Clinical trials: Ageing
Nutrient Sensing
Nutrient Sensing & Signaling in Aging Muscle
This research seeks to better understand how cellular and molecular bases of changes associated with aging contribute to decreased function and increased incidence of disease.
- Trial name
- NCT02999802
- Testing
- Exercise
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
HIV/AIDS, Cognitive Impairment
A Randomized Pilot Trial Evaluating the Impact of a Yoga Intervention on Cognition in Older Adults Infected With HIV
Approximately 50% of people living with HIV (and as many as 80% over the age of 50) have difficulties with cognitive functions such as memory and thinking that can have a profound negative impact on activities of daily living and…
- Conditions
- HIV/AIDS, Cognitive Impairment, Aging, Mobility Limitation
- Trial name
- NCT03071562
- Testing
- Yoga-mindfulness
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Adria Quigley
Hypertriglyceridemia
Effects of Amino Acids on Regional Lipid Metabolism
Elevated fat level in blood is a risk factor for coronary heart disease, a major cause of death in America. The overall goal of this project is to test a novel treatment using nutrient (amino acid) supplementation against this…
- Trial name
- NCT01150188
- Testing
- Amino acids
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Respiratory Tract Infections, Aging
TINO: T Cells in the Nose of Older Adults
Rationale: Individuals with advanced age are at a progressively increasing risk of acquiring lower respiratory tract infections.
- Trial name
- TINO (NCT06039527)
- Where
- Netherlands
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Mild Cognitive Impairment, MCI
Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease
A double-blind, placebo-controlled study that aims to investigate the effect of 2-week and 12-week administration of USP methylene blue (MB) on cerebral blood flow, functional connectivity, memory and attention cognitive…
- Conditions
- Mild Cognitive Impairment, MCI, Aging, Alzheimer's Disease
- Trial name
- MB2 (NCT02380573)
- Testing
- Methylene Blue, FD&C Blue # 2, Phenazopyridine hydrochloride
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment
Ginkgo Leaf Extract and Armillariella Mellea Powder Oral Solution for the Treatment of Motoric Cognitive Risk Syndrome
This is a multi-centre, randomised, double blind, placebo controlled study on participants with Motoric Cognitive Risk Syndrome to evaluate the efficacy and safety of Ginkgo Leaf Extract and Armillariella Mellea Powder Oral…
- Conditions
- Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment, Aging, Locomotive Syndrome
- Trial name
- NCT04492241
- Testing
- Ginkgo Leaf Extract and Armillariella Mellea Powder Oral Solution, Simulation of Ginkgo Leaf Extract and Armillariella Mellea Powder Oral Solution
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Beijing Tiantan Hospital
Hearing Loss
Aging, Cognition, and Hearing Evaluation in Elders Study
The investigators will conduct a small pilot study that will randomize ~ 40 70-84 year-old adults with hearing loss to best-practices hearing rehabilitative treatment (hearing assessment, counseling, fitting of amplification…
- Trial name
- ACHIEVE-P (NCT02412254)
- Testing
- Best practices hearing rehabilitative treatment, Successful aging intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Undernutrition, Aging
Feasibility and Effectiveness of Nutritional Telemonitoring in Community-dwelling Elderly.
An optimal nutritional status is essential for healthy ageing. Telemonitoring might contribute to maintaining or improving nutritional status in elderly people.The objectives of this effect study are to test the feasibility and…
- Trial name
- NCT03240094
- Testing
- Nutritional telemonitoring
- Where
- Netherlands
- Volunteers
- 213 people
- Sponsor
- Wageningen University
Physical Activity, Cognition
Ecological Momentary Cognitive Assessment
The purpose of this study is to characterize the relationships between changes in cognitive functioning across the day and patterns of physical activity in older adults.
- Conditions
- Physical Activity, Cognition, Aging
- Trial name
- DEACS (NCT07710339)
- Testing
- Exercise, Daylong Movement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Physical Inactivity, Aging
Motivating Activity Through Text Communications - Helping Adults Increase Movement
The goal of this clinical trial is to compare the effect of different types of text messages on physical activity levels of middle-aged and older adults and to determine whether these messages are effective in adults age 40 and…
- Conditions
- Physical Inactivity, Aging, Cognitive Ability, Behavior Change
- Trial name
- MATCH AIM (NCT07593677)
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cardiovascular Disease, Diabetes
Diet and Activity Promotion Among Older Working Adults
The trial will test whether the Alive email-delivered health behavior program can improve subjects' physical activity, fruits and vegetables and saturated/trans fats and added sugars.
- Conditions
- Cardiovascular Disease, Diabetes, Obesity, Aging
- Trial name
- ALIVE (NCT01233063)
- Testing
- Physical Activity and Diet Intervention via Alive2
- Where
- United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- Berkeley Analytics, Inc.
Social Isolation, Aging
A Personalized Health Behavior System
The objectives of this study are to examine the usability and efficacy, for diverse older adults, of a new tablet-based dynamic system: the Fittle Senior System (FSS) that will provide: (1) personalized behavior-change programs…
- Conditions
- Social Isolation, Aging, Physical Activity
- Trial name
- FITTLESenior (NCT03538158)
- Testing
- Intervention Condition, Control Condition
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Sarcopenia, Aging
The Study of Sarcopenia and Aging Biomarkers by the Metabolomics
With the rapid growth of the global elderly population, the studies of the biomarkers of the sarcopenia and aging are under investigation in different ways.
- Trial name
- NCT03121326
- Testing
- blood and urine sampling
- Where
- Taiwan
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer Disease
PET Changes in Alzheimer's Disease (AD)
The purpose of this study is to identify the earliest predictors of memory and brain deterioration in pre-clinical Alzheimer's disease using positron emission tomography (PET) to monitor brain glucose metabolism.
- Trial name
- NCT00094913
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Aging, Alzheimer Disease
Couples Coping With Alzheimer's Disease
The purpose of this study is to test the efficacy of a new couples counseling intervention for people recently diagnosed with early Alzheimer's disease and their spouses.
- Conditions
- Aging, Alzheimer Disease, Dementia
- Trial name
- NCT00438724
- Testing
- Information, counseling and support
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Alzheimer's Association
Head and Neck Cancer
Finding Predictors of Side Effects to Chemoradiation Treatment in Elderly Patients With Head and Neck Cancer
To look at what types of measures can be used to predict how an older person will tolerate chemoradiation treatment for head and neck cancer. This study uses surveys and a blood draw to look at the different measures.
- Trial name
- NCT01688323
- Testing
- Collect Blood and Survey Instruments
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Social Cognition, Healthy Aging
Immersive Group Dance in Virtual Reality and Perceived Social Cohesion in Older Adults
This is a two-arm, parallel-group randomized controlled trial designed to evaluate the effects of an immersive virtual reality (VR)-based group dance program on perceived social cohesion among community-dwelling older adults…
- Conditions
- Social Cognition, Healthy Aging, Loneliness, Social Isolation
- Trial name
- VR-GD-COHESION (NCT07850479)
- Testing
- Immersive VR Group Dance Program, Conventional Light Physical Activity Program
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Multidomain Intervention
Effects of Passive Lower-limb Exoskeleton-assisted Training on Motor and Daily Function Improvements in Older Adults
According to National Development Council estimation, Taiwan is about to enter a super-aged society in 2025, and health promotion for the elderly are critical issues nowadays.
- Trial name
- NCT06543888
- Testing
- passive exoskeleton- assisted gait training programs, Conventional gait training
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Aging, Postoperative Cognitive Dysfunction
Postoperative Cognitive Function and EEG
In the elderly patients undergoing elective non-cardiac major surgery, the differences of EEG parameters between those with and without postoperative cognitive dysfunction were observed to determine the characteristic changes of…
- Conditions
- Aging, Postoperative Cognitive Dysfunction, EEG With Periodic Abnormalities
- Trial name
- POEM (NCT04219033)
- Testing
- EEG(Electroencephalogram) change
- Where
- 18 sites in China
- Volunteers
- 1,250 people
- Sponsor
- Air Force Military Medical University, China
Aging
Morning-Evening Specific Longevity Food Supplement
The use of food supplements with the aim of increasing longevity in the general population is rapidly increasing, while high-quality clinical evidence on the efficacy of comprehensive formulations and their impact on biomarkers…
- Trial name
- NCT07416396
- Testing
- Morning- and evening-specific compound food supplement, Control
- Where
- Slovenia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Primorska