Clinical trials: Adipose Tissue
Fasting, Non-alcoholic Fatty Liver Disease (NAFLD)
Regulation of FGF21 by Nutritional Challenges
The purpose of this study is to examine how acute nutritional challenges affect levels of several proteins involved in metabolism. These proteins will be measured in blood and fat tissue. This study will have several aims.
- Trial name
- NCT00968747
- Testing
- Fasting, Diet, oral carbohydrate challenge
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Multiple Sclerosis
Outcomes Data of Adipose Stem Cells to Treat Multiple Sclerosis
The purpose of this study is to determine the impact that treatment with a cellular concentrate derived from an individual's own fat, known as the stromal vascular fraction (SVF), has on the quality of life of people with…
- Trial name
- NCT02157064
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- StemGenex
Lipid Metabolism Disorders, Metabolic Disease
Study of White Adipose Tissue Remodeling by Cryolipolysis in Humans
The sample will comprise 12 adult women (aged 18 to 40 years) and overweight (BMI> 24.9 kg / m² and <30.0 kg / m²). The experimental design will consist of four assessments.
- Trial name
- NCT04819321
- Testing
- CoolSculpting® System
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Osteoarthritis, Knee
A Phase 2b/3a Study to Evaluate the Efficacy and Safety of JointStem in Patients Diagnosed as Knee Osteoarthritis
This study is a double-blind, randomized, placebo controlled, multi-center, superiority study to evaluate the efficacy and safety of JointStem, autologous adipose tissue derived mesenchymal stem cells (AdMSC), in patients…
- Trial name
- NCT04368806
- Testing
- JointStem
- Where
- 9 sites in United States, South Korea
- Volunteers
- 173 people
- Sponsor
- Nature Cell Co. Ltd.
Type1diabetes
Brown Adipose Tissue in Type 1 Diabetes
Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type…
- Trial name
- NCT02984514
- Testing
- Positron emission tomography with tracer 18F-deoxy glucose
- Where
- Sweden
- Volunteers
- 11 people
- Sponsor
- Per-Ola Carlsson
Lipoma
Evaluating the Efficacy and Safety of Embella (Deoxycholic Acid, Produced by Espad Pharmed Co.) Injection in the Management of Superficial Lipomas
Lipoma is a relatively common, slow-growing mesenchymal neoplasm originating from adipose tissue. Patients seek treatment for lipomas for various reasons, such as concerns about their growth and spread, aesthetic issues, or…
- Trial name
- NCT07014163
- Testing
- Embella (Deoxycholic acid, produced by Espad Pharmed Co.)
- Where
- 2 sites in Iran
- Volunteers
- 10 people
- Sponsor
- Espad Pharmed
Knee Osteoarthritis
Treatment of Knee Osteoarthritis With Autologous Adipose-derived Mesenchymal Stem Cells
The purpose of this study is to explore the efficacy and safety of autologous adipose-derived mesenchymal stem cells (AMSCs) plus autologous platelet rich plasma (PRP) in the treatment of severe knee osteoarthritis.
- Trial name
- NCT04212728
- Testing
- Auotologous AMSCs plus autologous PRP, Auotologous PRP
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yantai Yuhuangding Hospital
D017202
ADR-002K for Patients With Ischemic Cardiomyopathy Who Undergo Coronary Artery Bypass Surgery
Ischemic cardiomyopathy undergoing coronary artery bypass surgery
- Trial name
- NCT04695522
- Testing
- ADR-002K administration
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Osaka University
Healthy
Circadian Brown Adipose Tissue Metabolism
Brown adipose tissue is poorly understood fat that can metabolize glucose in order to generate heat. Since activated brown fat has a high metabolic rate, it is of great interest as a potential target to combat obesity.
- Trial name
- NCT02285270
- Testing
- FDG PET/CT
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Inclusion Body Myositis
Cell Therapy for IBM by Muscle Injection of ADSVF
Inclusion Body Myositis is a slowly but disabling myopathy, the most frequent in patients over 50 years old. No treatments (in particular immunosuppressive) are known to be efficient.
- Trial name
- ADSVF-in-IBM (NCT05032131)
- Testing
- ADSVF
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections
HIV Fat Redistribution and the Evaluation of Brown Fat
The specific aims of this study are to determine whether HIV-infected patients with significant fat redistribution and ectopic fat accumulation have increased brown adipose tissue using 18F-FDG Positron Emission Tomography…
- Trial name
- NCT01098045
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypertension, Blood Pressure
Focused Power Ultrasound Mediated Inferior Perirenal Adipose Tissue Modification Therapy for Essential Hypertension
This randomized, double blinded, sham-control trial aims to evaluate the efficacy and safety of a novel focused power ultrasound mediated inferior perirenal adipose tissue modification therapy for essential hypertension.
- Conditions
- Hypertension, Blood Pressure, Cardiovascular Diseases
- Trial name
- PARADISE-HTN (NCT05049096)
- Testing
- focused power ultrasound mediate inferior perirenal adipose tussue modification
- Where
- 3 sites in China
- Volunteers
- 103 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Lipoma, Branchial Cleft Anomalies
Radiological Diagnosis of Pediatric Neck Swellings
Various diagnostic imaging modalities have been utilized in the assessment of pediatric neck lesions, including gray-scale and Doppler ultrasonography, conventional and three-dimensional computed tomography (CT), magnetic…
- Conditions
- Lipoma, Branchial Cleft Anomalies, Cystic Hygroma (Macro-cystic Lymphatic Malformation), Rhabdomyosarcoma
- Trial name
- NCT07734805
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Obesity
Integrating Quantitative Energetics Determines the Microbiome's Contribution to Energy Balance
We propose to study the role of the gut microbiome in the development of obesity, and whether we can change the microbiome's contribution to host energy balance through diet.
- Trial name
- NCT02939703
- Testing
- Diet
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Atrial Fibrillation (AF), Obesity (Disorder)
Improving Outcomes After AF Ablation in Obese Patients
Improving Outcomes After AF Ablation in Obese Patients
- Trial name
- OBESE-AF (NCT07618741)
- Testing
- Cardiac Rehabilitation and Lifestyle Modification, Usual Care
- Where
- Taiwan
- Volunteers
- 520 people
- Sponsor
- National Taiwan University Hospital
Obesity, Aging
Obesity, Inflammation and Aging: Effects of Physical Exercise and Omega-3 Fatty Acids.
Dysfunction of adipose tissue in obesity, inflammation and aging: mechanisms and effects of physical exercise and omega-3 fatty acids.
- Conditions
- Obesity, Aging, Inflammation
- Trial name
- OBELEX (NCT03300388)
- Testing
- Omega-3 (DHA-rich dietary supplement), Resistance training
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Erectile Dysfunction, Impotence, Vasculogenic
Effectiveness and Safety of Adipose-Derived Regenerative Cells for Treatment of Erectile Dysfunction
Autologous adipose-derived regenerative cells (ADRC) extracted using Celution 800/CRS System (Cytori Therapeutics Inc) from a portion of the fat harvested from the patient's front abdominal wall.
- Trial name
- NCT02472431
- Testing
- Intracavernosal administration of autologous ADRC, Liposuction, ADRC isolation
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Myxoid Liposarcoma, Round Cell Liposarcoma
Immune Changes Following Trabectedin in Patients With Metastatic or Unresectable Sarcoma
This research trial studies the immune changes following trabectedin in patients with sarcoma that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable).
- Conditions
- Myxoid Liposarcoma, Round Cell Liposarcoma, Stage III Soft Tissue Sarcoma AJCC v7, Stage IV Soft Tissue Sarcoma AJCC v7
- Trial name
- NCT03397186
- Testing
- Biopsy, Laboratory Biomarker Analysis, Trabectedin
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Gynecomastia, Male Breast Enlargement
UltraShape Device for Non-Invasive Fat Reduction in the Male Breast (Pseudogynecomastia)
Male volunteers who suffer from Pseudogynecomastia and seek noninvasive breast fat reduction will be enrolled into two arms to receive three biweekly UltraShape treatments.
- Trial name
- NCT02711605
- Testing
- UltraShape focused ultrasound device
- Volunteers
- healthy volunteers welcome
- Sponsor
- Syneron Medical
Obesity, Type 2 Diabetes
Maternal Adipose Tissue and Placental Dysfunction Programs the Fetus for Type 2 Diabetes (PlacentA-DM)
The purpose of this study is to discover the characteristics of pregnant women which increases risk for their babies to develop diabetes, later on in life.
- Trial name
- PlacentA-DM (NCT02211651)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute