Clinical trials: Adverse Outcomes
Diabetes Mellitus, Coronary Artery Disease
Optical Coherence Tomography Morphologic and Fractional Flow Reserve Assessment in Diabetes Mellitus Patients
Title: Combined Optical Coherence Tomography Morphologic and Fractional Flow Reserve Hemodynamic Assessment of Non-Culprit Lesions to Better Predict Adverse Event Outcomes in Diabetes Mellitus Patients COMBINE (OCT-FFR)…
- Conditions
- Diabetes Mellitus, Coronary Artery Disease, Coronary Atheroscleroses
- Trial name
- COMBINE (NCT02989740)
- Testing
- Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 550 people
- Sponsor
- Diagram B.V.
Prevention of In-hospital Adverse Events
Electronically Recorded National Early Warning Scores, Pain Scores and PONV Scores Among Hospitalized Patients
National early warning score (NEWS) enables early detection of patient deterioration in hospital floors. However, there is limited data on the prognostic value of NEWS among actual general ward patients.
- Trial name
- NCT04055350
- Where
- Finland
- Volunteers
- 30,000 people
- Sponsor
- Tampere University Hospital
Gram-Negative Bacterial Infections
A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Minocin® (Minocycline) for Infections Caused by Gram-negative Bacteria in a Real World Setting
This study is a retrospective, observational study to evaluate minocycline use in participants under real world conditions.
- Trial name
- NCT03160040
- Testing
- Minocycline IV
- Where
- 6 sites in United States
- Volunteers
- 71 people
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
Peripheral Vascular Disease
Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting
In this investigation, the investigators will attempt to demonstrate that patients who have received nerve blocks (regional anesthesia) prior to open surgical vascular bypass of the lower extremities (infrainguinal bypass…
- Trial name
- NCT01803165
- Testing
- Single shot femoral and sciatic nerve block
- Sponsor
- University of Nebraska
COVID-19, Myocardial Reperfusion Injury
Myocardial Injury and Major Adverse Outcomes in Patients With COVID-19
The study will analyze the incidence, clinical outcomes and predictors of myocardial injury in a large patient population with COVID-19 treated in Mount Sinai Hospital (MSH) system.
- Conditions
- COVID-19, Myocardial Reperfusion Injury, Cardiovascular Diseases
- Trial name
- NCT04397939
- Where
- United States
- Volunteers
- 4,695 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
High-risk, Non-cardiovascular Surgeries
Esmolol for Treatment of Perioperative Tachycardia
The purpose of this study is to find out if Esmolol is a safe and effective alternative treatment compared to standard treatment using a long acting beta blocker drug, in controlling abnormal heart rate before, during and…
- Trial name
- NCT01208402
- Testing
- Esmolol
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Duke University
Trigeminal Neuralgia (TN)
Developing a Clinical Prediction Model for Adverse Outcomes in Percutaneous Trigeminal Ganglion Balloon Compression
This clinical study aims to investigate adverse outcomes following percutaneous balloon compression (PBC) of the trigeminal ganglion, establish a predictive model, and assess the probability of postoperative complications.The…
- Trial name
- NCT06998420
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Affiliated Hospital of Nantong University
Metabolic Syndrome, Pregnant Women
Progression of Metabolic Syndrome Components During Pregnancy
The goal of this cohort study is to investigate the underlying risk factors to develop metabolic syndrome (MetS) during pregnancy, and the associations of MetS and its indicators with birth outcomes in southwest Ethiopia.
- Conditions
- Metabolic Syndrome, Pregnant Women, Birth Outcomes, Dietary Habits
- Trial name
- MetS_Preg (NCT05935904)
- Testing
- Exposure, Non exposure
- Where
- Ethiopia
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- University Ghent
Periodontal Diseases, Pregnancy
The 4th Month Oral Consultation at Pregnant Women
Epidemiological studies have suggested that maternal periodontitis affects the fetal-placental unit, with an increased risk of adverse pregnancy outcome.
- Trial name
- C4M (NCT03132207)
- Testing
- Non interventionel study
- Where
- 2 sites in France
- Volunteers
- 622 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Acute Kidney Injury, Cardiorenal Syndrome
Renal Venous Flow and Cardiac Surgery-associated Acute Kidney Injury
The prospective single-center study investigates the association between changes in Doppler-derived renal venous flow and cardiac surgery-associated acute kidney injury (CSA-AKI).
