Clinical trials: Advanced
PRF
The Efficacy of A-PRF+ on Postoperative Outcomes Following Surgical Removal of Impacted Mandibular Third Molars (A-PRF+: Advanced Platelet Rich Fibrin)
Objectives: This study aims to evaluate the effects of A-PRF+ on postoperative pain, swelling, and trismus after surgical removal of impacted mandibular third molars.
- Trial name
- A-PRF+ (NCT05824793)
- Testing
- A-PRF+
- Where
- Vietnam
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Family Members, Cancer
Evaluation of FROM-16 in ATMP Patients & Families
Poor health, and its treatment, has impact beyond the healthcare system into wider society. A person's productivity, taxable earnings, benefit payments and community contribution may all be adversely affected by poor health.
- Trial name
- NCT05141318
- Testing
- FROM-16 Questionnaire, Semi-structured two-part interview
- Where
- 5 sites in United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Swansea University
Myopia, Corneal Crosslinking
Advanced Cross Linking for Low-grade Myopia
To evaluate the improvement in myopic refractive error and the corneal endothelial safety with a corneal crosslinking treatment regimen for mild myopia.
- Trial name
- PiXLO2 (NCT03197272)
- Testing
- PiXL
- Where
- Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Umeå University
Cancer Patients With Cachexia
Evaluation of the Effects of a Mixture of Amino Acids (Amixea) on Lean Body Mass and Muscle Strengh of Patients With Unresectable Advanced Non-small Cell Lung Cancer
The primary objectives of this study are to evaluate the effects of an amino acid mixture (Amixea) on the body composition as assessed by DXA, and on QMVC as assessed by strain gauge, in advanced NSCLC patients, compared to…
- Trial name
- NCT02877966
- Testing
- Amixea
- Where
- 3 sites in Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Helsinn Healthcare SA
Cardiovascular Disease Acute, Emergency Department Patient
Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers
The aim of this study is to assess emergency medicine physician and advanced practice provider (APP) knowledge and technical skill in performance of a point-of-care ultrasound simulation and just-in-time training pathway to…
- Conditions
- Cardiovascular Disease Acute, Emergency Department Patient, Heart Failure Acute, Pulmonary Embolism (Diagnosis)
- Trial name
- NCT07159269
- Testing
- Cardiac point-of-care ultrasound (POCUS) training and clinical pathway
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Duke University
Periodontitis, Adult
Advanced Platelet-rich Fibrin Combined With Open Debridement in Management of Suprabony Periodontal Defects
in this clinical trial, patients with periodontal defects will be treated with advanced platelet-rich fibrin in conjunction with open debridement
- Trial name
- NCT05730153
- Testing
- advanced PRF
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Alzheimer Disease, Lewy Body Dementia (LBD)
The Role of Advanced Electroencephalographic Data as Marker of Pathology and Prognosis in Primary Dementias
The study aims to use advanced brainwave recordings of electroencephalogram (EEG) to understand early signs of Alzheimer's disease (AD) in people with mild memory problems, known as amnestic Mild Cognitive Impairment (MCI).
- Conditions
- Alzheimer Disease, Lewy Body Dementia (LBD), Mild Alzheimer Disease, Frontotemporal Dementia (FTD)
- Trial name
- NCT06826157
- Testing
- Electroencephalogram, 3 Tesla MRI, Apolipoprotein E genetic test
- Where
- Italy
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis, Inflammatory Demyelinating Disease
A Study of Imaging in Demyelinating Diseases
This purpose of this study is research the usefulness of MRI with PET/CT imaging for measuring brain inflammation and its relation to Multiple Sclerosis (MS).
- Trial name
- NCT05805839
- Testing
- C-11 ER176 Radiotracer, C11 Pittsburgh Compound B, PET/CT scan
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nonsquamous Nonsmall Cell Neoplasm of Lung
Evaluate the Safety and Efficacy of BLEX 404 Oral Liquid Combined With Pemetrexed + Cisplatin Therapy
Maitake is reported with immunomodulatory functions against tumor growth in terms of its unique molecular structure, β-glucan polysaccharides within 1, 6 main chain having 1, 3 branches and a 1, 3 main chain having 1, 6 branches…
- Trial name
- NCT05764928
- Testing
- BLEX 404
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rgene Corporation
Athlete Foot
Advanced Footwear Technology in Federated Athletes
Background. Athletics is one of the sports modalities with the greatest growth in the number of federative licenses in our country.
- Trial name
- NCT06919107
- Testing
- Survey of athletes
- Where
- Spain
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
ACP, Nurse's Role
Exploring Advanced Clinical Practitioner's Experience Developing Clinical Competence and Opinions on Role Identity
In the United Kingdom, there is an urgent need to reshape the National Health Service (NHS) workforce to equip it to meet the changing demands of the population it serves and deliver the vision set out in the Next Steps on the…
- Conditions
- ACP, Nurse's Role, Development, Consensus
- Trial name
- NCT04183127
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Self Care, Family Caregivers
Feasibility Study of a Home-based Physical Activity Intervention for Family Caregivers of People With Advanced Cancer
The purpose of this study is to develop an individually tailored home-based physical activity intervention for family caregivers of people with advanced cancer and assess the feasibility of a future randomized controlled trial…
- Trial name
- NCT02211092
- Testing
- Physical activity intervention, Usual care
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Solid Tumor, Solid Tumor, Adult
Psychotherapy Intervention for Latinos With Adv Cancer
The purpose of this study is to adapt a counseling intervention called Meaning Centered Psychotherapy to make it culturally relevant for Latinos. Cancer affects patients and their loved ones.
- Conditions
- Solid Tumor, Solid Tumor, Adult, Solid Tumor, Unspecified, Adult
- Trial name
- NCT04537936
- Testing
- Meaning Centered Psychotherapy for Latinos, Functional Assessment of Cancer Therapy - Spiritual Well-Being Scale, Meaning Centered Psychotherapy for Latinos for Waitlist Control Patients
- Where
- 4 sites in United States, Puerto Rico
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gingival Recession
Mucoderm or Connective Tissue Graft for Treatment of Gingival Recessions
Coronally advanced flap plus connective tissue graft (CTG) is the gold standard therapy for root coverage. The bioabsorbable porcine collagen matrix (CM) has been widely used in periodontal and mucogingival surgery as a…
- Trial name
- NCT03675334
- Testing
- Root coverage with collagen matrix graft, Root coverage with subepithelial connective tissue graft, Basic periodontal treatment
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Non-small Cell Lung Cancer
FMT+Immunotherapy+Chemotherapy As First-line Treatment for Driver-gene Negative Advanced NSCLC
This study plans to reconstruct intestinal microecology through fecal microbiota transplantation (FMT), and combine with standard first-line therapy to enhance the anti-tumor immune effect at the same time, thereby extending the…
- Trial name
- NCT06403111
- Testing
- Fecal Microbiota Transplantation (FMT)+chemotherapy+immunotherapy
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Changzhou No.2 People's Hospital
Pain, Postoperative, Trismus
Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar
In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus…
- Conditions
- Pain, Postoperative, Trismus, Swelling
- Trial name
- NCT03672669
- Testing
- Advanced Platelet Rich Fibrin (A-PRF), Leukocyte- and platelet-rich fibrin (L-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Advanced Squamous Cell Carcinoma, Squamous Cell Carcinoma of Head and Neck
Study of Docetaxel in Combination With Cisplatin and 5-Fluorouracil in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
The purpose of this study is to determine the appropriate dose, that dose which is found to give maximum effect with limited toxicity, of cisplatin in combination with docetaxel and 5-fluorouracil and then to further define the…
- Conditions
- Advanced Squamous Cell Carcinoma, Squamous Cell Carcinoma of Head and Neck, SSCHN
- Trial name
- NCT00139269
- Testing
- Docetaxel, Cisplatin, 5-Fluorouracil
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Knee Discomfort
Influence of Instaflex Advanced Supplement on Joint Function
Joint discomfort is reported by 32% of U.S. adults, and increases with age. The knee is the most common site of joint discomfort regardless of age.
- Trial name
- NCT03041077
- Testing
- Instaflex Advanced
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Hemodynamic Instability, Skin and Subcutaneous Tissue Disorders
Non Invasive Measurement of the Haemodynamic Parameters and of the Advanced Glycation End Products (AGEs) Levels
The aim of this study was to investigate the difference in accumulation of AGEs (advanced glycation end-products) in the tissues of individuals who smoke in comparison with individuals who do not as well as of individuals who…
- Trial name
- NONINVASHEMO (NCT02544165)
- Testing
- caffeine intake, cigarette smoking, Caffeine intake and Cigarette smoking
- Where
- Greece
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Technological Education Institute of Sterea Ellada
Colorectal Adenoma, Colorectal Polyps
Advanced Adenoma Detection With 3D Imaging Device During Colonoscopy
The goal of this clinical trial is to learn if 3-dimensional (3D) imaging device works to identify patients with high risk adenomas during colonoscopy to guide proper follow-up strategy.
- Trial name
- NCT06924489
- Testing
- Colonoscopy after bowel cleansing with 2D imaging device, Colonoscopy after bowel cleansing with 3D imaging device
- Where
- China
- Volunteers
- 1,566 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases