Clinical trials: Affective Psychoses
Schizophrenia, Schizo Affective Disorder
Telmisartan Pilot Study on Treatment Resistant Schizophrenia
This study is a 4-week pilot study for subjects with Schizophrenia or Schizoaffective Disorder who have not experienced a significant relief of symptoms from current anti-psychotic medication.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Treatment-resistant Schizophrenia
- Trial name
- NCT03868839
- Testing
- Telmisartan Pill
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Xiaoduo Fan
Schizoaffective Disorder, Schizophrenia
Smoking Cessation for Veterans With Severe and Persistent Mental Illness
The investigators have developed an intervention called Behavioral Treatment of Smoking Cessation in SPMI (BTSCS), an innovative intervention that supplements pharmacotherapy and education with contingency management and a…
- Conditions
- Schizoaffective Disorder, Schizophrenia, Affective Psychosis, Bipolar, Affective Disorders, Psychotic
- Trial name
- NCT00960375
- Testing
- BTSCS, StSST
- Where
- 2 sites in United States
- Volunteers
- 179 people
- Sponsor
- US Department of Veterans Affairs
Schizophrenia, Schizo Affective Disorder
Peripheral Immune System in Individuals With Schizophrenia
The investigators are seeking healthy volunteers and people with schizophrenia or schizoaffective disorder for a clinical study of the immune system in psychotic disorders.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Schizophreniform Disorders
- Trial name
- NCT05109065
- Testing
- SCID (Standardized Clinical Interview for DSM-V), PSS (Perceived Stress Score), Urine Toxicology Screen
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Stanford University
Schizophrenia, Schizo-Affective Disorder
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
This is a study of the efficacy and safety of BXCL501 in children and adolescents with acute agitation and either bipolar disorder or schizophrenia.
- Conditions
- Schizophrenia, Schizo-Affective Disorder, Schizophreniform; Schizophrenic, Bipolar Disorder I
- Trial name
- NCT05025605
- Testing
- BXCL501 80 Micrograms, BXCL501 120 Micrograms, BXCL501 60 Micrograms
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- BioXcel Therapeutics Inc
Affective Disorders, Psychotic
Clinical Validation of the Rating Scale for Psychotic Depression (RAS-PD)
The aim of this study is to develop a scale to measure the severity of depression with psychotic symptoms (psychotic depression).
- Trial name
- NCT01518049
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Søren Dinesen Østergaard
Severe Mental Illness, Schizophrenia
The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial
The investigators programme of research will evaluate an existing physical health care screening intervention with the aim of helping Community Psychiatric Nurses (CPN) to improve the physical health wellbeing of people with a…
- Conditions
- Severe Mental Illness, Schizophrenia, Schizoaffective Disorder, Bipolar Affective Disorder
- Trial name
- CHIP (NCT02453217)
- Testing
- Chinese CHIP, Treatment as usual
- Volunteers
- 144 people
- Sponsor
- Wai-Tong Chien
Major Depressive Disorder, Schizo Affective Disorder
Getting Out of the House: Using Behavioral Activation to Increase Community Participation
The goal of this study is to evaluate the effectiveness of an behavioral activation intervention to increase meaningful activity and community participation for people with serious mental illness.
- Conditions
- Major Depressive Disorder, Schizo Affective Disorder, Schizophrenia, Bipolar Disorder
- Trial name
- NCT06336616
- Testing
- Behavior Activation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Temple University
SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder
Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways
This study investigates the ability of transcranial direct current stimulation (tDCS) applied over the motion processing area of the brain (area MT) to improve face emotion recognition (FER) ability.
- Trial name
- ButtomVP (NCT07469384)
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Schizophrenia, Schizo Affective Disorder
Clinical Trial of an IL-23 Inhibitor for Immune Activation in Clinical Trial of an IL-23 Inhibitor for Immune Activation in People With Schizophrenia
This 16 week clinical trial investigates a precision-medicine approach to schizophrenia by targeting a biologically distinct subgroup,-approximately one-third of patients-characterized by the presence of anti-gliadin antibodies…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Healthy
- Trial name
- NCT07615075
- Testing
- IL-23
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Psychotic Disorders, Schizophrenia
Examining the Efficacy of a Virtual Reality Cognitive Remediation Program for People Living With Psychosis
Individuals living with a psychotic disorder often experience changes to their thinking and social skills that can lead to challenges with work, school, relationships and living independently.
- Conditions
- Psychotic Disorders, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT05973110
- Testing
- Cognitive Remediation, Active Control
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Affective Disorders, Anxiety Disorders
Routine Outcome Monitoring in Mental Health Outpatient
Scientific Background: Inherent gaps exist between the worlds of research and clinical therapy, especially in mental-health systems.
- Conditions
- Affective Disorders, Anxiety Disorders, Psychotic Disorders, Personality Disorders
- Trial name
- ROM-Shalvata (NCT02095457)
- Testing
- Frequent monitoring and feedback
- Where
- Israel
- Volunteers
- 900 people
- Sponsor
- Shalvata Mental Health Center
Affective Disorders, Psychotic, Depressive Disorder
Treatment of Psychotic Major Depression With Mifepristone
The purpose of this research study is to see how certain hormones cause changes in mood and thinking in some depressed patients and to determine the effectiveness of mifepristone in treating some forms of depression.
- Trial name
- NCT00867360
- Testing
- Mifepristone (RU-486)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Schizophrenia, Schizo-affective Disorder
Illness Management and Recovery for Veterans With Severe Mental Illness
The President's New Freedom Commission on Mental Health has called for a transformation of the mental health system to partner with consumers of those services in delivering effective interventions focused on recovery, and the…
- Trial name
- NCT00515671
- Testing
- Illness Management and Recovery, Problem Solving
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- VA Office of Research and Development
Schizophrenia, Schizophrenia Relapse
3-year Follow-up of Clinical Outcome After Antipsychotic Treatment Discontinuation in Psychosis Individuals
This open-label, non-randomized, prospective study will evaluate the risk of symptoms recurrence during the three years after antipsychotic discontinuation in a sample of functionally recovered first-episode patients with…
- Conditions
- Schizophrenia, Schizophrenia Relapse, Schizophrenia Spectrum and Other Psychotic Disorders
- Trial name
- ADARFEP (NCT02220504)
- Testing
- Antipsychotic treatment discontinuation, Maintenance antipsychotic treatment
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Fundación Marques de Valdecilla
Psychosis, Schizophrenia
Remote State Representation in Early Psychosis
The purpose of this study is to examine state representation in individuals aged 18-30 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis.
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder, Schizoaffective Disorder
- Trial name
- Rem-STEP (NCT05538832)
- Testing
- BrainHQ Computerized Cognitive Training - Visual Perception Training Paradigm, BrainHQ Computerized Cognitive Training - Visual Cognitive Control Training Paradigm
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Schizophrenia, Bipolar Disorder
Skills for Wellness
Severe mental illness such as schizophrenia and mood disorders typically develops at a young age and can cause life-long disability. Currently available treatments cannot cure severe mental illness.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depression
- Trial name
- SWELL (NCT01980147)
- Testing
- maCBT
- Where
- 2 sites in Canada
- Volunteers
- 360 people
- Sponsor
- Nova Scotia Health Authority
Psychosis, Schizophrenia
Virtual Reality Avatar Therapy for People Hearing Voices
Hearing voices is probably the worst form of acoustic hallucinations; which can be experienced as severely disturbing and is influenced by diverse factors including the ability of the individual to influence and control the…
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder, Hearing Voices When No One is Talking (Symptom)
- Trial name
- NCT04099940
- Testing
- Virtual Reality Avatar Therapy (VRAT), Assertiveness Training Program (ATP)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Psychiatric University Hospital, Zurich
Schizophrenia, Schizoaffective Disorder
Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia
In this trial, researchers aim to investigate if prolonged-release melatonin can facilitate the withdrawal of chronic benzodiazepine administration in patients with schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Affective Disorder
- Trial name
- SMART (NCT01431092)
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 86 people
- Sponsor
- Lone Baandrup
Treatment, Active Control
Cognitive Training Delivered Remotely to Individuals With Psychosis (ROAM)
Primary study: This study is a single-site, double-blind, randomized, controlled clinical trial to compare an evidence-based structured program of 30-35 hours of on-line cognitive and social cognitive training exercises performed…
- Conditions
- Treatment, Active Control, Schizophrenia, Psychosis
- Trial name
- NCT02782442
- Testing
- Structured Cognitive Training & PRIME, Computer Games Control & PRIME
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- University of Minnesota
Schizophrenia, Bipolar Affective Disorder
A Study on the Preference of Risperidone Dosage Forms
This study aimed to understand patients' needs and preferences for antipsychotic dosage forms.
- Conditions
- Schizophrenia, Bipolar Affective Disorder, Autism Spectrum Disorder, Conduct Disorder
- Trial name
- NCT06657430
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Mental Health Center