Biosciences Inc.
Hyperpigmentation, Skin Ageing
Evaluation of the Safety and Tolerability of a Brightening Treatment Paired With a Skincare Regimen
A12-week single-center, open-label, clinical study is being conducted to assess the efficacy and tolerability of the Brightening Treatment paired with a skincare regimen on healthy female subjects aged 20-65 years with…
- Conditions
- Hyperpigmentation, Skin Ageing, Post Inflammatory Hyperpigmentation, Skin Roughness
- Trial name
- NCT07501000
- Testing
- Brightening Treatment
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Physiological Stress, Disorder of Aging
Non-inferiority of Belotero® Basic Versus Juvéderm® Ultra 3
This study will investigate the non-inferiority of Belotero® Basic versus Juvéderm® Ultra 3 in the treatment of nasolabial folds
- Conditions
- Physiological Stress, Disorder of Aging, Skin Diseases, Wrinkles
- Trial name
- NCT01305187
- Testing
- Hyaluronic Acid Filler
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Skin Condition, Hair Fragility
Assessment of Anti-aging Efficacy of Marine Collagen Peptides
To assess the anti-aging efficacy of Marine Collagen Peptides on skin, hair and finger nails for human
- Conditions
- Skin Condition, Hair Fragility, Nails, Ingrown
- Trial name
- NCT06306105
- Testing
- Marine Collagen Peptides
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Healthy Aging, Alzheimer's Disease
The Feasibility, Safety and Tolerability of VR-based Audiovisual Stimulation
This single-session, within-subject, sham-controlled early feasibility study evaluated the safety, tolerability, and feasibility of delivering 40 Hz audiovisual (gamma sensory) stimulation through a virtual reality (VR) headset…
- Conditions
- Healthy Aging, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- CFS (NCT06234930)
- Testing
- Audiovisual stimulation VR system
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Clarity Health Technologies, Inc
Sarcopenia, Frailty
Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty
The study will be conducted to investigate the efficacy, tolerability and pharmacokinetics of MYMD1 in participants with chronic inflammation associated with sarcopenia/frailty, a condition linked to elevated levels of…
- Conditions
- Sarcopenia, Frailty, Aging
- Trial name
- NCT05283486
- Testing
- MYMD-1 600MG, MYMD-1 750mg, MYMD-1 900mg
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- TNF Pharmaceuticals, Inc.
Alzheimer's Disease, Plaque, Amyloid
Cognitive Health in Ageing Register: Investigational, Observational and Trial Studies in Dementia Research: Prospective Readiness Cohort Study
The purpose of this study is to prospectively investigate the longitudinal change of the components of the Preclinical Alzheimer Cognitive Composite (PACC) and the components (index scores) of the Repeatable Battery for the…
- Trial name
- CHARIOT:PRO (NCT02114372)
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,136 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Hearing Loss, Well Aging
Development of Physical Activity Features for Ear-worn Devices
This study incorporates data collection to aid in development of software features related to physical activity for users of ear-worn devices.
- Trial name
- NCT05350046
- Testing
- Ear-worn prototype devices
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- 57GGardner
Frailty, Sarcopenia
Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older Adults
The study is a single-center, randomized, placebo-control double-blind study in frail older adults over 65yrs. to investigate the impact of Mitopure (Urolithin A) supplementation on muscle mitochondrial quality in frail older…
- Conditions
- Frailty, Sarcopenia, Aging, Muscle Atrophy
- Trial name
- MitoEM (NCT06556706)
- Testing
- Mitopure (Urolithin A)
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Amazentis SA