Clinical trials: Adverse Event
Early Gastric Cancer, Advanced Gastric Cancer
Evaluation of the Effectiveness of Managing Chemotherapy Side Effects Using ePRO and a Standardized Telenursing Program for Cancer Patients
This is a multicenter randomized controlled clinical trial designed to evaluate the clinical efficacy and cost-effectiveness of a digital health platform that integrates a symptom reporting and management software with a…
- Conditions
- Early Gastric Cancer, Advanced Gastric Cancer, Early Lung Cancer, Advanced Lung Cancer
- Trial name
- NCT07405931
- Testing
- Standardized Telenursing, Smart Cancer Care Plus
- Where
- 5 sites in South Korea
- Volunteers
- 414 people
- Sponsor
- Ulsan University Hospital
Cardiotoxicity, Heart Failure
Novel Biomarkers and Echocardiography for Subclinical Cardiac Toxicity in Breast Cancer Patients Receiving Anthracyclines
This is a pilot prospective cohort study, in adult female subjects 18-85 years old with a diagnosis of invasive breast cancer who are planned for anthracycline-inclusive chemotherapy and followed up for a time period of 6 months…
- Conditions
- Cardiotoxicity, Heart Failure, Breast Cancer, Anthracycline Induced Cardiomyopathy
- Trial name
- NCT03155802
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Stony Brook University
Ulcerative Colitis
A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).
- Trial name
- NCT06257875
- Testing
- Lutikizumab, Adalimumab
- Where
- 191 sites in United States, Australia and 28 more
- Volunteers
- 156 people
- Sponsor
- AbbVie
Any Advanced Solid Tumors
Study of Sarilumab With Immune Checkpoint Inhibitor Rechallenge in Patients With Clinically Significant Immune Related Adverse Events
The study will enroll patients with history of malignancy treated with immune checkpoint inhibitors (ICI) that have developed a grade 2 or higher immune related adverse event requiring treatment discontinuation as deemed by the…
- Trial name
- IRIS (NCT07836101)
- Testing
- Sarilumab, ICI Therapy
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Advanced Solid Tumors Cancer, Non Small Cell Lung Cancer (NSCLC)
Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid Tumors
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. Non-Small Cell Lung Cancer (NSCLC) is a solid tumor, a disease in which cancer cells form in the tissues of the lung.
- Trial name
- NCT04721015
- Testing
- ABBV-637, Docetaxel, Osimertinib
- Where
- 33 sites in United States, Australia and 6 more
- Volunteers
- 81 people
- Sponsor
- AbbVie
Breast Cancer, Colon Cancer
Testing a Spanish Version of a Patient Toxicity Questionnaire
Background: The Common Terminology Criteria for Adverse Events (CTCAE) is a list of toxicities and side effects that may occur when people are having cancer treatment.
- Conditions
- Breast Cancer, Colon Cancer, Lung Cancer, Lymphoma
- Trial name
- NCT01517152
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Cancer Institute (NCI)
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cardiotoxicity, Systolic Dysfunction
Aerobic Exercise is Cardio-protective in Hemato-oncological Disease and New-onset Chemotherapy
Oncological diseases are the main cause of death in developed countries and also in Uruguay. Advances in therapeutics have made possible to aspire to cure and in other cases long-term remission with a significant increase in…
- Conditions
- Cardiotoxicity, Systolic Dysfunction, Exercise, Aerobic
- Trial name
- AEROHEMONCO (NCT04476576)
- Testing
- Aerobic exercise (experimental), Flexibility exercise (active comparator)
- Where
- Uruguay
- Volunteers
- 38 people
- Sponsor
- Lucía Florio
Breast Cancer, Cardiac Toxicity
Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab
RATIONALE: Lisinopril or Coreg CR®, may help reduce side effects caused by trastuzumab. It is not yet known whether lisinopril or Coreg CR® are more effective than a placebo in reducing side effects caused by trastuzumab.
- Trial name
- NCT01009918
- Testing
- Coreg CR®, lisinopril
- Where
- 174 sites in United States
- Volunteers
- 468 people
- Sponsor
- University of South Florida
Ulcerative Colitis, Crohn's Disease
Study of Oral Upadacitinib to Assess Change in Disease Activity and Adverse Events in Adult Participants With Ulcerative Colitis or Crohn's Disease
Ulcerative colitis (UC) is an idiopathic, chronic, inflammatory disease affecting the colon. Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract.
