Clinical trials: Age-related Cataract
Age Related Cataracts
A Multicenter, Randomized, Double-Masked, Placebo-Controlled Pilot Study to Evaluate the Efficacy and Safety of ZOC2017217 in Subjects With Age-Related Cataract
This is a multicenter, randomized, double-masked, placebo-controlled pilot study conducted in the United States (US) in subjects with age-related cataract in one or both eyes.
- Trial name
- NCT07395986
- Testing
- 0.4% ZOC2017217, Control
- Where
- 21 sites in United States
- Volunteers
- 8 people
- Sponsor
- Ocusun Ophthalmic Pharmaceutical (Guangzhou) Co., Ltd.
Cataract Senile
Study on Visual Performance of a Monofocal Intraocular Lens
Retrospective/Prospective Study on Visual Performance of a Monofocal Intraocular Lens (IOL). The objective is to compare best corrected distance visual acuity (CDVA) between 1-3-month and 12- month follow-up.
- Trial name
- NCT04740788
- Testing
- Monofocal IOL
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Carl Zeiss Meditec AG
Macular Degeneration, Age Related, Cataract
Effect of Minimizing Light Exposure Intensity on Macular Function After Cataract Surgery in Patients With Early or Intermediate AMD
Cataract surgery is one of the most frequently performed surgical interventions worldwide. The microscope light-induced retinal toxicity after cataract surgery has been described in several reports even in short procedures…
- Trial name
- EMERGING (NCT05988827)
- Testing
- NGenuity
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Elsan
Dry Eye Disease, Meibomian Gland Dysfunction
Preoperative iLux on Cataract Surgery Derived Dry Eye Disease Due to Meibomian Gland Dysfunction
This prospective study will investigate the effect of pre-operative Systane iLux system administration in treated cataract induced dry eye disease.
- Conditions
- Dry Eye Disease, Meibomian Gland Dysfunction, Cataract Senile, Dry Eye Syndromes
- Trial name
- NCT06483750
- Testing
- Systane iLux Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- George Washington University
Age-related Cataract
Effective Lens Position After Cataract Surgery
Cataract patients were implanted with different types of intraocular lenses for grouping. SSOCT scanning was used to measure ELP and optometry.
- Trial name
- NCT04443101
- Testing
- different types of intracular lens
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Wenzhou Medical University
Age Related Cataract, Cataract
Effect of Trypan Blue on Corneal Endothelial Cell Count During Phacoemulsification
This randomized controlled trial evaluated the effect of trypan blue on corneal endothelial cell count in patients undergoing phacoemulsification for age-related cataract.
- Trial name
- NCT07735000
- Testing
- Trypan Blue, Phacoemulcification
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Corneal Astigmatism, Intraocular Pressure
How Astigmatism Influences Corneal Biomechanics and Intraocular Pressure
The aim of the study was to identify whether preoperative corneal astigmatism can influence corneal biomechanics and the assessment of intraocular pressure (IOP) following micro-incision phacoemulsification.
- Conditions
- Corneal Astigmatism, Intraocular Pressure, Cataract Senile
- Trial name
- NCT03162471
- Testing
- non-contact measurement of intraocular pressure
- Volunteers
- 39 people
- Sponsor
- Medical University of Lodz
Lens Opacity
Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population
With the rapid growing aging population, age-related eye diseases including cataract are becoming more prevalent. The demand for cataract surgery and post-surgical care posed enormous financial burdens to the government.
- Trial name
- NCT01142960
- Testing
- Starch, Lycium Barbarum
- Where
- Hong Kong
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Age Related Cataracts
The Safety and Efficacy Study of Ethylenediaminetetraacetic Acid (EDTA) Ophthalmic Solution in Patients With Loss of Contrast Sensitivity Due to Age-Related, Low-Grade Nuclear Cataract
The study objectives were: To evaluate the efficacy of EDTA 1.3% and 2.6% ophthalmic solution (C-KAD) in improving visual function as assessed by contrast sensitivity; To evaluate the safety and tolerability of two doses of EDTA…
- Trial name
- NCT06365762
- Testing
- EDTA Ophthalmic Solution 2.6%, EDTA Ophthalmic Solution 1.3%
- Where
- 6 sites in United States
- Volunteers
- 111 people
- Sponsor
- Livionex Inc.
Age Related Cataracts
Changes in Prostaglandin Levels in Laser Cataract Surgery (LCS) Subject to Laser Prevalence
The investigational device is an approved femtosecond laser (FSL) device with an integrated imaging system to perform certain steps of the cataract procedure.
