Clinical trials: Advanced Pancreatic Carcinoma
Pancreatic Cancer
Gemcitabine and Z650 in Treating Patients With Metastatic or Recurrent Pancreatic Cancer
This phase IB trial is studying how well giving gemcitabine together with Z650 works in treating patients with metastatic or recurrent pancreatic cancer.
- Trial name
- NCT04131192
- Testing
- Z650, Gemcitabine
- Where
- 2 sites in China
- Volunteers
- 13 people
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Sarcoma, Carcinoma
A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Solid Tumors
20 participants are expected to be enrolled for this open，Single-armed clinical trial to evaluate the safety and efficacy of the recombinant herpes simplex virus Ⅰ, R130 in patients with advanced solid tumors.
- Conditions
- Sarcoma, Carcinoma, Breast Cancer, Pancreatic Cancer
- Trial name
- NCT05860374
- Testing
- Recombinant oncolytic herpes simplex virus type 1 (R130)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Yunying Medical Technology
Pancreatic Cancer
Onvansertib in Combination With NALIRIFOX for First Line Treatment of Advanced Pancreatic Cancer
Pancreatic cancer is a deadly disease and will be the second leading cause of cancer related death behind lung cancer by 2030. Over 62,000 people are diagnosed each year in the United States with about 90% succumbing to the…
- Trial name
- PANCONVA (NCT06736717)
- Testing
- Onvansertib, NALIRIFOX
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Kansas Medical Center
Pancreatic Cancer
MRI-guided Dose Intensification Program Locally Advanced Pancreatic Cancer
The goal of this clinical trial is to learn if the use of dose-escalated MRI-guided irradiation increases the rates of disease control in patients with pancreatic cancer
- Trial name
- NCT07132060
- Testing
- MR-guided Irradiation
- Volunteers
- 30 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Locally Advanced Pancreatic Adenocarcinoma
Effect Of Preoperative Chemotherapy On Short-Term Outcome After Pancreatic Resection
No comparative trial investigating the effect of preoperative chemotherapy for locally advanced pancreatic cancer on short-term postoperative outcome has been published so far.
- Trial name
- NCT01278368
- Testing
- Pancreatic resection after preoperative chemotherapy, Pancreatic resection
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università Vita-Salute San Raffaele
Pancreatic Cancer
OSI-774 (Tarceva) Plus Gemcitabine in Patients With Locally Advanced, Unresectable or Metastatic Pancreatic Cancer.
The purpose of this study is to determine if OSI-774 will improve overall survival when combined with a standard dose of the chemotherapy drug gemcitabine, to individuals with pancreatic cancer.
- Trial name
- NCT00040183
- Testing
- Tarceva (erlotinib HCl, OSI-774)
- Where
- 140 sites in United States, Argentina and 15 more
- Volunteers
- 569 people
- Sponsor
- OSI Pharmaceuticals
Gastric Cancer, Pancreatic Cancer
NKG2D/CLDN18.21 CAR-T(KD-496) in the Treatment of Advanced NKG2DL+/CLDN18.2+ Solid Tumor
This is a Phase 1, single-arm, single-center, open-label study to evaluate the safety and effectiveness of NKG2D/CLDN18.2-based CAR-T cells infusion in the treatment of advanced NKG2DL+/CLDN18.2+ solid tumors.
- Conditions
- Gastric Cancer, Pancreatic Cancer, Solid Tumor
- Trial name
- NCT06134960
- Testing
- KD-496
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking University
Pancreatic Cancer Metastatic
Phase Ib/II Study to Evaluate the Safety and Efficacy of IBI363 in Combination With Chemotherapy as Second-Line Therapy for Unresectable Locally Advanced or Metastatic Pancreatic Cancer
This study is an Ib/II phase clinical trial evaluating the safety and efficacy of IBI363 combined with chemotherapy as a second-line treatment for unresectable locally advanced or metastatic pancreatic cancer.
- Trial name
- NCT07342725
- Testing
- IBI363 + chemotherapy
- Volunteers
- 48 people
- Sponsor
- Ruijin Hospital
Locally Advanced Pancreatic Ductal Adenocarcinoma
A Study of GnP RegimenCombined With Serplulimab and Stereotactic Body Radiation Therapy as First-line Treatment for Locally Advanced Pancreatic Cancer
This study is a single-arm phase II clinical trial. The study targets patients aged 18-75 years with ECOG performance status 0-2, diagnosed with locally advanced pancreatic ductal adenocarcinoma based on comprehensive assessment…
- Trial name
- NCT07101679
- Testing
- LICSBR
- Where
- China
- Volunteers
- 23 people
- Sponsor
- West China Hospital
Pain, Visceral Pain
TMS for the Treatment of Pancreatic Cancer Pain
This is a phase II study that aims to investigate prospectively a new therapy for a cohort of patients with chronic pain attributed to pancreatic cancer.