- Trial name
- NCT06459297
- Where
- 14 sites in South Korea
- Volunteers
- 105 people
- Sponsor
- AbbVie
Allergic Reaction
Analysis of Adverse Events in Anesthesia Using Artificial Intelligence
The interest of health databases in anesthesia is no longer to be demonstrated. The aim of this research was to develop a natural language processing approach to establish a classification of adverse events observed during the…
- Trial name
- ADVENTURE (NCT05185479)
- Where
- France
- Volunteers
- 9,559 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiac Disease, Cancer
Evaluation of Reporting of Cardio-vascular Adverse Events With Antineoplastic and Immunomodulating Agents (EROCA)
Antineoplastic and immunomodulating agents may lead to various cardio-vascular adverse reactions. This study investigates reports of cardio-vascular toxicities for treatment including Anatomical Therapeutic Chemical (ATC)…
- Trial name
- EROCA (NCT03530215)
- Testing
- Antineoplastic and Immunomodulating Agents
- Where
- France
- Volunteers
- 500,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Adverse Drug Event, Adverse Drug Reaction
Evaluating ActionADE in Reducing Adverse Drug Reactions
Repeat exposures to culprit medications are a common cause of preventable adverse drug events. Health information technologies have the potential to reduce repeat adverse drug events by improving information continuity.
- Trial name
- NCT04568668
- Testing
- ActionADE
- Volunteers
- 3,600 people
- Sponsor
- University of British Columbia
Preoperative Care, Surgery--Complications
Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study
The proportion of noncardiac surgeries performed as same-day surgery is increasing worldwide, with more complex surgeries being performed on higher risk patients in the outpatient setting.
- Conditions
- Preoperative Care, Surgery--Complications, Myocardial Infarction
- Trial name
- VALIANCE (NCT04973397)
- Where
- 16 sites in United States, Canada and 2 more
- Volunteers
- 15,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Psychoses
DNA Diagnostics for Minimizing Metabolic Side-Effects of Antipsychotics
The purpose of this study is to assess patients treated with the antipsychotics aripiprazole (Abilify®), olanzapine (Zyprexa®), quetiapine (Seroquel®), risperidone (Risperdal®), or ziprasidone (Geodon®) and to identify genetic…
- Trial name
- DIMS (NCT00752960)
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Genomas, Inc
Esophageal Cancer, Nutrition Aspect of Cancer
Nutritional Support During Induction Therapy for Esophageal Cancer
Patients diagnosed with esophageal cancer have difficulty eating, as the food pipe becomes obstructed by the cancer. This may impair the ability for the patient to receive appropriate calorie intake, especially during…
- Trial name
- NCT05314946
- Testing
- No feeding tube placed, Placement of a percutaneous feeding tube
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Mehdi Qiabi
Carcinoid Syndrome
TELESTAR (Telotristat Etiprate for Somatostatin Analogue Not Adequately Controlled Carcinoid Syndrome)
The primary objective of the study is to confirm that at least 1 or more doses of telotristat etiprate compared to placebo is effective in reducing the number of daily bowel movements (BMs) from baseline averaged over the 12-week…
- Trial name
- NCT01677910
- Testing
- Telotristat etiprate
- Where
- 75 sites in United States, Australia and 10 more
- Volunteers
- 135 people
- Sponsor
- Lexicon Pharmaceuticals
Side Effects of Creatine Monohydrate Dosing
Gastrointestinal and Fluid Retention Symptoms Associated With Creatine Monohydrate With and Without Loading Dose Over 28 Days of Supplementation
This study aimed to investigate the incidence and severity of GI symptoms associated with daily CM supplementation, with and without a loading phase, in healthy male and female adults.
- Trial name
- NCT07176325
- Testing
- Creatine Monohydrate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vireo Systems, Inc.
Schizophrenia, Bipolar Disorder
A Study to Evaluate the Safety and the Effects of Risperidone Compared With Other Atypical Antipsychotic Drugs on the Growth and Sexual Maturation in Children
The purpose of this study is to evaluate the effects of risperidone compared with other atypical antipsychotic drugs on the physical maturity, growth and development of children, and the risk of prolactin-related adverse events…
- Conditions
- Schizophrenia, Bipolar Disorder, Autistic Disorder, Conduct and Other Disruptive Behavior Disorders
- Trial name
- NCT01050582
- Testing
- Risperidone, Other atypical antipsychotic drugs
- Where
- 28 sites in United States, Belgium and 4 more
- Volunteers
- 244 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Dental Plaque, Side Effects
Clinical Effects of Two New Chlorhexidine Digluconate Formulations: 0.12% and 0.03%.
In the current study we tested the hypothesis that new 0.05% Cetylpyridinium chloride (CPC) mouthrinse formulations containing 0.12% or 0.03% chlorhexidine digluconate (CHX): 1) yield similar or better clinical results regarding…
- Trial name
- NCT02194023
- Testing
- 0.12%NF, 0.03%NF, PAT
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya