Clinical trials: Adult Cardiac Surgery
Cardiac Surgery, Thoracic Surgery
Heart Lung Machine Registry
The HeaLMe post-market clinical follow-up registry is undertaken to evaluate the safety and performance of the index devices Heart Lung Machine HL 40 and Temperature Probes TPO-D-HLM L1.8 Adult / Pediatric in patients undergoing…
- Conditions
- Cardiac Surgery, Thoracic Surgery, Vascular Surgery, Cardiopulmonary Bypass
- Trial name
- HeaLMe (NCT06159517)
- Where
- 3 sites in Italy, Spain
- Volunteers
- 184 people
- Sponsor
- Maquet Cardiopulmonary GmbH
CAD, Arrhythmia Ventricular
Adding Lidocaine to Custodiol Mixture
The Bretschneider solution, also known as Custodiol, has been widely used in open-heart surgery requiring cardiopulmonary bypass (CPB) since its introduction in 1970.
- Trial name
- NCT07205757
- Testing
- Lidocaine Hydrochloride, Custodiol Solution
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Pain, Acute, Pain, Chronic
Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients
This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial Goal and Questions: The primary goal is to evaluate if a combination of taurine and butyrate can reduce chronic…
- Conditions
- Pain, Acute, Pain, Chronic, Chronic Post Operative Pain
- Trial name
- NCT07144033
- Testing
- Butyrate and Taurine
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
Intensive Care Unit, Coronary Artery Bypass Grafting (CABG)
Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients
The MODIFY CSX study is a prospective, randomized, placebo-controlled trial conducted in heart centers in Germany and Italy. A total of 550 high-risk cardiac surgery patients will receive either 0.20 g fish oil/kg body weight…
- Conditions
- Intensive Care Unit, Coronary Artery Bypass Grafting (CABG), High Risk Patients, Cardiopulmonary Bypass
- Trial name
- MODIFY CSX (NCT06279793)
- Testing
- Fish Oil, Intravenous 0.9% Sodium Chloride
- Where
- 10 sites in Germany
- Volunteers
- 550 people
- Sponsor
- GCP-Service International West GmbH
Cardiac Surgery, Insulin Resistance
Impact of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Adult Cardiac Surgery Patients
The goal of this clinical trial is to investigate the effect of preoperative oral carbohydrate on insulin resistance in adult cardiac surgery patients with a cardiopulmonary bypass machine.
- Trial name
- NCT07212153
- Testing
- Oral Carbohydrate Drink (Maltodextrin)
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Rifdhani Fakhrudin Nur
Spinal Anesthesia
Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Adult Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia
Patients undergoing lower extremity surgery with spinal anesthesia are often sedated to reduce patient discomfort due to large noises during surgery and also to reduce anxiety.
- Trial name
- NCT03322150
- Testing
- Atropine, Glycopyrrolate
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Yonsei University
Anesthesia
Effect of Nebulized Milrinone on Right Ventricular Hemodynamics in Adult Cardiac Surgery
The primary aim of this study was to investigate the effect inhaled milrinone given before CPB on improving the right ventricular function measured by transesophageal echocardiography (TEE) at time of CPB separation.
- Trial name
- NCT05132153
- Testing
- Milrinone, Normal saline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Endocrine System Diseases, Cardiac Surgery
Endocrine Changes in Adults Undergoing Cardiac Surgery
In this prospective study the investigators want to measure the serum level changes of the thyroid hormones (thyroid-stimulating hormone, reverse triiodothyronine, serum free T4), brain natriuretic peptide (BNP), testosterone and…
- Conditions
- Endocrine System Diseases, Cardiac Surgery, Quality of Life, Psychology, Social
- Trial name
- NCT03736499
- Where
- 3 sites in Hungary
- Volunteers
- 500 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Postoperative Pain, Cardiac Surgery
Efficacy of Serratus Posterior Superior Intercostal Plane Block on Post-operative Pain in Cardiac Surgery.
Cardiac surgery, particularly procedures involving median sternotomy, is associated with significant postoperative pain. Acute postoperative pain is severe in cardiac patients undergoing sternotomy, and pain intensity is more…
- Trial name
- NCT07175298
- Testing
- conventional opioid-based technique, SPSIPB Group
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Dyspnea, Cardiopulmonary Dysfunction
Effect of Different Breathing Techniques on Dyspnea and Cardiopulmonary Parameters Among Patients After Open Heart Surgery
Open heart surgery is often associated with postoperative pulmonary complications, reduced lung expansion, dyspnea, and impaired cardiopulmonary function.
- Conditions
- Dyspnea, Cardiopulmonary Dysfunction, Postoperative Respiratory Dysfunction, Coronary Artery Disease
- Trial name
- NCT07591987
- Testing
- Segmental Breathing Exercises, Active Cycle Breathing Technique, Standard postoperative care
- Where
- 3 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
Pain, Post Operative
Pectointercostal Fascial Plane Block Versus Transversus Thoracic Plane Block In Adult Cardiac Surgery Patients
The study will be designed to compare the analgesic effect of ultrasound-guided pectointercostal fascial plane block versus tansversus thoracic plane block in adult cardiac surgery.
- Trial name
- NCT05323305
- Testing
- ultrasound guided regional block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Adult Cardiac Surgery
Assessment of the Force Frequency Relationship of the Myocardium After On-pump CABG Surgery
The aim of the study is to determine whether increasing the heart rate by epicardial atrial pacing after surgery improves the contractile force of the myocardium.
- Trial name
- NCT02407574
- Testing
- External Pacing Box
- Volunteers
- 20 people
- Sponsor
- University of Liege
Platelet Aggregation, Blood Transfusion
Validation of a Red Blood Cell Transfusion Prediction Model in a Low Transfusion Rate Population.
The transfusion risk and clinical knowledge (TRACK) allogeneic blood transfusion prediction model was developed more than ten years ago and demonstrated good discriminative ability in patients with increased risk for allogeneic…
- Trial name
- TRACK-TCT (NCT05581238)
- Testing
- TRACK-TCT
- Where
- Netherlands
- Volunteers
- 6,428 people, healthy volunteers welcome
- Sponsor
- Medisch Spectrum Twente
Surgical Site Infection After Major Surgery, Surgical Site Infections
Assessing the Effect of the Silver Dressing on Surgical Site Infections in Adult Patients Post Cardiac Surgery: a Single Center Randomized Control Trial
RCT on post-cardiac surgery patients using silver dressings vs. standard care. Conducted in ICU, CCU, telemetry units. Outcomes assessed via checklist \& modified Parsonnet Score.
- Trial name
- NCT07008040
- Testing
- Silver dressing
- Where
- Saudi Arabia
- Volunteers
- 145 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Surgical Site Infection
24 Vs 48 Hours of Cefazolin or Cefuroxime as Prophylaxis
A randomized control trial studying the effect of prophylactic antibiotics to reduce surgical site infections following cardiac surgery in adults using 1st generation cephalosporin (Cefazolin) or 2nd generation cephalosporin…
- Trial name
- NCT04303390
- Testing
- Cefuroxime, Cefazolin, 24 hours
- Where
- Saudi Arabia
- Volunteers
- 568 people
- Sponsor
- Saud Al Babtain Cardiac Center
Frailty, Resilience
Older Adults' Recovery Dynamics After Cardiac Surgery
Population aging has increased the number of older adults exposed to interventions with high physiological demand, which are associated with frequent adverse outcomes such as delirium, organ dysfunction, and delayed functional…
- Conditions
- Frailty, Resilience, Cardiac Surgery Recovery
- Trial name
- ODYSSEY (NCT07793708)
- Where
- Chile
- Volunteers
- 75 people
- Sponsor
- University of Chile
Enhanced Recovery, Prehabilitation
Prehabilitation in Adult Patients Following Selective Cardiac Surgery: A Randomized Controlled Trial
Aim: To determine the impact of an evidence-based comprehensive prehabilitation (EBCPrehab) program on pre- and postoperative capacity, functional capacity and health related quality of life (HRQoL) in patients awaiting elective…
- Conditions
- Enhanced Recovery, Prehabilitation, Cardiac Surgery
- Trial name
- NCT05503004
- Testing
- Prehabilitation, Standard care
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Myocardial Ischemia, Coronary Arteriosclerosis
Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery
The purpose of this study is to determine if the study drug (TP10), which blocks complement release, can reduce such side effects of complement inflammation as chest pain or heart attacks and be taken safely in women who undergo…
- Conditions
- Myocardial Ischemia, Coronary Arteriosclerosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- NCT00082121
- Testing
- TP10
- Where
- 18 sites in United States
- Volunteers
- 300 people
- Sponsor
- Avant Immunotherapeutics
Coronary Artery Disease, Mitral Valve Insufficiency
The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery
Abstract Anaesthetic support for cardiac surgery significantly influences the course of the intraoperative period and the success of the postoperative period.
- Conditions
- Coronary Artery Disease, Mitral Valve Insufficiency, Aortic Valve Insufficiency
- Trial name
- NCT05695287
- Testing
- Propofol, Isoflurane, Sevoflurane
- Where
- Kazakhstan
- Volunteers
- 89 people
- Sponsor
- Astana Medical University
Acute Kidney Injury Following Cardiac Surgery
A Multi-center Study to Evaluate the Safety, Tolerability and Efficacy of TIN816 in Patients at Risk for Acute Kidney Injury Following Cardiac Surgery.
This was a randomized, multi-centric, placebo-controlled, participant and investigator-blinded study to evaluate the safety, tolerability and efficacy of TIN816 in adult patients at risk for acute kidney injury following cardiac…
- Trial name
- NCT05524051
- Testing
- TIN816
- Where
- 37 sites in United States, Argentina and 13 more
- Volunteers
- 102 people
- Sponsor
- Novartis Pharmaceuticals