- Trial name
- NCT03753607
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Giessen
Twin; Pregnancy, Affecting Fetus or Newborn
Birth Weight-discordance in Twins Pregnancy: a Multicenter Retrospective Study
The rate of twin pregnancies in China has increased by 50 percent over the past decade and now stands at about 3 percent. This is significantly higher than the European and American countries.
- Trial name
- NCT05674214
- Where
- China
- Volunteers
- 13,440 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
Acute Myocardial Infarction
Impact of OCT on Outcomes in AMI
This protocol describes a retrospective, single-center study intended to test the impact of optical coherence tomography(OCT) on long term clincical outcomes in patients with acute myocardial infarction(AMI).
- Trial name
- NCT05266547
- Testing
- OCT guided coronary intervention
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Luhe Hospital
Undifferentiated Shock
The Epidemiology and Approach to Differentiating Etiologies of Shock in the Emergency Department
The Shock Tool study is designed to improve the clinical evaluation for differentiating shock in the emergency department. The goal of this study is to evaluate and improve the accuracy of physicians differentiating causes of…
- Trial name
- NCT02164799
- Volunteers
- 2,500 people
- Sponsor
- Beth Israel Deaconess Medical Center
Neoplasm, Breast, Heart Failure
Breast Cancer Long-term Outcomes on Cardiac Functioning: a Longitudinal Study
Rationale: In addition to surgery, effective breast cancer (BC) treatment typically requires chemotherapy, radiotherapy, or both.
- Conditions
- Neoplasm, Breast, Heart Failure, Cardiotoxicity, Ventricular Dysfunction
- Trial name
- BLOC-II (NCT05851053)
- Testing
- Echocardiography
- Where
- Netherlands
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Postpartum Psychiatric Disorders
Mindfulness, Optimism, and Resilience for Perinatal Health and Equity Study
Dispositional optimism (the general assumption that more good things than bad will occur across various life domains) has been tied to improved somatic and mental health outcomes.
- Trial name
- MORPHE (NCT05840900)
- Testing
- Digital Mindfulness Training
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Nina Ayala
Hypoxic-Ischemic Encephalopathy
PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns
Double-blind, placebo controlled Phase III trial of erythropoietin for hypoxic ischaemic encephalopathy in infants receiving hypothermia.
- Trial name
- PAEAN (NCT03079167)
- Testing
- Epoetin Alfa, Normal saline
- Where
- 24 sites in Australia, New Zealand and 1 more
- Volunteers
- 313 people
- Sponsor
- University of Sydney
Carcinoid Syndrome
Real-world Evidence Study EvaLuating PAtient-Reported Outcomes With XERMELO
The primary objective of the study is to estimate the proportion of carcinoid syndrome (CS) patients who are satisfied with their overall symptom control, 6 months after initiating treatment with telotristat ethyl (XERMELO).
- Trial name
- RELAX (NCT03223428)
- Testing
- Xermelo
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- TerSera Therapeutics LLC
Pregnancy Related, Influenza Virus Vaccine Adverse Reaction
Maternal and Fetal Outcomes Following Influenza Vaccination in Pregnancy
This is a nationwide cohort study to assess maternal and fetal outcomes following vaccination with a quadrivalent influenza vaccine (QIV) during pregnancy.
- Trial name
- NCT04579822
- Testing
- influenza vaccine
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Sungkyunkwan University
Cearean Section Rate, Maternal Adverse Outcomes
Twin Vaginal Breech Deliveries Before and After Starting Training Skills and Clinical Approach in Labor Ward
In January 2021 Dept of ObGyn of Santo Spirito Hospital Pescara Italy, and in July 2022 Dept of ObGyn of San Giovanni di Dio Hospital Florence Italy, started regular training in management of obstetric emergencies.
- Conditions
- Cearean Section Rate, Maternal Adverse Outcomes, Neonatal Adverse Outcomes
- Trial name
- TVBD (NCT06628843)
- Testing
- cesarean section rate
- Where
- 2 sites in Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University