Clinical trials: Adverse Drug Reaction (ADR)
Sedative Adverse Reaction, Analgesic Adverse Reaction
The Use of Midazolam and Remifentanil During Dialysis Access Procedures
BACKGROUND: Sedation and analgesia are related to unexpected adverse events in chronic renal failure patients undergoing arteriovenous fistula placement procedures under monitored anesthesia care (MAC).
- Conditions
- Sedative Adverse Reaction, Analgesic Adverse Reaction, Midazolam Adverse Reaction, Adverse Reaction to Drug
- Trial name
- NCT04226443
- Testing
- Midazolam intravenous injection, Remifentanil intravenous bolus dose
- Volunteers
- 99 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Adverse Drug Event, Non-Adherence, Medication
Evaluating ActionADE on Adverse Drug Event Due to Non-Adherence
Repeat non-adherence to medications is a common cause of preventable adverse drug events. Health information technologies have the potential to improve information continuity.
- Trial name
- NCT04574648
- Testing
- ActionADE
- Volunteers
- 2,000 people
- Sponsor
- University of British Columbia
Diabetes, Cholesterol
Interprofessional Pharmacogenomics (IPGx) Registry and Repository
This program collects genetic and health information to help doctors choose the right medications for patients.
- Conditions
- Diabetes, Cholesterol, Cancer, Blood Pressure Disorders
- Trial name
- IPGx Registry (NCT06726590)
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Texas A&M University
ALL, Childhood, Pediatric Cancer
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia
A five-year prospective observational cohort study. The study is focused on observing the relation between static germline variants and therapeutic response in Indian children with acute lymphoblastic leukemia (ALL).
- Conditions
- ALL, Childhood, Pediatric Cancer, Toxicity, Drug, Adverse Drug Event
- Trial name
- MPGx-INDALL (NCT05512169)
- Where
- 2 sites in India
- Volunteers
- 556 people
- Sponsor
- University of Geneva, Switzerland
Central Line-Associated Bloodstream Infection (CLABSI), Venous Thromboembolism
Patient Safety Learning Laboratory: Making Acute Care More Patient-Centered
The Brigham and Women's Hospital (BWH) Patient Safety Learning Laboratory (PSLL) focuses on developing health information technology (HIT) tools to engage patients, family, and professional care team members in reliable…
- Conditions
- Central Line-Associated Bloodstream Infection (CLABSI), Venous Thromboembolism, Patient Fall, Catheter-Associated Infection
- Trial name
- PSLL (NCT02969343)
- Testing
- Patient Safety health information technology
- Where
- United States
- Volunteers
- 21,000 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Adverse Drug Reaction
Pharmacists' Knowledge and Attitudes About ADRs Reporting and Pharmacovigilance Practice in Egyptian Hospitals
The present study has assessed the knowledge, attitude and practice of ADRs reporting among pharmacists, and the perceived factors that may influence reporting.
- Trial name
- NCT05224804
- Testing
- knwoledge
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Fayoum University
Metabolic Side Effects of Drugs
Studies of Sulfur Metabolism in Humans
The study test whether the NSAID allosteric site of human sulfotransferase 1A1 (SULT1A1) is operative in humans. The study will test the effects of mefenamic acid (MEF) on the sulfonation of acetaminophen (APAP, a SULT1A1…
- Trial name
- NCT03383133
- Testing
- SULT Allosteric Inhibition
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Albert Einstein College of Medicine
Polypharmacy, Pharmacogenetics
Individual Risk Profiles for Adverse Drug Reactions in Geriatric Patients
This project will generate a prospective cohort of geriatric patients with polypharmacy which will be characterized for vulnerability profiles of adverse drug reactions.
- Conditions
- Polypharmacy, Pharmacogenetics, Pharmacogenomic Testing, Drug-Related Side Effects and Adverse Reactions
- Trial name
- NCT05247814
- Testing
- Pharmacogenomic testing of a panel of important pharmacogenes to detect genetic variants and evaluate the association between genetically predicted and measured drug metabolism, Adverse Drug Reaction detection, Falls Efficacy Scale International (FES-I)
- Volunteers
- 2,000 people
- Sponsor
- RWTH Aachen University
Depression
Prediction of Antidepressant Response Using Pharmacogenetics and Peripheral Lymphocytic Phenotype
The purpose of this study is to determine whether pharmacogenomic study of bioamine transporters and peripheral lymphatic biomarkers(phenotype) predict antidepressant responsiveness in advance before the appearance of the drug…
- Trial name
- NCT01352559
- Testing
- responders, non-responders
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Adverse Effect of Drug Therapy Metabolism Medications (Diagnosis)
Bupropion Stereoselective Disposition and CYP2D6-mediated Drug Interactions in Healthy Volunteers
Primary objectives: 1. To comprehensively characterize steady state stereoselective pharmacokinetics of bupropion and its primary and secondary metabolites in healthy volunteers 2.