- Trial name
- Femto-PG (NCT03390400)
- Testing
- Femtosecondlaser-assisted, Anterior Capsulotomy, Lens Fragmentation
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Rupert Menapace
Cataract Senile, Pseudophakia
Tecnis Eyhance Versus Rayner RayOne Study
Cataract surgery involves replacing milky lens with a plastic intraocular lens. This plastic lens can be either monofocal (fixates for distance or near without glasses), extended depth of focus (EDOF)(fixates for intermediate and…
- Trial name
- NCT04175951
- Testing
- Intraocular lens
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Age Related Cataract, Pain Management During Cataract Surgery
Prednisolone Acetate Eye Drops for Pain Intervention in Second Eye Cataract Surgery
This study aims to evaluate the efficacy, safety, and potential mechanisms of prednisolone acetate eye drops for pain management in patients undergoing second-eye surgery for age-related cataracts.
- Trial name
- NCT06614348
- Testing
- Prednisolone acetate eye drop group, Sodium hyaluronate eye drops
- Volunteers
- 70 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Cataract, Dry Eye Syndromes
Optimization of the Ocular Surface Prior to Cataract Surgery Using PROKERA
The purpose of the study is to assess whether PROKERA can sufficiently stabilize the ocular surface prior to cataract surgery and improve post operative outcomes patients with moderate to severe dry disease.
- Conditions
- Cataract, Dry Eye Syndromes, Cataract Senile, Dry Eye
- Trial name
- NCT05148507
- Testing
- PROKERA
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Jeff Wongskhaluang
Cataract Senile
Evaluation of a Trifocal Lens
Evaluation of the clinical safety and effectiveness of hydrophilic acrylic intraocular lens
- Trial name
- NCT04545671
- Testing
- trifocal lens
- Where
- Germany
- Volunteers
- 389 people
- Sponsor
- Carl Zeiss Meditec AG
Cataract, Age-Related
An Early Feasibility, Prospective, Single-Arm Study of the Polaris System
A multicenter, single-arm, prospective, non-randomized, non-masked study.
- Trial name
- NCT06990074
- Testing
- cataract surgery
- Where
- El Salvador
- Volunteers
- 30 people
- Sponsor
- Horizon Surgical Systems Inc.
Age- Related Macular Degeneration, Diabetic Retinopathy
A Case-Control Study Revealing Intraocular Microenvironment Characteristics in Patients With Ocular Diseases Based on Multi-Omics Analysis
This project systematically investigates the role of the intraocular microbiome in various ocular diseases, including age-related macular degeneration, diabetic retinopathy, and cataracts.
- Conditions
- Age- Related Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion, Central Serous Chorioretinopathy
- Trial name
- NCT07897513
- Testing
- Not applicable- observational study
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Age-related Cataract, Phacoemulsification
Study to Evaluate the Safety of the Viscoelastic Substance PRO-149, Compared to Healon® EndoCoat.
Pilot, controlled, parallel group, open, randomized clinical trial to evaluate the safety of the viscoelastic substance PRO-149 (sodium hyaluronate 3%) after trans-surgical administration as a device in performing…
- Trial name
- PRO-149 (NCT04702802)
- Testing
- Sodium hyaluronate 3%
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Primary Glaucoma
Changes of Trace Elements in Aqueous Humor, Blood and Tears and Analysis of Related Factors
Trace elements are one of the indispensable substances in human body and play an important physiological role. Zinc is a trace element second only to iron in organisms, which is widely distributed in various systems and organs…
- Trial name
- NCT04515030
- Where
- China
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Age Related Cataracts, Astigmatism
Femtosecond Laser-assisted Astigmatism Treatment
The investigational device is an approved femtosecond laser (FSL) device with an integrated imaging system to perform certain steps of the cataract procedure including arcuate incisions (AI) correcting astigmatism, also referred…
- Trial name
- FLAAT (NCT04321226)
- Testing
- Femtosecond Laser guided Arcuate Keratotomy
- Where
- Austria
- Volunteers
- 130 people
- Sponsor
- Medical University of Vienna
Age-related Cataract, Vision Loss
Long-term Safety & Performance of REVISYON SDS100 in Mild to Moderate Cataract: Extension Study (EB-CE-02)
A non-interventional, extension study on the long-term maintenance of safety and performance of the REVISYON SDS 100 medical device in subjects with mild-to-moderate cataract.
- Conditions
- Age-related Cataract, Vision Loss, Cataract, Mild Cataract
- Trial name
- EB-CE-02 (NCT07246915)
- Where
- 6 sites in Romania
- Volunteers
- 47 people
- Sponsor
- Edinburgh Biosciences Ltd