- Conditions
- Pain, Visceral Pain, Pancreatic Cancer
- Trial name
- NCT00324428
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pancreatic Cancer Non-resectable, Pancreatic Cancer Metastatic
Medical Cannabis in Patients With Advanced Pancreatic and Colorectal Cancer
Many patients with advanced pancreatic cancer and colorectal cancer experience burdensome and difficult-to-treat symptoms. The impact of multiple symptoms (called "symptom burden") can negatively affect a patient's quality of…
- Conditions
- Pancreatic Cancer Non-resectable, Pancreatic Cancer Metastatic, Colorectal Cancer Metastatic
- Trial name
- CanPan-C (NCT06605430)
- Testing
- Medical Cannabis
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- HealthPartners Institute
Advanced Pancreatic Cancer
Paricalcitol Trial: Phase II, Open Label Clinical Trial of Paricalcitol in Combination With Gemcitabine/ Nab-Paclitaxel Therapy in Advanced Pancreatic Cancer
The trial is designed to establish whether adding a vitamin D analogue, Paricalcitol, to standard chemotherapy treatment, Gemcitabine and Nab-paclitaxel, can improve the outcomes for patients with advanced pancreatic cancer.
- Trial name
- NCT04617067
- Testing
- Paricalcitol, Gemcitabine (GEM) and Nab-paclitaxel
- Where
- 6 sites in Ireland
- Volunteers
- 15 people
- Sponsor
- Cancer Trials Ireland
Advanced Cancer, Pancreas Cancer
Celiac Plexus Radio-Surgery for Pain Management
Many cancer patients, especially those with pancreatic cancer, suffer from severe lower back / upper abdominal pain. This pain is often poorly managed with standard treatments; the doses of painkiller required often induce side…
- Conditions
- Advanced Cancer, Pancreas Cancer, Pain
- Trial name
- NCT03323489
- Testing
- Celiac Plexus Radiosurgery
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 125 people
- Sponsor
- Dr. Yaacov Lawrence
Pancreatic Carcinoma
L-CARnitine in the Palliative Treatment of Advanced PANcreatic Cancer (CARPAN)
The study investigated the role of L-Carnitine supplementation on proinflammatory immune response, malnutrition, cancer cachexia and cancer related fatigue in advanced and inoperable pancreatic cancer, UICC Stage IV .
- Trial name
- CARPAN (NCT01330823)
- Testing
- L-Carnitine
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- University Medicine Greifswald
Solid Tumor, Pancreatic Cancer
A Phase I/II Study of AST-001 in Subjects With Advanced Solid Tumors
A first-in-human open-label, Phase I/II study to evaluate the safety, tolerability, MTD/RP2D, PK, and preliminary efficacy of AST-001 administered as a single agent.
- Trial name
- NCT06245330
- Testing
- AST-001
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ascentawits Pharmaceuticals, Ltd
Pancreatic Cancer
Decitabine Combined With Gemcitabine in First-line Treatment of AdvancedPancreatic Cancer
The purpose of this study is to investigate the effect of very low dose decitabine combinate with gemcitabine in the first-line treatment of locally advanced, unresectable and metastatic pancreatic cancer.
- Trial name
- SLOWDOSE001 (NCT02685228)
- Testing
- Decitabine, Gemcitabine
- Volunteers
- 20 people
- Sponsor
- The First Hospital of Jilin University
Pancreatic Cancer
Early Palliative Care for Patients With Advanced Pancreatic Cancer.
Pancreatic adenocarcinoma is one of the deadliest cancers. Patients with pancreatic cancer experience marked physical suffering, psychological distress and resource-demanding care at the end-of-life.
- Trial name
- EarlyCarePan (NCT04632303)
- Testing
- Early Palliative Care
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Inna Chen, MD
Advanced Pancreatic Cancer
A Study of Mitoxantrone Hydrochloride Liposome Injection in Patients With Advanced Pancreatic Cancer
The purpose of this study is to evaluate the safety, tolerability, and efficacy of mitoxantrone hydrochloride liposome injection in patients with advanced pancreatic cancer.
- Trial name
- NCT05100329
- Testing
- Mitoxantrone Hydrochloride Liposome injection
- Volunteers
- 38 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Cancer of Pancreas
Induction Chemotherapy, FOLFIRINOX Followed With Concurrent Capecitabine and Radiation Therapy in Inoperable Locally Advanced Cancer of the Pancreas
This prospective cohort, phase II, trial is studying induction chemotherapy combination, FOLFIRINOX regimen, consisted of oxaliplatin, irinotecan, leucovorin and fluorouracil (5-FU), for 4 cycles, followed by consolidation…
- Trial name
- NCT02311439
- Testing
- FOLFIRINOX + CRT
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Assiut University
Advanced Cancer
Autologous Cytokine-induced Killer Cells Combined Chemotherapy in Advanced Pancreatic Cancer
The purpose of this study is to determine whether Cytokine induced killer cells combined chemotherapy is more effective in the treatment of advanced Pancreatic Cancer.
- Trial name
- NCT03002831
- Testing
- Cytokine-induced Killer Cells, Tegafur-Gimeracil-Oteracil Potassium
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Henan Cancer Hospital