- Trial name
- NCT03420469
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Indiana University
Medication Errors
Observational Study to Reduce Medication Errors
A medication error is a failure in the treatment process that leads to, or has the potential to lead, to harm to the patient.1 Medication errors are a common unfortunate occurrence in hospital.
- Trial name
- OSME (NCT01734642)
- Where
- 4 sites in Italy
- Volunteers
- 8,000 people
- Sponsor
- Universita di Verona
Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses
NATIENS: Optimal Management and Mechanisms of SJS/TEN
The North American Therapeutics in Epidermal Necrolysis Syndrome (NATIENS) study is a multicenter double-blind randomized controlled assessment of two arms - one of systemic immunomodulatory therapy (etanercept) and one of…
- Trial name
- NATIENS (NCT02987257)
- Testing
- Harmonized supportive care, Etanercept 50 mg sc day 1 and day 4
- Where
- 14 sites in United States
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University Medical Center
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Adult Hepatocellular Carcinoma, Recurrent Hepatocellular Carcinoma
Oral Thalidomide and Tegafur-uracil to Decrease Hepatocellular Carcinoma Recurrence
This single-centered phase II clinical study is to obtain preliminary information on 1-year recurrence-free survival rate, recurrence-free survival and safety profile of thalidomide in combination with tegafur-uracil in…
- Conditions
- Adult Hepatocellular Carcinoma, Recurrent Hepatocellular Carcinoma, Adverse Reaction to Drug, Vascular Endothelial Growth Factor Overexpression
- Trial name
- NCT02447679
- Testing
- thalidomine, tegafur-uracil
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
DRESS Syndrome
Interest of a Targeted Therapy for the Treatment of a Severe Form of Hypersensitivity to Drug (DRESS Syndrome)
Drug Reaction with eosinophilia and Systemic Symptoms (DRESS) is a rare and severe multiorgan drug reaction whose pathophysiological mechanisms underlying remain unclear, but may involve the role of several immune cells like…
- Trial name
- BENRADRESS (NCT06734884)
- Testing
- Benralizumab 30 MG/ML [Fasenra]
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Lille
Myeloma, Heart Failure
Cardiovascular Complications of Carfilzomib
Cardiovascular toxicity of carfilzomib, a last generation proteasome inhibitor, is highly incident according to retrospective data. Prospective cohort study of patients initiated on carfilzomib.
- Conditions
- Myeloma, Heart Failure, Hypertension
- Trial name
- ICARE (NCT04407858)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- European Georges Pompidou Hospital
Adverse Drug Reaction
Prevention of Adverse Drug Events (ADEs) in Hospitalised Older Patients
The next four decades will see a marked expansion of the elderly population in Ireland, in particular people aged over 80 yrs. Persons aged over 80 are the highest consumers of prescription medicines in Ireland and have the…
- Trial name
- NCT01467050
- Testing
- Application of STOPP/START criteria, Normal pharmaceutical care
- Where
- Ireland
- Volunteers
- 732 people
- Sponsor
- University College Cork
Non-steroidal Anti-inflammatory Drug Adverse Reaction
Research for Prevention and Treatment of NSAIDs Related Gastrointestinal Side Effects
We aim to evaluate the protective effects of eradication of HP and continue using Geranylgeranylacetone (GGA) on NSAIDs related gastroenterological lesions.
- Trial name
- NCT01547559
- Testing
- part1:teprenone, part1:EAC-T, part1:EA-EMC-T
- Where
- 2 sites in China
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Toxic Epidermal Necrolysis, Immunotherapy
New Therapeutic Target for Toxic Epidermal Necrolysis (TEN) Using Anti-CD38+ Monoclonal Antibodies.
Toxic Epidermal Necrolysis (TEN) are rare diseases that are dermatologic emergencies characterized by widespread epidermal necrosis and sloughing of skin. A hundred patients are affected each year in France.
- Conditions
- Toxic Epidermal Necrolysis, Immunotherapy, Cutaneous Adverse Drug Reactions (CADR)
- Trial name
- NET-CD38 (NCT07110662)
- Testing
- DARATUMUMAB (DARZALEX®)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Hospices Civils de Lyon
Adverse Drug Reaction
Post-marketing Safety Surveillance of the Injection of DanShenDuoFenSuanYan A Real World Study
Magnesium Lithospermate B, the main constituent of the Injection of DanShenDuoFenSuanYan (the Injection of Depsides Salts From Salvia Miltiorrhiza), is the active ingredient of Salvia Miltiorrhiza.
- Trial name
- NCT01872520
- Where
- 36 sites in China
- Volunteers
- 30,180 people
- Sponsor
- Peking University Third Hospital